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- Wiley Online Library
- Wiley Online Library

... and flows right to left via the duct, and then passes retrograde around the aortic arch The coronary arteries are a very long way back from the perfusing (right) ventricle. Right-sided ventricles are more likely to dilate in the context of volume loading (which is inherently greater in single ventri ...
Diagnosis of Heart Failure in Adults
Diagnosis of Heart Failure in Adults

... Systolic dysfunction is caused by impaired myocardial contractility and low ejection fraction. It is associated most often with coronary artery disease (especially myocardial infarction), idiopathic dilated cardiomyopathy, hypertension, and valvular disease. The five types of heart failure resulting ...
Dare, P
Dare, P

... three years is because organ donation rates have remained stagnant in Ontario, and across Canada, in recent years. The fate of patients needing a new heart rests with families of the small number of brain-dead patients at hospitals. About one per cent of hospital deaths involve patients who are brai ...
Annual prognostic factors in chronic heart failure in patients over 80
Annual prognostic factors in chronic heart failure in patients over 80

... criteria were as follows: pre-existing CHF with signs and symptoms unchanging during at least one month with stable therapy, II to IV (ambulatory) New York Heart Association (NYHA) functional class, age ≥ 80 years, and optimal medical therapy according to the recommendations of the European Society ...
Echocardiographic Effects of Eplerenone and Aldosterone in
Echocardiographic Effects of Eplerenone and Aldosterone in

... Heart failure with preserved ejection fraction in the community is more prevalent in women (7). If female gender has a different effect on hypertensive echocardiographic changes, these effects may not have been detected by a study that involved only male rats. The increase in cardiac mass (LVH) was ...
9 Cardiology
9 Cardiology

... This is the most common congenital heart defect (30% of all CHD). The symptoms and signs depend on the size of the hole and any other cardiac defects present. Large ventricular septal defects (VSDs) are less likely to ...
HowTheHeartBeats
HowTheHeartBeats

Ligation of the Outflow Graft of the Left Ventricular
Ligation of the Outflow Graft of the Left Ventricular

... LVAD outflow graft ligation has not been previously described for the management of pump related hemolysis. Baldwin et al [4] described various HeartMate II explant options in the setting of left ventricular recovery in which the technique of outflow graft ligation has been successfully demonstrated ...
cardilogy mcq - WordPress.com
cardilogy mcq - WordPress.com

... d. There is a 50% mortality rate if the patient present in cardiogenic shock. e. Free wall rupture usually occurs within the first 12 hours of AMI and is often fatal. 11. A 30 yr old man presents with crushing chest pain, with ECG criteria for anterior AMI. He volunteers that he uses cocaine on a re ...
Full Text  - J
Full Text - J

... and late deaths combined), there was no significant difference between the 79 patients of our study group and patients with preserved LV function and LV dimension. We were unable to identify predictors for mortality and late survival. Brown et al showed that decreased LVEF and increased LV dimension ...
- Wiley Online Library
- Wiley Online Library

... wave interval; Figure 1C and 1G). Counteracting this point, despite having increased QT-c and a reduction in heart rate in association with a thin ventricle wall, leucine treatment strongly prevented the T wave increase, reducing the higher QT-c interval (11% lower than group W and similar to group ...
130228-jf-FINAL-Surgical Ablation Booklet
130228-jf-FINAL-Surgical Ablation Booklet

... Rate Control Drugs try to control your heart rate during AF, and Rhythm Control Drugs (antiarrhythmics) try to bring your heart back into a normal and consistent rhythm. These drugs can offer a degree of success, but some people have problems with side effects. Cardioversion For some individuals with ...
a PDF of this article. - Journal of Invasive Cardiology
a PDF of this article. - Journal of Invasive Cardiology

... (55.9 ± 11.5 ms) vs preprocedure (47.3 ± 7.8 ms) (P<.001). The antegrade Wenckebach point was observed to be significantly prolonged postprocedure (354.4 ± 41.3 ms) vs preprocedure (333.7 ± 45.4 ms) (P=.001). Despite atrial-His interval prolongation, it was not statistically significant. After the p ...
Aldo-HF trial - Dr Richard Bogle
Aldo-HF trial - Dr Richard Bogle

... a Data are expressed as mean (SD) unless otherwise specified. Higher values indicate better performance for LV ejection fraction, medial e’ wave velocity, duration of exercise, peak V̇O2, ATVO2, Borg scale, walk distance, SF-36 Physical Functioning Scale, and SF-36 global self assessment. Lower valu ...
Post-mortem study of the association between cardiac iron and
Post-mortem study of the association between cardiac iron and

... Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney ...
Effects of Flecainide and Propafenone on Systolic
Effects of Flecainide and Propafenone on Systolic

... agents, related side effects. The flecainide are well known,’2 ...
Checklist for Examination of the Cardiovascular System
Checklist for Examination of the Cardiovascular System

... • With established pulmonary hypertension, there is gradually increasing cyanosis and heart failure • The 'Eisenmenger complex' describes large ventricular septal defects with right-to-left shunts producing cyanosis • Eisenmenger's syndrome describes pulmonary hypertension at systemic level due to p ...
Slide 1
Slide 1

... • Right ventricular placement is confirmed on ECG with LBBB pattern and LAD – Note that RBBB may indicate coronary sinus placement or septal perforation and LV pacing • Look for cannon waves present on exam of the neck veins • Listen for tricuspid insufficiency murmur due to obstruction from the cat ...
Self-Powered, One-Stop, and Multifunctional
Self-Powered, One-Stop, and Multifunctional

... limits the operation lifetimes of these devices and therefore constrains the implementation of real-time or continuous biomedical monitoring.17−20 For example, the new-generation ICMs only have a functioning lifespan of around 36 months.6 Depleted batteries have to be periodically replaced by surgic ...
Cardiac function assessed by systolic time intervals
Cardiac function assessed by systolic time intervals

... in group I was unaltered, with pre- and postoperacardiograms. tive values of 134 and 133 msec, respectively (Fig. Preoperative systolic time intervals 2). Group II patients, on the other hand, underwent The study population was separated into two sub- a shortening of the pre-ejection phase index fro ...
The Incidence of Symptomatic Bradyarrhythmias in Patients with
The Incidence of Symptomatic Bradyarrhythmias in Patients with

... • High degree AV block associated with inferior wall MI is located above the His bundle in 90 percent of patients . For this reason, complete heart block often results in only a modest usually transient bradycardia with junctional or escape rhythm rates above 40 beats per minute. It is not uncommon ...
Epidemiology of Acute Myocardial Infarction
Epidemiology of Acute Myocardial Infarction

... The Perfect Storm for a Heart Attack It is Monday morning, the day after Christmas. You are suddenly awakened at 6:00 a.m. to the shaking and rattling of an Oklahoma earthquake. Because of the surprise of the earthquake, you forget to take your aspirin, plavix, lipitor, metoprolol and metformin. Yo ...
Matrix Metalloproteinases and Their Tissue Inhibitors in Cardiac
Matrix Metalloproteinases and Their Tissue Inhibitors in Cardiac

... or mutated transthyretin [TTR]). We therefore tested the hypothesis that determinants of proteolytic activity of the extracellular matrix, the matrix metalloproteinases (MMPs), and their tissue inhibitors (TIMPs) would have distinct patterns and contribute to the pathogenesis of AL-CMP versus TTR-re ...
11-heart [Compatibility Mode]
11-heart [Compatibility Mode]

...  Coronary sinus—a large vein on the posterior of the heart, receives blood from cardiac veins  Blood empties into the right atrium via the coronary sinus ...
Correlation of Echocardiographic Left Ventricular Mass Index and
Correlation of Echocardiographic Left Ventricular Mass Index and

... the hypertrophied heart is particularly predisposed to morbid events. It is prone to angina, myocardial infarction, arrhythmias and sudden cardiac death. LVH is prognostic indicator of future events in hypertensive patients. various modalities are available to detect it. ECG and Echocardigraphy are ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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