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Direct-To-Consumer Genetic Testing - GEC-KO
Direct-To-Consumer Genetic Testing - GEC-KO

... combination codeine and acetaminophen after birth for episiotomy pain, however you recall Jane had also had some pharmacogenomic testing (her predicted response to certain medication based on her genotype) ...
Genetic Drift - Ms. Stevens` Class
Genetic Drift - Ms. Stevens` Class

... limited gene pool, and is an example of the founder effect. The mutated genes have been traced back to one couple who came to the area in 1744, and it has now been passed on to their kids, grandkids, great grandchildren, and so on. ...
Idaho Medicaid Drug Utilization Review Program
Idaho Medicaid Drug Utilization Review Program

... cardiovascular risks (including heart attack) of rosiglitazone has been added to the product labeling and patient Medication Guide. This information was first announced by the FDA on September 23, 2010 as part of new restrictions for prescribing and use of this drug. In addition to describing the ca ...
Dr. Sitar's presentation
Dr. Sitar's presentation

... one of which reduces pain. Some people can convert the inactive form to the active form Acetaminophen will not work well for pain caused by inflammation Caffeine will increase the efficacy of OTC drugs sold to treat pain Different drugs have different durations of action ti For persistent pain, drug ...
VIDEO SUMMARIES: GENETIC VARIATION
VIDEO SUMMARIES: GENETIC VARIATION

... the%environment%tend%to%survive%and%produce%offspring% •  Purpose:%to%help%the%survival%of%the%popula4on% •  Chatham%Island%(NZ)%Black%Robin% •  All%from%5%one%female% •  Now%250+% •  No%inbreeding%effects% •  Due%to%small%popula4on%must%have%naturally%selected%for%no%inbreeding% alleles% ...
Genetics Slides
Genetics Slides

... eature=related • OR this url • http://video.pbs.org/video/1525107473/ • (can go to 2:30 to start) ...
Placebo Versus Antidepressant Review: The Emperor`s New Drugs
Placebo Versus Antidepressant Review: The Emperor`s New Drugs

... Health, completed the first comprehensive review of the clinical pharmacology of the two original antidepressant medications, tricyclic antidepressants (named for their chemical structure; how they worked was unknown at the time) and monoamine oxidase inhibitors (named for the enzyme such drugs were ...
4-15-2016 PPT
4-15-2016 PPT

... carbamazepine who is experiencing a small rash that started this morning. You should tell her it will likely go away in a few days. If it doesn’t, then follow up with her physician. • A patient experienced SJS syndrome while on carbamazepine. Switching to oxcarbazepine is likely good treatment optio ...
Stadol Nasal Spray (butorphanol tartrate)
Stadol Nasal Spray (butorphanol tartrate)

... The initial dose sequence outlined above may be repeated in 3-4 hours as required after the second dose of the sequence. For the management of severe pain, an initial dose of 2mg (1 spray in each nostril) may be used in patients who will be able to remain recumbent in the event drowsiness or dizzine ...
The Human Genome
The Human Genome

... circadian rhythm problems • Death due to health complications in 15-20 yrs ...
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File

... What is dopamine??  Dopamine is a neurotransmitter that helps control the brain’s ...
bYTEBoss CNS herbs2
bYTEBoss CNS herbs2

... advice, and doses should not exceed 300 mg/day. ...
Standards for the Safe and Effective Provision of
Standards for the Safe and Effective Provision of

... Compliance packaging is available in various formats including single medication blister cards, multi-medication blister cards, hard packs and strip packaging. Multi-medication compliance packaging offers a safe and effective approach to managing medication therapy by placing different medications i ...
Genetics Quiz Study Guide
Genetics Quiz Study Guide

... 12. What mechanism contributes to variation in a population? 13. What is the difference between chromosomal disorders and genetic disorders? 14. What are dysfunctional genes and missing genes?? 15. What is nondisjunction, what disorders does it cause? 16. Know the genetic disorders from the notes 17 ...
Pharmacokinetic Phase
Pharmacokinetic Phase

... • For a drug to be absorbed and used by the body, it must first pass through various anatomical barriers • For example, an oral dosed drug must first reach the epithelial lining of the stomach or intestine, traverse the lipid membrane barrier of the cells - only then can it be absorbed into the bloo ...
Genetics
Genetics

... the study of traits or genes that are passed from parent to offspring • Each parent gives 1 gene to the child for a total of 2 genes per trait Ex: hair color: B from mom + B from dad BB for child Blood type: A from mom + B from dad AB for child ...
Genetic Evolution Lecture
Genetic Evolution Lecture

... percentage of one allele in a gene pool. For example, 50% of the alleles might have been B’s, but after the change, it might have dropped to 10%. Recall that only GROUPS can evolve, not individuals. If this is true, then genetic evolution can only occur if there is a change in the allele frequency o ...
Factors affecting drug metabolism
Factors affecting drug metabolism

...  Can be defined as the genetic differences in the natural ...
1-Introduction,Nomeclature & ROA(1,2&3)
1-Introduction,Nomeclature & ROA(1,2&3)

... A mode of endocytosis used for extracellular fluids Small particles coming into the cells by forming an invagination The formed vesicles will fuse with lysosymes and the enzymes release their contents The hydrolysis needs energy through ATP but at the end due the usage of energy from engulfed liquid ...
to open the MS Word version of the Quarterly Action Agenda
to open the MS Word version of the Quarterly Action Agenda

... One of the most important ways to prevent medication errors is to learn about problems that have occurred in other organizations and to use that information to prevent similar problems at your practice site. To promote such a process, the following selected items from the April—June 2015 issues of t ...
ironwood and forest announce linaclotide new drug application for
ironwood and forest announce linaclotide new drug application for

... Pharma Inc. for development and commercialization in Japan, Indonesia, Korea, the Philippines, Taiwan, and Thailand. About Irritable B owel S yndrome with C ons tipation (IB S -C ) IBS-C is a chronic functional gastrointestinal disorder characterized by abdominal pain, abdominal discomfort, and blo ...
AJWC New Drug Update 2011
AJWC New Drug Update 2011

... months compared with an observation-only arm (34.8 months versus 25.5 months), according to an FDA statement. ...
OPIOID ANTAGONIST DRUG CLASS Movantik (naloxegol) / Relistor
OPIOID ANTAGONIST DRUG CLASS Movantik (naloxegol) / Relistor

... Movantik and Relistor are opioid receptor antagonists used to treat opioid induced constipation in adult patients. Movantik is indicated for patients with chronic non-cancer pain, while Relistor is indicated for patients with advanced illness who are receiving palliative care. Movantik and Relistor ...
Document
Document

Slides Return to Pedigree Studies Dalton Conley MIP
Slides Return to Pedigree Studies Dalton Conley MIP

... • Typical population based modeling of vGWAS has no way of untangling mean / variation effects ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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