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Event or Presentation Name Here
Event or Presentation Name Here

... Prognosis of Drug Shortage The condition is serious caused by multiple factors the greatest of which is economic. Low profitability on generic manufactured drugs will to discourage production. Pressure or enticement to ensure adequate drug supply is necessary ...
5-FU - DavisPlus - FA Davis Company
5-FU - DavisPlus - FA Davis Company

Chapter 4 Mendelian Inheritance
Chapter 4 Mendelian Inheritance

... usually contribute to oocytes and therefore these traits are always passed from mothers only. Linked genes are transmitted on the same chromosome. Mendel's second law applies to genes transmitted on different chromosomes. ...
2. ITMATHealthCare IndustryEconomics10-20
2. ITMATHealthCare IndustryEconomics10-20

... – Focus on understanding “pathways”, not individual proteins ...
completed enrolment of half the patients required for phase IIb RA
completed enrolment of half the patients required for phase IIb RA

... Prof. Pnina Fishman, CEO of Can-Fite: “We are very pleased with the current rate of enrolling, more than half the patients required for the trials over this period of time, which shows that we are within the expected timelines is a remarkable achievement. This is a significant progress in the clinic ...
ZYBAN - Action on Smoking and Health
ZYBAN - Action on Smoking and Health

... patients. Since its marketing at least 419,000 patients are estimated to have used Zyban. We have received over 5,000 Yellow Card reports, of which 126 were reports of seizures (in approximately 50% of these the patients had predisposing factors for seizure). ...
Drug Metabolism and the Liver
Drug Metabolism and the Liver

... / or hydrolysis Following Phase Ⅰ,the drug may be activated, unchanged, or most often, inactivated ...
2015-04
2015-04

... We report on a patient with a recognizable phenotype of intellectual disability, multiple congenital anomalies, musculoskeletal anomalies and craniofacial dysmorphisms, carrying a de novo 0.4 Mb duplication of chromosome region 16p13.3 detected by SNP-array analysis. In addition, myopia, microcephal ...
Summary The Food and Drug Administration
Summary The Food and Drug Administration

... for new drug and biologic license applications, for drugs and biologics that have already been approved, and for supplemental applications seeking approval of a new indication for use of the drug if the REMS is necessary to ensure that the drug’s benefits outweigh its risks. The only mandatory requi ...
adrenergic drugs
adrenergic drugs

Get it on time
Get it on time

... experts • They know the importance of taking meds on time and how to most effectively control their symptoms • Many carry a PSC medication card that lists their meds, dosages and times. • Listen to the patient and carepartner when they say they need their medication – Possess knowledge that may not ...
Allele frequencies
Allele frequencies

... 2. Q =number of dominant/total number of alleles ...
Slide 1
Slide 1

... *Dose-normalized to a 100-mg daily dose. 18. Portenoy RK, Sciberras A, Eliot L, Loewen G, Butler J, Devane J. Steady-state pharmacokinetic comparison of a new, extended-release, once-daily, morphine formulation, AVINZA®, and a twice-daily controlled release morphine formulation in patients with chro ...
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute

... FDA by setting breakpoints and quality control ranges of antimicrobial drugs, thereby saving FDA resources. F. Alan Andersen (President Elect of the NCCLS) presented the NCCLS stakeholder position. Representatives from the FDA and the pharmaceutical industry expressed viewpoints that differed from t ...
Drug Names and Classes
Drug Names and Classes

... drug the sponsor will apply for a proprietary or trademark name. When a drug patent expires, other companies may market the same compound under their own brand name. Remember that a drug can have many brand names, but only one generic (nonproprietary name). ...
Hardy Weinberg Principle
Hardy Weinberg Principle

Why patients don*t adhere
Why patients don*t adhere

... needed, the dose may be increased to 10 mg once daily. Children and adolescents: Should not be used. Contraindications: Urinary retention, severe gastrointestinal condition (including toxic megacolon), myasthenia gravis or narrow-angle glaucoma and in patients at risk for these conditions. Patients ...
Pharmacology (translated questions from the Dutch master) 2012 1
Pharmacology (translated questions from the Dutch master) 2012 1

Harnal® Capsule
Harnal® Capsule

... concomitant use of sildenafil exhibit an α–blocking citrate and other α-blockers activity, the vasodilatory may cause hypotension hypotensive action of accompanied by subjective sildenafil citrate may be symptoms such as dizziness enhanced by concomitant use. ...
Sex Inheritance and Multiple Allele Genetics Test Review
Sex Inheritance and Multiple Allele Genetics Test Review

... 14. Define Barr bodies, who has them and how many 15. Know about calico cats ( genetic key) 16. Male pattern baldness is a _____ trait. 17. Describe the difference between Praderwilli syndrome and Angelman syndrome and what deletion causes both? 18. Describe characteristics of y-linked traits 19. Wh ...
Sheet 4 (slide9)
Sheet 4 (slide9)

... which does not necessarily have a causal relationship with this treatment. (there is no cause effect relationship between the drug and the untoward medical condition). Ex. patient developed a dry cough after initiating treatment of Atenolol. We don’t know if the dry cough is caused by the drug or no ...
plans to overhaul the way prescription medication benefits are
plans to overhaul the way prescription medication benefits are

... B. Pre-approval is an approach used by payers to decide if they are going to pay for a particular medication for a particular patient in a particular instance before the drug is dispensed. C. It is incumbent on the prescribing physician to obtain pre-approval based upon the WCB established formulary ...
lect13a
lect13a

... -5 drug candidates in 5000 that enter preclinical trials reach clinical trials -1 of the 5 is approved for clinical use -40% of candidates pass Phase I trials -50% of those passing Phase I trials pass Phase II trials ...
Risk Lists for Informed Consent
Risk Lists for Informed Consent

Adrenochromes Pink Adrenaline
Adrenochromes Pink Adrenaline

... Adrenochrome is a by product of oxidized adrenaline. Its chemical name is 3-hydroxy-1-methyl-5, 6-indoline -dione. Adrenochrome can refer to two things: a metabolite of endogenous epinephrine or a product of metabolized pharmaceutical epinephrine. This drug is controversial because there are debates ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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