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Bosentan in Pulmonary Arterial Hypertension Secondary to Scleroderma
Bosentan in Pulmonary Arterial Hypertension Secondary to Scleroderma

... patients completed 18 months of bosentan therapy, were lost to followup, or stopped bosentan therapy because of an adverse drug effect. Baseline data were defined as the most recent test results recorded prior to the study. Two investigators independently collected data from charts, and discrepancie ...
Heart failure with systolic dysfunction complicating acute myocardial
Heart failure with systolic dysfunction complicating acute myocardial

... Nearly half of all patients with acute myocardial infarction (AMI) present left ventricular systolic dysfunction (LVSD) and one quarter show symptoms of heart failure (HF), both of which are associated with poor outcomes [1—6]. Nevertheless, the Global Registry of Acute Coronary Events (GRACE) has s ...
Patient , s Guide - Deutsches Herzzentrum München
Patient , s Guide - Deutsches Herzzentrum München

... a single roof has become well established, having since been applied to numerous other areas of medical specialisation over the decades. Cardiovascular disease concerns us all. It is still the most frequent cause of death in industrialised nations. The number of people suffering from heart disease h ...
Sudden Transitional Death Risk: When an ICD Isn`t the
Sudden Transitional Death Risk: When an ICD Isn`t the

... What are the current ICD guidelines? Multiple guidelines have been issued over the years, but there is the most recent update, Figure 10. To simplify the guideline, for primary and secondary prophylactic therapy--ischemic and nonischemic patients are included--the patient should be on optimal medica ...
Spinal Anaesthesia in a Neonate with Hypoplastic Left Heart
Spinal Anaesthesia in a Neonate with Hypoplastic Left Heart

... have been abdominal surgery and severe cardiac abnormalities. Caudal anaesthesia could have been considered as another option in the management of this patient. However, we preferred spinal anaesthesia due to its faster onset, profound sensory blockage and flaccid paralysis with a smaller dose of lo ...
Pacing Artifact May Masquerade as Capture
Pacing Artifact May Masquerade as Capture

... monitored. Heart rate detectors, if active during pacing, may not accurately count intrinsic QRS complexes or pacemaker generated complexes. The heart rate detector may incorrectly identify artifact as QRS complexes leading to false high readings. Also, intrinsic complexes which fall within the pace ...
cardiac pressure-volume loops cardiac terminology afterload
cardiac pressure-volume loops cardiac terminology afterload

... End diastolic pressure volume relationship.  End diastolic pressure volume relationship (EDPVR) describes the passive filling curve for the ventricle and thus  the passive properties of the myocardium. The slope of the EDPVR at any point along this curve is the  reciprocal of ventricular compliance  ...
Fluid build-up between the heart and the sac
Fluid build-up between the heart and the sac

... (ascites), but may lead to side effects and patient weakness  Vitamin K—indicated for patients with rodenticide-anticoagulant (such as warfarin) poisoning  Antibiotics are indicated in animals with infection/inflammation of the sac around the heart (infectious pericarditis)  Chemotherapy—may be u ...
The Assessment of Left Ventricular Ejection Fraction in Patients with
The Assessment of Left Ventricular Ejection Fraction in Patients with

... assess the fluctuations in radioactivity by eye these shorter sample times increased the difference in radioactivity between systole and diastole, so increasing ejection fraction. However, for routine use curve-fitting techniques with computer facilities would then be needed. Increasing the dose of ...
Outcomes 2014 - Inova Heart and Vascular Institute
Outcomes 2014 - Inova Heart and Vascular Institute

living with atrial fibrillation
living with atrial fibrillation

... heart muscles from contracting properly. This means the heart cannot pump blood as effectively as it should. Since blood is not properly pumped away from the heart, it may collect or ‘pool’ in the heart chambers, leading to the formation of a clot. The clot can break off from the heart wall and trav ...
Moderate Exercise Training Improves Survival and Ventricular
Moderate Exercise Training Improves Survival and Ventricular

... prevent or delay the occurrence of heart failure in high-risk subjects also remains unclear. Chronic left ventricular (LV) volume overload diseases such as aortic valve regurgitation (AR) are well tolerated for many years before heart failure occurs. There is currently no treatment proven effective ...
What is hemodynamic monitoring? There are both invasive and
What is hemodynamic monitoring? There are both invasive and

... One of the obvious indications for hemodynamic monitoring is decreased cardiac output. This could be from dehydration, hemorrhage, G. I. bleed, Burns, or surgery. All types of shock, septic, cardiogenic, neurogenic, or anaphylactic may require invasive hemodynamic monitoring. Any deficit or loss of ...
pericardial effusion
pericardial effusion

... (ascites), but may lead to side effects and patient weakness  Vitamin K—indicated for patients with rodenticide-anticoagulant (such as warfarin) poisoning  Antibiotics are indicated in animals with infection/inflammation of the sac around the heart (infectious pericarditis)  Chemotherapy—may be u ...
Chapter 9 Exercise Prescription for Patients with Cardiovascular and
Chapter 9 Exercise Prescription for Patients with Cardiovascular and

View PDF or right-click to save - College of Family Physicians
View PDF or right-click to save - College of Family Physicians

... in ECGs in competitive athletes. This isolated QRS voltage criteria for left ventricular hypertrophy (LVH) with no other ECG and clinical findings is an unusual pattern in hypertrophic cardiomyopathy.17 Other minor alterations in the athletes’ ECG that are considered normal include increased PR inte ...
File - Respiratory Therapy Files
File - Respiratory Therapy Files

... ECG does not show a significant amount of the tissue supplied by the RCA • Adistal, inferior: II, III, AVF • Blarger amount of tissue, larger infarction: no leads look at the posterior wall, so you will only see indicative changes in II, III, AVF • Cproximal, produces infarction in both ventricle ...
A Cineradiographic Study of the Snake Heart
A Cineradiographic Study of the Snake Heart

... could be seen. It originated slightly to the left of the atrio-ventricular valves and could be followed to a point at the left posterolateral aspect of the ventricle. This last point was marked by a small indentation, which was most clearly observed before the isometric contraction started (fig. 2, ...
Connecting Leads to Boston Scientific Pacemakers, Defibrillators
Connecting Leads to Boston Scientific Pacemakers, Defibrillators

... Boston Scientific cardiac resynchronization therapy pacemakers (CRT-Ps) are indicated for patients with moderate to severe heart failure (NYHA Class III/IV) including left ventricular dysfunction (EF <=35%) and QRS duration >= 120 ms and remain symptomatic despite stable optimal pharmacological ther ...
The Art and Science of Diagnosing and Treating Lung and Heart
The Art and Science of Diagnosing and Treating Lung and Heart

... Patients with chronic liver disease are at risk of extrahepatic complications related to cirrhosis and portal hypertension, as well as organ-specific complications of certain liver diseases. These complications can compromise quality of life, while also increasing morbidity and mortality before and a ...
Cardiopulmonary Physiology
Cardiopulmonary Physiology

... interpretations suggest that they are caused by vibrations in the chamber walls and blood brought about by the abrupt valve closure. The third heart sound appears to be caused by blood decelerating as it enters the distended ventricle at the end of the rapid filling period. Normally, this sound is h ...
PDF file - Nowotwory
PDF file - Nowotwory

... and QT interval, QTU alternans, early afterdepolarizations, and torsade de pointes ventricular tachyarrythmia (TdP VT). Hyperkalemia affects up to 8% of hospitalized patients mainly in the setting of compromised renal function. The ECG manifestation of hyperkalemia depends on serum K+ level. At 5.5– ...
Perioperative Management of the Wolff-Parkinson
Perioperative Management of the Wolff-Parkinson

... from a few select articles. In the 1930s, Louis Wolff, Sir John Parkinson, and Paul Dudley White described 11 patients who had occasional episodes and electrocardiographic (ECG) findings of sinus tachycardia, a bundle-branch block QRS morphology, and a shortened PR interval.1 Then, in 1967, during ep ...
Valvular Heart Disease : Diagnosis and Management
Valvular Heart Disease : Diagnosis and Management

... Asymptomatic patients with severe AS behave like normal adults of the same age group. In a prospective study of 123 asymptomatic adults with an initial jet velocity of at least 2.6 m per second, the rate of symptom development was 38% at 3 years for the total group.59 A study of 622 asymptomatic hem ...
Randomized controlled trial of home-based
Randomized controlled trial of home-based

... There is evidence that multiple benefits can be obtained through exercise training that leads to increases in peak oxygen consumption (VI O2). It is unclear whether significant improvements can also be achieved through unsupervised low-budget home-based training regimes, especially in terms of cardi ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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