Guidance on tiered risk assessment for plant protection products for
... The European Food Safety Authority (EFSA) asked the Panel on Plant Protection Products and their Residues (PPR) to prepare a revision of the Guidance Document on Aquatic Ecotoxicology under Council Directive 91/414/EEC (SANCO/3268/2001 rev.4 (final), 17 October 2002; EC, 2002a). The PPR Panel was th ...
... The European Food Safety Authority (EFSA) asked the Panel on Plant Protection Products and their Residues (PPR) to prepare a revision of the Guidance Document on Aquatic Ecotoxicology under Council Directive 91/414/EEC (SANCO/3268/2001 rev.4 (final), 17 October 2002; EC, 2002a). The PPR Panel was th ...
NANoREG D2.08 TG Document for Environmental Exposure
... 2.4.1. MNM pre-test for aggregation and sedimentation An understanding of the aggregation and settling behaviour of test MNMs in the water phase of aqueous exposure solutions is necessary for all aquatic ecotoxicity studies. This TGD document recommends the implementation of simplified 'pre-study' ...
... 2.4.1. MNM pre-test for aggregation and sedimentation An understanding of the aggregation and settling behaviour of test MNMs in the water phase of aqueous exposure solutions is necessary for all aquatic ecotoxicity studies. This TGD document recommends the implementation of simplified 'pre-study' ...
Toxic Baby Bottles in Canada
... per year and demand for the compound has risen significantly in recent years. Most human exposure to bisphenol A is suspected to be through ingestion. The Government of Canada has recommended an acceptable daily intake for bisphenol A at 25 µg/kg bodyweight/day. The European Food Safety Authority re ...
... per year and demand for the compound has risen significantly in recent years. Most human exposure to bisphenol A is suspected to be through ingestion. The Government of Canada has recommended an acceptable daily intake for bisphenol A at 25 µg/kg bodyweight/day. The European Food Safety Authority re ...
International Journal of Ayurveda and Pharma Research
... generally believed to be safe. But due to its toxicity it causes adverse effect. Calotropis procera consumption are reported to cause blisters, lesions and eruptions when taken by patients for the treatment of joint pains and gastrointestinal problems caries tooth and ocular toxicity. The preparatio ...
... generally believed to be safe. But due to its toxicity it causes adverse effect. Calotropis procera consumption are reported to cause blisters, lesions and eruptions when taken by patients for the treatment of joint pains and gastrointestinal problems caries tooth and ocular toxicity. The preparatio ...
pregnenolone - National Custom Compounding Pharmacy
... throughout the ninth year. This is followed by a progressive rise until adulthood, when adults are found to have pregnenolone levels that are three to four times higher than those found during the first decade of life. Brain concentrations peak at around age thirty and later decrease to 5% of that v ...
... throughout the ninth year. This is followed by a progressive rise until adulthood, when adults are found to have pregnenolone levels that are three to four times higher than those found during the first decade of life. Brain concentrations peak at around age thirty and later decrease to 5% of that v ...
Fluoride Fact on Human Health and Health Problems: A Review
... fluoride alone involved or in addition other factors come in to play too for such outcomes (Table 1). ...
... fluoride alone involved or in addition other factors come in to play too for such outcomes (Table 1). ...
Cumene Report on Carcinogens, Thirteenth Edition
... of methylphenol, ethylphenol, and isopropylphenol were incubated with rat-liver microsomes, reactive quinone methide intermediates were readily formed (Thompson et al. 1995). Studies on Mechanisms of Carcinogenesis The mechanisms by which cumene causes cancer in experimental animals are not known. D ...
... of methylphenol, ethylphenol, and isopropylphenol were incubated with rat-liver microsomes, reactive quinone methide intermediates were readily formed (Thompson et al. 1995). Studies on Mechanisms of Carcinogenesis The mechanisms by which cumene causes cancer in experimental animals are not known. D ...
EURL ECVAM strategy to replace, reduce and refine the use of
... "The methods selected should avoid, as far as possible, death as an end-point due to the severe suffering experienced during the period before death. Where possible, it should be substituted by more humane end-points using clinical signs that determine the impending death, thereby allowing the anima ...
... "The methods selected should avoid, as far as possible, death as an end-point due to the severe suffering experienced during the period before death. Where possible, it should be substituted by more humane end-points using clinical signs that determine the impending death, thereby allowing the anima ...
Unclassified ENV/JM/MONO(2003)15 ENV/JM/MONO
... mutual concern, and work together to respond to international problems. Most of the OECD's work is carried out by more than 200 specialised Committees and subsidiary groups composed of Member country delegates. Observers from several countries with special status at the OECD, and from interested int ...
... mutual concern, and work together to respond to international problems. Most of the OECD's work is carried out by more than 200 specialised Committees and subsidiary groups composed of Member country delegates. Observers from several countries with special status at the OECD, and from interested int ...
(2013) XXX draft COMMISSION RECOMMENDATION of XXXX
... purpose. The Parliament considered that both ‘adverse effect’ and ‘endocrine mode of action’ must be examined and considered in parallel in a comprehensive assessment. The Parliament considers that observed effects should be assumed to be harmful when there is scientific data indicating so. It stres ...
... purpose. The Parliament considered that both ‘adverse effect’ and ‘endocrine mode of action’ must be examined and considered in parallel in a comprehensive assessment. The Parliament considers that observed effects should be assumed to be harmful when there is scientific data indicating so. It stres ...
Workplace Silica Hazards
... • Symptoms include severe shortness of breath, weakness, and weight loss • The onset of symptoms takes longer than in acute silicosis ...
... • Symptoms include severe shortness of breath, weakness, and weight loss • The onset of symptoms takes longer than in acute silicosis ...
Early lactic acidosis after acetaminophen overdose
... combined with lactic acidosis and an indistinct consolidation in the lung. Broad-spectrum antibiotics and goal-directed fluid therapy were initiated. Unexpectedly, the patient regained consciousness within four hours, was extubated and showed a very swift clinical recovery. Lactate concentration nor ...
... combined with lactic acidosis and an indistinct consolidation in the lung. Broad-spectrum antibiotics and goal-directed fluid therapy were initiated. Unexpectedly, the patient regained consciousness within four hours, was extubated and showed a very swift clinical recovery. Lactate concentration nor ...
Level 2 - GreenFacts
... a PCB molecule can be broken down or transformed depends on the number of chlorine atoms it contains and where they are located. PCBs are mainly broken down either by the effect (direct or indirect) of sunlight or by microorganisms. In general, the persistence of PCB congeners increases with the num ...
... a PCB molecule can be broken down or transformed depends on the number of chlorine atoms it contains and where they are located. PCBs are mainly broken down either by the effect (direct or indirect) of sunlight or by microorganisms. In general, the persistence of PCB congeners increases with the num ...
33. Botulinum Toxins
... The surgical care he received was surprisingly good, even when judged by today’s standards. Heydrich’s initial postoperative course was satisfactory, although he was modestly febrile and there was drainage from the wound of entrance. His condition worsened suddenly on the seventh postoperative day a ...
... The surgical care he received was surprisingly good, even when judged by today’s standards. Heydrich’s initial postoperative course was satisfactory, although he was modestly febrile and there was drainage from the wound of entrance. His condition worsened suddenly on the seventh postoperative day a ...
Ozone - Corona Supplies
... and on potential sources of exposure. General advice on precautionary measures, control techniques and legal requirements is given. 2. Ozone, O3, is a toxic gas possessing a distinctive odour and is a normal constituent of the earth’s atmosphere. Ozone is produced deliberately for a variety of indus ...
... and on potential sources of exposure. General advice on precautionary measures, control techniques and legal requirements is given. 2. Ozone, O3, is a toxic gas possessing a distinctive odour and is a normal constituent of the earth’s atmosphere. Ozone is produced deliberately for a variety of indus ...
what you need to know about zinc
... job. A third way zinc can enter your body is through the skin but not much is absorbed through the skin. The most likely source of exposure in those living near hazardous sites is through drinking water containing high levels of zinc. Children living near hazardous sites can theoretically be more at ...
... job. A third way zinc can enter your body is through the skin but not much is absorbed through the skin. The most likely source of exposure in those living near hazardous sites is through drinking water containing high levels of zinc. Children living near hazardous sites can theoretically be more at ...
IPCS Risk Assessment Terminology
... documents and sources, to their respective networks of experts. The list of selected items is provided in Annex 1 to Part 1 of this document, and the list of the source documents is provided in Annex 2. The survey results are summarized in Annex 3. The IPCS/OECD Terminology Planning Working Group an ...
... documents and sources, to their respective networks of experts. The list of selected items is provided in Annex 1 to Part 1 of this document, and the list of the source documents is provided in Annex 2. The survey results are summarized in Annex 3. The IPCS/OECD Terminology Planning Working Group an ...
Arsenic - AEP.com
... plants poses a significant risk to human health. EPA has evaluated the potential health risks of breathing arsenic for people who live near power plants that burn coal and oil. EPA estimates that a person living all his life near one of these plants would have one chance in a million (or less) of de ...
... plants poses a significant risk to human health. EPA has evaluated the potential health risks of breathing arsenic for people who live near power plants that burn coal and oil. EPA estimates that a person living all his life near one of these plants would have one chance in a million (or less) of de ...
6 ALPHABETICAL LIST OF SELECTED GENERIC TERMS IN
... definition provides useful indications on the semantic content of the term. It is defined as a process intended to break up (see etymol. ana+lúein = dissolve) an object of study in its constituent parts, to capture their determinants and to characterize them as accurately as possible and necessary, ...
... definition provides useful indications on the semantic content of the term. It is defined as a process intended to break up (see etymol. ana+lúein = dissolve) an object of study in its constituent parts, to capture their determinants and to characterize them as accurately as possible and necessary, ...
Additivity and Interactions in Ecotoxicity of Pollutant Mixtures: Some
... desensitization, infraadditiveness, subadditivity, negative synergy, etc., have been used. Therefore, there was a need for consistent and clear terminology to describe toxicological interactions; in this regard, EPA [9], Mumtaz and Hertzberg [10], Hertzberg et al. [11], EPA [12], and ATSDR [13] prov ...
... desensitization, infraadditiveness, subadditivity, negative synergy, etc., have been used. Therefore, there was a need for consistent and clear terminology to describe toxicological interactions; in this regard, EPA [9], Mumtaz and Hertzberg [10], Hertzberg et al. [11], EPA [12], and ATSDR [13] prov ...
Chromium
... glucose tolerance, fasting hyperglycemia, glucosuria, elevated percent body fat, decreased lean body mass, maturity-onset diabetes, cardiovascular disease, decreased sperm count, and impaired fertility. Trivalent (Cr [III]) and hexavalent (Cr [VI]) compounds are thought to be the most biologically s ...
... glucose tolerance, fasting hyperglycemia, glucosuria, elevated percent body fat, decreased lean body mass, maturity-onset diabetes, cardiovascular disease, decreased sperm count, and impaired fertility. Trivalent (Cr [III]) and hexavalent (Cr [VI]) compounds are thought to be the most biologically s ...
Glutathione-Related Enzyme Activity in Liver and Kidney of Rats
... 2. Cd group – the animals were administered an aqueous solution of cadmium chloride at the concentration of 50 mg Cd/dm3 as the only drinking fluid; 3. EtOH group – the rats drank redistilled water and received EtOH p.o. in a total dose of 5 g/kg body wt./24 h divided into two equal doses of 2.5 ...
... 2. Cd group – the animals were administered an aqueous solution of cadmium chloride at the concentration of 50 mg Cd/dm3 as the only drinking fluid; 3. EtOH group – the rats drank redistilled water and received EtOH p.o. in a total dose of 5 g/kg body wt./24 h divided into two equal doses of 2.5 ...
1. Part 1: Supplemental hazard information
... 3.1.4.1. Evidence of conformity with the above standards may be certified only by laboratories which conform with European Standards Series EN 45 00015. 3.1.4.2. Specific cases If it seems obvious that packaging is sufficiently safe for children because they cannot get access to the contents without ...
... 3.1.4.1. Evidence of conformity with the above standards may be certified only by laboratories which conform with European Standards Series EN 45 00015. 3.1.4.2. Specific cases If it seems obvious that packaging is sufficiently safe for children because they cannot get access to the contents without ...
Statement of Need and Reasonableness (SONAR) (PDF: 1.05MB/196 pages)
... genetic factors, pre-existing health conditions, age, diet, and a host of other factors. Infants and children are more highly exposed than adults because for their body weight, they drink more than adults. There are also reasons to believe that at certain life stages, such as organ development, peop ...
... genetic factors, pre-existing health conditions, age, diet, and a host of other factors. Infants and children are more highly exposed than adults because for their body weight, they drink more than adults. There are also reasons to believe that at certain life stages, such as organ development, peop ...
Organophosphate poisoning
Organophosphate poisoning results from exposure to organophosphates (OPs), which cause the inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine (ACh) in the body. Organophosphate poisoning most commonly results from exposure to insecticides or nerve agents. OPs are one of the most common causes of poisoning worldwide, and are frequently intentionally used in suicides in agrarian areas. There are around 1 million OP poisonings per year with several hundred thousand resulting in fatalities annually.Organophosphates inhibit AChE, causing OP poisoning by phosphorylating the serine hydroxyl residue on AChE, which inactivates AChE. AChE is critical for nerve function, so the irreversible blockage of this enzyme, which causes acetylcholine accumulation, results in muscle overstimulation. This causes disturbances across the cholinergic synapses and can only be reactivated very slowly, if at all. Paraoxonase (PON1) is a key enzyme involved in OP pesticides and has been found to be critical in determining an organism's sensitivity to OP exposure.