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Profile Documents Logout
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Document
Document

... • Blocking metabolism - re-uptake inhibitors allow the natural molecule (cocaine dopamine; Prozac etc - serotonin) to remain longer at the site of action • May have beneficial or detrimental effects • May also act as an antidote ...
A1979HV72000001
A1979HV72000001

... August 21, 1979 "In 1968 when I was in Japan, Hubby and Throckmorton published a paper on the proportion of different isozymes between two sibling or non-sibling species of Drosophila.1 Looking at the summary of the paper I wondered whether this sort of data would permit any estimate of the number o ...
Cancer-gene data sharing boosted
Cancer-gene data sharing boosted

... useful it becomes for interpreting the results of any individual gene test. Of the thousands of possible variations on the spelling of the DNA bases that make up the BRCA genes, only some will be linked to cancer. If a particular variant is significantly more frequent among those who develop cancer ...
Suboxone/Buprenorphine Agreement
Suboxone/Buprenorphine Agreement

Treatment + research activism in India Challenges and opportunities
Treatment + research activism in India Challenges and opportunities

... US tax credits grants for clinical research cost during development waiver of FDA prescription drug user fees. Additional incentives EC includes the possibility of EMEA fee waivers. Some EU members states provide additional incentives: free scientific advice, exemptions from fees and taxes ...
SMARxT Disposal Program - Drug
SMARxT Disposal Program - Drug

...  Study from 20 water treatment facilities showed medications in the parts-per-trillion range; too small to have human effects  One part per trillion is equal to 1 second in 32,000 years or 1 penny for 10 billion dollars. ...
Antidepressant Overview
Antidepressant Overview

... medications. The second column lists the usual or typical adult dose. The third column lists the usual or typical initial/starting dose. The fourth column lists how drying (anticholinergic) the medication is on a scale of zero to five with zero being a dash and five being five plus signs. Similar ra ...
pharmacokinetics - Dr. Brahmbhatt`s Class Handouts
pharmacokinetics - Dr. Brahmbhatt`s Class Handouts

... • The time elapsed from the time of administration to the time that the peak plasma level is reached is known as the time to peak – Important in making clinical judgments about the use of a drug • From the peak plasma level the concentration declines since the amount of drug being eliminated exceeds ...
QA170_3_Liver_kinetics_and_dynamics_2014_update
QA170_3_Liver_kinetics_and_dynamics_2014_update

... hepatic cell mass due to cirrhosis may lead to a subsequent reduction in drug metabolising enzymes, accumulation of active drug and the potential for an enhanced response and increased adverse effects. If metabolites are also active, this will complicate the picture and it may be impossible to predi ...
False-positive DOA testing results due to prescription
False-positive DOA testing results due to prescription

... pseudoephedrine, ephedrine, or other sympathomimetic amines interfere with screening tests for amphetamines but do not cause positive test results in the gas chromatography/ mass spectrometric, or GC/MS, confirmation, thus pose no serious challenge in drugs-of-abuse (DOA) testing. In contrast, sever ...
National Medicines Information Centre DRUG INTERACTIONS I
National Medicines Information Centre DRUG INTERACTIONS I

... isoforms, resulting in altered drug response.13 Genetic polymorphisms resulting in reduced activity of CYP 2C9 and 2D6 enzymes have been noted in approximately 6% and 10% of Caucasian populations respectively;16,17 this may make the carrier more prone to drug toxicity.16 However, other factors such ...
Early clinical trials of new compounds reported at AACR
Early clinical trials of new compounds reported at AACR

... decrease tumor flow on dynamic contrast-enhanced MRI scans of 25 patients with solid tumors and lymphomas, with 7 achieving stable disease (abstract LB-202). The compound is proceeding into phase Ib/II trials in solid tumors, reported Monica Mita, MD, of the Institute for Drug Development, San Anton ...
L4-Anti-rheumatic dr..
L4-Anti-rheumatic dr..

...  Concurrent therapy with methotrexate decreases the prevalence of human antichimeric antibodies ...
PowerPoint
PowerPoint

... – resistance from (rare) spontaneous mutations (usually result in a change in the drug ...
Mutations
Mutations

... – resistance from (rare) spontaneous mutations (usually result in a change in the drug ...
“Phos” confusion - UF Health Professionals
“Phos” confusion - UF Health Professionals

... without a risk of renal damage. Uric acid levels drop rapidly, which reduces the incidence of tumor lysis syndrome and its associated morbidity (renal failure) and mortality. Hypersensitivity reactions, including anaphylaxis have been reported with rasburicase. Patients with G6PD deficiency may exper ...
Drug Discovery and Development
Drug Discovery and Development

... The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year. It soon became a great succes ...
Fact Sheet on Narcotic Analgesics
Fact Sheet on Narcotic Analgesics

... Morphine- First medicinal plant alkaloid ever isolated. Extracted from opium in 1817, and was used to kill pain on civil war battlefields in the United States. It became known as “Soldiers Disease,” and is a controlled substance in the U.S. Heroin- Chemical acetic anhydride used in producing Diacety ...
8000. pharmacologica..
8000. pharmacologica..

... caregivers. MAOI’s are best prescribed by geriatric psychiatrists with extensive experience with these drugs. Patients who fail a six-week trial with one antidepressant and then fail with a second antidepressant from a different class should be referred for evaluation and further management to a ger ...
(a) Tony Thomas - Critical Care Symposium
(a) Tony Thomas - Critical Care Symposium

... to safe levels and clearly display the drug being infused and use specific bar coding of syringes so that only the correct drug can be infused should on face value improve medication safety. Unfortunately there is a lack of evidence for the effectiveness of these interventions [9]. This lack of evid ...
Arrest Referral - Scottish Drugs Forum
Arrest Referral - Scottish Drugs Forum

... of accessible services including prescribing, housing, health and social services ► Real and Practical ► Full Drug Action Team support ► Police commitment across all levels (commander to turnkey) ► Good reporting on progress. ...
Monitoring (cont`d)
Monitoring (cont`d)

... its passage from the liver into the circulation – A drug given via the oral route may be extensively metabolized by the liver before reaching the systemic circulation (high firstpass effect) – The same drug—given IV— bypasses the liver, preventing the first-pass effect from taking place, and more dr ...
Drug interactions detected using Electronic Care Records
Drug interactions detected using Electronic Care Records

...  Chelation (4)  Lercanidipine (2)  Others include COC, anti-hypertensive, warfarin, tamoxifen ...
Effects of OPRM1, ABCB1 and CYP2D6 single nucleotide
Effects of OPRM1, ABCB1 and CYP2D6 single nucleotide

... 12.5% bradycardia occurred, and evident difference was observed in mutant homozygote when compared with wild-type homozygote and heterozygote (all P<0.05). Conclusion: These findings reveal that OPRM1 All8G, ABCB1 C3435T and CYP2D6*10 gene polymorphisms have negative effects on anesthetic efficacy o ...
Prescribing Pattern of Drugs in the Geriatric Patients in
Prescribing Pattern of Drugs in the Geriatric Patients in

... drug parameters (name of drug, strength, frequency, duration together with starting and ending dates, dosage form and route of administration) were extracted from medical record files using data collection sheet. The patients aging 65 years or more were used in the study. Patient parameters (name, a ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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