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the cardiovascular system: the heart
the cardiovascular system: the heart

Pre-Hospital Thrombolysis Aditi Vaishnav , Avani Vaishnav , Santosh Khandekar
Pre-Hospital Thrombolysis Aditi Vaishnav , Avani Vaishnav , Santosh Khandekar

... h. The difference was less dramatic for PPCI (Table 2). Overall, time delay was central to the benefit incurred by any type of reperfusion, but loss of benefit with increasing delay was less pronounced with PPCI. Therefore, the authors concluded that within 2 h of symptom onset, patients should rece ...
The Circulatory System:
The Circulatory System:

... • sinus rhythm - normal heartbeat triggered by the SA node – set by SA node at 60 – 100 bpm – adult at rest is 70 to 80 bpm (vagal tone) ...
Effects of Ecstasy on Mouse Cardiac Histopathology
Effects of Ecstasy on Mouse Cardiac Histopathology

... the form of powder, capsule or tablet in ...
Results of surgical repair of atrial septal defects in
Results of surgical repair of atrial septal defects in

... presence of a partial right bundle-branch 'block pattern in 21 and a complete right bundlezbranch block pattern in four. The remaining patient showed a left bundle-branch block pattern. Evidence of right ventricular hypertrophy as judged by the R:S ratio in lead Vi was present in 20. Ten patients ha ...
Haemodynamic Effects of Continuous Positive Airway Pressure in
Haemodynamic Effects of Continuous Positive Airway Pressure in

... there would be a dose-related alteration in cardiac and stroke volume indices in response to continuous positive airway pressure in normal subjects and patients with congestive heart failure and that the direction of response among those with heart failure would be related to left ventricular preloa ...
Correlation between Heart Rate Variability and Left Ventricular
Correlation between Heart Rate Variability and Left Ventricular

... analysis produces certain diagnostic indices that are obtained from spectral analysis of RR interval acquired for 3-5minutes. Heart Rate: heart rate at rest is known as basal heart rate. Basal heart rate of a normal healthy person is 60 beats per minute. Heart rate goes on increasing with age. Diabe ...
A Unique Milieu for Perioperative Care of Adult Congenital Heart
A Unique Milieu for Perioperative Care of Adult Congenital Heart

... by ventricular tachycardia and died 5 days after her operation as a result of ventricular fibrillation. Patient 2: a 27 year-old-male who underwent patch repair of a ventricular septal defect with fenestration at the atrial level resulting from pulmonary hypertension. The patient received multimodal ...
Efficacy, safety and tolerability of metoprolol CR/XL in patients with
Efficacy, safety and tolerability of metoprolol CR/XL in patients with

... were pre-specified—including an analysis of patients with diabetes mellitus for safety reasons. The present analyses focus on the subgroup of patients with a history of diabetes (n ⫽ 985). A subgroup analysis of patients with diabetes and more severe heart failure defined as New York Heart Associati ...
cardiac rhythm interpretation
cardiac rhythm interpretation

... dysrhythmia during the first couple of weeks after their attack. Half of these will be life threatening and will lead to cardiac arrest (sudden stoppage of adequate cardiac output) unless properly treated. In order to analyze and treat a dysrhythmia correctly, you must have a systematic approach to ...
The Heart A Muscle Activity
The Heart A Muscle Activity

... in the classroom and is not as sensitive a subject as body mass.) Cardiac output is an important indicator of heart health. It can be reduced if the heart valves are damaged and/or the arteries are narrowed because of heart disease. Reduced cardiac output will tend to increase the heart rate, and a ...
Medtronic Cardiac Rhythm and Heart Failure ICD
Medtronic Cardiac Rhythm and Heart Failure ICD

...  Codes are alpha-numeric and can be 3 to 7 digits long. Category ...
Control of Cardiac Output 2 - Dr. Ford
Control of Cardiac Output 2 - Dr. Ford

... decreases. This decrease increases ventricular transmural pressure and increases the flow of blood into the ventricles. This is most important for the right ventricle. Thus inspiration increases venous return to the right heart and increases right heart output. During expiration the pressure within ...
Secondary prevention through cardiac rehabilitation: from
Secondary prevention through cardiac rehabilitation: from

... BP, blood pressure; BMI, body mass index; CCS, Canadian Class Score; CR, cardiac rehabilitation; DASH, dietary approaches to stop hypertension; ET, exercise training; HDL-C, high-density lipoprotein cholesterol; HR, heart rate; LDL, low-density lipoprotein cholesterol; NYHA, New York Heart Associati ...
Table of Contents - Northwestern University
Table of Contents - Northwestern University

... allowed for implantable cardioverter defibrillators (ICDs), which provide electrical therapy immediately as needed. What is an ICD? For people who suffer from excessively rapid heartbeats called ventricular tachycardia or ventricular fibrillation, ICDs have become the dominant treatment method. Thes ...
Mario S. Verani Sanjiv Kaul, Warren K. Laskey, Dudley J. Pennell
Mario S. Verani Sanjiv Kaul, Warren K. Laskey, Dudley J. Pennell

... For regional analysis of left ventricular function or myocardial perfusion, the left ventricle should be divided into equal thirds perpendicular to the long axis of the heart. This will generate 3 circular basal, mid-cavity, and apical short-axis slices of the left ventricle. For echocardiography, a ...
Rate vs rhythm control in patients with atrial fibrillation
Rate vs rhythm control in patients with atrial fibrillation

... 4 weeks before and after electrical cardioversion. Rate arm anticoagulated if more than 65 year-old or cardiac disease. Digitalis, non-dihydropyridine calcium-channel blocker and beta-blocker Electrical cardioversion and sotalol, flecainide, propafenone or amiodarone ...
How to set up a successful TAVI program
How to set up a successful TAVI program

... for several reasons. Firstly, it is a useful discriminator between shortness of breath from respiratory causes ie. it doesn’t improve the symptoms, and patients who improve dramatically with temporary relief of their aortic stenosis. BAV is also a useful bridge to definitive therapy, which allows a ...
Cardiopulmonary Exercise Testing Variables
Cardiopulmonary Exercise Testing Variables

... significant correlation (P  .05) between both E and the E/E ratio and peak V̇O2 in 59 subjects with systolic HF. In a separate systolic HF cohort (n  53), Hadano et al25 likewise found a significant correlation (all P  .01) between peak V̇O2 and both E and E/E, again in agreement with the pre ...
ECG Workshop - Kentucky Academy of Physician Assistants
ECG Workshop - Kentucky Academy of Physician Assistants

... What is the most common form of SVT?  ...
Isolated Perfused Heart Models in Rats and Mice
Isolated Perfused Heart Models in Rats and Mice

Electrocardiography changes in bipolar patients during - EU-GEI
Electrocardiography changes in bipolar patients during - EU-GEI

... channels in sinus nodal pacemaker activity, lithium may cause a sinus node dysfunction through the failure of impulse generation or conduction into the adjacent atrial myocardium [24,26]. The decrease in adrenergic response and the complex interaction between sodium and pacemaker (L-type calcium and ...
Standardized Myocardial Segmentation and Nomenclature for
Standardized Myocardial Segmentation and Nomenclature for

... For regional analysis of left ventricular function or myocardial perfusion, the left ventricle should be divided into equal thirds perpendicular to the long axis of the heart. This will generate 3 circular basal, mid-cavity, and apical short-axis slices of the left ventricle. For echocardiography, a ...
T400-Series Surgical Protocol
T400-Series Surgical Protocol

... • Contractile Force via a force transducer attached to the apex of the heart. • Electrical Activity is monitored via electrodes attached to the apex and atria. Working Heart Method Fig. 2: Schematic of the working heart model of The Langendorff isolated heart method was modified an isolated perfus ...
The Contribution of Doppler Echocardiography to the Assessment of
The Contribution of Doppler Echocardiography to the Assessment of

... analysis of all 16 LV segments. This index is a numeric expression of the dispersion of time to minimum regional volume in each of the 16 LV segments. It has been shown to be able to quantify global LV function and increases with worsening LV systolic function. The systolic dyssynchrony index could ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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