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study on the prescribing patterns of drugs used in heart failure
study on the prescribing patterns of drugs used in heart failure

... including Nepal. The prevalence of Heart failure increases with age and accounts for most of the adult hospital admissions. The objective of the study was to study the prescribing patterns of drugs used in the heart failure. The study included both the in-patients and outpatients conducted at 2 diff ...
File
File

... and ventricles from contracting at the same time. • Rate is 40-60 beats/minute • Bundle of His= Distal portion of the AV node • Splits into the Right and Left Bundle Branch, stimulating the right and left ventricle ...
How to diagnose Blunt Cardiac Injury?
How to diagnose Blunt Cardiac Injury?

Normal Heart Pumping: When the ventricles are in diastole they
Normal Heart Pumping: When the ventricles are in diastole they

... Sympathetic Effects on Excitation of the Heart: 1. Phos of L-type Ca channels by catecholamines increases channels probability of opening and the average time the channel remains open once activated. 2. Phos of ryanodine receptor increases the amount of Ca released by the SR. This is part of the fig ...
“Dyspnea” A Cardiologist Perspective
“Dyspnea” A Cardiologist Perspective

... You request the cardiac evaluation and PFTs that were done last year. In the meantime, you order a CBC, TSH and chest X ray that return are normal. You even check a BNP that returns at 88. Her ECG shows sinus rhythm with possible left atrial enlargement and a left anterior hemi-block with late trans ...
The comparison of physical examination and PA catheter in
The comparison of physical examination and PA catheter in

... Joly HR, Weil MH. Temperature of the great toe as an indication of the severity of shock. Circulation. 1969;39:131-138. Butman SM, Ewy GA, Standen JR, et al. Bedside cardiovascular examination in patients with severe chronic heart failure: importance of rest or inducible jugular venous distension. J ...
Other Cardiac Conditions and the ECG
Other Cardiac Conditions and the ECG

... •  In pericarditis the T wave is initially upright and elevated but then during the recovery phase it inverts. The ST segment is elevated and usually flat or concave. •  Substantial pericardial effusion can occur with pericarditis and produce ECG changes which include low voltage QRS complexes in al ...
Comparison Between Valsartan and Amlodipine Regarding
Comparison Between Valsartan and Amlodipine Regarding

...  The NHS showed no difference between the valsartan-based and amlodipine-based antihypertensive treatment in terms of preventing composite major cardiovascular outcomes.  Valsartan-based treatment significantly reduced the risk of CHF as compared to amlodipine-based treatment.  Our results will h ...
Complications of Myocardial Infarction
Complications of Myocardial Infarction

... significant reduction in cardiac output  Atrial fibrillation in AMI is associated with increased mortality and stroke ...
EMS_April_2016 - S. Blake Wachter, MD, PhD Advanced Heart
EMS_April_2016 - S. Blake Wachter, MD, PhD Advanced Heart

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Rhythm Control in Atrial Fibrillation — One Setback
Rhythm Control in Atrial Fibrillation — One Setback

... Third, as was described by investigators in the AF-CHF study, atrial fibrillation may be a marker of poor prognosis, in which the primary problem is poor ventricular function, neurohormonal activation, or inflammation, with no independent effect of atrial fibrillation on outcome. Finally, the result ...
Young Investigator Award
Young Investigator Award

... Objective: To develop a scoring system for the prediction of in-hospital mortality and morbidity after heart valve surgery at Heart and Vascular Center Harapan Kita Hospital. Methods: This is a prognostic study performed at Heart and Vascular Center Hospital Harapan Kita, toward patients who underwe ...
Repeat MitraClip Procedures - JACC: Cardiovascular Interventions
Repeat MitraClip Procedures - JACC: Cardiovascular Interventions

... (71% with functional MR), 27 patients had an SLDA event (4.8%), with all but 1 diagnosed within 6 months of the index procedure. Of these 27 patients, 10 had additional MitraClip procedures, 6 underwent mitral valve surgery, and 11 had no additional therapy (4). Finally, in the STS/ACC TVT (Society ...
Non-Invasive Cardiovascular Examination
Non-Invasive Cardiovascular Examination

... during depolarization and repolarization. As an electrical recording modality, the ECG is of primary diagnostic importance (sensitivity 100%) in diagnosis of cardiac electrical abnormalities of repolarization and depolarization (arrhythmias and conduction abnormalities). The ECG is a secondary diagn ...
Cardiac Resynchronization Therapy in 2015
Cardiac Resynchronization Therapy in 2015

... pacing – namely, Pacing Therapies for Congestive Heart Failure (PATH-CHF) [24], Multisite Stimulation in Cardiomyopathies (MUSTIC) [25], Multicenter InSync Randomized Clinical Evaluation (MIRACLE) [26], Multicenter InSync ICD Randomized Clinical Evaluation II (MIRACLE-ICD) [27], Cardiac Resynchroniz ...
ANATOMY I, CHAPTER 18, STUDY GUIDE Read: pages: 661 to 673
ANATOMY I, CHAPTER 18, STUDY GUIDE Read: pages: 661 to 673

... Read: pages: 661 to 673 (up to, “Mechanisms and Events of Contractions”) The student should be able to: 1. State what two divisions make up the cardiovascular system 2. Describe the function of the heart.. 3. Describe the size, shape, locationand orientation of the heart in the thorax (chest cavity) ...
Study of signs and symptoms of cardiovascular involvement
Study of signs and symptoms of cardiovascular involvement

... essentially opposite effects on the cardiovascular system. In this study fatigue (50%) was the commonest cardiac symptom in hypothyroid patients. Dyspnea (34.09%) was present in many of the hypothyroid patients. Chest pain was present in 9 patients i.e. (20%) Watanakunakom et al have reported fatigu ...
New Cardiac Technologies
New Cardiac Technologies

Physiology of cardiac rate and rhythm
Physiology of cardiac rate and rhythm

... SURGERY ...
Heart Diseases and Disorders
Heart Diseases and Disorders

... Millions of people experience irregular heartbeats, called arrhythmias, at some point in their lives. Most of the time, arrhythmias are harmless and happen in healthy people free of heart disease. However, some abnormal heart rhythms can be serious or even deadly. Having other types of heart disease ...
tricyclic antidepressants
tricyclic antidepressants

... activity and/or inhibition of norepinephrine uptake by tricyclic antidepressants.  Hypotension: The blood pressure may be elevated in the early stages after overdose, presumably due to the inhibition of norepinephrine uptake.  hypovolaemia,  decreased peripheral resistance due to alpha-adrenergic ...
Resting and Action Potential of the Heart Resting cell potential is a
Resting and Action Potential of the Heart Resting cell potential is a

... the right atrium at the level of its junction with the superior vena cava. This so-called pacemaker for the entire heart. Its depolarization normally generates the current that leads to depolarization of all other cardiac muscle cells, and so its discharge rate determines the heartbeats, (number of ...
Hypertrophic Cardiomyopathy Lange-pp. 362
Hypertrophic Cardiomyopathy Lange-pp. 362

...  Though LV outflow gradient is classic, symptoms are primarily related to diastolic dysfunction  Echocardiogram shows septal hypertrophy, which is usually asymmetric, and enhanced contractility. Systolic anterior motion of the anterior mitral valve is present if there is outflow tract obstruction. ...
CHFmodule FY2011Q2
CHFmodule FY2011Q2

... An implantable cardioverter-defibrillator (ICD) is a device designed to quickly detect a life-threatening, rapid heartbeat coming from the ventricles of the heart. The ICD attempts to convert an abnormal rhythm back to normal by delivering an electrical shock to the heart. This action is called defi ...
Low Voltage Electric Injury induced Atrial Fibrillation as a Presenting
Low Voltage Electric Injury induced Atrial Fibrillation as a Presenting

... most vulnerable to electrical injury. Electrical injury may cause direct necrosis of the myocardium or cardiac dysrhythmia. Asystole and ventricular fibrillation are the most serious of the cardiac complications of electrical injury.1 Other possible rhythm disturbances include sinus tachycardia, bra ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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