17
... ratios. The stepwise synthesis of dendrimers provides macromolecules with a unique MW or very narrow polydispersity. Moreover, the branched structures of dendrimers may also impede their passage through small pores, such as those of the glomerular filtration barrier, and, thus, a dendrimer may be el ...
... ratios. The stepwise synthesis of dendrimers provides macromolecules with a unique MW or very narrow polydispersity. Moreover, the branched structures of dendrimers may also impede their passage through small pores, such as those of the glomerular filtration barrier, and, thus, a dendrimer may be el ...
Emerging options for the management of scorpion stings
... worsening of envenoming, is low at about 0.8 cases per million children,38 but is often fatal. Therefore, it is necessary to assess the risk/benefit ratio, taking into account that 15%–20% of scorpion stings can show severe progression and 0.5%–1% of these stings can be fatal in children, and consid ...
... worsening of envenoming, is low at about 0.8 cases per million children,38 but is often fatal. Therefore, it is necessary to assess the risk/benefit ratio, taking into account that 15%–20% of scorpion stings can show severe progression and 0.5%–1% of these stings can be fatal in children, and consid ...
Plasma Pharmacokinetics of Adriamycin and
... Binding Studies. For nonradioactive drug (n = 12), Adriamycin the 2 patterns of Adriamycin therapeutic and toxic effects which was 74 ±1.7% (S.D.) bound, and adriamycinol was 76 ±1.4% have been observed: those due to high peak concentrations, bound. The percentage bound was independent of plasma c ...
... Binding Studies. For nonradioactive drug (n = 12), Adriamycin the 2 patterns of Adriamycin therapeutic and toxic effects which was 74 ±1.7% (S.D.) bound, and adriamycinol was 76 ±1.4% have been observed: those due to high peak concentrations, bound. The percentage bound was independent of plasma c ...
Prescribing Information
... the prophylaxis of organ rejection in kidney transplant patients in combination with other immunosuppressants (1) Limitation of Use: Not interchangeable or substitutable with other tacrolimus products (1, 5.4) ----------------------DOSAGE AND ADMINISTRATION---------------------- Take consistently ...
... the prophylaxis of organ rejection in kidney transplant patients in combination with other immunosuppressants (1) Limitation of Use: Not interchangeable or substitutable with other tacrolimus products (1, 5.4) ----------------------DOSAGE AND ADMINISTRATION---------------------- Take consistently ...
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... diagnosis of neonatal seizure (11). Neonates can make jerky movements that may be misinterpreted as seizures and may receive multiple antiepileptic drugs (AEDs) over many days, become sedated, cannot ...
... diagnosis of neonatal seizure (11). Neonates can make jerky movements that may be misinterpreted as seizures and may receive multiple antiepileptic drugs (AEDs) over many days, become sedated, cannot ...
Effect of compression force, humidity and disintegrant concentration
... Introduction For tablets containing sparingly watersoluble drugs, the start of dissolution is often delayed by the poor wettability of the tablet surface and/or slow liquid penetration into the tablet matrix. This property causes increased disintegration time and retarded drug release that can be ov ...
... Introduction For tablets containing sparingly watersoluble drugs, the start of dissolution is often delayed by the poor wettability of the tablet surface and/or slow liquid penetration into the tablet matrix. This property causes increased disintegration time and retarded drug release that can be ov ...
[Product Monograph Template
... reactions except one (a single case of upper respiratory infection) were reported as mild or moderate in severity; however, long-term clinical trial data on nasal safety is available in a limited number of subjects [see Adverse Reactions]. Patients should be instructed to report any nasal symptoms o ...
... reactions except one (a single case of upper respiratory infection) were reported as mild or moderate in severity; however, long-term clinical trial data on nasal safety is available in a limited number of subjects [see Adverse Reactions]. Patients should be instructed to report any nasal symptoms o ...
Vedani Nicola
... with the moricizine and placebo arms only. The trial was prematurely terminated because of a trend towards an increase in mortality in the moricizine treated group. The applicability of these results to other populations or other antiarrhythmic agents is uncertain, but at present it is prudent to co ...
... with the moricizine and placebo arms only. The trial was prematurely terminated because of a trend towards an increase in mortality in the moricizine treated group. The applicability of these results to other populations or other antiarrhythmic agents is uncertain, but at present it is prudent to co ...
New Hepatitis C Therapies: The Toolbox, Strategies, and
... development include only inhibitors of HCV polyprotein maturation (NS3-4A protease inhibitors) and inhibitors of HCV RNA synthesis (ie, viral replication; all the other DAAs or HTAs in development). Both antiviral approaches efficiently shutdown virus production in infected cells. Inhibition of viral ...
... development include only inhibitors of HCV polyprotein maturation (NS3-4A protease inhibitors) and inhibitors of HCV RNA synthesis (ie, viral replication; all the other DAAs or HTAs in development). Both antiviral approaches efficiently shutdown virus production in infected cells. Inhibition of viral ...
VA Medicaid PDL List (effective 07/01/2011)
... o Patient’s condition is clinically unstable; changing to a medication not requiring service approval might cause deterioration of the patient’s condition. Document clinically compelling information 2. The requested medication may be approved if both of the following are true: 1. If there has been a ...
... o Patient’s condition is clinically unstable; changing to a medication not requiring service approval might cause deterioration of the patient’s condition. Document clinically compelling information 2. The requested medication may be approved if both of the following are true: 1. If there has been a ...
Newly Approved Anticoagulants
... Loss of function, results in increased sensitivity to warfarin and increased potential for drug interactions because VKORC1 does not function normally to produce vitamin K dependent clotting factors (II, VII, IX, X, proteins C and S) – 37% of Caucasians, 14% of AAs, 89% of Asians have at least one v ...
... Loss of function, results in increased sensitivity to warfarin and increased potential for drug interactions because VKORC1 does not function normally to produce vitamin K dependent clotting factors (II, VII, IX, X, proteins C and S) – 37% of Caucasians, 14% of AAs, 89% of Asians have at least one v ...
article
... (WHO), 70–95% of the populations in developing countries rely on traditional medicines for primary care while 70% and 90% of population in industrialized countries have used traditional medicines [5, 6]. In conjunction with this increasing use of herbal remedies worldwide, several reports about adve ...
... (WHO), 70–95% of the populations in developing countries rely on traditional medicines for primary care while 70% and 90% of population in industrialized countries have used traditional medicines [5, 6]. In conjunction with this increasing use of herbal remedies worldwide, several reports about adve ...
Opioids for persistent pain: Good practice The British Pain Society's
... This guidance has been written for all healthcare professionals who manage patients with persistent pain, to help their understanding of the role of opioids in pain management. The document outlines good practice regarding decision making in relation to opioid therapy, ongoing monitoring of treatmen ...
... This guidance has been written for all healthcare professionals who manage patients with persistent pain, to help their understanding of the role of opioids in pain management. The document outlines good practice regarding decision making in relation to opioid therapy, ongoing monitoring of treatmen ...
Simvastatin Decreased Coenzyme Q in the Left Ventricle and
... effectively cholesterol level and morbidity and mortality in patients with coronary heart disease and/or dyslipoproteinemia. Statins inhibit synthesis of mevalonate, a precursor of both cholesterol and coenzyme Q (CoQ). Inhibited biosynthesis of CoQ may be involved in some undesirable actions of sta ...
... effectively cholesterol level and morbidity and mortality in patients with coronary heart disease and/or dyslipoproteinemia. Statins inhibit synthesis of mevalonate, a precursor of both cholesterol and coenzyme Q (CoQ). Inhibited biosynthesis of CoQ may be involved in some undesirable actions of sta ...
Averrhoa Carambola: An Updated Review
... almost exclusively on traditional medicine for their primary healthcare needs [5]. WHO has listed over 21000 plant species used around the world for medicinal purposes. In India, about 2500 plant species belonging to more than 100 genera are being used in indigenous systems of medicine [6]. India ra ...
... almost exclusively on traditional medicine for their primary healthcare needs [5]. WHO has listed over 21000 plant species used around the world for medicinal purposes. In India, about 2500 plant species belonging to more than 100 genera are being used in indigenous systems of medicine [6]. India ra ...
Vancomycin Assay - Beckman Coulter
... Assay at least one control every 8 hours, alternating the control levels tested. Ensure that a minimum of two levels of control material are assayed in every 24-hour period. If controls are within their control limits, calibration is verified. If any control is not within its control limits, rerun t ...
... Assay at least one control every 8 hours, alternating the control levels tested. Ensure that a minimum of two levels of control material are assayed in every 24-hour period. If controls are within their control limits, calibration is verified. If any control is not within its control limits, rerun t ...
Elocom Cream, Ointment and Lotion Physicians` Prescribing
... by the oral, topical and/or subcutaneous routes. Effects noted were umbilical hernia in rats, cleft palate in mice, and gall bladder agenesis, umbilical hernia, and flexed front paws in rabbits. There were also reductions in maternal body weight gains, effects on fetal growth (lower fetal body weigh ...
... by the oral, topical and/or subcutaneous routes. Effects noted were umbilical hernia in rats, cleft palate in mice, and gall bladder agenesis, umbilical hernia, and flexed front paws in rabbits. There were also reductions in maternal body weight gains, effects on fetal growth (lower fetal body weigh ...
E - Morgan Joseph
... incorporating AZN’s blockbuster Nexium (esomeprazole) and naproxen. PN400 offers the potential benefit of having comparable efficacy of other NSAIDS while reducing GI side effects (e.g., nausea, vomiting, gastrointestinal bleeding, ulceration and/or perforation of the stomach), which occur in about ...
... incorporating AZN’s blockbuster Nexium (esomeprazole) and naproxen. PN400 offers the potential benefit of having comparable efficacy of other NSAIDS while reducing GI side effects (e.g., nausea, vomiting, gastrointestinal bleeding, ulceration and/or perforation of the stomach), which occur in about ...
Can high dose loperamide be used to reduce stoma output?
... and Drug Administration (FDA) has published a safety alert regarding the misuse or abuse of high doses (23). In the majority of cases patients have taken much higher doses than would normally be recommended for reducing stoma output, often over a prolonged period of time, and the contribution of con ...
... and Drug Administration (FDA) has published a safety alert regarding the misuse or abuse of high doses (23). In the majority of cases patients have taken much higher doses than would normally be recommended for reducing stoma output, often over a prolonged period of time, and the contribution of con ...
her2-negative breast cancer – global drug forecast and market
... be a highly lucrative market for companies to test their assets. The sheer size of the adjuvant population, and the high number of treatment cycles that can be administered in this setting, are the reasons for its lucrativeness. This is expected to be true for both the HR+ and TNBC settings. By 2023 ...
... be a highly lucrative market for companies to test their assets. The sheer size of the adjuvant population, and the high number of treatment cycles that can be administered in this setting, are the reasons for its lucrativeness. This is expected to be true for both the HR+ and TNBC settings. By 2023 ...
PDF - American College of Gastroenterology
... documents cover topics for which the evidence base, experience with technology, or clinical practice is not considered sufficiently well developed to be evaluated by the formal ACCF/ AHA Practice Guidelines process. Often, the topic is the subject of considerable ongoing investigation. Thus, the rea ...
... documents cover topics for which the evidence base, experience with technology, or clinical practice is not considered sufficiently well developed to be evaluated by the formal ACCF/ AHA Practice Guidelines process. Often, the topic is the subject of considerable ongoing investigation. Thus, the rea ...
Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients
... Multidrug-resistant tuberculosis (MDR-TB) is an infectious disease of major concern, especially in countries with a high TB burden [1–3]. Treatment of MDR-TB poses challenges such as designing an effective second-line antituberculosis regimen, entailing a combination of multiple drugs and a long dur ...
... Multidrug-resistant tuberculosis (MDR-TB) is an infectious disease of major concern, especially in countries with a high TB burden [1–3]. Treatment of MDR-TB poses challenges such as designing an effective second-line antituberculosis regimen, entailing a combination of multiple drugs and a long dur ...
lustral - Pharmaline
... medical judgment should be exercised when switching, particularly from long-acting agents such as fluoxetine. The duration of washout period which should intervene before switching from one SSRI to another has not been established. Preclinical Data Extensive chronic safety evaluation studies in anim ...
... medical judgment should be exercised when switching, particularly from long-acting agents such as fluoxetine. The duration of washout period which should intervene before switching from one SSRI to another has not been established. Preclinical Data Extensive chronic safety evaluation studies in anim ...
1.1. Ibuprofen and Stevens Johnson Syndrome/Toxic Epidermal
... far-reaching disability (blindness), needing further surgical treatment. Case A, reported by the father of the patient involved is well documented. Patient recovered partially and awaits corneal transplantation. Case B, reported by an internist, concerns an 81-year aged female with limited medical ...
... far-reaching disability (blindness), needing further surgical treatment. Case A, reported by the father of the patient involved is well documented. Patient recovered partially and awaits corneal transplantation. Case B, reported by an internist, concerns an 81-year aged female with limited medical ...
Cozaar
... human milk, but significant levels of both of these compounds have been found in the milk of lactating rats. Because many drugs are excreted in human milk, and because of their potential for affecting the nursing infant adversely, a decision should be made whether to discontinue nursing or discontin ...
... human milk, but significant levels of both of these compounds have been found in the milk of lactating rats. Because many drugs are excreted in human milk, and because of their potential for affecting the nursing infant adversely, a decision should be made whether to discontinue nursing or discontin ...