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Chapter 14
Chapter 14

... • Venous return rate • Compliance • (2) Residual blood in ventricles after ejection ...
Cardio Objectives
Cardio Objectives

... mechanism of action including Starling's Law, venous return, autonomic nervous input, hemorrhage (blood loss). Contrast the sympathetic and parasympathetic nervous system influence on cardiac output. Identify which is dominant at rest (para) and during exercise (symp). Discuss their mechanisms of ac ...
nicorandil
nicorandil

... potassium to flow across the membranes of the cells. In particular, a type known as the ATP-sensitive potassium channel is thought to be involved. Since nicorandil is an ATP-sensitive potassium channel opener, it is thought that it may be able to mimic this natural phenomenon, and work to preconditi ...
study for circulatory system
study for circulatory system

... Isoelectric line = baseline, reference line, horizontal axis = timing of events, frequency P wave = depolarization of atria QRS wave=depolarization of ventricles (repolarization of atria hidden within QRS wave) T wave = repolarization of ventricles Vertical axis = strength & direction of current Obs ...
Properties of Cardiac Muscle
Properties of Cardiac Muscle

... timing and strength of each heart beat but do not establish the fundamental rhythm. ...
atrial fibrillation atrial flutter
atrial fibrillation atrial flutter

... Oral anticoagulation should be initiated with a target INR of 2-3 and continued until further notice. ...
Myocardial Infarction - Acute - Secondary Prevention
Myocardial Infarction - Acute - Secondary Prevention

... a dose of 75 mg/day. The lower dose is as effective with fewer side effects and is generally the recommended dose. Studies have not shown that other antiplatelet agents have advantages over aspirin. ACE inhibitors: The long-term use of an angiotensin converting enzyme (ACE) inhibitor reduces mortal ...
Arctic Front Advance™ Cardiac Cryoballoon Backgrounder
Arctic Front Advance™ Cardiac Cryoballoon Backgrounder

...  The Freezor® MAX Cardiac CryoAblation Catheter, which is a single‐point  catheter used to provide additional ablations, as needed; and   The CryoConsole, which houses the coolant, electrical and mechanical  components that run the catheters during a cryoablation procedure.  ...
CHAPTER 20 CARDIOVASCULAR SYSTEM: THE HEART
CHAPTER 20 CARDIOVASCULAR SYSTEM: THE HEART

... the fact that they must grasp heart anatomy, blood flow through the heart and to the heart, and heart physiology before they can begin to understand heart dysfunction. It is also important for students to realize how lifestyle (even at their age) can influence heart and vascular health. Early in the ...
Prognostic Value of Myocardial Perfusion Imaging In Patients
Prognostic Value of Myocardial Perfusion Imaging In Patients

... Conclusions - High sum rest scores typically indicate prior myocardial infarction, and this was independently associated with higher mortality in our cohort. Increased left ventricular end systolic volume on stress compared to rest images is likely to be secondary to subendocardial ischaemia due to ...
The Thoratec System Implanted as a Modified Total Artificial Heart
The Thoratec System Implanted as a Modified Total Artificial Heart

... The CardioWest™ temporary total artificial heart (SynCardia Systems, Tucson, AZ, USA) is the world’s first and only FDA-approved total artificial heart (TAH). It received FDA approval in October 2004 following a 10-year pivotal clinical study. The TAH orthotopically replaces both native cardiac ventric ...
Advanced Heart Failure and Transplant Cardiology Fellowship
Advanced Heart Failure and Transplant Cardiology Fellowship

... The Greenberg Division of Cardiology at Weill Cornell offers an Advanced Heart Failure and Transplant Cardiology Fellowship accredited by ACGME. The heart failure service has a high volume of clinical activities related to all aspects of heart failure, mechanical circulatory support, pulmonary hyper ...
Cardiovascular System - Western Washington University
Cardiovascular System - Western Washington University

... circulation, including the example shown in this figure. Do the lungs receive a portion of the systemic cardiac output? Why or why not? Why does fetal circulation allow mixing of blood between the two circuits? ...
Circulatory heart
Circulatory heart

... (sugars that are stored in our bodies). – Best for strength training and body sculpting. ...
Biol 155 Human Physiology - University of British Columbia
Biol 155 Human Physiology - University of British Columbia

... Elongated, branching cells containing 1-2 centrally located nuclei Contains actin and myosin myofilaments Intercalated disks: Specialized cell-cell contacts Desmosomes hold cells together and gap junctions allow action potentials Electrically, cardiac muscle behaves as single unit ...
Congestive Heart Failure
Congestive Heart Failure

... Ischemic heart disease Dilated cardiomyopathy: first degree AV block, LBBB, Left anterior fascicular block ...
PowerPoint **
PowerPoint **

... Perfusion pressures across the systemic vasculature ...
Clinical Pharmacy Program Guidelines for Multaq Program Prior
Clinical Pharmacy Program Guidelines for Multaq Program Prior

... Reworded requirement for permanent atrial fibrillation (see section 1 of criteria); Removed requirement that the patient has one CV risk factor; Removed prescriber requirement; Added requirement that the patient is currently receiving antithrombotic therapy; Added requirement that the patient is in ...
Chapter 14
Chapter 14

... ankles and over the lower tibias. His blood pressure was 115/80. The chest x-ray examination showed an enlarged heart and diffuse density (indicative of fluid in the lungs) at both lung bases. An electrocardiogram (ECG) showed normal sinus ...
Purpose of test NICE CG 187 Acute Heart Failure and NICE CG 108
Purpose of test NICE CG 187 Acute Heart Failure and NICE CG 108

... NICE CG 187 Acute Heart Failure and NICE CG 108 Chronic Heart failure currently recommend the use of NTproBNP/BNP as a first line test in ruling out HF and thus obviating the need for specialist input or Doppler ...
Management of chronic heart failure
Management of chronic heart failure

Evolving role of cardiac resynchronization therapy
Evolving role of cardiac resynchronization therapy

... Fonarow GC, et al. Circ Heart Fail. 2008;1:98–106. *Underutilization more common in women 79% vs 52% (Hoang et al Heart Rhythm ...
Medtronic Launches Large-Scale Clinical Trial to Examine Impact of
Medtronic Launches Large-Scale Clinical Trial to Examine Impact of

at the forefront
at the forefront

... for dinner together afterwards, Reiter recalls. This year, the Heart Rhythm Society’s confab in Boston is expecting 13,000 people. These specialists serve patients whose hearts have a wide variety of electrical problems. Among them: atrial fibrillation, in which one or both of the heart’s upper cham ...
Slide 1
Slide 1

... • Extracorporeal perfusion started in 1963,s • Since that time many new medically valuable procedures and technologies have been developed and utilized by perfusionists. • This dynamic field continues to develop and improve. • perfusion as a profession. ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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