DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION
... Objective: To develop and validate simple, sensitive, precise, rapid and cost effective method for determination of Maraviroc in bulk and pharmaceutical formulations as per ICH Guidelines. Methods: A simple double beam UV Spectrophotometric method has been developed and validated with different para ...
... Objective: To develop and validate simple, sensitive, precise, rapid and cost effective method for determination of Maraviroc in bulk and pharmaceutical formulations as per ICH Guidelines. Methods: A simple double beam UV Spectrophotometric method has been developed and validated with different para ...
USMLE Step 1 Web Prep — Antiarrhymic Drugs 145295 >>> 0:00
... Choice) for arrhythmias following attempted cardioversion. Rapid first pass effects preclude oral use. Adverse effects: CNS toxicity culminating in seizures in severe OD. Least cardiotoxic of conventional antiarrhythmics. ...
... Choice) for arrhythmias following attempted cardioversion. Rapid first pass effects preclude oral use. Adverse effects: CNS toxicity culminating in seizures in severe OD. Least cardiotoxic of conventional antiarrhythmics. ...
NOVARTIS OPHTHALMICS AND QLT ANNOUNCE FDA
... or improved vision (as defined by a loss of less than 8 letters on a standard eye chart) in 72% of patients versus 44% on placebo at month 12. In an open label safety study involving 26 patients with ocular histoplasmosis, visual acuity improved by an average of more than 1 line on a standard eye ch ...
... or improved vision (as defined by a loss of less than 8 letters on a standard eye chart) in 72% of patients versus 44% on placebo at month 12. In an open label safety study involving 26 patients with ocular histoplasmosis, visual acuity improved by an average of more than 1 line on a standard eye ch ...
Taste Masked Suspension - The Pharma Innovation Journal
... than at the pH value of the mouth, which is around 5.9. Some pharmaceutical compositions have utilized this concept and suspended the drug at a pH in which it remains insoluble. In this condition, the drug can be insufficiently solubilised to be available to taste if the equilibrium concentration is ...
... than at the pH value of the mouth, which is around 5.9. Some pharmaceutical compositions have utilized this concept and suspended the drug at a pH in which it remains insoluble. In this condition, the drug can be insufficiently solubilised to be available to taste if the equilibrium concentration is ...
pharma 2
... If it happened during childhood, it is characterized by disapropriate increased body fat and decreased muscle mass, but if it happened during adult life, it is characterized by low lean body mass ...
... If it happened during childhood, it is characterized by disapropriate increased body fat and decreased muscle mass, but if it happened during adult life, it is characterized by low lean body mass ...
Gilead Sciences (7-03
... Approximately 1.2 million Americans are living with HIV and half are not being treated. Half a million people world wide are treating HIV with one of Gilead’s products which generated revenues of 3 billion in 2007. Hepsera is the leading antiviral to treat Hepatitis B, there are more than 400 milli ...
... Approximately 1.2 million Americans are living with HIV and half are not being treated. Half a million people world wide are treating HIV with one of Gilead’s products which generated revenues of 3 billion in 2007. Hepsera is the leading antiviral to treat Hepatitis B, there are more than 400 milli ...
Natural health product–HIV drug interactions: a
... individuals,23 due to disease state, co-medications and other unknown factors. In addition, due to ethical considerations of toxic exposure or the potential for drug resistance with some HIV drugs, the healthy participants are exposed to short-term dosing of the PIs, dissimilar from the treatment of ...
... individuals,23 due to disease state, co-medications and other unknown factors. In addition, due to ethical considerations of toxic exposure or the potential for drug resistance with some HIV drugs, the healthy participants are exposed to short-term dosing of the PIs, dissimilar from the treatment of ...
Pharmacology and Clinical Pharmacology
... metabolism in the body. This is important for duration of drug action plus the toxicity of drugs often involves metabolism, either through a lack of metabolism resulting in higher than expected concentrations or conversion to a chemicallyreactive metabolite. Such reactive intermediates may interact ...
... metabolism in the body. This is important for duration of drug action plus the toxicity of drugs often involves metabolism, either through a lack of metabolism resulting in higher than expected concentrations or conversion to a chemicallyreactive metabolite. Such reactive intermediates may interact ...
The Use of Propensity Scores and Instrumental Variable Methods to Adjust For Treatment Selection Bias
... Angrist, J., G. Imbens, and D. Rubin. 1996. "Identification of Causal Effects Using Instrumental Variables." Journal of the American Statistical Association 91: 444-55. Hogan, J. et al. 2004. “Instrument Variables and Inverse Probability Weighting for Causal Inference from Longitudinal Observational ...
... Angrist, J., G. Imbens, and D. Rubin. 1996. "Identification of Causal Effects Using Instrumental Variables." Journal of the American Statistical Association 91: 444-55. Hogan, J. et al. 2004. “Instrument Variables and Inverse Probability Weighting for Causal Inference from Longitudinal Observational ...
Antiviral drugs
... didanosine, zidovudine and protease inhibitors, etc.). In other cases toxic synergistic effects preclude concurrent administration of two antiviral drugs (i.e. zidovudine and acyclovir, zidovudine and ...
... didanosine, zidovudine and protease inhibitors, etc.). In other cases toxic synergistic effects preclude concurrent administration of two antiviral drugs (i.e. zidovudine and acyclovir, zidovudine and ...
Classification of research and development activities
... As small molecules are defined chemical entities with molecular weight <800 Daltons, that may serve as regulator of biological processes or enzyme substrate. They usually bind to a biopolymer such as protein, nucleic acid, or polysaccharide and acts as an effector (agonist or antagonist) altering th ...
... As small molecules are defined chemical entities with molecular weight <800 Daltons, that may serve as regulator of biological processes or enzyme substrate. They usually bind to a biopolymer such as protein, nucleic acid, or polysaccharide and acts as an effector (agonist or antagonist) altering th ...
Essay B5 Chem 151 Professor Whitesell Amphetamines Imagine for
... Edeleanu received his Ph.D in Chemistry the same year for finding synthetic methods to build the compound and its discovery. As a chemist, Edeleanu was not a capable pharmacologist and did not attempt to study the physiological properties of the drug he synthesized. Hence, Amphetamine’s drug effects ...
... Edeleanu received his Ph.D in Chemistry the same year for finding synthetic methods to build the compound and its discovery. As a chemist, Edeleanu was not a capable pharmacologist and did not attempt to study the physiological properties of the drug he synthesized. Hence, Amphetamine’s drug effects ...
Pages 12-15 - eCM journal
... in solid tumors with good efficacy. However, radiation exposure to normal tissue surrounding the tumor or in the path to a tumor is the limiting step of this therapy [7]. The MTC technology could overcome these limitations by direct localization of MTCs labeled with radionuclides inside the tumor. I ...
... in solid tumors with good efficacy. However, radiation exposure to normal tissue surrounding the tumor or in the path to a tumor is the limiting step of this therapy [7]. The MTC technology could overcome these limitations by direct localization of MTCs labeled with radionuclides inside the tumor. I ...
The AL-1 Story
... Simultaneous use of AZT is not recommended, as it can inhibit the intracellular phosphorylation of stavudine. Other anti-HIV drugs do not possess this property. ...
... Simultaneous use of AZT is not recommended, as it can inhibit the intracellular phosphorylation of stavudine. Other anti-HIV drugs do not possess this property. ...
17.Ramdas T. Dolas, Dr. Avinash Hosmani and Sachin B. Somwanshi
... on delivery systems which enhance desirable therapeutic objectives while minimizing side effects. Gastro Retentive Drug Delivery are the most commonly formulated but still offer highest attention in the area of novel drug delivery systems. This system can also help in optimizing oral controlled deli ...
... on delivery systems which enhance desirable therapeutic objectives while minimizing side effects. Gastro Retentive Drug Delivery are the most commonly formulated but still offer highest attention in the area of novel drug delivery systems. This system can also help in optimizing oral controlled deli ...
Medical Pressure
... • Identify factors that control blood pressure • Identify the pharmacologic classes of drugs used in treatment of hypertension • Know examples of each class. ...
... • Identify factors that control blood pressure • Identify the pharmacologic classes of drugs used in treatment of hypertension • Know examples of each class. ...
Muscle Relaxants
... B. Sedatives (to calm and make patients unaware of their environment) C. Hypnotics (cause sleep/extreme sedation resulting in further CNS depression and sleep) II. Uses 1. Geriatric pts: comprise only 12% of our pop, but they consume 35-45% of the sedative-hypnotic drugs - for those in long-term car ...
... B. Sedatives (to calm and make patients unaware of their environment) C. Hypnotics (cause sleep/extreme sedation resulting in further CNS depression and sleep) II. Uses 1. Geriatric pts: comprise only 12% of our pop, but they consume 35-45% of the sedative-hypnotic drugs - for those in long-term car ...
Drotaverine
... In peptic ulcer, it is expedient to combine Drotaverine Hydrochloride with atropine or atropine like compounds. Injection Subcutaneously or intramuscularly - Usually 2 to 4 ml (1 - 2 ampoules) injection, 1-3 times daily. In case of acute stone colic, 2 to 4 ml (1 - 2 ampoules) may be given by slow i ...
... In peptic ulcer, it is expedient to combine Drotaverine Hydrochloride with atropine or atropine like compounds. Injection Subcutaneously or intramuscularly - Usually 2 to 4 ml (1 - 2 ampoules) injection, 1-3 times daily. In case of acute stone colic, 2 to 4 ml (1 - 2 ampoules) may be given by slow i ...
01 NEUROMUSCULAR BLOCKERS(BLOCK 1st year).
... • First opening of the Na+ channel occurs resulting in depolarization, muscle twitching occurs , continued binding of drug make the receptor incapable of transmitting the impulses PARALYSIS OCCURS. ...
... • First opening of the Na+ channel occurs resulting in depolarization, muscle twitching occurs , continued binding of drug make the receptor incapable of transmitting the impulses PARALYSIS OCCURS. ...
CHRONIC TREATMENT OF DIABECON IN THE REGULATION OF ALLOXAN INDUCED
... degradation of bio-membranes produces malondialdehyde (MDA), an important LPO product that has been extensively used as oxidative damage marker[6-8]. To get rid of diabetes and it’s related problems, different classes of antidiabetic drugs have been used, though, very few proved to be satisfactorily ...
... degradation of bio-membranes produces malondialdehyde (MDA), an important LPO product that has been extensively used as oxidative damage marker[6-8]. To get rid of diabetes and it’s related problems, different classes of antidiabetic drugs have been used, though, very few proved to be satisfactorily ...
VolkowandLi Drug Addiction.2004
... Environmental factors. Environmental factors that have been consistently associated with the propensity to self-administer drugs include low socio-economic class, poor parental support and drug availability. Stress might be a common feature in a wide variety of environmental factors that increase th ...
... Environmental factors. Environmental factors that have been consistently associated with the propensity to self-administer drugs include low socio-economic class, poor parental support and drug availability. Stress might be a common feature in a wide variety of environmental factors that increase th ...
(PK) study with BEKINDA ™ 12 mg (RHB-102)
... cases of IBS-D3. The U.S. potential market for IBS-D treatments is estimated to exceed $1.25 billion by 2020. 5-HT3 antagonists such as ondansetron, the active pharmaceutical ingredient in BEKINDA™, have been shown to slow intestinal transit time in humans4. Alosetron (Lotronex®), a 5-HT3 antagonis ...
... cases of IBS-D3. The U.S. potential market for IBS-D treatments is estimated to exceed $1.25 billion by 2020. 5-HT3 antagonists such as ondansetron, the active pharmaceutical ingredient in BEKINDA™, have been shown to slow intestinal transit time in humans4. Alosetron (Lotronex®), a 5-HT3 antagonis ...
Recognizing Drug Use in Adolescents
... use to achieve the feeling obtained at their first use. Overdose information: The chemical properties of cocaine cause blood vessels to decrease in size and cause the heart to beat more rapidly. The combination of these two effects can result in a heart attack, burst blood vessel, or a seizure. At h ...
... use to achieve the feeling obtained at their first use. Overdose information: The chemical properties of cocaine cause blood vessels to decrease in size and cause the heart to beat more rapidly. The combination of these two effects can result in a heart attack, burst blood vessel, or a seizure. At h ...
STUDIES ON DISSOLUTION ENHANCEMENT OF LOVASTATIN USING SOLUPLUS BY SOLID
... humidity, photo-stability, compatibility with solvents etc. Among all these, Solubility is the most important property for developing formulations. The present study is an attempt to improve the solubility and dissolution rate using solid dispersion of a poorly soluble drug Lovastatin by using Solup ...
... humidity, photo-stability, compatibility with solvents etc. Among all these, Solubility is the most important property for developing formulations. The present study is an attempt to improve the solubility and dissolution rate using solid dispersion of a poorly soluble drug Lovastatin by using Solup ...
(PK) of LOXO-101 During the First-in-Human
... dosing, the AUC between 0 and 12 hours was calculated by log-linear extrapolation of the measured concentrations at 6 and 8 hours through 12 hours. The extrapolated AUC was 9% of the AUC in all cases. For BID dosing, AUC0-24 was calculated as 2 x AUC0-12. ...
... dosing, the AUC between 0 and 12 hours was calculated by log-linear extrapolation of the measured concentrations at 6 and 8 hours through 12 hours. The extrapolated AUC was 9% of the AUC in all cases. For BID dosing, AUC0-24 was calculated as 2 x AUC0-12. ...
Pharmaceutical industry
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.