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http://www - TeacherWeb
http://www - TeacherWeb

... would get lucky, as Fleming did in 1928, but most of their efforts were wasted. The odds started to improve in the 1970s and early '80s as researchers used recombinant-DNA technology to mix and match bits and pieces of hereditary material. Suddenly they had a front-row seat from which to watch genes ...
Opioid Prescribing in “Naive” or “Tolerant” Patients
Opioid Prescribing in “Naive” or “Tolerant” Patients

... of a treatment algorithm that included palivizumab, usually for patients with severe disease. Most lacked a comparator group, making it difficult to determine efficacy. In each study, the authors were unable to conclude that palivizumab alone had an effect on clinical outcomes. Drawing from the limi ...
Risks with use of Maraviroc (Selzentry**, UK
Risks with use of Maraviroc (Selzentry**, UK

... The drugs used in this study may have side effects, some of which are listed below. Please note that these lists do not include all the side effects seen with these drugs. These lists include the more serious or common side effects with a known or possible relationship. If you have questions concern ...
Improving medication management in the emergency
Improving medication management in the emergency

... Pharmacy...........……..… Ph........… ...
What is Xolair (omalizumab)
What is Xolair (omalizumab)

... (0.5%)] compared with one of every 500 control volunteers (patients who did not take the drug in studies of asthma and other allergic disorders [5 of 2236 (0.2%)]. A panel of cancer specialists asked to review this information concluded that there was no evidence to suggest that this drug actually c ...
key concepts in acute pain management
key concepts in acute pain management

... – NSAID decreases pain, morphine’s effect unappossed Gain control of acute pain with fast onset, short acting opioid(fentanyl) Add NSAID adjunct early Monitor closely for sedation and respiratory depression after pain is alleviated by any means ...
Drug Awareness Forensic Drug Chemistry
Drug Awareness Forensic Drug Chemistry

... What are Narcotics ? Strictly speaking a Narcotic is a substance which is CNS depressant that has a numbing effect. Some experts use the term as Opiates. Narcotics and Opiates are interchangeable terms. OPIATES : They are derived from opium poppy PAPVER Somniferum. The term also applies to the c ...
Pharmacy Monthly Newsletter
Pharmacy Monthly Newsletter

... Pharmacy—Clinical Sound Bytes: ...
AB_tox_07ho
AB_tox_07ho

... low risk: narrow spectrum agents (e.g. penicillin G) high: e.g. (chloramphenicol, tetracyclines clindamycin) highest: broad spectrum cephalosporins, fluoroquinolones ...
Synthetic Drugs What every parent and caregiver needs to know
Synthetic Drugs What every parent and caregiver needs to know

... intended use Each package can have a unique and potentially more harmful effect than product sold in identical packaging ...
Overall survival data indicates that PledOx® does not
Overall survival data indicates that PledOx® does not

... difference in overall survival was noted between the patients who received PledOx® and those who received placebo. There was also no indication of any difference in survival between the different doses of PledOx® included in the study. It can therefore be concluded that treatment with PledOx® does n ...
milk thistle (milkthis-ul) - DavisPlus
milk thistle (milkthis-ul) - DavisPlus

... GI: Laxative effect, nausea, bloating, anorexia. Misc: Allergic reactions. ...
Chapter 10
Chapter 10

... sources of information Gene expression/activity is affected by context or environment Context is affected by hormones, light, nutrition, etc. ...
DISORDERSKIUTS
DISORDERSKIUTS

... Your dialogue-screenplay/SKIT should do the following: 1. Describe the symptoms of the genetic disorder and teach the audience what it would be like to have the disorder. 2. Explain the causes of the genetic disorder (is it dominant, recessive, sex linked, autosomal?) What chromosome is it on? ...
Word file - SLT by Ellex
Word file - SLT by Ellex

... patients eventually become intolerant to the drugs, which leaves surgery as their only treatment option.” As SLT is an in-office laser treatment, patient compliance is not an issue. And even in the event that patients may eventually need a combination treatment of SLT and drugs, it still means that ...
Drug - respiratorytherapyfiles.net
Drug - respiratorytherapyfiles.net

... • Syllabus and Course Outline • Discuss what Pharmacology is ...
Bio-identical Hormone Therapy: What`s the Harm?
Bio-identical Hormone Therapy: What`s the Harm?

New Psychoactive Substances – DAWG JUNE 2014
New Psychoactive Substances – DAWG JUNE 2014

... For example, use of the term ‘NPS’ allows us to avoid the confusion which currently exists in relation to drugs like mephedrone (meow/m-cat), which was banned by the UK government in April 2010 - but it is still referred to as a ‘legal high’ by some sources (notably the mass media).  Legal highs: u ...
Acute iritis
Acute iritis

... May present with:  Pain, photophobia, unilateral red eye  The inflammation is more pronounced on the sclera adjacent to the cornea  The pupil is small and may be irregular  Inflammatory (pus) cells may settle at the bottom of the anterior chamber forming a collection called a hypopyon ...
Mammals follow Mendel’s laws - University of California
Mammals follow Mendel’s laws - University of California

... adults, to being relatively well even until old age. Increasing numbers of genetic loci have now been identified that can modulate sickle cell disease phenotype, from nucleotide motifs within the beta-globin gene cluster, to genes located on different chromosomes. With recent success of the human ge ...
Pharmacologic Management of the Geriatric Patient
Pharmacologic Management of the Geriatric Patient

... A meta-analysis reviewing data from over 50,000 patients showed that aspirin nonadherence/withdrawal was associated with a three-fold higher risk for major adverse cardiac events. 3 Risk was even greater among patients with coronary stents. Risk was amplified by a factor of 89 in patient who had und ...
Document
Document

... You must consider two factors when choosing an IV catheter: gauge and length. The larger the gauge (the smaller the number), and the shorter the length, the more fluid that can be infused through it. Over-the-needle catheters are the most commonly used IV catheters in the prehospital setting. Cannul ...
Initial Genetic Assessment - Test Code 4010
Initial Genetic Assessment - Test Code 4010

... Traditional Sanger sequencing-based detection of individual mutations can be time-consuming and costly when testing for mutations in large numbers of genes. Next-generation sequencing, on the other hand, allows sequencing of numerous genes simultaneously. Thus, NGS targeted at disease-associated gen ...
Mrs. Deringerʼs Vocabulary for Heredity Unit
Mrs. Deringerʼs Vocabulary for Heredity Unit

... represented by a capital letter when doing Punnett Squares. 6. recessive allele - a variation of a gene that is hidden by a dominant allele. It is represented by a lower case letter when doing Punnett Squares. 7. genes - segments of DNA that carry hereditary information from the parents to the offsp ...
Chapter 3 - Genetics
Chapter 3 - Genetics

... • Chorionic Villus Sampling (CVS) - extract tissue from chorion (membrane surrounding fetus) - 7th/8th week ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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