Protective Effect of Honey and Propolis against Carbon Tetrachloride
... The human body is exposed nowadays to increasing attacks by toxic compounds in polluted air, industrially processed foods, alcohol and drug consumption that increase liver toxicity, leading to more and more severe cases of hepatic disorders (Andritoin et al., 2014). The focus of our interest was to ...
... The human body is exposed nowadays to increasing attacks by toxic compounds in polluted air, industrially processed foods, alcohol and drug consumption that increase liver toxicity, leading to more and more severe cases of hepatic disorders (Andritoin et al., 2014). The focus of our interest was to ...
PIC Chemicals - Rotterdam Convention
... approval of any particular product or company. As it is not possible to include all trade names currently in use, only a number of commonly used and published trade names have been included. Contact the Secretariat for more information: [email protected] ...
... approval of any particular product or company. As it is not possible to include all trade names currently in use, only a number of commonly used and published trade names have been included. Contact the Secretariat for more information: [email protected] ...
Lead di(acetate)
... Some lead salts are already placed on the candidate list of substances of very high concern, on basis of their reprotoxic effects. Inclusion of lead di(acetate) on the candidate list would prevent the risk that lead di(acetate) will be used as an alternative for the lead salts which are already on t ...
... Some lead salts are already placed on the candidate list of substances of very high concern, on basis of their reprotoxic effects. Inclusion of lead di(acetate) on the candidate list would prevent the risk that lead di(acetate) will be used as an alternative for the lead salts which are already on t ...
NEUROBEHAVIORAL PROFILE OF F1 AND F2 GENERATION
... had significantly reduced immobility profiles when compared to the unexposed control group of mice. Many of the tested behaviors under open field test are assigned to dopaminergic neurotransmission in associated brain areas (18-20). It appears that zidovudine exposure leaves significant and perhaps ...
... had significantly reduced immobility profiles when compared to the unexposed control group of mice. Many of the tested behaviors under open field test are assigned to dopaminergic neurotransmission in associated brain areas (18-20). It appears that zidovudine exposure leaves significant and perhaps ...
2 PERFLUOROOCTANOIC ACID (PFOA) IN DRINKING WATER
... that the estimated drinking-water exposures to PFOA are lower than the estimated exposures associated with health effects in both children and adults. Although the margins-of-protection are not as large as those provided by the health advisory, the margins-of-protection are still large enough to in ...
... that the estimated drinking-water exposures to PFOA are lower than the estimated exposures associated with health effects in both children and adults. Although the margins-of-protection are not as large as those provided by the health advisory, the margins-of-protection are still large enough to in ...
downloading
... • Kaminsky presented and gave those present until August 6 to find a solution to the Cache Poisoning problem he had found. • Secrecy around the issue was maintained until July 21 when a “security expert” leaked the flaw. • The temporary solution is known as “source port randomization”. The permanent ...
... • Kaminsky presented and gave those present until August 6 to find a solution to the Cache Poisoning problem he had found. • Secrecy around the issue was maintained until July 21 when a “security expert” leaked the flaw. • The temporary solution is known as “source port randomization”. The permanent ...
WayneBryden (95
... School of Animal Studies, University of Queensland, Gatton, QLD 4343 Australia Mycotoxins are secondary fungal metabolites that can be produced in crops and other food commodities both pre- and post-harvest. When ingested, mycotoxins may cause a mycotoxicosis which can result in an acute or chronic ...
... School of Animal Studies, University of Queensland, Gatton, QLD 4343 Australia Mycotoxins are secondary fungal metabolites that can be produced in crops and other food commodities both pre- and post-harvest. When ingested, mycotoxins may cause a mycotoxicosis which can result in an acute or chronic ...
Deliverable 4.2 - Guidelines for appropriate “biomarker of exposure
... “biomarker of exposure” selection for EWAS studies WP4 Human Biomonitoring Version number 1 (January 2015) ...
... “biomarker of exposure” selection for EWAS studies WP4 Human Biomonitoring Version number 1 (January 2015) ...
Non-Cancer Risk Assessment for Nickel Compounds: Issues
... individual (rather than group) basis; differences between individual- and group-based biological significance in the definition of benchmark response (BMR) levels are elucidated. In particular, it is shown that BMDs defined using group-based BMRs may be more like LOAELs than NOAELs. Application of c ...
... individual (rather than group) basis; differences between individual- and group-based biological significance in the definition of benchmark response (BMR) levels are elucidated. In particular, it is shown that BMDs defined using group-based BMRs may be more like LOAELs than NOAELs. Application of c ...
NA/320 - NICNAS
... 28 days under the test conditions and could be classed as readily biodegraded. However, while unsaturated fatty acids are more susceptible to oxidation than saturated fatty acids and are expected to undergo addition reactions at their double bonds, biodegradation would be expected to proceed more sl ...
... 28 days under the test conditions and could be classed as readily biodegraded. However, while unsaturated fatty acids are more susceptible to oxidation than saturated fatty acids and are expected to undergo addition reactions at their double bonds, biodegradation would be expected to proceed more sl ...
9. evaluation of toxicological data
... However, it was also estimated that around 10% of the chemical (23 kg/day, or annually a maximum of 8.4 tonnes) would remain in the process water from the paper manufacturing stages and this would be mixed with other effluent streams and treated at an on site waste water treatment facility before be ...
... However, it was also estimated that around 10% of the chemical (23 kg/day, or annually a maximum of 8.4 tonnes) would remain in the process water from the paper manufacturing stages and this would be mixed with other effluent streams and treated at an on site waste water treatment facility before be ...
Annex XV report PROPOSAL FOR IDENTIFICATION OF A
... that adverse health effects of the respiratory sensitiser Hexahydromethylphthalic anhydride (MHHPA) are irreversible because the induction phase of an allergy is irreversible. Since the development of allergic skin reactions occur according to the same principles as allergic lung reactions, the skin ...
... that adverse health effects of the respiratory sensitiser Hexahydromethylphthalic anhydride (MHHPA) are irreversible because the induction phase of an allergy is irreversible. Since the development of allergic skin reactions occur according to the same principles as allergic lung reactions, the skin ...
EFFECTS OF ACUTE COMBINED INHALATION EXPOSURE TO n
... The pain sensitivity measured as latency of the paw-lick response was changed in rats exposed to n-butyl alcohol, n-butyl acetate and their (1:1) mixture. The changes were concentration-dependent (Fig. 2). Both solvents and their m ixture decrease sensitivity to the pain. Effect of n-butyl acetate w ...
... The pain sensitivity measured as latency of the paw-lick response was changed in rats exposed to n-butyl alcohol, n-butyl acetate and their (1:1) mixture. The changes were concentration-dependent (Fig. 2). Both solvents and their m ixture decrease sensitivity to the pain. Effect of n-butyl acetate w ...
Invertebrate Alternatives for Toxicity Testing: Hydra Stakes its
... 1998). Around 80-100 pharmaceutical chemicals and their metabolites have been measured in both effluent and surface waters in several countries (Fent et al., 2006). Exposure of the public to inadequately tested drugs or environmental agents has resulted in several notable disasters. These include se ...
... 1998). Around 80-100 pharmaceutical chemicals and their metabolites have been measured in both effluent and surface waters in several countries (Fent et al., 2006). Exposure of the public to inadequately tested drugs or environmental agents has resulted in several notable disasters. These include se ...
To whom correspondence may be addressed
... also likely to have different characteristics and in particular different complexation capacities, compared to fluvial material [28, 29]. Thus, data on copper speciation and DOM concentrations and complexation capacity are necessary for the development of a marine version of the BLM. Furthermore, so ...
... also likely to have different characteristics and in particular different complexation capacities, compared to fluvial material [28, 29]. Thus, data on copper speciation and DOM concentrations and complexation capacity are necessary for the development of a marine version of the BLM. Furthermore, so ...
Glyphosate and Cancer
... • Monsanto found guilty of false/misleading advertising by NY State AG in 1996 and 1998 – “Practically non-toxic” – based on amount required to kill rats, nothing to do with human risk – “Biodegrades into natural materials” – persists long enough for substantial human exposure ...
... • Monsanto found guilty of false/misleading advertising by NY State AG in 1996 and 1998 – “Practically non-toxic” – based on amount required to kill rats, nothing to do with human risk – “Biodegrades into natural materials” – persists long enough for substantial human exposure ...
Triclopyr - Oregon State University
... of Triclopyr in Human Volunteers. Hum. Toxicol. 1989, 8 (6), 431-7. 5. Hanley, T. R. Jr., Thompson D. J.; Palmer, A. K.; Beliles, R. P.; Schwetz, B. A. Teratology and Reproduction Studies with Triclopyr in the Rat and Rabbit. Fundam. Appl. Toxicol.. 1984, 4 (5 Oct), 872-82. 6. Timchalk, C.; Nolan, R ...
... of Triclopyr in Human Volunteers. Hum. Toxicol. 1989, 8 (6), 431-7. 5. Hanley, T. R. Jr., Thompson D. J.; Palmer, A. K.; Beliles, R. P.; Schwetz, B. A. Teratology and Reproduction Studies with Triclopyr in the Rat and Rabbit. Fundam. Appl. Toxicol.. 1984, 4 (5 Oct), 872-82. 6. Timchalk, C.; Nolan, R ...
Lead neurotoxicity in children: basic mechanisms and clinical
... 10 mg/dl, which is equivalent to 0.48 mM.] Exposure to low to moderate levels of lead during development (0±21 days), resulting in blood lead levels of 19±60 mg/dl at 21 days of age, produced selective loss of rod and bipolar cells, the dying cells exhibiting signs of apoptosis. Similar results were ...
... 10 mg/dl, which is equivalent to 0.48 mM.] Exposure to low to moderate levels of lead during development (0±21 days), resulting in blood lead levels of 19±60 mg/dl at 21 days of age, produced selective loss of rod and bipolar cells, the dying cells exhibiting signs of apoptosis. Similar results were ...
Synthesis and Pharmacological Screening of novel 1,5
... cardiac tissue compared to hepatic and other tissues. Exposure for 14-21 days has resulted in significant increase in serum AST. As the transaminase is an intracellular enzyme, the increase could be due to cellular damage in the cardiac tissue releasing this enzyme. Coadministration of hydroalcoholi ...
... cardiac tissue compared to hepatic and other tissues. Exposure for 14-21 days has resulted in significant increase in serum AST. As the transaminase is an intracellular enzyme, the increase could be due to cellular damage in the cardiac tissue releasing this enzyme. Coadministration of hydroalcoholi ...
full public report daran sl143
... toxic characteristics as they are not transported readily across biological membranes. Any environmental effects will be physical rather than chemical, eg deposition of polymer particles. However, as the polymer will be transported away from the point of discharge until dehydrochlorination destroys ...
... toxic characteristics as they are not transported readily across biological membranes. Any environmental effects will be physical rather than chemical, eg deposition of polymer particles. However, as the polymer will be transported away from the point of discharge until dehydrochlorination destroys ...
A Close Look at "Multiple Chemical Sensitivity"
... In 1985, the ad hoc Committee on Environmental Hypersensitivity Disorders of the Ontario Ministry of Health consulted proponents and reviewed their literature with the hope of defining “environmental hypersensitivity.” Although skeptical of clinical ecology’s tenets, the committee developed this “wo ...
... In 1985, the ad hoc Committee on Environmental Hypersensitivity Disorders of the Ontario Ministry of Health consulted proponents and reviewed their literature with the hope of defining “environmental hypersensitivity.” Although skeptical of clinical ecology’s tenets, the committee developed this “wo ...
TOX/2013/02 - Committee on Toxicity
... under realistic conditions, phenylalanine plasma levels would not exceed 240 µM in normal or PKU heterozygous individuals. This was considerably below the concentrations at which adverse effects in the fetus are reported and is also below the current clinical guideline (360 µM) for prevention of eff ...
... under realistic conditions, phenylalanine plasma levels would not exceed 240 µM in normal or PKU heterozygous individuals. This was considerably below the concentrations at which adverse effects in the fetus are reported and is also below the current clinical guideline (360 µM) for prevention of eff ...
Summary Aluminium And Aluminium Compounds
... cognitive skills and changes in quantitative EEG. In none of these studies, exposure-response relationships could be established. Furthermore, there was frequently co-exposure to compounds that may induce similar effects. Studies in workers in the aluminium production industry demonstrated increased ...
... cognitive skills and changes in quantitative EEG. In none of these studies, exposure-response relationships could be established. Furthermore, there was frequently co-exposure to compounds that may induce similar effects. Studies in workers in the aluminium production industry demonstrated increased ...
Rana ridibunda
... activity as protein synthesis, lipogenesis, or glycogenesis (ELLMAN & GAN 1969) which may be reflected in a higher content of rough endoplasmic reticulum. Sulfhydryl levels therefore represent a measure of the activity potential of cells for maintenance, recovery from damage, or more generally, thei ...
... activity as protein synthesis, lipogenesis, or glycogenesis (ELLMAN & GAN 1969) which may be reflected in a higher content of rough endoplasmic reticulum. Sulfhydryl levels therefore represent a measure of the activity potential of cells for maintenance, recovery from damage, or more generally, thei ...
Organophosphate poisoning
Organophosphate poisoning results from exposure to organophosphates (OPs), which cause the inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine (ACh) in the body. Organophosphate poisoning most commonly results from exposure to insecticides or nerve agents. OPs are one of the most common causes of poisoning worldwide, and are frequently intentionally used in suicides in agrarian areas. There are around 1 million OP poisonings per year with several hundred thousand resulting in fatalities annually.Organophosphates inhibit AChE, causing OP poisoning by phosphorylating the serine hydroxyl residue on AChE, which inactivates AChE. AChE is critical for nerve function, so the irreversible blockage of this enzyme, which causes acetylcholine accumulation, results in muscle overstimulation. This causes disturbances across the cholinergic synapses and can only be reactivated very slowly, if at all. Paraoxonase (PON1) is a key enzyme involved in OP pesticides and has been found to be critical in determining an organism's sensitivity to OP exposure.