Research Report Series: MDMA (Ecstasy) Abuse
... Because of its stimulant properties and the environment in which it is often taken, MDMA is associated with vigorous physical activity for extended periods. This can lead to one of the most significant, although rare, acute adverse effects -- a marked rise in body temperature (hyperthermia). Treatme ...
... Because of its stimulant properties and the environment in which it is often taken, MDMA is associated with vigorous physical activity for extended periods. This can lead to one of the most significant, although rare, acute adverse effects -- a marked rise in body temperature (hyperthermia). Treatme ...
Biochemical Toxicity Induced By Tramadol
... Tarkkila et al., 1998). Seizures have been reported in patients receiving recommended doses but are more likely associated with abuse of this medication (Jick et al., 1998; Gasse et al., 2000). When seizures do occur, they are commonly of short duration and are easily treatable (Spiller et al., 1997 ...
... Tarkkila et al., 1998). Seizures have been reported in patients receiving recommended doses but are more likely associated with abuse of this medication (Jick et al., 1998; Gasse et al., 2000). When seizures do occur, they are commonly of short duration and are easily treatable (Spiller et al., 1997 ...
Hepatotoxicity of Antituberculosis Therapy
... ALT, is the strongest confirmation of the diagnosis (3). Rechallenge may, in some instances, endanger the patient and is usually confined to essential drugs or used when multiple potentially hepatotoxic drugs have been administered concomitantly (4). Dimensions of the Problem ...
... ALT, is the strongest confirmation of the diagnosis (3). Rechallenge may, in some instances, endanger the patient and is usually confined to essential drugs or used when multiple potentially hepatotoxic drugs have been administered concomitantly (4). Dimensions of the Problem ...
Antibiotic distribution into the CNS
... Doxycycline is lipophilic, with protein binding over 80% CNS penetration 0.2 in absence and presence of inflammation of meninges (usually dose 400mg per day) Not inferior to Ceftriaxone in treating neuroborreliosis. Can be used for neurobrucellosis and even neurosyphilis Tigecycline – CNS penetratio ...
... Doxycycline is lipophilic, with protein binding over 80% CNS penetration 0.2 in absence and presence of inflammation of meninges (usually dose 400mg per day) Not inferior to Ceftriaxone in treating neuroborreliosis. Can be used for neurobrucellosis and even neurosyphilis Tigecycline – CNS penetratio ...
PhD thesis
... The effect of metabolites on the aromatase enzyme assay was evaluated using the SSRI sertraline. The evaluation was performed using both “compound by compound” testing and “effect based” testing. Based on the results a testing strategy for including metabolites in in‐vitro screening w ...
... The effect of metabolites on the aromatase enzyme assay was evaluated using the SSRI sertraline. The evaluation was performed using both “compound by compound” testing and “effect based” testing. Based on the results a testing strategy for including metabolites in in‐vitro screening w ...
Annex Ib : Final CSP (clean version)
... Epirubicin is mainly used in combination with other cytotoxic drugs. Additive toxicity may occur especially with regard to bone marrow/hematologic and gastro-intestinal effects (see section 4.4). The use of epirubicin in combination chemotherapy with other potentially cardiotoxic drugs, as well as t ...
... Epirubicin is mainly used in combination with other cytotoxic drugs. Additive toxicity may occur especially with regard to bone marrow/hematologic and gastro-intestinal effects (see section 4.4). The use of epirubicin in combination chemotherapy with other potentially cardiotoxic drugs, as well as t ...
HydrALAZINE Hydrochloride Injection, USP
... and female mice given hydralazine continuously in their drinking water at a dosage of about 250 mg/kg per day (about 80 times the maximum recommended human dose). In a 2-year carcinogenicity study of rats given hydralazine by gavage at dose levels of 15, 30, and 60 mg/kg/day (approximately 5 to 20 t ...
... and female mice given hydralazine continuously in their drinking water at a dosage of about 250 mg/kg per day (about 80 times the maximum recommended human dose). In a 2-year carcinogenicity study of rats given hydralazine by gavage at dose levels of 15, 30, and 60 mg/kg/day (approximately 5 to 20 t ...
Effects of Antidepressants on Inhibitory Avoidance in
... 2008) nor the precise mechanism of antidepressant efficacy are completely understood (Dudra-Jastrzebska et al., 2007). Indeed, antidepressants are widely prescribed for anxiety and disorders other than depression. For example, they are the drug therapy of choice for severe anxiety disorders such as ...
... 2008) nor the precise mechanism of antidepressant efficacy are completely understood (Dudra-Jastrzebska et al., 2007). Indeed, antidepressants are widely prescribed for anxiety and disorders other than depression. For example, they are the drug therapy of choice for severe anxiety disorders such as ...
Stability Testing of Pharmaceutical Products
... been established. Stability of the reference material also includes the stability of reagents as well as consistency of the performance of the instrument to be used throughout the period of stability testing. However, system performance and control for drift and discontinuity resulting from changes ...
... been established. Stability of the reference material also includes the stability of reagents as well as consistency of the performance of the instrument to be used throughout the period of stability testing. However, system performance and control for drift and discontinuity resulting from changes ...
Changes in antacid use over a 9-year period in a general
... still commonly used self-prescribed drugs1,2. However, their importance has diminished since the development of histamine-2-receptor antagonists and more recently proton pump inhibitors. Based on the drug wholesale statistics in Norway, the sale of antacids decreased from 7.6 DDD/1000 inhabitants/da ...
... still commonly used self-prescribed drugs1,2. However, their importance has diminished since the development of histamine-2-receptor antagonists and more recently proton pump inhibitors. Based on the drug wholesale statistics in Norway, the sale of antacids decreased from 7.6 DDD/1000 inhabitants/da ...
Antiparasitic Chemotherapy for Human and Veterinary Use 3rd
... 9:20 Descoteaux A., INRS- Institut Armand-Frappier, Laval, Canada (COST invited ...
... 9:20 Descoteaux A., INRS- Institut Armand-Frappier, Laval, Canada (COST invited ...
Pleiotropic Effects of Statins
... The currently available statins are lovastatin, simvastatin, pravastatin, atorvastatin, fluvastatin and rosuvastatin. Cerivastatin was withdrawn from the market in 2001 due to increased number of fatal rhabdomyolyses.13 It seems that the process of metabolization of statins is important from the saf ...
... The currently available statins are lovastatin, simvastatin, pravastatin, atorvastatin, fluvastatin and rosuvastatin. Cerivastatin was withdrawn from the market in 2001 due to increased number of fatal rhabdomyolyses.13 It seems that the process of metabolization of statins is important from the saf ...
How to Protect Yourself Against Malaria
... mosquitoes for months. But, although this residual insecticide reversed the odds in the struggle, within a few years the Anopheles had developed a resistance to these chemicals. Other pesticides followed, always with the same inglorious result. Today, many species of Anopheles have been reported res ...
... mosquitoes for months. But, although this residual insecticide reversed the odds in the struggle, within a few years the Anopheles had developed a resistance to these chemicals. Other pesticides followed, always with the same inglorious result. Today, many species of Anopheles have been reported res ...
Drugs and Thyroid - Journal of the Association of Physicians of India
... esting of thyroid function is becoming common in clinical practice. Many patients tested, are on multiple medications for various medical conditions. This is particularly true of elderly patients. It is widely recognized that certain drugs can alter thyroid hormone measurements and can cause confusi ...
... esting of thyroid function is becoming common in clinical practice. Many patients tested, are on multiple medications for various medical conditions. This is particularly true of elderly patients. It is widely recognized that certain drugs can alter thyroid hormone measurements and can cause confusi ...
Herbal Medicines and Perioperative Care
... alternatives.19-22 Moreover, herbal medications, especially those of Eastern origin, can be adulterated with heavy metals, pesticides, and even conventional drugs.23-25 Some herbal manufacturers have tried to standardize their herbal products to fixed concentrations of selected chemical constituents ...
... alternatives.19-22 Moreover, herbal medications, especially those of Eastern origin, can be adulterated with heavy metals, pesticides, and even conventional drugs.23-25 Some herbal manufacturers have tried to standardize their herbal products to fixed concentrations of selected chemical constituents ...
Mephedrone: use, subjective effects and health risks
... Mephedrone initiation and typical session Eighty‐eight participants first used mephedrone in 2009 (the remainder using first between 2008‐2010). Participants’ first mephedrone session lasted for a median of 6 hours (IQR 4‐10), in which a median of 4 doses were taken (IQR 2‐7), with each dose bein ...
... Mephedrone initiation and typical session Eighty‐eight participants first used mephedrone in 2009 (the remainder using first between 2008‐2010). Participants’ first mephedrone session lasted for a median of 6 hours (IQR 4‐10), in which a median of 4 doses were taken (IQR 2‐7), with each dose bein ...
Ephedra - Living Heart Foundation
... As a medicine, it is used in herbal teas and in a variety of products prescribed by licensed naturopathic physicians. Because it is marketed in this country as a dietary supplement, not a drug, it mostly, but not entirely, is free of more stringent regulations through the Food and Drug Administratio ...
... As a medicine, it is used in herbal teas and in a variety of products prescribed by licensed naturopathic physicians. Because it is marketed in this country as a dietary supplement, not a drug, it mostly, but not entirely, is free of more stringent regulations through the Food and Drug Administratio ...
Rhythm Management
... “Before choosing rate control as a long-term strategy, the clinician should consider how permanent AF is likely to affect the patient in the future. RACE…and AFFIRM…do not necessarily apply to younger patients without heart disease or to patients whose dependency upon sinus rhythm is likely to chang ...
... “Before choosing rate control as a long-term strategy, the clinician should consider how permanent AF is likely to affect the patient in the future. RACE…and AFFIRM…do not necessarily apply to younger patients without heart disease or to patients whose dependency upon sinus rhythm is likely to chang ...
Anabolic Steroids
... The history of anabolic steroids can be traced back to as early as the 1930’s, before the term steroid was even used. In the 1930’s, a team of scientists was able to create a synthetic form of testosterone to help treat men who were unable to produce enough of the hormone for normal growth, developm ...
... The history of anabolic steroids can be traced back to as early as the 1930’s, before the term steroid was even used. In the 1930’s, a team of scientists was able to create a synthetic form of testosterone to help treat men who were unable to produce enough of the hormone for normal growth, developm ...
Gastrokinetic and Gastroprotective Activity of Gasex
... Most of the herbs used in this formulation have been reported for its effect on gastrointestinal disorders. Aconitum palmatum is found to be effective in dyspepsia, stomach irritability and nausea. Cowrie, a naturally processed calcium carbonate, is used in dyspepsia, indigestion, sprue, duodenal an ...
... Most of the herbs used in this formulation have been reported for its effect on gastrointestinal disorders. Aconitum palmatum is found to be effective in dyspepsia, stomach irritability and nausea. Cowrie, a naturally processed calcium carbonate, is used in dyspepsia, indigestion, sprue, duodenal an ...
Pharmacokinetics of Antimony in Children Treated for Leishmaniasis
... Results. Children (vs. adults) who received 20 mg/kg had a 42% lower AUC0–24 (mean SE, 111 7 vs. 190 10 mg ⫻ h/L, compared with adults; P ! .001), a 16% lower peak concentration (32.7 0.9 vs. 38.8 2.1 mg/L; P p .04), and a 75% higher weight-adjusted clearance (0.185 0.013 vs. 0.106 0.0 ...
... Results. Children (vs. adults) who received 20 mg/kg had a 42% lower AUC0–24 (mean SE, 111 7 vs. 190 10 mg ⫻ h/L, compared with adults; P ! .001), a 16% lower peak concentration (32.7 0.9 vs. 38.8 2.1 mg/L; P p .04), and a 75% higher weight-adjusted clearance (0.185 0.013 vs. 0.106 0.0 ...