... statistically significant differences (P > 0.05) between the two brands. In addition, 90% confidence interval demonstrated that the ratio of the AUC0-t or AUC0-∞ of the two brands lie within the FDA accepted range 80-125%. For bioequivalence evaluation, t-student statistical procedure was performed ...
Age and Risks of FDA–Approved Long-Acting  -Adrenergic Receptor Agonists 2
... asthma exacerbation” or was “otherwise asthma-related.” Although it was not feasible for FDA staff members to validate the manufacturers’ event adjudications, an earlier review of pediatric asthma events from the Salmeterol Multicenter Asthma Research Trial by one of the authors (Dr Mosholder) showe ...
... asthma exacerbation” or was “otherwise asthma-related.” Although it was not feasible for FDA staff members to validate the manufacturers’ event adjudications, an earlier review of pediatric asthma events from the Salmeterol Multicenter Asthma Research Trial by one of the authors (Dr Mosholder) showe ...
24-hour blood pressure monitoring: its efficacy and
... assessing the efficacy of BP-lowering drugs [26,27,7079]. In the earliest of these studies, atenolol taken once daily in the morning was shown to lower BP during the day but to have little effect on either nighttime BP or the morning rise in BP. The prescient conclusions of this study merit quoting ...
... assessing the efficacy of BP-lowering drugs [26,27,7079]. In the earliest of these studies, atenolol taken once daily in the morning was shown to lower BP during the day but to have little effect on either nighttime BP or the morning rise in BP. The prescient conclusions of this study merit quoting ...
Keppra® (levetiracetam)
... children and adults in association with KEPPRA use, including Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Such serious skin reactions may be life-threatening, and some patients have required hospitalization with ...
... children and adults in association with KEPPRA use, including Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Such serious skin reactions may be life-threatening, and some patients have required hospitalization with ...
Cannabis
... • Canada is was the only country which allows Medical use (medical exemption by ‘prescription’; physicians are allowed to prescribe drugs in whatever dose and for whatever reason they deem fit/e.g. pediatrics and & psychiatry) ...
... • Canada is was the only country which allows Medical use (medical exemption by ‘prescription’; physicians are allowed to prescribe drugs in whatever dose and for whatever reason they deem fit/e.g. pediatrics and & psychiatry) ...
Drugs Acting on the Respiratory System
... with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment. The inflammation also causes an associated increase in the existing bronchial hyperresponsiveness to a variety of stimuli. ...
... with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment. The inflammation also causes an associated increase in the existing bronchial hyperresponsiveness to a variety of stimuli. ...
XIFAXAN Tablets contain rifaximin, a semi-synthetic, nonsystemic antibiotic. The chemical name S
... Pediatric: The pharmacokinetics of rifaximin has not been studied in pediatric patients of any age. Gender: The effect of gender on the pharmacokinetics of rifaximin has not been studied. Renal Insufficiency: The pharmacokinetics of rifaximin in patients with impaired renal function has not been stu ...
... Pediatric: The pharmacokinetics of rifaximin has not been studied in pediatric patients of any age. Gender: The effect of gender on the pharmacokinetics of rifaximin has not been studied. Renal Insufficiency: The pharmacokinetics of rifaximin in patients with impaired renal function has not been stu ...
Comparison of the effects of cimetidine and hyoscine-n
... change in the study protocol may affect the absorption of co-administered drugs via an effect thought to occur by a decreased rate of gastric emptying. The present study therefore seeks to evaluate the effect of Cimetidine on Paracetamol pharmacokinetics when it is administered one hour prior to Par ...
... change in the study protocol may affect the absorption of co-administered drugs via an effect thought to occur by a decreased rate of gastric emptying. The present study therefore seeks to evaluate the effect of Cimetidine on Paracetamol pharmacokinetics when it is administered one hour prior to Par ...
pharmacology_2
... 32.Antihypertensive agents must be used with caution. The medical condition for which propranolol is most contraindicated is: A. renal insufficiency B. congestive heart failure C. mental depression D. liver disease E. asthma ANSWER: E 33.Antihypertensive agents must be used with caution. The medical ...
... 32.Antihypertensive agents must be used with caution. The medical condition for which propranolol is most contraindicated is: A. renal insufficiency B. congestive heart failure C. mental depression D. liver disease E. asthma ANSWER: E 33.Antihypertensive agents must be used with caution. The medical ...
File
... of thienopyridine agents. The BIM allows adjustments to provide estimates for relevant populations who are to be treated with a thienopyridine drug. Clinical trials are currently being conducted to determine treatment with a thienopyridine after one year to be beneficial. With this assumption, patie ...
... of thienopyridine agents. The BIM allows adjustments to provide estimates for relevant populations who are to be treated with a thienopyridine drug. Clinical trials are currently being conducted to determine treatment with a thienopyridine after one year to be beneficial. With this assumption, patie ...
... with standard drugs [1]. In addition, HIV/AIDS increases the risk for developing active TB and renders TB difficult to diagnose and treat. The TB-HIV/AIDS coinfection rate in South Africa is distressingly high, with an estimated 73 percent of new TB patients coinfected with HIV [2]. The search for new ...
Antimicrobial resistance - WHO archives
... Medicine is that they take a 'holistic' approach towards the sick individual and treat disturbances on the physical, emotional, mental and living environment levels simultaneously. Briefing on TBS Training course 18 Sep 2006 Geneva ...
... Medicine is that they take a 'holistic' approach towards the sick individual and treat disturbances on the physical, emotional, mental and living environment levels simultaneously. Briefing on TBS Training course 18 Sep 2006 Geneva ...
Lipids - Ministry of Health
... or alcoholic abuse. If the level of either of these 2 transaminases is elevated but < 1.5 times the upper limit of the normal range, statins can be given. If the level is ≥ 1.5 times but < 3 times the upper limit of the normal range, statins can still be given but with caution. In both situations, t ...
... or alcoholic abuse. If the level of either of these 2 transaminases is elevated but < 1.5 times the upper limit of the normal range, statins can be given. If the level is ≥ 1.5 times but < 3 times the upper limit of the normal range, statins can still be given but with caution. In both situations, t ...
(PSD) July 2016 PBAC Meeting
... In both arms of trial CA209-025, patients were able to continue receiving treatment beyond progression if they were assessed as still deriving clinical benefit and tolerating treatment. The submission claimed that progression based on discontinuation of treatment would be more clinically representat ...
... In both arms of trial CA209-025, patients were able to continue receiving treatment beyond progression if they were assessed as still deriving clinical benefit and tolerating treatment. The submission claimed that progression based on discontinuation of treatment would be more clinically representat ...
Full Text PDF
... to pustules.31 In drug induced pustular psoriasis, similar mechanisms may be involved in the pathogenesis of pustules. Drug specific T cells in pustular psoriasis may release acute phase cytokines, including IL-1, IL-6, CXCL8, and TNF-α, that trigger flare-up of psoriasis and formation of generalize ...
... to pustules.31 In drug induced pustular psoriasis, similar mechanisms may be involved in the pathogenesis of pustules. Drug specific T cells in pustular psoriasis may release acute phase cytokines, including IL-1, IL-6, CXCL8, and TNF-α, that trigger flare-up of psoriasis and formation of generalize ...
DISSOLUTION PROFILING OF BILAYERED CONVENTIONAL RELEASE PARACETAMOL AND
... tive metabolite of phenacetin, responsible for its analgesic effect 3, 4. Paracetamol a weak prostaglandin inhibitor in peripheral tissues and possesses no significant ant inflammatory effects. Its one of the most important drugs used for the treatment of mild to moderate pain when an anti inflammat ...
... tive metabolite of phenacetin, responsible for its analgesic effect 3, 4. Paracetamol a weak prostaglandin inhibitor in peripheral tissues and possesses no significant ant inflammatory effects. Its one of the most important drugs used for the treatment of mild to moderate pain when an anti inflammat ...
Biochemical Toxicity Induced By Tramadol
... Tarkkila et al., 1998). Seizures have been reported in patients receiving recommended doses but are more likely associated with abuse of this medication (Jick et al., 1998; Gasse et al., 2000). When seizures do occur, they are commonly of short duration and are easily treatable (Spiller et al., 1997 ...
... Tarkkila et al., 1998). Seizures have been reported in patients receiving recommended doses but are more likely associated with abuse of this medication (Jick et al., 1998; Gasse et al., 2000). When seizures do occur, they are commonly of short duration and are easily treatable (Spiller et al., 1997 ...
Misoprostol in obstetrics and gynecology
... promising in the developing world where maternal mortality is high and where an effective, low-cost and stable prostaglandin is urgently needed. The benefits of misoprostol in settings with few resources have since been widely demonstrated. It has been possible to reduce failed inductions and the pr ...
... promising in the developing world where maternal mortality is high and where an effective, low-cost and stable prostaglandin is urgently needed. The benefits of misoprostol in settings with few resources have since been widely demonstrated. It has been possible to reduce failed inductions and the pr ...
Research Report Series: MDMA (Ecstasy) Abuse
... Because of its stimulant properties and the environment in which it is often taken, MDMA is associated with vigorous physical activity for extended periods. This can lead to one of the most significant, although rare, acute adverse effects -- a marked rise in body temperature (hyperthermia). Treatme ...
... Because of its stimulant properties and the environment in which it is often taken, MDMA is associated with vigorous physical activity for extended periods. This can lead to one of the most significant, although rare, acute adverse effects -- a marked rise in body temperature (hyperthermia). Treatme ...
Use of antihistamines in pediatrics
... that the efficacy results in adolescents /adults are also valid for children. For children under two years of age, where immune reaction is considered to be different, specific efficacy studies are required. In all the age groups the safety data are of greater importance, and studies involving one t ...
... that the efficacy results in adolescents /adults are also valid for children. For children under two years of age, where immune reaction is considered to be different, specific efficacy studies are required. In all the age groups the safety data are of greater importance, and studies involving one t ...