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... • A significant number of patients with CTEPH do not have any history of pulmonary embolism or deep vein thrombosis • It is recommended that patients with acute pulmonary embolism should be routinely screened for CTEPH during follow-up. • CTEPH patients with at least moderate pericardial effusion sh ...
Digoxin in heart failure and cardiac arrhythmias
Digoxin in heart failure and cardiac arrhythmias

... effective refractive period of the atrial myocardium and, if anything, would be expected to make atrial fibrillation more likely to occur and persist. It is certainly possible that, in patients with concomitant heart failure, the beneficial effects of digitalis on the myocardium may improve haemodyn ...
Dysfunction: systolic vs. diastolic
Dysfunction: systolic vs. diastolic

... • Called Heart failure with normal EF (HFnlEF) • Diastolic dysfunction can occur along with systolic dysfunction ...
How to diagnose diastolic heart failure: a consensus statement on
How to diagnose diastolic heart failure: a consensus statement on

... age, gender, and body size suggesting that early stages of remodelling are already occurring in HFNEF.38 Such an evolution has also been observed in hypertensive heart disease,39–42 especially in African43–45 and Asian46,47 populations. In many of these studies, interval clinical events, such as myo ...
Dysfunction: systolic vs. diastolic
Dysfunction: systolic vs. diastolic

... • Called Heart failure with normal EF (HFnlEF) • Diastolic dysfunction can occur along with systolic dysfunction ...
How to diagnose diastolic heart failure: a consensus
How to diagnose diastolic heart failure: a consensus

... data on diastolic LV dysfunction therefore provided no additional diagnostic information and was therefore only of confirmatory significance. As this study looked at patients with a well-established history of heart failure, these results cannot be extrapolated to patients presenting solely with sympt ...
Matters of the Heart
Matters of the Heart

... Jesus Christ ...
Hypertrophic Cardiomyopathy Distance Learning Module
Hypertrophic Cardiomyopathy Distance Learning Module

... communities. Currently in the UK, anecdotal evidence suggests that twelve young people die per week as a cause of previously undiagnosed inherited cardiac disease. It has been suggested that 81 % of these deaths occur during or immediately following exercise with 6 % occurring in competitive athlete ...
Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder

... „ Sudden deaths, stroke, and myocardial infarction have been ...
Asymptomatic Left Ventricular Systolic Dysfunction in
Asymptomatic Left Ventricular Systolic Dysfunction in

... Abstract—Prevalence, determinants, and prognostic value of asymptomatic left ventricular systolic dysfunction (LVSD) in uncomplicated subjects with essential hypertension are still incompletely known. We studied 2384 initially untreated subjects with hypertension, no previous cardiovascular disease, ...
Urinary albumin excretion in heart failure with preserved ejection
Urinary albumin excretion in heart failure with preserved ejection

... was successfully closed in March 2010 with 10 219 patients registered from the 24 participating hospitals. All data and events will be surveyed at least once a year until March 2013. In the CHART-2 study, left ventricular ejection fraction (LVEF) was measured by echocardiography at the time of enrol ...
ATHEROSCLEROSIS
ATHEROSCLEROSIS

... With all mother tinctures, there is a physical component and the danger of side effects or toxicity. It can be easy for homeopaths to forget this, so dosage needs to be considered respectfully when using material doses Although perfectly safe, it may rapidly become intolerable for compromised system ...
Transcatheter Aortic Valve Implantation, Patient Selection Process
Transcatheter Aortic Valve Implantation, Patient Selection Process

... symptomatic aortic stenosis who are rejected for surgery because of increased age and left ventricular dysfunction or coexisting comorbidities.3,4 During the last ...
Familial Trifascicular Block with Autosomal Dominant Inheritance
Familial Trifascicular Block with Autosomal Dominant Inheritance

... (RBBB) and left anterior fascicular block (LAFB). Twenty-four hour Holter monitoring showed ventricular pause up to 16 seconds during syncope. Radiofrequency catheter ablation was performed for atrial flutter. An additional ECG indicated a trifascicular block (RBBB, LAFB, and first-degree AV block). ...
EKG Reference Manual - Penn State Hershey Medical Center
EKG Reference Manual - Penn State Hershey Medical Center

... Vector from the Late Ventricle”. Learn to NEVER confuse RBBB and LBBB. Page 6. Ventricular Hypertrophy, the concept. Why you cannot make the diagnosis of ventricular hypertrophy with BBB- not with LBBB, not with RBBB. Why you CAN make the diagnosis of Q-MI with RBBB but NOT with LBBB. Page 7. Q-Wave ...
Tasers -Circulation-2012-Zipes-2417-22
Tasers -Circulation-2012-Zipes-2417-22

... replicate the clinical scenario of a frightened/fleeing/fighting individual. Several epidemiological studies have not shown a link between ECD shocks and sudden cardiac death.22,23 However, a recent review24 determined that single shocks in healthy people “…could have deleterious effects when used i ...
Correction of Respiratory Acidosis by Continuous Renal
Correction of Respiratory Acidosis by Continuous Renal

... correct solute abnormalities. However, when volume overload is present in a patient who is hemodynamically unstable, CRRT offers an advantage over IHD. In addition, CRRT offers the ability to “fine tune” a patient’s pH. In the patient presented, the pCO2 remained uniformly elevated. When the pCO2 is ...
Imaging right ventricular function to predict outcome in pulmonary
Imaging right ventricular function to predict outcome in pulmonary

... RV function such as RAP, SV or PVR or SV/PP did not independently predict outcome. Furthermore, there was no added value of combining invasive measurements of pressure with non-invasive measurements of volumes to assess RV–arterial coupling. The present study confirms previous reports that RV contrac ...
Obstructive sleep apnea characteristic in systolic heart failure patients
Obstructive sleep apnea characteristic in systolic heart failure patients

... characteristics of sleep apnea in patients with heart failure. A retrospective, clinical study was conducted on 29 heart failure patients in our tertiary care center. Patients who reported snoring, witnessed apnea episodes and excessive daytime sleepiness underwent full-night polysomnography. Baseli ...
Pdf version - Polish Archives of Internal Medicine
Pdf version - Polish Archives of Internal Medicine

... In several studies, either new-onset or pre-existing AF was shown to have a negative impact on prognosis in patients with CAD treated with PCI (TABLE 1 ).31-35 AF may result in progressive deterioration of systolic function if heart rate is not controlled. It confers an increased stroke risk and req ...
Lab 03: Heart Anatomy (10 points)
Lab 03: Heart Anatomy (10 points)

... system, on various heart models, diagrams, and by sheep heart dissection. Lab Outcome 5: Describe and demonstrate patterns of blood circulation throughout the human body, including systemic, pulmonary, cerebral, coronary, hepatic portal, and fetal circulations on models, diagrams and dissected cat s ...
Mechanisms of Cardiac Arrhythmias (PDF Available)
Mechanisms of Cardiac Arrhythmias (PDF Available)

... 2. Cardiac action potential and its ionic contributions The cardiac action potential results from the sequential opening and closing of ion channel proteins that span the plasma membrane of individual myocytes. Its conduction through the heart depends on electrical coupling between these cells, whic ...
A Clinical Approach to Palpitations
A Clinical Approach to Palpitations

Teacher`s Guide - Activity B13: EKG – Demonstration
Teacher`s Guide - Activity B13: EKG – Demonstration

... Background ...
Correlation Between Regional Wall Motion Abnormalities via 2
Correlation Between Regional Wall Motion Abnormalities via 2

... hours and continues for several days to months.Therefore follow-up 2D echocardiographic imaging is useful in detecting reperfused myocardial segments or infarct expansion (1) (9).T he segmental numerical model of regional wall motion score can be matched and corresponds well with coronary artery dis ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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