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Cardiac endocrine function is an essential component of the
Cardiac endocrine function is an essential component of the

... Wall stretch is the most important stimulus for synthesis and secretion of ANP in the atrial walls (30, 31, 105, 136, 145, 152). For this reason, any physiological condition associated with an acute increase in venous return (preload), such as physical exercise, rapid changes from standing to supine ...
Hypoplastic left heart - British Heart Foundation
Hypoplastic left heart - British Heart Foundation

... This helps to protect the lungs. After the surgery, your baby will have a scar down the middle of his or her chest. What are the risks of the hybrid procedure? This is a relatively new procedure and the technique is still being evaluated. Your paediatric cardiologist will discuss this with you in m ...
PDF Article
PDF Article

... subjects were positioned comfortably in a IO° head-up position on a tilt table . An intravenous cunnula was placed in a vein in an arm or hand to obtain blood samples . Baseline heart rate and arterial pressure were recorded by an automated cuff. A 30-min rest period was then observed . after which ...
Cardiac Pulmonary Edema and Cardiogenic Shock
Cardiac Pulmonary Edema and Cardiogenic Shock

... recommended for patients < 75 years old with ST elevation or new LBBB who develop shock unless further support is futile due to patient’s wishes or unsuitability for further invasive care. Fibrinolytic therapy should be administered to STEMI patients with cardiogenic shock who are unsuitable for fur ...
Leaflet Adrenaline ampoules
Leaflet Adrenaline ampoules

... Half doses of adrenaline may be safer for patients who are taking amitriptyline, ipramine or a beta blocker. Children: The following doses of adrenaline 1/1,000 are recommended: Age Over 12 years ...
Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis
Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis

... promotes traveling of dendritic cells into the allograft, resulting in increased graft immunogenicity and recipient alloimmune response. While older age and male sex of the donors are associated with higher risk, older age of the recipient is associated with lower risk for CAV (14,38,39). CAV severi ...
Assessment of inpatient multimodal cardiac imaging
Assessment of inpatient multimodal cardiac imaging

... number (31) from site 3. Overall more SPECT studies were performed by GIM than Cardiology (33 vs. 13). All were classifiable using the AUC for SPECT. There were no rarely appropriate studies and few studies that were classified as may be appropriate (2 at site 2 and 1 at site 3). The appropriateness ...
2 - JACC: Cardiovascular Interventions
2 - JACC: Cardiovascular Interventions

... gating of the data. The 3-dimensional dataset of the contrast-enhanced scan was reconstructed in 10% increments over the cardiac cycle, generating 4-dimensional computed tomography data for assessment of the dynamic motion of the aortic valve annulus. Our results revealed a potentially dramatic chan ...
Narrow Complex Tachycardias - Calgary Emergency Medicine
Narrow Complex Tachycardias - Calgary Emergency Medicine

... 78 yo F presents w/ NCT Hx of PSVT – ECG looks identical Had severe side effects w/ adenosine previously & refuses repeat Does not want to be shocked either When you ask for Verapamil the nurse points out her pressure is only 88/65 What can you do? ...
Congenital pericardial defects
Congenital pericardial defects

... right bundle-branch block. These signs suggest the diagnosis of atrial septal defect, which is not uncommonly present in association with complete absence of the left pericardium (as in case 1 in this paper and the patients reported by Fisher and Ehrenhaft (1964) and Tabakin et al. (1965)). This sho ...
The Autonomic Nervous System and Atrial Fibrillation:The
The Autonomic Nervous System and Atrial Fibrillation:The

... junctional reentry (AVNRT) atrial flutter (AFL) and ventricular arrhythmias, clinical electrophysiologists have focused on the myocardial basis of atrial fibrillation (AF). Thus, the strategy for ablation of drug and cardioversion refractory AF was to isolate the myocardial connections from the foca ...
Point of View Maladies Attributed to Myxomatous Mitral
Point of View Maladies Attributed to Myxomatous Mitral

... has not always been excluded by echocardiography in controls.55,5758 Third, some studies have drawn conclusions from measuring catecholamines at rest or during passive standing.56,58 It is preferable to study changes in circulating catecholamines during orthostatic stress and isometric exercise. We ...
Internal atrial cardioversion in atrial fibrillation
Internal atrial cardioversion in atrial fibrillation

... Electrical cardioversion is usually performed using the transthoracic technique with delivery of monophasic shocks at 200360 J and the efficacy results are 61-94%1,2. However as little as 4% of the current from an external shock effectively penetrates cardiac tissue, while the majority follows other ...
Triage® BNP Test Product Insert
Triage® BNP Test Product Insert

... It is estimated that 5.8 million people in the United States have heart failure with approximately 670,000 new cases occurring each year.1 Congestive heart failure (CHF) occurs when the heart cannot deliver a sufficient amount of blood to the body.2 This condition can occur at any age but is most pr ...
- Journal of Pharmacognosy and Phytochemistry
- Journal of Pharmacognosy and Phytochemistry

... stimulate the need to understand how blue cohosh can been safely and holistically used, and without side effects in pregnant women. In 1997, a case study followed an expectant mother who was ingesting blue cohosh under the supervision of her midwife for three weeks prior to her due date. The mother ...
20 Pregnancy and Heart Disease Patrizia Presbitero, Giacomo G. Boccuzzi, Christianne J.M.
20 Pregnancy and Heart Disease Patrizia Presbitero, Giacomo G. Boccuzzi, Christianne J.M.

... during pregnancy because of the low peripheral resistance; however, if systemic hypertension, NYHA class III– IV, an ejection fraction around 40% or ventricular arrhythmias are present, it becomes a high-risk condition. Counselling, surveillance and treatment of women with cardiac disease should be ...


... The following phases are distinguished in the care program for heart patients: 1. Preoperative phase. This phase preferably starts 4 weeks before cardiac surgery. Patients who have to undergo an open heart operation (coronary artery bypass grafting [CABG] and/or valve replacement) and are at increas ...
The Cardiovascular System The Cardiovascular System
The Cardiovascular System The Cardiovascular System

... specialized group of cells located low in the atrial septum. Here the impulse is delayed before passing down the bundle of His and its branches to the ventricular myocardium. Muscular contraction follows: first the atria, then the ventricles. The normal conduction pathway is diagrammed in simplified ...
X35129134
X35129134

... palpitation, syncope, weakness etc. Studies on scatter plots of normal, Intracardiac atrial fibrillation and other arrhythmic ECGs can be done ...
High-Intensity Intermittent Exercise Training for
High-Intensity Intermittent Exercise Training for

... remain active for a longer period of time at the end of the protocol; it cannot be safe for more complicated patients. The training duration varied more, with a minimum of 10 weeks and one study evaluating the 1 year effect of HIIE. The most common training duration was of 12 weeks (3 months). Howev ...
risks of exercise
risks of exercise

... Recent epidemiologic studies have shown that each 1-MET increase in exercise capacity confers an 8% to 17% reduction in cardiovascular and all-cause mortality (Franklin 2007). One possible mechanism by which regular physical activity, improved aerobic fitness, or both, may provide cardioprotective b ...
Regulation of Ventricular Contraction
Regulation of Ventricular Contraction

... the shorter duration of ejection and the more rapid relaxation were consistent and noteworthy. Changes of the type observed can be seen in figure 6 (lower). In 8 of the 19 function curve experiments described above (under stellate stimulation), left ventricular end diastolic pressure, as well as mea ...
Chapter 96 - Extras Springer
Chapter 96 - Extras Springer

... the premature atrial beat that also initiates SVT. This phase 3 block of the left bundle is followed by conduction over the right bundle and retrograde invasion into the left bundle branch. This makes the left bundle branch refractory when the next supraventricular impulse passes through the AV node ...
Garvey 1 EKG Lecture RACE May 2013
Garvey 1 EKG Lecture RACE May 2013

... Chest Leads: V1 – V6 V1 – 4th IC space, R of sternum V2 – 4th IC space, L of sternum V3 – between V2 and V4 V4 – 5th IC space, Mid clav line V5- Lat to V4, Anterior Ax line V6 – Lat to V4 and V5, Mid Ax ...
Role of Pacing in the Management of Neurocardiogenic
Role of Pacing in the Management of Neurocardiogenic

... pacemaker. The patient's are relatively hypovolemic. As such, they require atrial pacing to maintain the atrial contribution to ventricular filling which would not be available with a VVI pacemaker although this will support the heart rate. The increased in vagal tone which is the final common pathw ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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