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Congestive Heart Failure
Congestive Heart Failure

... Congestive heart failure simply means that the pulmonary blood volume is expanded and, therefore, the pulmonary circulation is congested with blood. The congestion arises because of elevated left ventricular end-diastolic pressure (LVEDP). An elevated LVEDP is a hallmark of uncompensated congestive ...
Cardio60-Intro
Cardio60-Intro

... ii. Important diseases with coronary problems This graph shows the blood distribution throughout the body a. Shows all three circuits listed above b. Blood to GI system, skin, kidneys This is “Wigger’s Diagram” a. Shows sequence of events in cardiac cycle b. P & QRS wave described below Cardiac func ...
Case report for V. grade students Cardiology Dr. Kemény Viktória
Case report for V. grade students Cardiology Dr. Kemény Viktória

... operated on within the first 6 months of life Surgery should be delayed for infants who respond to medical therapy If the PA pressure is more than 50% of systemic pressure, surgical closure should be done by the end of the first year Older infants with large VSD and elevated PVR should be operated o ...
Left Ventricular Assistive Device as a Destination Therapy
Left Ventricular Assistive Device as a Destination Therapy

... physiological and psychological advancements that were observed, it appears that the prognosis for A.S. is quite good ...
Discovery of a congenitally corrected transposition of the great
Discovery of a congenitally corrected transposition of the great

... The congenitally corrected transposition of the great arteries represents a very rare congenital heart defect. It is characterized by an atrioventricular discordance on the one hand, and a ventriculoarterial discordance on the other hand. Besides a switch of the great arteries, the physiological seq ...
NSAIDs and Radiographic Progression in Ankylosing Spondylitis
NSAIDs and Radiographic Progression in Ankylosing Spondylitis

... AS. This finding raise interest in the potential disease modifying effects of NSAIDs Haroon et. al., continuance of NSAIDs may reduce radiographic progression in AS patients on biologic therapy. Arthritis Rheum. 2011 ...
Unit One: Introduction to Physiology: The Cell and General Physiology
Unit One: Introduction to Physiology: The Cell and General Physiology

... a. Sinus (Sinoatrial node)-located in the wall of the right atrium and has almost no contractile muscle filaments b. Automatic rhythmicity-cardiac fibers with the ability of self-excitation ...
primacor
primacor

... structure and mode of action from either the digitalis glycosides or catecholamines. PRIMACOR, at relevant inotropic and vasorelaxant concentrations, is a selective inhibitor of peak III cAMP phosphodiesterase isozyme in cardiac and vascular muscle. This inhibitory action is consistent with cAMP med ...
ADVANCED CONCEPTS IN CARDIOVASCULAR NURSING FINAL
ADVANCED CONCEPTS IN CARDIOVASCULAR NURSING FINAL

... 2.) List ten reasons for discontinuing a graded exercise stress test with brief rationales? The reasons for discontinuing a graded exercise stress test are divided up into absolute indications and relative indications. The first absolute reason for discontinuing the test is a drop of the systolic bl ...
Anesthetic Challenges in the EP Lab
Anesthetic Challenges in the EP Lab

... risk of stroke and alleviation of symptoms. Patients with both paroxysmal and persistent atrial fibrillation as well as those with ventricular tachycardia related to extreme cardiomyopathy and poor ventricular function are frequently treated with oral anticoagulants. Symptom relief of atrial fibrill ...
Artificial hearts and blood pumps in the treatment of
Artificial hearts and blood pumps in the treatment of

... motion translator are positioned between the two prosthetic ventricles. A microprocessor-based control system has been used for right-left output balance. This artificial heart has been used in a calf and has provided complete circulatory support for over 5 months. ...
Cardiomyopathy - Lock Haven University
Cardiomyopathy - Lock Haven University

... actually do better with increased SVR Slow controlled emptying from increased SVR ...
New Segmental Regional Wall Motion Abnormalities on TEE
New Segmental Regional Wall Motion Abnormalities on TEE

... therapy to increase coronary perfusion pressure as well as myocardial contractility. In this case, there were NRWMA that did not improve with time or therapy. An angiogram revealed what was suspected, which was a complete occlusion of the circumflex artery; a normal circumflex was visualized in an a ...
Simulation of Pulsatile Left Ventricular Assist Device - AMAC-2017
Simulation of Pulsatile Left Ventricular Assist Device - AMAC-2017

... Introduction: Mechanical left ventricular assist devices (LVADs) have been developed for bridging patients to transplantation, but are increasingly being used as destination therapy or temporary aid until recovery. When selecting a pulsatile flow LVAD therapy, the interaction between the mechanical ...
A heart made for dancing
A heart made for dancing

Heart Failure - Dartmouth
Heart Failure - Dartmouth

... A double-blind, randomized, placebo-controlled study of 2289 euvolemic patients who had symptoms of heart failure at rest or on minimal exertion for at least 2 months and an ejection fraction of <25%. Krum H et al. JAMA. 2003;289:712–718. ...
Running head: Acute Myocardial Infarction Acute Myocardial
Running head: Acute Myocardial Infarction Acute Myocardial

... ESR also rises because of inflammation. ABGs may be ordered to assess acid-base balance and ...
The Heart The cardiovascular system is divided into two circuits The
The Heart The cardiovascular system is divided into two circuits The

... • The heart is located in the anterior chest wall directly posterior to the sternum • The heart is surrounded by the pericardial cavity, which is lined with the pericardium • The pericardium is lined with a serous membrane which can be subdivided into the visceral pericardium and parietal pericardiu ...
Mechanical Circulatory Support Device Database of the
Mechanical Circulatory Support Device Database of the

... A total of 1,081 post-implantation adverse events were reported in 305 (71%) patients, corresponding to 2.5 events per patient. Infection and bleeding were the 2 most common complications (Table 9), and their cumulative frequency over time is depicted in Figure 9. A variety of events were reported t ...
Atrial Tachycardia Atrial Fibrillation Atrial Flutter AV Nodal Reentrant
Atrial Tachycardia Atrial Fibrillation Atrial Flutter AV Nodal Reentrant

Myocardial Infarction (Heart Attack)
Myocardial Infarction (Heart Attack)

... • First detectable in 3-4 hours, peaks in 8-24 hours, lasts for 3-4 days • Not very specific – abnormal in skeletal and smooth muscle injury, severe CNS injury • Peak value commonly used as a index of MI ...
Atrial Tachycardia
Atrial Tachycardia

... activated leading to a rapid arrhythmia arising from a single spot within the pumping chambers. Because this is more rapid than the heart's natural electrical activity, it takes over the heart beat for the duration of the arrhythmia. Because it is so rapid, and is occurring in a damaged heart, and b ...
Antidysrhythmic and Antihypertensive Agents
Antidysrhythmic and Antihypertensive Agents

Diagnosis and Management of Life Threatening Cardiac Emergencies
Diagnosis and Management of Life Threatening Cardiac Emergencies

... Recognition & treatment of life threatening arrhythmias (ventricular tachycardia (VT) & ...
Cardiomyopathy
Cardiomyopathy

... HCM: Surgical Treatment For severe symptoms with large outflow gradient (>50mmHg) Does not prevent Sudden Cardiac Death Myomyectomy removal of small portion of upper IV septum +/- mitral valve replacement 5 year symptomatic benefit in ~ 70% of patients Dual Camber (DDD pacemaker) pacing decreases L ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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