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Changes in cardiac troponin I concentration and in stallions
Changes in cardiac troponin I concentration and in stallions

... The actual half life (T1/2) of circulating cTnI is relatively short (2 hours).6 Small amounts are initially released from the cytoplasm, resulting in early diagnostic sensitivity, while cTn reaches and persists in circulation following myocardial cell necrosis due to the continual slow release and d ...
Professional Rescuer CPR - Emergency Care and Safety Institute
Professional Rescuer CPR - Emergency Care and Safety Institute

... pressurized oxygen, or pneumatic (vacuum) devices. These units require familiarity with the mechanisms for their use, as well as regular maintenance and service checks (Figure 6.2). Like manual suction devices, these mechanical devices also create a vacuum that draws obstructing materials from the p ...
Temporary epicardial pacing after cardiac surgery
Temporary epicardial pacing after cardiac surgery

... bradycardia with low cardiac output, nodal or junctional arrhythmias, or AV block [7]. Whereas in one study only 2.6% of patients without diabetes, preoperative arrhythmia or the need for pacing to separate from bypass required pacing in the postop period [8], many centres find this risk unacceptabl ...
Increasing myocardial contraction and blood pressure in - AJP
Increasing myocardial contraction and blood pressure in - AJP

... L, 25 mg in 40 ml, Sigma; St. Louis, MO) and finally sectioned in small parts, which were directly transferred into normal Tyrode solution (composition as described above) but with 1.8 mM CaCl2 instead of EGTA plus trypsin inhibitor (0.167 mg/ml, Sigma). In this solution, the pieces were disintegrat ...
Measurement of cardiac output during exercise in patients with
Measurement of cardiac output during exercise in patients with

... fatigue, shortness of breathing during light exercise and fluid retention and often result in decreased exercise capacity. [2] Once the diagnosis of chronic heart has been established, patients in stable condition should be encouraged to carry out some physical activity and leisure time activities t ...
Pulmonary Arterial Hypertension: A Two
Pulmonary Arterial Hypertension: A Two

... 2DSTE is an angle-dependent modality that uses a nonDoppler-based algorithm to quantify the strain by taking advantage of the motion of the ultrasound beam-derived “speckles” embedded in the myocardium. 2DSTE has now practically replaced 1DTDI because of its far superior reproducibility and very nig ...
AHA/ACC/ASH Scientific Statement
AHA/ACC/ASH Scientific Statement

... for nearly 60% of all excess IHD, overall cardiovascular disease (CVD), or all-cause mortality.9 Epidemiological data show that lower BP levels are associated with lower disease risks, suggesting that future coronary events can be prevented by reducing BP.10 Elevated BP represents a substantial popu ...
USING BALLISTOCARDIOGRAPHY TO EVALUATE CARDIAC
USING BALLISTOCARDIOGRAPHY TO EVALUATE CARDIAC

... During exercise the demand on the heart increases considerably. Evidence suggests that long-term exercise training causes adaptations to the heart that are not present in the sedentary, and is commonly referred to as athlete’s heart. It is not unusual for the cardiac adaptations to mimic certain pat ...
Intermediate Outcome of Transcatheter Closure of Secundum Atrial
Intermediate Outcome of Transcatheter Closure of Secundum Atrial

... assess the intermediate term outcome of the procedure and the data were compared with the preintervention and short term follow up data. The 30 patients were 12 males (40%) and 18 females (60%) with age ranging from 3 to 40 years and median of 10 years. The weight of the patients ranged from 15 to 1 ...
Cardiovascular mortality and N-terminal
Cardiovascular mortality and N-terminal

... this intervention study. All citizens aged between 70 and 88 years (n = 1320) had previously participated in an epidemiological study and had been continuously followed with medical examinations since 1998. A total of 876 people accepted the invitation to that study. We invited these participants to ...
PDF - Research Review NZ
PDF - Research Review NZ

... During the last 10 years, an expanding range of treatment options has dramatically improved outcomes for patients with PAH, improving quality of life and increasing survival. However, many patients still have a very poor prognosis, with their condition deteriorating rapidly. One of the key factors i ...
Early Fetal Echocardiography at the Time of 11 –13 Weeks Scan
Early Fetal Echocardiography at the Time of 11 –13 Weeks Scan

... with intact ventricular septum and hyperdynamic DV velocimetry or even reverse A – wave during atrial contraction.19 Connection of specific type of cardiac anomalies and increased NT was investigated. Hyett and co-workes17 and Orvos et al.14 found a significant association with left heart lesions an ...
The Role Of Renin Angiotensin System In Atrial Fibrillation
The Role Of Renin Angiotensin System In Atrial Fibrillation

... AF.3,6,23,24 The activation of RAS plays an integral part in the neurohumoral processes leading to changes seen in systemic hypertension and heart failure. There is some evidence to suggest that RAS is associated with the development of AF in subjects with systemic hypertension and heart failure.22, ...
Herz Significance of Late Gadolinium Enhancement in
Herz Significance of Late Gadolinium Enhancement in

... from the bright blood in the left ventricular cavity. The additional use of a short inversion time can help in this case and further improve the diagnostic accuracy of LGE-CMR [15]. LGE is also useful for detecting very small infarcts which may occur during interventional procedures [42]. Although s ...
HeartStart MRx and XL AED Algorithm
HeartStart MRx and XL AED Algorithm

... Shockable rhythms have certain characteristics that can be used to distinguish them from non-shockable rhythms. The feature extraction component of the HeartStart MRx/XL AED algorithm measures these key characteristics and provides the measurements to the rhythm classification component of the algor ...
Effects of a Left Ventricular Assist Device with a Centrifugal Pump on
Effects of a Left Ventricular Assist Device with a Centrifugal Pump on

... assess left ventricular diastolic function. Pulsatile pumps have valves and operate independently of LV pressure and contraction. In contrast, rotary pumps have no valves and operate in synchronicity with LV pressure and contraction, as there is continuous flow through the pump.22) Comparing the pos ...
Estimation of left ventricular operating stiffness from - AJP
Estimation of left ventricular operating stiffness from - AJP

... vein, mitral annulus, and leaflet tips were acquired during suspended ventilation before cardiopulmonary bypass, during partial (1.5–2 l/min) cardiopulmonary bypass, and after surgery. Ventilation was suspended for at most 20–30 s at a time during which time data collection was performed. All patien ...
Intraoperative Recording of Specialized Atrioventricular Conduction
Intraoperative Recording of Specialized Atrioventricular Conduction

... AV conduction tissue was explored with a hand-held probe 3-5 mm in diameter, with three biopolar pairs of electrodes (1 mm apart). The patients' esophageal temperatures were maintained between 30-37°C. Each bipolar pair of electrodes was connected to a Hewlett-Packard high impedance differential amp ...
Posterior Pericardial Ascending-to-Descending Aortic
Posterior Pericardial Ascending-to-Descending Aortic

... septal myectomy, mitral valve replacement, aortoplasty, subaortic stenosis resection, ventricular septal defect closure, and ascending aorta replacement in 1 patient each. All patients survived the operation and were alive with patent CoA bypass at a mean follow-up of 45 months. No graft-related com ...
The normal and diseased pericardium: Current concepts of
The normal and diseased pericardium: Current concepts of

... A D R ENE R G I CST I M U L A T ION ...
Asymmetrical Dimethylarginine in Idiopathic Pulmonary Arterial
Asymmetrical Dimethylarginine in Idiopathic Pulmonary Arterial

... important role in regulation of NOS activity.24 A relevant role of ADMA in the pathogenesis of IPAH could derive from reduced activity of DDAH with increasing severity of the disease, eventually as a result of increased oxidant stress as well as hypoxia.9 This assumption is corroborated by findings ...
Physical Examination of the Cardiovascular System
Physical Examination of the Cardiovascular System

... Cardiac physical examination skills have waned [1]. While portable ultrasound can aid in the accuracy of the bedside cardiovascular evaluation, the cardiac physical is cheap, of diagnostic value, and establishes rapport between patient and physician [2]. First, it is important to be systematic. Seco ...
Cardiac repolarization analysis using the surface - DIEC
Cardiac repolarization analysis using the surface - DIEC

... In this section, a review of ECG indices proposed in the literature to assess spatial heterogeneity of ventricular repolarization is presented, together with their value for assessing the risk of suffering from malignant ventricular arrhythmias. (a ) Dispersion of repolarization reflected on ECG inte ...
Termination and Inhibition of Recurrent Tachyeardias
Termination and Inhibition of Recurrent Tachyeardias

... the first of a series of episodes of VT requiring hospitalization for pharmacologic or electrical cardioversion. At first these episodes occurred twice a year and he appeared to benefit from antiarrhythmic therapy with quinidine and propranolol, and later with procaine amide. Between June and Septem ...
chapter 1. overview - IMIB-CHD
chapter 1. overview - IMIB-CHD

... coexist. The hearts described as ‘criss-cross hearts’ almost invariably show the inlet of one ventricle located superior to the inlet of the other ventricle. The right ventricular inlet is almost always superior to the left ventricular inlet. However, the positions of the apices of the ventricles va ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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