Making sense of genetic variation!
... Population genetics describes variation within and between species There are two major areas of interest: •!Describe degrees of genetic variation within and between individuals and/or population •!infer the evolutionary mechanisms responsible for the origins and maintenance of genetic variation Muta ...
... Population genetics describes variation within and between species There are two major areas of interest: •!Describe degrees of genetic variation within and between individuals and/or population •!infer the evolutionary mechanisms responsible for the origins and maintenance of genetic variation Muta ...
Leukaemia Section del(11)(p12p13) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... Note: Ectopic expression of the LMO2 oncogene due to the removal of a negative regulatory element situated upstream of the LMO2 gene, leading to activation of the proximal LMO2 promoter. In one T-ALL case, this recurrent deletion resulted in a RAG2-LMO2 fusion gene, bringing the LMO2 gene under the ...
... Note: Ectopic expression of the LMO2 oncogene due to the removal of a negative regulatory element situated upstream of the LMO2 gene, leading to activation of the proximal LMO2 promoter. In one T-ALL case, this recurrent deletion resulted in a RAG2-LMO2 fusion gene, bringing the LMO2 gene under the ...
TAN Huarong
... The current researches in this group fall into two major areas: 1. Molecular regulation of differentiation in Streptomyces The development and differentiation is an important research field in modern biology. Streptomyces gradually become the most attractive model system, because of its complex life ...
... The current researches in this group fall into two major areas: 1. Molecular regulation of differentiation in Streptomyces The development and differentiation is an important research field in modern biology. Streptomyces gradually become the most attractive model system, because of its complex life ...
Investigation 1: Identify the Transcriptional Unit
... proteins are required for transcription? How does it work mechanistically? What is/are the products of transcription? (students discuss in pairs, then as a class) Work through the genome browser investigation, then identify where transcription starts and ends for the tra gene. How long is the pre-mR ...
... proteins are required for transcription? How does it work mechanistically? What is/are the products of transcription? (students discuss in pairs, then as a class) Work through the genome browser investigation, then identify where transcription starts and ends for the tra gene. How long is the pre-mR ...
Introduction to the Analysis of Microarray Data
... data points up a bit as you can see on the MA plot before and after normalization. The biological reason to normalize in this case was that one dye because of its chemical stability, not because of the expression of the genes it labels, always gives a higher value than the other dye, introducing an ...
... data points up a bit as you can see on the MA plot before and after normalization. The biological reason to normalize in this case was that one dye because of its chemical stability, not because of the expression of the genes it labels, always gives a higher value than the other dye, introducing an ...
Genome Research 13, 8 - Tel
... Department of Computer Science, Tel-Hai Academic College, Upper Galilee 12210, Israel A new measure for gene prediction in eukaryotes is presented. The measure is based on the Discrete Fourier Transform (DFT) phase at a frequency of 1/3, computed for the four binary sequences for A, T, C, and G. Ana ...
... Department of Computer Science, Tel-Hai Academic College, Upper Galilee 12210, Israel A new measure for gene prediction in eukaryotes is presented. The measure is based on the Discrete Fourier Transform (DFT) phase at a frequency of 1/3, computed for the four binary sequences for A, T, C, and G. Ana ...
module 2: transcription part i
... proteins are required for transcription? How does it work mechanistically? What is/are the products of transcription? (students discuss in pairs, then as a class) Work through the genome browser investigation, then identify where transcription starts and ends for the tra gene. How long is the pre-mR ...
... proteins are required for transcription? How does it work mechanistically? What is/are the products of transcription? (students discuss in pairs, then as a class) Work through the genome browser investigation, then identify where transcription starts and ends for the tra gene. How long is the pre-mR ...
what`s in your genes
... The factors (alleles) segregate (separate) during gamete (sperm & egg) formation Each gamete contains only one factor (allele) from each pair Fertilization gives the offspring two factors for each trait ...
... The factors (alleles) segregate (separate) during gamete (sperm & egg) formation Each gamete contains only one factor (allele) from each pair Fertilization gives the offspring two factors for each trait ...
LECTURE 5: LINKAGE AND GENETIC MAPPING
... working with maize, and Stern, working with Drosophila, showed that recombination depends upon the physical exchange of equal parts between maternal and paternal chromosomes during meiosis. Recombination frequencies for pairs of genes reflect the distances between them along a chromosome. Since gene ...
... working with maize, and Stern, working with Drosophila, showed that recombination depends upon the physical exchange of equal parts between maternal and paternal chromosomes during meiosis. Recombination frequencies for pairs of genes reflect the distances between them along a chromosome. Since gene ...
A molecular probe for Basidiomycota: the spermidine
... Alignment of chimeric genes with their corresponding independent homologs A comparison of the chimeric gene Spe-Sdh nucleotide sequence from the Basidiomycota species reported in databases with the independent Spe and Sdh genes present in species of Ascomycota (S. cerevisiae and Aspergillus fumigatu ...
... Alignment of chimeric genes with their corresponding independent homologs A comparison of the chimeric gene Spe-Sdh nucleotide sequence from the Basidiomycota species reported in databases with the independent Spe and Sdh genes present in species of Ascomycota (S. cerevisiae and Aspergillus fumigatu ...
Population genomics of human gene expression
... sions. Of the 47,294 probes analyzed, 4,829 and 6,482 (10% and 13%, different cell line batch. The RNA labeling, hybridization and normalrespectively) demonstrated heritability greater than 0.2 in CEU and ization were also done independently. The high degree of correlation YRI, respectively, with an ...
... sions. Of the 47,294 probes analyzed, 4,829 and 6,482 (10% and 13%, different cell line batch. The RNA labeling, hybridization and normalrespectively) demonstrated heritability greater than 0.2 in CEU and ization were also done independently. The high degree of correlation YRI, respectively, with an ...
Mycobacterium tuberculosis
... This Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Database was built on October 20, 2010; this build date reflected in the filename Mt-Std_External_20110303.gdb. All date fields internal to the Gene Database (and not usually seen by regular GenMAPP users) have been filled with this ...
... This Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Database was built on October 20, 2010; this build date reflected in the filename Mt-Std_External_20110303.gdb. All date fields internal to the Gene Database (and not usually seen by regular GenMAPP users) have been filled with this ...
tAIg = w
... them to have a threefold difference in translation rate (21.6 and 6.4 codons per second, respectively). Remarkably, the wi of these codons, which is based on the tRNA pool and affinity of codon-anti-codon coupling and is the basis for the tAI calculation, captures the ratio of translation rate betwe ...
... them to have a threefold difference in translation rate (21.6 and 6.4 codons per second, respectively). Remarkably, the wi of these codons, which is based on the tRNA pool and affinity of codon-anti-codon coupling and is the basis for the tAI calculation, captures the ratio of translation rate betwe ...
Gene Therapy
... that carries a serious genetic defect before implantation into the mother or by altering the germ cells of an afflicted adult so that the defect does not get passed on to their offspring. • Because of the unknown effects germline therapy has on future generations, it is the most controversial. ...
... that carries a serious genetic defect before implantation into the mother or by altering the germ cells of an afflicted adult so that the defect does not get passed on to their offspring. • Because of the unknown effects germline therapy has on future generations, it is the most controversial. ...
A Quantitative Overview to Gene Expression Profiling in Animal
... 3. The random gene array in (AG) models the effects for each spot and it serves to account for the spot-to-spot variability inherent in spotted microarray data. It allows us to extract appropriate information about the treatments and obviates the need to form ratios (Wolfinger et al., 2001). 4. Th ...
... 3. The random gene array in (AG) models the effects for each spot and it serves to account for the spot-to-spot variability inherent in spotted microarray data. It allows us to extract appropriate information about the treatments and obviates the need to form ratios (Wolfinger et al., 2001). 4. Th ...
Extent of Gene Duplication in the Genomes of
... is well known that codon usage is highly biased in some genes in these organisms (Ikemura 1982; Akashi, Kliman, and Eyre-Walker 1998). A negative correlation between synonymous rate (KS) and strength of codon usage bias in Drosophila suggests that in some genes synonymous changes are not neutral (Sh ...
... is well known that codon usage is highly biased in some genes in these organisms (Ikemura 1982; Akashi, Kliman, and Eyre-Walker 1998). A negative correlation between synonymous rate (KS) and strength of codon usage bias in Drosophila suggests that in some genes synonymous changes are not neutral (Sh ...
Primary sequence analysis of Xac catalases
... identity) [6], which have not been characterized so far (Figure S3). Amino acid sequence ...
... identity) [6], which have not been characterized so far (Figure S3). Amino acid sequence ...
Development of a codominant PCR-based marker for the wheat Wx
... allele. It was previously determined that the entire coding region of the wheat Wx-B1 gene is deleted in the most common null allele. However, the extent and breakpoints of the deletion have not been established. In this study, the position of the 3’ deletion breakpoint was refined by mapping with P ...
... allele. It was previously determined that the entire coding region of the wheat Wx-B1 gene is deleted in the most common null allele. However, the extent and breakpoints of the deletion have not been established. In this study, the position of the 3’ deletion breakpoint was refined by mapping with P ...
WormBase-Oct2004 - Gene Ontology Consortium
... README File As per discussion at the GO Annotation Camp, we will now be routinely submitting a README file that explains the types of annotations in our gene association file, our curation approach, and where to go for questions or additional information about ...
... README File As per discussion at the GO Annotation Camp, we will now be routinely submitting a README file that explains the types of annotations in our gene association file, our curation approach, and where to go for questions or additional information about ...
Transposable elements, genes and recombination in a 215
... one recombination event was detected, representing a genetic distance of 0.065 cM (0.052–0.078, 95% confidence interval). Based on this value, the ratio of physical to genetic distance in this region can be estimated to be about 2,700 kb cM–1 (2,243–3,365 kb cM–1, 95% confidence interval). Genes pre ...
... one recombination event was detected, representing a genetic distance of 0.065 cM (0.052–0.078, 95% confidence interval). Based on this value, the ratio of physical to genetic distance in this region can be estimated to be about 2,700 kb cM–1 (2,243–3,365 kb cM–1, 95% confidence interval). Genes pre ...
Enlis Genome Research - Release Notes
... - Variation Filter tool: Added "Ignore No-call positions" to "Not in single genome" and "Not in genome set" filters. This allows for improved comparisons between genomes where one only wants to view positions that were called in both genomes - Variation Filter tool: Fixed bug in family trio analysis ...
... - Variation Filter tool: Added "Ignore No-call positions" to "Not in single genome" and "Not in genome set" filters. This allows for improved comparisons between genomes where one only wants to view positions that were called in both genomes - Variation Filter tool: Fixed bug in family trio analysis ...
Xenopus tropicalis Ken-ichi T. S and Hisato I
... information on CYP1 genes in amphibians is relatively scarce. In the present study, we attempt to characterize CYP1 genes in Xenopus tropicalis, the only amphibian species whose genome has been sequenced. A novel CYP1 gene, CYP1D was identified in the X. tropicalis genome sequence, besides the genes ...
... information on CYP1 genes in amphibians is relatively scarce. In the present study, we attempt to characterize CYP1 genes in Xenopus tropicalis, the only amphibian species whose genome has been sequenced. A novel CYP1 gene, CYP1D was identified in the X. tropicalis genome sequence, besides the genes ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.