BCM Theory
... complex spikes, making it possible to lump the activity of the PC population together. We also verified the equivalence of the two models by following the trajectory of the PC population output and DCN activity of the original model up to one day in simulation time after lesion (see Supplementary Fi ...
... complex spikes, making it possible to lump the activity of the PC population together. We also verified the equivalence of the two models by following the trajectory of the PC population output and DCN activity of the original model up to one day in simulation time after lesion (see Supplementary Fi ...
Traveling Theta Waves along the Entire
... (septal) to intermediate sites of the CA1 layer (Figures 2E, 3F, and S3). Theta waves were phase shifted by approximately a half cycle, i.e., 180 between the septal and ventral (temporal) sites (Figures 3F, 3G, and S4). Theta oscillations were less regular, lower in amplitude, and more intermittent ...
... (septal) to intermediate sites of the CA1 layer (Figures 2E, 3F, and S3). Theta waves were phase shifted by approximately a half cycle, i.e., 180 between the septal and ventral (temporal) sites (Figures 3F, 3G, and S4). Theta oscillations were less regular, lower in amplitude, and more intermittent ...
Simulating in vivo-like Synaptic Input Patterns in Multicompartmental
... pharmacological manipulations, such as elevating the external potassium concentration or bath application of low concentrations of the potassium channel blocker 4-aminopyridine (4-AP) have been shown to induce high levels of spontaneous synaptic input in brain slice preparations (Avoli et al. 2002). ...
... pharmacological manipulations, such as elevating the external potassium concentration or bath application of low concentrations of the potassium channel blocker 4-aminopyridine (4-AP) have been shown to induce high levels of spontaneous synaptic input in brain slice preparations (Avoli et al. 2002). ...
Simulation of myelinated neuron with focus on conduction speed
... Myelin sheath is a protective coat around the axon of a neuron and acts as an insulator to the electrical signal that is conducted down the axon as a neuron fires. This increases the conduction speed of action potential and thus is a critical factor in maintaining the proper communication within the ...
... Myelin sheath is a protective coat around the axon of a neuron and acts as an insulator to the electrical signal that is conducted down the axon as a neuron fires. This increases the conduction speed of action potential and thus is a critical factor in maintaining the proper communication within the ...
Spiking Neurons - Computing Science and Mathematics
... recorded from and the stimulus . In practice, to get sensible averages, several spikes should occur within the time window . Values of T = 100ms or T = 500 ms are typical , but the duration may also be longer or shorter. This definition of rate has been successfully used in many preparations , parti ...
... recorded from and the stimulus . In practice, to get sensible averages, several spikes should occur within the time window . Values of T = 100ms or T = 500 ms are typical , but the duration may also be longer or shorter. This definition of rate has been successfully used in many preparations , parti ...
1 OSCILLATORY ENTRAINMENT OF THALAMIC NEURONS BY
... of this calculation, which is based on what will be the local input to the recorded signal, but ...
... of this calculation, which is based on what will be the local input to the recorded signal, but ...
Spike sorting: the overlapping spikes challenge
... dissimilarity due to the characteristic amplitude distribution and consequently provides a better separability. The runtime and the computational effort increase with rising number of channels. However, the optimal number of channels is yet unknown. The runtime increases massively with rising number ...
... dissimilarity due to the characteristic amplitude distribution and consequently provides a better separability. The runtime and the computational effort increase with rising number of channels. However, the optimal number of channels is yet unknown. The runtime increases massively with rising number ...
Mechanisms to synchronize neuronal activity
... is reasonable if it can be extended to a region around the limit cycle, such that perturbations can be studied within the same framework (Kuramoto 1984; Ermentrout and Kopell 1984, 1991). We start with a general system of coupled ordinary dierential equations of the form dX F X : dt ...
... is reasonable if it can be extended to a region around the limit cycle, such that perturbations can be studied within the same framework (Kuramoto 1984; Ermentrout and Kopell 1984, 1991). We start with a general system of coupled ordinary dierential equations of the form dX F X : dt ...
Brain oscillations and memory - Wellcome Trust Centre for
... theta cycle, but only in a given gamma subcycle. During maintenance, sequential items are active in sequential gamma subcycles, thereby encoding sequence order and achieving a temporal compression of the naturally occurring timing of item separation into one that is suitable for active maintenance. ...
... theta cycle, but only in a given gamma subcycle. During maintenance, sequential items are active in sequential gamma subcycles, thereby encoding sequence order and achieving a temporal compression of the naturally occurring timing of item separation into one that is suitable for active maintenance. ...
Predicting spike timing of neocortical pyramidal neurons by simple
... shown to constitute a universal model for spike-frequency adaptation (Benda and Herz, 2003) and has already been applied in a similar context (La Camera et al., 2004). During the model estimation, we use as a first step a traditional constant threshold denoted by ϑ(t) = ϑcst which is then transforme ...
... shown to constitute a universal model for spike-frequency adaptation (Benda and Herz, 2003) and has already been applied in a similar context (La Camera et al., 2004). During the model estimation, we use as a first step a traditional constant threshold denoted by ϑ(t) = ϑcst which is then transforme ...
PDF
... 2000), and the source code is available from the authors upon request. The statistical properties of the synthetic spike trains conform to known physiological constraints, such as average strength and precision of correlation, and for this reason, we will refer to them as physiologically realistic i ...
... 2000), and the source code is available from the authors upon request. The statistical properties of the synthetic spike trains conform to known physiological constraints, such as average strength and precision of correlation, and for this reason, we will refer to them as physiologically realistic i ...
Inferring spike-timing-dependent plasticity from spike train data
... One of the fundamental questions in computational neuroscience is how synapses are modified by neural activity [1, 2]. A number of experimental results, using intracellular recordings in vitro, have shown that synaptic plasticity depends on the precise pairing of pre- and post-synaptic spiking [3]. ...
... One of the fundamental questions in computational neuroscience is how synapses are modified by neural activity [1, 2]. A number of experimental results, using intracellular recordings in vitro, have shown that synaptic plasticity depends on the precise pairing of pre- and post-synaptic spiking [3]. ...
Ion Channels in Bursting Neurons
... In general, the physiological behavior of a neuron, i.e., how it responds to input and generates output, is determined by the types of conductances found in its membranes and the interaction between them. In this chapter we specifically consider a set of ionic conductances that interact to produce p ...
... In general, the physiological behavior of a neuron, i.e., how it responds to input and generates output, is determined by the types of conductances found in its membranes and the interaction between them. In this chapter we specifically consider a set of ionic conductances that interact to produce p ...
Does the Conventional Leaky Integrate-and
... The method common in the cited studies (Hermann et al 1995, Marsalek 1997, Feng 1997, Burkitt 1999, Diesmann 1999), is to present a number of spikes with a known temporal distribution (a pulse packet) as an input to a pulse generating neuron (or neuron pool) and investigating the spike response of t ...
... The method common in the cited studies (Hermann et al 1995, Marsalek 1997, Feng 1997, Burkitt 1999, Diesmann 1999), is to present a number of spikes with a known temporal distribution (a pulse packet) as an input to a pulse generating neuron (or neuron pool) and investigating the spike response of t ...
LiuPoster - Department of Mathematics
... Phase delayed inhibition can in fact act as a synchrony detector: the decoder neuron only fires when synchrony is above a certain value. The time constants Ti and Te played an important role in determining how phase delayed inhibition works; we discussed how it was having Ti>Te that allowed phase de ...
... Phase delayed inhibition can in fact act as a synchrony detector: the decoder neuron only fires when synchrony is above a certain value. The time constants Ti and Te played an important role in determining how phase delayed inhibition works; we discussed how it was having Ti>Te that allowed phase de ...
THE NEURON
... 2. Motor neurons carry impulses from the CNS (brain and the spinal cord) to muscles and glands. 3. Interneurons process information from sensory neurons and then send commands to other interneurons or motor neurons. ...
... 2. Motor neurons carry impulses from the CNS (brain and the spinal cord) to muscles and glands. 3. Interneurons process information from sensory neurons and then send commands to other interneurons or motor neurons. ...
Brain Oscillations Control Timing of Single
... 5Functional Neurosurgery Unit, Tel-Aviv Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel ...
... 5Functional Neurosurgery Unit, Tel-Aviv Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel ...
Chapter 17: The binomial model of probability
... • “She misses the bull’s eye at least once” • Implicit is the fact that she shoots 6 arrows. • This also calls for a clever response, unless you want to be calculation 6! permutations! • The clever response is that we only need to calculate the case where she NEVER misses, which is 6 successive succ ...
... • “She misses the bull’s eye at least once” • Implicit is the fact that she shoots 6 arrows. • This also calls for a clever response, unless you want to be calculation 6! permutations! • The clever response is that we only need to calculate the case where she NEVER misses, which is 6 successive succ ...
How Spike Generation Mechanisms Determine the Neuronal
... the present study, we show that simple conductance-based (CB) models behave differently. Using a combined analytical and numerical approach, we investigated theoretically how neuronal properties affect the response of neurons to fluctuating inputs. In particular, we demonstrate that the suppression ...
... the present study, we show that simple conductance-based (CB) models behave differently. Using a combined analytical and numerical approach, we investigated theoretically how neuronal properties affect the response of neurons to fluctuating inputs. In particular, we demonstrate that the suppression ...
Cellular mechanisms underlying network synchrony in the medial
... cells with overlapping place fields along an animal’s trajectory could fire at progressively earlier phases of the theta oscillation. ...
... cells with overlapping place fields along an animal’s trajectory could fire at progressively earlier phases of the theta oscillation. ...
Article - Dynamic Connectome Lab
... 100,000 neurons. As most such models implement singlecompartment neurons and may not include spatial information (e.g. Izhikevich 2006; Lumer et al. 1997; Potjans and Diesmann 2012), the LFP can only be estimated by some proxy that will not necessarily preserve the spatial and frequency-scaling feat ...
... 100,000 neurons. As most such models implement singlecompartment neurons and may not include spatial information (e.g. Izhikevich 2006; Lumer et al. 1997; Potjans and Diesmann 2012), the LFP can only be estimated by some proxy that will not necessarily preserve the spatial and frequency-scaling feat ...
Granger causality analysis of state dependent functional connectivity
... connections and exhibited a few ”out degree” hub neurons, while during transitions from rhythmic chews to swallows, the numbers of excitatory and inhibitory connections became comparable, and more temporarily varying ”in degree” hub neurons emerged. Furthermore, based on shared connections between n ...
... connections and exhibited a few ”out degree” hub neurons, while during transitions from rhythmic chews to swallows, the numbers of excitatory and inhibitory connections became comparable, and more temporarily varying ”in degree” hub neurons emerged. Furthermore, based on shared connections between n ...
Coefficient of Variation (CV) vs Mean Interspike Interval (ISI) curves
... D. R. Smith and G. K. Smith, A statistical analysis of the continuous activity of single cortical neurons in the cat unanesthetized isolated forebrain, Biophys. J. 5 (1965) 47-74. ...
... D. R. Smith and G. K. Smith, A statistical analysis of the continuous activity of single cortical neurons in the cat unanesthetized isolated forebrain, Biophys. J. 5 (1965) 47-74. ...
Neuroscience and Behavior
... neuron create an overall negative electrical charge of 70 millivolts (mv) inside the neuron relative to the outside. This state is called the resting potential and the neuron is polarized. ...
... neuron create an overall negative electrical charge of 70 millivolts (mv) inside the neuron relative to the outside. This state is called the resting potential and the neuron is polarized. ...