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Topics in Toxicology 2007
Topics in Toxicology 2007

... Improves conduction in Purkinje system  Restores pacemaker activity ...
Heart Failure With Normal Ejection Fraction
Heart Failure With Normal Ejection Fraction

... with HFNEF & in these patients reduction of BP reduces pulmonary congestion, relieves cardiac ischemia & in the long run leads to regression of LVH. Since the prevalence of diabetes (DM) and LVH is quite high among these patients, there is a compelling indication for ACE Inhibitors or ARBs to treat ...
Pacemaker - Louisiana Heart Center
Pacemaker - Louisiana Heart Center

... body, which are a sign of increased or decreased activity. If the heart's own stimulation system does not respond to these changes in activity, these rateresponse pacemakers raise or lower the heartbeats to the appropriate level of 60 to 150 beats per minute. The pacemaker generator can be reprogram ...
Goldberger`s Triad in Dilated Cardiomyopathy—Can it Predict the
Goldberger`s Triad in Dilated Cardiomyopathy—Can it Predict the

... patients with more advanced disease, and hence, poorer left ventricular function. To test this hypothesis, we studied patients with dilated cardiomyopathy, and compared the left ventricular function—as assessed by echocardiographic examination—of subjects with Goldberger’s triad versus those without ...
The Importance of Heart Rate in Coronary Artery
The Importance of Heart Rate in Coronary Artery

... Beta blockers are among the current treatment options to lower heart rate, improve cardiac function, and reduce cardiovascular events in postmyocardial infarction patients and in heart failure patients.7-9 Heart rate reduction seems to be the principal mechanism of action of beta blockers and revers ...
Acute Decompensated Heart Failure : Medical Management
Acute Decompensated Heart Failure : Medical Management

... been expressed regarding risks and benefits of individual therapies, especially nesiritide , but few studies have compared the relative safety of varied intravenous therapies on clinical outcomes. Nesiritide when given with diuretics as currently used in clinical practice do not increase inpatient m ...
Heart As An Endocrine Organ
Heart As An Endocrine Organ

... pumps, and also to the pressure against which the ventricles (especially the left) have to work. Heart failure is a condition in which the heart cannot pump all the blood it receives without increasing the filling pressure. This is a serious consequence of many cardiovascular diseases, such as hyper ...
天 津 医 科 大 学 授 课 教 案
天 津 医 科 大 学 授 课 教 案

... Alcoholic cardiomyopathy consume large quantities of alcohol over many years may develop. stopping alcohol consumption--- may halt the progression, ---even reverse the course of this disease, unlike the idiopathic variety. Treatment: total and permanent abstinence. Peripartum cardiomyopathy Cardiac ...
2 nd Generation
2 nd Generation

... 140 cc (similar to a pack of ...
Application of Morlet Transform Wavelet in the Detection of
Application of Morlet Transform Wavelet in the Detection of

... reverse in the appearance of A2 and P2 within the second heart sound. With the collaboration of the Cardiology Department at Brighton and Sussex University Hospital in England, and using a newly build data acquisition system developed at the University of Sussex, a number of patients with LBBB (Left ...
New Options for Atrial Fibrillation Patients with
New Options for Atrial Fibrillation Patients with

... achieving and maintaining a normal heart rhythm (rhythm control strategy) or may focus on maintaining a normal heart rate (rate control strategy). To obtain normal rhythm, anti-arrhythmic drugs, such as flecainide, sotalol, amiodarone and dofetilde are used. In most patients, rate control strategies ...
The Heart Part Two
The Heart Part Two

... (c) Second-degree heart block. (d) Ventricular fibrillation. These chaotic, grossly irregular ECG Some P waves are not conducted deflections are seen in acute through the AV node; hence more heart attack and electrical shock. P than QRS waves are seen. In this tracing, the ratio of P waves to QRS wa ...
N155 Assessment of the Heart, Great vessels of the neck, and
N155 Assessment of the Heart, Great vessels of the neck, and

... ƒ Visualized in about 50% adults. • More visible in children and patients with thin chest walls. o Retractions o Heaves or lifts (a lifting in the cardiac area; a strong outward thrust of the chest wall and occurs during systole) o Palpation o Apical impulse (PMI point of maximal impulse) indicates ...
How and Artificial Pacemaker Stimulates a Heart
How and Artificial Pacemaker Stimulates a Heart

... defective, causing irregular heart rhythms, it may be replaced with either a permanent or temporary artificial pacemaker. Artificial pacemakers are battery operated devices that use electrical impulses to stimulate the heart back to a regular rhythm. By placing an electrode on the heart wall, the de ...
MLC-1 (MYOSIN LIGHT CHAINS-1) IN DIFFERENTIAL DIAGNOSIS
MLC-1 (MYOSIN LIGHT CHAINS-1) IN DIFFERENTIAL DIAGNOSIS

... higher MLC levels and dynamics of changes are impaired after myocardial necrosis. To date, several papers have reported on increased MLC-1 in stabilized patients with myocardial dysfunction (NYHA III); MLC-1 concentration may be used for mortality prediction in these patients1, 5. One reason for inc ...
Rapid ventricular pacing versus adenosine administration for
Rapid ventricular pacing versus adenosine administration for

... transient (10-15 sec) high degree atrioventricular (AV) block. This is enough time for rapid baloon inflation and deflation at the level of the aortic valve determined by fluoroscopy and transesophageal echocardiography. 55 patients were studied. ...
Chapter 18
Chapter 18

... Semi – lunar valves • Valves that prevent ...
Cardiac muscle tissue
Cardiac muscle tissue

... artery. Backflow is most often due to prolapse (the flaps of the valve flop or bulge back into an upper heart chamber during a heartbeat). ...
Heart - Cloudfront.net
Heart - Cloudfront.net

... • Recording of currents from cardiac conduction on skin = electrocardiogram (EKG or ECG) • P wave= atrial depolarization • QRS complex= Ventricular depolarization Contraction of ventricle ...
View Full PDF
View Full PDF

... A deterioration in neuropsychological performance compared With pre-operative scores occurred in 33% of patients at eight weeks (70% CL. 26%-40%). Neuropsychological impairment at eight days and eight weeks did not correlate with changes in CBF, PaC02 , CMR02, or CER02 during surgery. On the basis o ...
Acute Inferior Myocardial Infarction With Complete Heart Block in a
Acute Inferior Myocardial Infarction With Complete Heart Block in a

... Association offers level Ib evidence in support of permanent pacemaker placement if there is a persistent third-degree heart block. Furthermore, much of the current recommendations are derived from dated literature and poorly conducted studies. One of the most relevant studies (Clemmensen, 1991) spe ...
The changing state of surgery for adult congenital heart disease
The changing state of surgery for adult congenital heart disease

... less invasive for the patient than traditional surgery, there are situations where surgery is more appropriate, and a sensible team approach with discussion is best. Sometimes a combined surgical and cardiological approach is appropriate, for example, placing a pulmonary artery stent in a narrowed p ...
Pathogenesis of cardiac failure
Pathogenesis of cardiac failure

... promotes the retention of fluid. The increase in fluid volume secondary to compensatory mechanisms can be deleterious in heart failure because it increases preload and raises venous pressures, leading to pulmonary and systemic oedema. Pulmonary oedema occurs when left atrial pressure rises, usually ...
Electrocardiography
Electrocardiography

... • Conducting cells interconnect the two nodes and distributethe contractile stimulus throughout the myocardium. In the atria, conducting cells are found in internodal pathways, which distribute the contractile stimulus to atrial muscle cells as this electrical impulse travels from the SA node to the ...
CirculatorySystem_TheHeart
CirculatorySystem_TheHeart

... • (c) move from node into A-V bundle (Bundle of His) – it travels into the ventricular septum and branches into a left & right branch ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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