Clinical evaluation of colon specific drug delivery
... Employ less total drug and eliminate local side effects Better utilization of the drugs More uniform effect Better control over the drug absorption. DISADVANTAGES: High cost Dose dumping Unpredictable or poor invitro-invivo correlation Reduced potential for dosage adjustment Increas ...
... Employ less total drug and eliminate local side effects Better utilization of the drugs More uniform effect Better control over the drug absorption. DISADVANTAGES: High cost Dose dumping Unpredictable or poor invitro-invivo correlation Reduced potential for dosage adjustment Increas ...
Specific ADRs
... and specific peak plasma concentrations have not been correlated with efficacy. – Monitor those at highest risk for therapeutic failure or potential drug toxicity, which includes pediatric patients who have high clearances and short half-lives ...
... and specific peak plasma concentrations have not been correlated with efficacy. – Monitor those at highest risk for therapeutic failure or potential drug toxicity, which includes pediatric patients who have high clearances and short half-lives ...
Medications - Delaware Association of Home and Community Care
... • Adverse Drug Reactions (ADR)-any unintended or toxic response to a medication (ex. Someone w/high BP takes pseudoephedrine, BP elevates) • Adverse Drug Events (ADE)- an injury resulting from the use of a drug (ex. Arthritis-NSAID therapy=GI bleed) Zwicker, D. & Fulmer, T. (2008) pg.258-259 ...
... • Adverse Drug Reactions (ADR)-any unintended or toxic response to a medication (ex. Someone w/high BP takes pseudoephedrine, BP elevates) • Adverse Drug Events (ADE)- an injury resulting from the use of a drug (ex. Arthritis-NSAID therapy=GI bleed) Zwicker, D. & Fulmer, T. (2008) pg.258-259 ...
Medication Use in the Elderly: Presentation and Speaker`s
... His delirium slowly clears and he is able to participate in physical therapy and is able to return home after rehabilitation. Before he goes home, his medications are carefully reviewed, including OTC medications. ...
... His delirium slowly clears and he is able to participate in physical therapy and is able to return home after rehabilitation. Before he goes home, his medications are carefully reviewed, including OTC medications. ...
COGNITIVE MODEL OF EMOTIONAL DISTRESS
... A limited number of tablets should be prescribed to reduce the risk of overdose for all patients, especially those at risk of suicide A maximum prescription equivalent to 2 weeks’ supply of 75 mg per day should be considered in patients with increased risk factors for suicide at initiation of treatm ...
... A limited number of tablets should be prescribed to reduce the risk of overdose for all patients, especially those at risk of suicide A maximum prescription equivalent to 2 weeks’ supply of 75 mg per day should be considered in patients with increased risk factors for suicide at initiation of treatm ...
PowerPoint 簡報
... Limitation of drug resistance 1. Maintain sufficiently high levels of the drug in the tissue to inhibit both the original population and first-step mutants. 2. Simultaneously administer two drugs that do not give cross-resistance. 3. Avoid exposure of microbes to a particular drug by limiting its u ...
... Limitation of drug resistance 1. Maintain sufficiently high levels of the drug in the tissue to inhibit both the original population and first-step mutants. 2. Simultaneously administer two drugs that do not give cross-resistance. 3. Avoid exposure of microbes to a particular drug by limiting its u ...
Ototoxic Medications
... an already existing problem. It is important that you, the patient, take responsibility in knowing which drugs you should try to avoid. Usually any hearing problem will only be caused by exceeding the recommended dosage of the medications. Often these problems are reversible upon discontinuation of ...
... an already existing problem. It is important that you, the patient, take responsibility in knowing which drugs you should try to avoid. Usually any hearing problem will only be caused by exceeding the recommended dosage of the medications. Often these problems are reversible upon discontinuation of ...
Roach: Introduction to Clinical Pharmacology
... (free/bound drugs); blood flow; solubility (lipid-soluble drugs/water-soluble drugs) • Quick distribution: Heart; liver; kidneys • Slow distribution: Internal organs; skin; ...
... (free/bound drugs); blood flow; solubility (lipid-soluble drugs/water-soluble drugs) • Quick distribution: Heart; liver; kidneys • Slow distribution: Internal organs; skin; ...
Generic legislation of new psychoactive drugs
... Evaluation of the generic approach Clustering based on similarity of the chemical structure The generic approach is based on similarity of the chemical structure of an NPD to known illicit drug(s). The generic legislation describes clusters of compounds that have this similarity of chemical structur ...
... Evaluation of the generic approach Clustering based on similarity of the chemical structure The generic approach is based on similarity of the chemical structure of an NPD to known illicit drug(s). The generic legislation describes clusters of compounds that have this similarity of chemical structur ...
PPT here
... treatment of localized psoriasis. These studies suggest that niosomal methotrexate gel is more efficacious than placebo and marketed methotrexate gel. ...
... treatment of localized psoriasis. These studies suggest that niosomal methotrexate gel is more efficacious than placebo and marketed methotrexate gel. ...
Metabolic Transformations of Xenobiotics
... • Biotransformation is the process by which a drug is chemically altered by the body. • The liver is the principal, but not the only, site of drug biotransformation. The liver has enzymes that facilitate chemical reactions such as oxidation, reduction, and hydrolysis of drugs (phase I). It has other ...
... • Biotransformation is the process by which a drug is chemically altered by the body. • The liver is the principal, but not the only, site of drug biotransformation. The liver has enzymes that facilitate chemical reactions such as oxidation, reduction, and hydrolysis of drugs (phase I). It has other ...
Medical Pharmacology 201 The Florida State University College of Medicine
... 1. Demonstrate knowledge concerning each major drug class discussed in the course, including: a. prototype drug(s), b. mechanism(s) of action, c. important therapeutic actions and applications, and d. important (prevalent or life-threatening) adverse effects; 2. Demonstrate knowledge of the variatio ...
... 1. Demonstrate knowledge concerning each major drug class discussed in the course, including: a. prototype drug(s), b. mechanism(s) of action, c. important therapeutic actions and applications, and d. important (prevalent or life-threatening) adverse effects; 2. Demonstrate knowledge of the variatio ...
FDA`s Acetaminophen Notice: A Snapshot of the Current Regulatory
... Acetaminophen is widely recognized as an effective and well-tolerated drug when used as directed, and has been used successfully to treat ailments in millions of patients. Notably, acetaminophen use is not associated with gastrointestinal problems that are associated with many other pain drugs, such ...
... Acetaminophen is widely recognized as an effective and well-tolerated drug when used as directed, and has been used successfully to treat ailments in millions of patients. Notably, acetaminophen use is not associated with gastrointestinal problems that are associated with many other pain drugs, such ...
Labeling Aromatherapy Products
... “any food, drug, device, or cosmetic … and any other article, product, or commodity of any kind or class which is customarily produced or distributed for sale through retail sales agencies or instrumentalities for consumption by individuals, or use by individuals for purposes of personal care or in ...
... “any food, drug, device, or cosmetic … and any other article, product, or commodity of any kind or class which is customarily produced or distributed for sale through retail sales agencies or instrumentalities for consumption by individuals, or use by individuals for purposes of personal care or in ...
Slide 1
... NDC Number Each listed drug product listed is assigned a unique 10-digit, 3-segment number. This number, known as the NDC, identifies the labeler, product, and trade package size. The first segment, the labeler code, is assigned by the FDA. A labeler is any firm that manufactures (including repacker ...
... NDC Number Each listed drug product listed is assigned a unique 10-digit, 3-segment number. This number, known as the NDC, identifies the labeler, product, and trade package size. The first segment, the labeler code, is assigned by the FDA. A labeler is any firm that manufactures (including repacker ...
drug elimination ii
... systemtically available. This circle is called enterohepatic circulation • Drugs – glucuronide conjugate – hydrolyzed in the gut back to the parent drug by βglucuronidase enzyme present in the intestinal bacteria – the parent drug becomes available for reabsorption ...
... systemtically available. This circle is called enterohepatic circulation • Drugs – glucuronide conjugate – hydrolyzed in the gut back to the parent drug by βglucuronidase enzyme present in the intestinal bacteria – the parent drug becomes available for reabsorption ...
Pharmacokinetics and pharmacodynamics
... • Once daily dosage interval produces a wide swing in drug concentrations (high concentration after the drug is absorbed, possibly toxic, and a low concentration right before the next dose, possibly subtherapeutic). ...
... • Once daily dosage interval produces a wide swing in drug concentrations (high concentration after the drug is absorbed, possibly toxic, and a low concentration right before the next dose, possibly subtherapeutic). ...
patterns of drug-induced liver disease
... Valproate toxicity can also present in this pattern In advanced stages of Reye’s syndrome, many patients develop ...
... Valproate toxicity can also present in this pattern In advanced stages of Reye’s syndrome, many patients develop ...
Exam 1 - Solutions (10 points) 1. Find the equation of a line through
... 2. A calculus textbook dropped from the top of a 240 ft. tall building speeds up as it falls. It strikes the ground 3.87 seconds later. a. Draw a graph of the height of the book above the ground (measured in feet) as a function of the time since it was dropped (measured in seconds). Include labels a ...
... 2. A calculus textbook dropped from the top of a 240 ft. tall building speeds up as it falls. It strikes the ground 3.87 seconds later. a. Draw a graph of the height of the book above the ground (measured in feet) as a function of the time since it was dropped (measured in seconds). Include labels a ...
UNILAB`s RiteMed Initiative: Making Medicine Accessible to the Poor
... the marketing expense was factored into the product price, for which the consumer paid. “Many countries around the world have regulated this interesting practice of drug detailing,” noted Dr. Kenneth Hartigan-Go, Executive Director, Zuellig Pharma, Inc “but not in the Philippines.” 8 Appendix A look ...
... the marketing expense was factored into the product price, for which the consumer paid. “Many countries around the world have regulated this interesting practice of drug detailing,” noted Dr. Kenneth Hartigan-Go, Executive Director, Zuellig Pharma, Inc “but not in the Philippines.” 8 Appendix A look ...
P H A R M A G R A M
... Medical Center, if no new supplies arrive, it is estimated that we will exhaust our parenteral inventory of methylprednisolone (Solu Medrol), dexamethasone (Decadron) and betamethasone (Celestone) in about 2 to 4 months. The manufacturers and the FDA are anticipating these shortages to be ongoing fo ...
... Medical Center, if no new supplies arrive, it is estimated that we will exhaust our parenteral inventory of methylprednisolone (Solu Medrol), dexamethasone (Decadron) and betamethasone (Celestone) in about 2 to 4 months. The manufacturers and the FDA are anticipating these shortages to be ongoing fo ...
Pharmaceutical industry
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.