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CBP: Cardiac Arrest - UBC Critical Care Medicine, Vancouver BC
CBP: Cardiac Arrest - UBC Critical Care Medicine, Vancouver BC

... uniform and will vary in individual patients based on the severity of the ischemic insult, the cause of cardiac arrest, and the patient’s pre-arrest state of health. ...
Pulmonary Function Testing and Outcomes in
Pulmonary Function Testing and Outcomes in

Competing Risk of Cardiac Status and Renal Function During
Competing Risk of Cardiac Status and Renal Function During

... venous pressure; LVEF ¼ left ventricle ejection fraction; NT-proBNP ¼ N-terminal pro-B-type natriuretic peptide; NYHA ¼ New York Heart Association; SBP ¼ systolic blood pressure. ...
Heart Murmur in Neonates
Heart Murmur in Neonates

... and children and mostly originate from normal flow patterns with no structural or anatomic abnormalities of the heart or vessels and are referred to as innocent, physiological or normal murmurs; conversely, murmur may be created by abnormal flow patterns in the heart and vessels resulting from conge ...
New onset atrial fibrillation after initiating amphetamine
New onset atrial fibrillation after initiating amphetamine

... only a small risk of significant cardiovascular events of less than 5%.[6] ...
What Role Does Digitalis Serve in Medicinal
What Role Does Digitalis Serve in Medicinal

... Excessive amounts can lead to further heart problems—irregular pulse, convulsions Xanthopsia—Vincent Van Gogh ...
398 - PheKB
398 - PheKB

... Secondary problem list section of the clinical note for at least one positive mention of one of the heart failure terms. Positive mention is defined using ConText for assigning statuses to each NLP result – positive, probable, and negative 5-7. Thus a positive hit for this requirement equates to a n ...
Sample Chapter - Oncology Nursing Society
Sample Chapter - Oncology Nursing Society

... moves toward the apex, which contains fine trabeculations. Blood is then pumped with ventricular contraction toward the left ventricular outlet tract and out to the aorta through the aortic valve. Left ventricular tumors can present as left ventricular congestive heart failure (including symptoms of ...
Angiotensin II Type 2 Receptors and Cardiac
Angiotensin II Type 2 Receptors and Cardiac

... however did not contribute independently to LVMI. These findings suggest that AT2-Rs, like AT1-Rs, affect the plasma levels of renin, but that at the same time cardiac Ang II generation (and thus cardiac AT2-R stimulation) does not correlate directly with plasma renin levels. The latter might be exp ...
On-pump beating-heart versus conventional coronary artery bypass
On-pump beating-heart versus conventional coronary artery bypass

... cardiopulmonary bypass (CPB). In the last 20 years, many efforts have been undertaken to reduce the incidence of major intraoperative and postoperative complications related to the procedure. Myocardial revascularization in patients with left ventricular dysfunction is often performed to alleviate s ...
Vernakalant Hydrochloride for Rapid Conversion of
Vernakalant Hydrochloride for Rapid Conversion of

... urrently available antiarrhythmic agents have modest efficacy in converting atrial fibrillation (AF) to sinus rhythm, and the risk of proarrhythmia or hypotension is of concern.1–3 Time to conversion with these drugs often is unpredictable and may be long, especially with oral therapies.4 Although e ...
The Effect of Valvular Heart Disease on Maternal and
The Effect of Valvular Heart Disease on Maternal and

... and aortic stenosis (AS) were classified according to calculated valve area established by either cardiac catheterization or echocardiography as mild for valve area ⬎1.5 cm2, moderate 1.0 to 1.5 cm2, and severe ⬍1.0 cm2 (5). Four patients with predominant mitral regurgitation (MR) were included in t ...
Elevated plasma beta-endorphin levels in patients with
Elevated plasma beta-endorphin levels in patients with

... endorphin levels in patients with classes III and IV heart failure were significantly higher than those in control subjects (Fig. 1) . In individual patients in whom seyuc:aial follow-up blood sampling was performe'f . plasma betaendorphin levels changed with alteration in the patient's clinical sta ...
The Initiation of the Heart Beat - J
The Initiation of the Heart Beat - J

... generate normal sinus rhythm. Genetic mutations that affect a single clock do not always result in severe symptomatic bradycardia. Rather, many patients with reduced If are asymptomatic and can increase their heart rate to >150 beats/min during exercise. However, in common diseases such as atrial fi ...
Concealed Accessory Pathway in Late Presentation Wolff
Concealed Accessory Pathway in Late Presentation Wolff

... local GP over the course of an hour. However, at the time of presentation the patient was acutely unwell and did not reveal these details until after DC cardioversion. Certain guidelines (Frankel et al., 2015) will advocate the use of IV adenosine before DC cardioversion in the management of our cas ...
Device closure in adults with atrial septal defect in Shiraz
Device closure in adults with atrial septal defect in Shiraz

... occurred in 5 patients, 2 cases of atrial fibrillation (AF) and 3 cases of paroxysmal supraventricular tachycardia (PSVT) that all were successfully medically treated. There had been reports of these arrhythmias in previous studies.11 We had one patient with late device malposition that after 6 mont ...
PDF - 308 KB
PDF - 308 KB

... Human genetics in congenital heart disease We do not yet understand the causes of most complex genetic traits in humans, including congenital heart disease (CHD). For CHD, however, the study of chromosomal disorders and autosomal dominant syndromes, and the genetic linkage analysis of rare pedigrees ...
CSP
CSP

... benefits should be weighed against the potential hazards before is given during pregnancy, especially during the first trimester. Although the excretion in breast milk is minimal, nursing mothers are advised not to breast-feed while taking . ...
Class I: Na Channel Blockers
Class I: Na Channel Blockers

... Digoxin and amiodarone may be effective if LV dysfx and decompensated CHF to slow ventricular response. Digoxin alone rarely effective when patient sympathetically driven Avoid high dose digoxin with amiodarone as digoxin levels increase 2-fold with amiodarone ...
Sudden Cardiac Death in End-Stage Renal Disease
Sudden Cardiac Death in End-Stage Renal Disease

... among PD patients and 27% of all-cause death among hemodialysis patients in the United States are attributed to cardiac arrest/cause unknown.1 This observation is not surprising, given that PD patients are similarly subjected to kidney disease or uremia-related risk factors as in hemodialysis patien ...
RECENT ADVANCES IN SURGICAL AND PERCUTANEOUS
RECENT ADVANCES IN SURGICAL AND PERCUTANEOUS

... and it was reached in 55% of interventional and 73% of surgical patients in an intent-to-treat analysis (p=0.007). The combined safety endpoint (incidence of severe adverse events to 30 days) was reached in 15% of interventional and 48% of surgical patients (p<0.001), even though transfusion of ≥2 u ...
Early detection of anthracycline cardiotoxicity in a rabbit model: left
Early detection of anthracycline cardiotoxicity in a rabbit model: left

... serious adverse reaction that largely limits their therapeutic potential and threatens the cardiac function of cancer survivors. All anthracycline derivatives may induce cardiac damage that can result even in life-threatening complication of chemotherapy. The main risk is associated with their chron ...
Cardiovascular Quiz
Cardiovascular Quiz

... 1. The ________ artery is the largest among the two coronary arteries. 2. The right coronary artery arises from the ________ aortic sinus of ascending aorta 3. Posterior interventricular artery is a branch of ________ coronary artery. 4. The _________ artery supplies the left atrium and posterior pa ...
A Review of Causes and Systemic Approach to Cardiac Troponin
A Review of Causes and Systemic Approach to Cardiac Troponin

... epigastric, arm, wrist, or jaw discomfort with exertion or at rest, lasting for at least 20 minutes, with radiation to the arm, jaw, back, or shoulder, and may be associated with dyspnea, diaphoresis, nausea, vomiting,or lightheadedness. The discomfort is not positional and not affected by movement. ...
Exercise Training in Patients With Advanced Chronic Heart Failure
Exercise Training in Patients With Advanced Chronic Heart Failure

... written informed consent was obtained from all patients. The study consisted of 37 male patients ⱕ70 years of age with CHF as a result of ischemic heart disease or dilative cardiomyopathy as assessed by cardiac catheterization. All patients had clinical signs of CHF according to NYHA functional clas ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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