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(PSD) July 2016 PBAC Meeting - (Word 69KB)
(PSD) July 2016 PBAC Meeting - (Word 69KB)

Isolated congenital complete heart block
Isolated congenital complete heart block

... An electrocardiogram (ECG) and an echocardiogram (ultrasound) will be performed. The baby’s heart rhythm will also be monitored over a longer period of time, typically by a 24 hour tape. This involves having ECG stickers on the skin which are connected to a small box like an MP3 player. This records ...
Herbs and Dietary Supplements in the Prevention and Treatment of
Herbs and Dietary Supplements in the Prevention and Treatment of

... A placebo controlled study of 35 hypercholesterolemic renal transplant patients found a mild benefit of dried garlic tablets in a dose of 680 mg bid. Over six weeks TC decreased from 290 mg/dL to 276 mg/dL and LDL levels decreased from 193 mg/dL to 181 mg/dL; benefits were maintained at 12 weeks.12 ...
Update on Feline Cardiomyopathy: Diagnosis, Treatment and
Update on Feline Cardiomyopathy: Diagnosis, Treatment and

... euthanasia due to the patient’s discomfort and concurrent heart disease. The best method of prevention is not known, but one could consider a platelet inhibitor such as clopidogrel (Plavix), 18.75 mg/cat q 24 hrs (more potent than aspirin, described in Hogan et al. 2004). For cats that have had one ...
Tilburg University Improvement in diastolic function and left
Tilburg University Improvement in diastolic function and left

... Methods Fifty-two patients’ (36 male, 69 F 8 years, QRS duration 170 F 29 milliseconds) echo-Doppler was performed before and 3 and 12 months after CRT. Tissue Doppler early diastolic annular (Em) and color M-mode–derived flow propagation (Vp) velocities were used to estimate LV filling pressures by ...
The Diagnosis of Cardiac Arrhythmias
The Diagnosis of Cardiac Arrhythmias

... tachycardia; VF = ventricular fibrillation; RVOT = right ventricular outflow tract. Adapted from Zimetbaum et al. (1). ...
Advances in Arrhythmia and Electrophysiology
Advances in Arrhythmia and Electrophysiology

... the presence of an inverse relationship between local activation and repolarization times resulting in homogeneity of the activation-recovery intervals throughout the ventricle during normal activation. Initiation of ventricular pacing disrupted this relationship, but within 60 to 120 minutes of pac ...
Ativity 23 - PCC - Portland Community College
Ativity 23 - PCC - Portland Community College

... muscle, especially the ventricle • Diastole: The relaxation of the heart muscle. • Cardiac Cycle: A complete heartbeat consisting of systole and diastole of both atria plus systole and diastole of both ventricles. ...
Treating Three Types of Heart Failure
Treating Three Types of Heart Failure

... rapidly firing and then depolarizing in order to produce a beat. The heart is considered to be a four-chamber pump, with the right side receiving deoxygenated blood from the body at a low pressure and pumping it to the lungs (the pulmonary circulation). The left side receives oxygenated blood from ...
Palliative care needs in patients hospitalized with heart failure
Palliative care needs in patients hospitalized with heart failure

... assessment and treatment of pain and other problems, physical, psychosocial, and spiritual.6 Contemporary HF guidelines have begun to recommend that PC be considered in patients with advanced HF refractory to optimal, or maximally tolerated, contemporary, disease-modifying drug and device therapies, ...
Vasoactive Agents
Vasoactive Agents

... Vasoactive agents are a group of bioactive chemicals, which change vasomotor tone through their influence on various peripheral receptors. Most of these agents have inotropic effects (e.g. norepinephrine) as they bind with receptors positioned on the surface of the myocardium. Some pharmacologic age ...
this PDF file - The Tamil Nadu Dr. MGR Medical
this PDF file - The Tamil Nadu Dr. MGR Medical

... decreased RV diastolic filling, with increased risk of severe dyspnea, arrhythmias, and pulmonary thromboembolism. Isolated right ventricular hypertrophic obstructive cardiomyopathy presents as systolic murmur in left upper parasternal region with clinical and eletrocardiographic evidence of right v ...
Right Atrium - PCC - Portland Community College
Right Atrium - PCC - Portland Community College

... muscle, especially the ventricle • Diastole: The relaxation of the heart muscle. • Cardiac Cycle: A complete heartbeat consisting of systole and diastole of both atria plus systole and diastole of both ventricles. ...
Temporary right ventricular support following left ventricle assist
Temporary right ventricular support following left ventricle assist

... clinical condition and laboratory values. The University of Michigan RVF risk score was calculated based on the formula provided by Matthews et al. [17]. Scores higher than 5.5 were considered at high risk of postimplant RV failure. In patients under ECLS prior to LVAD implantation, right heart cath ...
Author`s contributions - Journal of Cardiothoracic Surgery
Author`s contributions - Journal of Cardiothoracic Surgery

... clamping of the patent IMA17, 18. Despite providing adequate control of blood flow through the graft, manipulation of the graft by itself can cause injury and should probably be avoided whenever possible. Here we report our experience with the combination of antegrade, retrograde and continuous retr ...
2 nd -Degree AV Heart Block, Type I
2 nd -Degree AV Heart Block, Type I

... • Usually transient and reversible, mostly resolving when the underlying condition is corrected • May progress to more serious blocks (particularly if it occurs early in myocardial infarction) ...
Management of Arrhythmias in Heart Failure
Management of Arrhythmias in Heart Failure

... hearts is a prolonged action potential duration, reflecting delayed terminal repolarization of the cardiac myocyte [24]. These cellular electrophysiological changes were mechanistically linked to downregulation of repolarizing potassium currents, an increase in late sodium current density, as well a ...
Distribution of left ventricular ejection fraction in angina patients with
Distribution of left ventricular ejection fraction in angina patients with

... >50% stenosis of the major epicardial vessels and/or >50% involvement of the left main coronary artery) deemed unfit for revascularization by interventional cardiologists and cardiac surgeons were identified from retrospective chart review of patients undergoing cardiac catheterization at Albert Ein ...
EUROPEAN HEART FAILURE AWARENESS DAY 2014 REPORT
EUROPEAN HEART FAILURE AWARENESS DAY 2014 REPORT

... with coronary heart disease, the main cause of heart failure, is increasing year on year in Scotland. Information is not collected centrally to allow statistics on the life expectancy of patients with heart failure to be compared directly with those in the rest of the UK. Recent data suggests that t ...
A Validated Risk Score for In-Hospital Mortality in Patients With
A Validated Risk Score for In-Hospital Mortality in Patients With

... not represent the general HF population, or the use of noncontemporary cohorts,7 which may have limited applicability to current practice. Other models have not been validated8,9; excluded patients with preserved left ventricular systolic function2; used complex clinical data that may not be availab ...
Cardio61-PericardiumAndHeart
Cardio61-PericardiumAndHeart

... 1. First sound, low-pitched and longer duration, occurs as the heart contracts and the AV valves close 2. Signifies the onset of systole (contraction) when ventricular pressure rises above atrial pressure 3. Associated with the palpable apex heart beat and arterial pulse B. Second Sound: dup 1. The ...
Autoregulation of cardiac output is overcome by adrenergic
Autoregulation of cardiac output is overcome by adrenergic

... regulation of the venous system to adjust stroke volume during tachycardia (e.g. Sandblom et al., 2005; Skals et al., 2005, 2006; Enok et al., 2016). By mobilizing blood from the veins, preload pressure may be maintained, or even increased, despite the increased heart rate during activity (Sandblom ...
section 2
section 2

... cardiac cell AP increases the duration of the AP to 300 msec,  The refractory period of cardiac cells is long (250 msec).  compared to 1-5 msec in neurons and skeletal muscle fibers. ...
Afterload Assessment With or Without Central Venous Pressure: A
Afterload Assessment With or Without Central Venous Pressure: A

... question, and limit, the use of these highly invasive hemodynamic monitors (Blot et al. 2005; Richards et al. 2000). Minimally-invasive hemodynamic monitors, specifically the EDM, have become well established as reliable, safe, and accurate (Madan et al. 1999; DiCorte et al. 2000; Dark and Singer 20 ...
Journal Club Pack - Circulation Research
Journal Club Pack - Circulation Research

... RVH (RV thickness/body surface area; r2=0.838 and r2=0.818, respectively; P<0.01). These results were recapitulated in the rat model. In modified Langendorff perfusions, ERAs (BQ-123 and bosentan 10−7,−6,−5 mol/L) decreased contractility in the hypertrophied, but not normal RV, in a dose-dependent m ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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