• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Chapter 4 Lesson 2 - Jefferson School District
Chapter 4 Lesson 2 - Jefferson School District

... Watkins of the R&B group, TLC. Many people with SCD grow up knowing that this disease could ...
File
File

... Nonrandom mating affects what alleles will be combined within individuals, but does not affect the overall frequencies within a population ...
No End in Sight: The Abuse of Prescription Narcotics
No End in Sight: The Abuse of Prescription Narcotics

... underlying withdrawal were confined to hyper-excitability after the neuroadaptations were disrupted, it now appears that other brain areas that were recruited during the development of dependence are affected as well, and responses by these areas may be just as—or even more important—than the direct ...
vis hysterical - International Research Journal of Pharmacy
vis hysterical - International Research Journal of Pharmacy

... of other persons and elicit attention, sympathy, and nurturance. Current theories about the etiology of conversion emphasize the role of communication. People, who have difficulty in verbally articulating psychosocial distress for any reason, may use conversion symptoms as a way of communicating the ...
Document printed from TOXBASE® 28
Document printed from TOXBASE® 28

... Severe opiate toxicity produces depression of the respiratory and central nervous systems and pin-point pupils. If untreated the depression of the level of consciousness can lead to deep coma, convulsions and respiratory arrest. The effects in overdosage will be potentiated by simultaneous ingestion ...
lecture26_Polymorphi..
lecture26_Polymorphi..

... Edwards AW. 2003. Human genetic diversity: Lewontin's fallacy. Bioessays 25: 798-801 even if the probability of misclassifying an individual’s race based on a single locus is as high as 30%, the misclassification probability based on 10 loci can drop to a few percent ...
15000 individuals - Terri L. Weaver, Ph.D.
15000 individuals - Terri L. Weaver, Ph.D.

... or neurocognitive performance that are hypothesized to be closer to the biology represented by the actions of risk genes than the observable manifestations of psychopathology, i.e., psychiatric symptoms  What does this mean? ...
a review on drug approval process for us, europe and india
a review on drug approval process for us, europe and india

... Developing a new drug requires great amount of research work in chemistry, manufacturing, controls, preclinical science and clinical trials. Drug reviewers in regulatory agencies around the world bear the responsibility of evaluating whether the research data support the safety, effectiveness and qu ...
211 Aerosolized Robinul
211 Aerosolized Robinul

... that are commonly associated with atropine.1 Studies that have investigated the bronchodilatory effects of Robinul, in both acute and stable asthma, have found it to be as effective as atropine or Metaproterenol, but without the systemic side effects of either drug.5 , 6 Indications The traditional ...
Document
Document

... Some parts of the sequence of an organism appear highly stable, while others show variation. A variation that is prevalent enough to occur in at least 1% of a population (not necessarily the human race as a whole) is called a polymorphism. The polymorphisms that have been most widely studied are sin ...
File
File

... increasing rate of elimination balances the amount administered over the dose interval  Plasma concentration plateaus and fluctuates about an average steady state level ...
Joint COPD Guidelines
Joint COPD Guidelines

... – consider adding theophylline if still symptomatic Offer pulmonary rehabilitation to all suitable people Refer patients who are breathless, have a single large bulla on a CT scan and an FEV1 less than 50% predicted for consideration of bullectomy Refer people with severe COPD for consideration of l ...
Drug use Evaluation - Home - KSU Faculty Member websites
Drug use Evaluation - Home - KSU Faculty Member websites

... care that require more detailed assessment in order to identify the cause. E.g. patient discharged on > x number of prescription medications ...
Metabolic stability methods
Metabolic stability methods

... Ibutilide has a relatively large volume of distribution among individual subjects, which is about 11 L/kg. Approximately 40% of the drug is bound with plasma albumin of healthy volunteers in a trial. This is also approximately close to patients with atrial fibrillation and flutter. Metabolism Ibutil ...
microarray_ALL_vs_AM..
microarray_ALL_vs_AM..

... So what? Where do we go from here? Above you saw the use of the microarray to diagnose ALL vs AML. We could already do this prior to the advent of microarrays. So what new information and abilities does the microarray allow? • Diagnosis - We now know all the genes that are differentially expressed b ...
What is the probability that an offspring will have black fur?
What is the probability that an offspring will have black fur?

... dominant a genetic factor that blocks another genetic factor recessive a genetic factor that is hidden by the presence of a dominant factor gene a section of DNA that has information about a specific trait of an organism law of segregation the two factors for each trait segregate or separate from ea ...
SBI 3U Genetics Test Review Sheet
SBI 3U Genetics Test Review Sheet

... inherited  from  her  mother  did  not  carry  the  colour-­‐blindness  allele,  and  she  is  therefore  heterozygous.  Her   husband  also  has  normal  vision,  so  his  X  chromosome  does  not  carry  the  colour-­‐blindness  allele. ...
file (Poison Prevention Outreach Mt. Lebanon High School)
file (Poison Prevention Outreach Mt. Lebanon High School)

... compared to aspirin Less life threatening, typically requiring a massive overdose to be fatal ...
RL 4 Chiral drugs
RL 4 Chiral drugs

... existence of chirality of drug receptor areas and the requirement of chiral specificity on drugs. In order to understand the biological effect of drugs, we have to distinguish the three main phases of their action. The first phase is the initial receptor differentiation phase, where different drugs ...
Chapter 15 Power Point Slides
Chapter 15 Power Point Slides

... (The HGP also set out to map the genomes of other species commonly used in scientific research.)  Mutant genes are the basis of genetic disorders—in humans and other organisms. Mutations were studied and cataloged, providing insight into genome organization (genomic maps). ...
Perphenazine Fact Sheet - The Main Line Center for the Family
Perphenazine Fact Sheet - The Main Line Center for the Family

... such as chlorpromazine and thioridazine, which are low-potency agents, and fluphenazine and Haldol (haloperidol), which are high-potency antipsychotics. Perphenazine is moderately sedating and less likely to lower blood pressure than the lower-potency agents. Perphenazine produces fewer EPS than the ...
7.1 Chromosomes and Phenotype KEY CONCEPT affect the expression of traits.
7.1 Chromosomes and Phenotype KEY CONCEPT affect the expression of traits.

... The chromosomes on which genes are located can affect the expression of traits. ...
Medication Study Guide
Medication Study Guide

... medications using weight based doses. Measuring with spoons or droppers has been shown to be inaccurate. o When tablets must be crushed mix in a small amount of sterile water, beverage, or soft food. Check with pharmacy for compatibility issues. Avoid mixing medication in essential food, like formul ...
Printable Version
Printable Version

... A theory that inherited traits blend from generation to generation. Most of the leading scientists in the 19th century accepted it. However, Gregor Mendel proved that it was not correct. Offspring that are the result of mating between genetically similar kinds of parents--the opposite of hybrid. Uni ...
Treatment of severe drug eruption
Treatment of severe drug eruption

... epidermal necrolysis drug eruption Skin lesions rapidly spread Lesions are macule or purpuric ...
< 1 ... 1008 1009 1010 1011 1012 1013 1014 1015 1016 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report