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pdf Sprint Quattro Portfolio Brochure ()
pdf Sprint Quattro Portfolio Brochure ()

... dexamethasone sodium phosphate may be contraindicated Warnings/Precautions People with metal implants such as pacemakers, implantable cardioverter defibrillators (ICDs), and accompanying leads should not receive certain forms of diathermy treatment. The interaction between the implant and diathermy ...
Outcomes of Primary Percutaneous Coronary Intervention (PCI) in
Outcomes of Primary Percutaneous Coronary Intervention (PCI) in

... The aim of the study is to determine the out comes of primary percutaneous coronary intervention (PCI) in patients with acute myocardial infarction in NICVD the only government cardiac hospital of Bangladesh where resources are very limited. Total 73 (male 70, female 3) patients were enrolled in thi ...
General Cardiac Pathophysiology II
General Cardiac Pathophysiology II

... 6. Organismic consequencies of the heart failure „Forward“ and „backward“ failure (Fig. 14 b) Systemic blood pressure of about 90 mmHg must be allways secured ...
to find the lecture notes for lecture 14 the Heart click here
to find the lecture notes for lecture 14 the Heart click here

... the PFs do not connect with every ventricular contractile cell so the impulse spreads via gap junctions through the ventricle muscle – similar to the atrial system diffusion through the PFs allow for simultaneous contraction of all ventricular cells ...
Pediatric Cardiology - Case Report
Pediatric Cardiology - Case Report

... The blood from the left superior caval vein empties directly into the left upper corner of the atrium flowing into the coronary sinus and into the right atrium. The direction of the flow in the presence of a large ventricular component will depend on the resistance to the outflow from the two ventri ...
A-A Bradycardia Booklet.indd
A-A Bradycardia Booklet.indd

... be involved and these commonly look for the causes as well as the nature of the different bradycardias. It is important to note that these will be tailored to the individual patient and are performed as part of a complete assessment done by your doctor, which also includes a careful review of your me ...
Management options for severe aortic stenosis in non
Management options for severe aortic stenosis in non

... demonstrate much difference in outcome.5 Conversely, Moura and coworkers found that patients with mild to moderate AS (with average AVA of 1.23cm2) treated with Rosuvastatin 20mg had significantly reduced rate of disease progression.6 Following on from these conflicting studies, Carabello and Paulou ...
A case of advanced second-degree atrioventricular block in a ferret
A case of advanced second-degree atrioventricular block in a ferret

... et al., 2006). Alternatively, it has been proposed the medical management with isoproterenol (Wagner, 2006). Unfortunately, the rapid deterioration of the patient’s conditions prevented us from attempting this approach. It is conceivable that AV block in our patient was secondary to its underlying n ...
Cardiac Diagnosis from Examination of Arteries and Veins
Cardiac Diagnosis from Examination of Arteries and Veins

... The degree of distention and the quality of the pulsations in the external and internal jugular veins should be examined in detail. The external jugular veins, which are often distended abnormally in patients with congestive heart failure, may at times be invisible because of increased venous tone. ...
Idiopathic Enlargement of the Right Atrium
Idiopathic Enlargement of the Right Atrium

... From the uniformity of clinical and laboratory findings cited above, it is believed that the diagnosis of idiopathic right atrial enlargement can be made on clinical grounds alone. Further, it is concluded that this disease represents a specific clinical entity. The cause of such an abnormality, how ...
Functional monitoring of anthracycline cardiotoxicity: a prospective
Functional monitoring of anthracycline cardiotoxicity: a prospective

... Based on empirical drug limitations about 10–15% of patients will develop congestive heart failure (CHF) with a mortality of ∼50% within 2 years on digitalo–diuretic therapy alone. To avoid CHF there is a consensus recommendation that cardiac function should be monitored in close connection with ant ...
Impact of New-Onset Persistent Left Bundle Branch Block on Late
Impact of New-Onset Persistent Left Bundle Branch Block on Late

... through transapical approach (p ¼ 0.005) and received a 29mm valve (p ¼ 0.041). Transapical approach (odds ratio: 1.90 [95% confidence interval (CI): 1.15 to 3.16]; p ¼ 0.013) and a larger valve size (29-mm valve) (odds ratio: 3.12 [95% CI: 1.22 to 7.97]; p ¼ 0.017) remained as independent predictors ...
Drugs for Dysrhythmias Expanded Key Concepts
Drugs for Dysrhythmias Expanded Key Concepts

... cell through calcium ion channels, although the influx is slower than that of sodium. The cell returns to its polarized state by the removal of K+ through potassium ion channels. 23.6 Non-pharmacologic therapy of dysrhythmias including cardioversion, ablation, and implantable cardioverter defibrilla ...
chapter-4-hypertension-lecture
chapter-4-hypertension-lecture

... Lecturer of Internal Medicine Delta University ...
Mitral Valve Repair: Settling the Controversies p3
Mitral Valve Repair: Settling the Controversies p3

... mitral valve disease (MR). Nonetheless, there are differences of opinion about when surgical repair should be recommended for patients with this condition. Should repair be performed early or late in the course of the disease? There are good arguments on both sides of the question. Recently, cardiac ...
Is the Instantaneous Wave-Free Ratio Equivalent to
Is the Instantaneous Wave-Free Ratio Equivalent to

... for the assessment of coronary stenosis. Hyperemic stenosis resistance (HSR) was used as a reference standard to determine when iFR and FFR disagreed as to which index was most representative of the hemodynamic significance of the stenosis. It was concluded that iFR and FFR had equivalent agreement w ...
Assessment of the Cardiovascular System
Assessment of the Cardiovascular System

... fibers can act as an intrinsic pacemaker, but their discharge rate is only 20 to 40 beats/min.  Thus these intrinsic pacemakers seldom initiate an electrical impulse ...
Atrial Fibrillation
Atrial Fibrillation

...  AFFIRM and RACE were the largest of the 5 trials.  All found no major difference in the primary end-point between the two strategies.  The primary reason to attempt rhythm control for patients who are highly symptomatic with atrial fibrillation and/or who cannot be well rate controlled. ...
Principles of Invasive Hemodynamics
Principles of Invasive Hemodynamics

... Because the PA line is not utilized as frequently as the CVP or arterial line this module will go into more detail about the PA line. Pulmonary artery catheter: PA catheters are indicated for patients with cardiogenic shock or congestive heart failure; in the presence of respiratory failure to assis ...
magnesium sulfate
magnesium sulfate

... ing, MgSO4 prevented the recurrence of TdP without shortening the QT interval. The fact that the QT interval remained unchanged despite the suppression of the ventricular arrhythmia suggests that the salutary effect of magnesium is not related to shortening of repolarization. Since magnesium is a co ...
Types of Anatomic Conformity of Cardiac Conduction System
Types of Anatomic Conformity of Cardiac Conduction System

... AV node is positioned at opening of coronary sinus, angle of AV bundle increases to 45º. Initial parts of branches and bundle form angles from 160º-180º, their configuration changes (Fig. 3). Between these types are numerous options relating to the intermediate forms. In all the age groups, regardle ...
Impact of Longitudinal Myocardial Deformation on the Prognosis of
Impact of Longitudinal Myocardial Deformation on the Prognosis of

... Background—Longitudinal myocardial deformation indexes appear superior to left ventricular ejection fraction (LVEF) in assessing myocardial contractility. However, few studies have addressed the prognostic value of longitudinal motion markers (velocity, strain, and strain rate) in predicting outcome ...
CCRN/PCCN Review Course Cardiovascular: Oxygenation
CCRN/PCCN Review Course Cardiovascular: Oxygenation

... • Blocks catecholamine effects on beta receptors in the ...
Acute Cardiology Cardiac Emergencies
Acute Cardiology Cardiac Emergencies

... 2. Biomarker elevation in the prescence of two of the criteria below: a- ECG and ischemic symptoms. b- Old Mİ: Q waves on ECG. c- ECG findings of acute ischemia: ST- T wave changes. (ST elevation, ...
REHABILITATION FOR SOLID ORGAN TRANSPLANTATION
REHABILITATION FOR SOLID ORGAN TRANSPLANTATION

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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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