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Effects of exercise training on left ventricular structure and function in
Effects of exercise training on left ventricular structure and function in

... size. Increased peak V02 and reduced abdominal fat, BP, and IR were associated with improved LV diastolic function. R-values ranged from 0.20-0.32 (P≥0.05). Conclusions: When examined by group assignment, exercise had no effect on cardiac size or LV diastolic function. When examining individual vari ...
Beyond ejection fraction: an integrative approach for assessment of
Beyond ejection fraction: an integrative approach for assessment of

... two-dimensional echocardiography requires inferences about ventricular shape in order to estimate a three-dimensional volume from a two-dimensional image. Various technical limitations, partly inherent to echocardiography as a non-tomographic technique, hamper the calculated LVEF values: poor image ...
Rehabilitation: Cardiac Rehabilitation Services (Outpatient)
Rehabilitation: Cardiac Rehabilitation Services (Outpatient)

... symptoms despite being on optimal heart failure therapy for at least 6 weeks. Stable patients are defined as patients who have not had recent (≤6 weeks) or planned (≤6 months) major cardiovascular hospitalizations or procedures. For additional information, see the NCD for Cardiac Rehabilitation Prog ...
Academic paper: Reversing Heart Failure: Diastolic Recoil in a
Academic paper: Reversing Heart Failure: Diastolic Recoil in a

... insufficient blood output from the heart and corresponding reduced blood flow, a compensating increase in blood volume, and the resulting congestion of the veins and lungs, leading to further deterioration of the heart. ...
Tetralogy of Fallot and its Radiologic Manifestation
Tetralogy of Fallot and its Radiologic Manifestation

... before adolescence. Fewer than 10% of cases survive into adulthood. • Complete surgical correction: closure of VSD and relief of right ventricular outflow obstruction • Palliative surgery: anastomosis of a systemic artery to a pulmonary artery to increase pulmonary blood flow. ...
Improvement of Cardiac Function During Enzyme
Improvement of Cardiac Function During Enzyme

... 4. Pieroni M, Chimenti C, Ricci R, et al. Early detection of Fabry cardiomyopathy by tissue Doppler imaging. Circulation. 2003;107:1978 –1984. 5. Heimdal A, Støylen A, Torp H, et al. Real-time strain rate imaging of the left ventricle by ultrasound. J Am Soc Echocardiogr. 1998;11:1013–1019. 6. Weide ...
Guidelines: Congenital Aortic Valve Stenosis
Guidelines: Congenital Aortic Valve Stenosis

... valve (autograft) and a biological valve is implanted in pulmonary position. Anticoagulation is not necessary. The operation can be performed at any age and offers the advantage that a vital valve with growth potential is placed in aortic position. However, due to unphysiological pressure and dilata ...
Cardiac Pacemaker System
Cardiac Pacemaker System

... – developments in the field of microprocessor technology will most likely lead to greater flexibility in the self-adjustment of rate, output, and the overall sensitivity of pacemakers. – The continued innovation of programmability and telemetry will increase the diagnostic capabilities of pacemakers ...
Print - Circulation
Print - Circulation

... patient is able to perform this amount of activity, he can earn a livelihood, although he must refrain from occupations which involve heavy physical labor; a woman can raise children, go marketing, and do all but the heaviest type of housework. Our experience has been that this is what is almost uni ...
Sudden Death And Exercise
Sudden Death And Exercise

... whereas other have found that more vigorous forms of exercise such as crosscountry skiing or running are associated with a five to seven fold greater risk of sudden death. Possibly the first detailed study of this question was reported by Thompson and his colleagues. They found that in the state of ...
Is left ventricular volume during diastasis the real equilibrium volume
Is left ventricular volume during diastasis the real equilibrium volume

... It is appropriate to define diastolic suction as Nikolic and others have, relative to an equilibrium volume, but this volume must reflect a mechanical equilibrium. Despite the presence of non-zero residual intramyocardial stress (23), all forces are balanced and the chamber remains static (nonmoving ...
Avian Medicine: Princilpes and Application
Avian Medicine: Princilpes and Application

... being restrained is higher than the heart rate obtained in the same bird if the rate had been determined using telemetry. A stress-induced increase in heart rate should resolve several minutes after the stressing factors are removed. Diagnostic aids that have proven to be effective in evaluating car ...
Principles of Cardiac Pacing
Principles of Cardiac Pacing

... Failure to Sense • Causes – Pacemaker not sensitive enough to detect the patient’s intrinsic electrical activity (mV) – Insufficient myocardial voltage – Dislodged, loose, fibrotic, or fractured electrode – Electrolyte abnormalities – Low battery voltage ...
Effects of acute intravenous iloprost on right ventricular
Effects of acute intravenous iloprost on right ventricular

... Abstract: The inotropic effects of prostacyclins in chronic pulmonary arterial hypertension (PAH) are unclear and may be important in directing patient management in the acute setting. We sought to study the effects of an acute intravenous (IV) infusion of iloprost on right ventricular (RV) contract ...
relation of the first and second heart sounds to events in the cardiac
relation of the first and second heart sounds to events in the cardiac

... "The chief value of the recorded heart sound is the possibility of accurately timing its occurrence in relation to the events of the cardiac cycle." This is even truer to-day than when Lewis first stated it (1915), because methods for recording events in the cardiac cycle have become more precise. I ...
Exercise training increases arterial compliance in patients with
Exercise training increases arterial compliance in patients with

... thus is a significant determinant of left ventricular work. Previous studies have suggested that arterial compliance may be reduced in patients with congestive heart failure (CHF), and that SAC is increased after a 4-week exercise training programme in healthy, sedentary individuals. The present stu ...
What do we know about the natural history of severe symptomatic
What do we know about the natural history of severe symptomatic

... After hypertension and coronary artery disease, aortic valve stenosis (AS) is the most frequent cardiovascular disease. AS is increasingly observed in octogenarians and even in nonagenarians. The prevalence of AS is currently reported to be 2.5% at the age of 75 years and almost 8% at 85 years [1] . ...
and Cavity Size: An Analysis of 1500 Human Hearts
and Cavity Size: An Analysis of 1500 Human Hearts

... ALTHOUGH it has been suggested that right ventricular dilatation can be distinguished from right ventricular hypertrophy on pathologic, if not on clinical, grounds,' there is experimental evidence that an increase in muscle mass follows an increase in hemodynamic load within hours.2' Because disting ...
Ventricular septal defect - ePrints
Ventricular septal defect - ePrints

... pulmonary vascular resistances. Symptoms include failure to thrive, along with the manifestations of the increase in flow of blood to the lungs. Diagnosis can be made by physical examination, but is confirmed by echocardiographic interrogation, which delineates the precise anatomy, and also provides ...
Patient Information for the Medtronic CoreValve
Patient Information for the Medtronic CoreValve

... stretches the valve opening and allows more blood to flow through the heart. This procedure does not require open-heart surgery. ...
Cardiac magnetic resonance imaging-based myocardial strain study
Cardiac magnetic resonance imaging-based myocardial strain study

... Trastuzumab, a humanized monoclonal antibody against the extracellular domain of human epidermal growth factor receptor 2 (HER2), improves clinical outcomes in patients with breast cancer overexpressing HER2. Adjuvant therapy using trastuzumab reportedly reduces the risk of relapse by about a half a ...
Biventricular Pacemakers (Cardiac Resynchronization Therapy) for
Biventricular Pacemakers (Cardiac Resynchronization Therapy) for

... placement of a device that paces both ventricles and which coordinates ventricular pacing to maximize cardiac pumping function and left ventricular ejection fraction (LVEF). Summary of Evidence Evidence from clinical trials and systematic reviews supports the benefit of cardiac resynchronization the ...
Print this article
Print this article

... invasive. It involves subxiphoid section and possibly a partial sternotomy or thoracotomy. It is often complicated by post-pericardiotomy syndrome.9 The usual epicardial leads are associated with a high incidence of rapidly increasing sensing and pacing thresholds after lead placement, necessitating ...
STRONG HEART STUDY LABORATORY PROCEDURES
STRONG HEART STUDY LABORATORY PROCEDURES

... projection allows one to measure the true, maximum LV diameter (Figure 2B). If, as is common in older subjects, the best parasternal window is in a low interspace, LV minor-axis dimensions and wall thicknesses should not be measured in the usual fashion, although it may be possible to measure correc ...
Functional assessment of the fetal heart: a review
Functional assessment of the fetal heart: a review

... finer trabeculations, making it appear smooth-walled on ultrasonography12 . The ventricles are also differentiated by their respective atrioventricular valves: the RV has the three-leaflet tricuspid valve, as opposed to the twoleaflet mitral valve of the LV, although the three leaflets may not be cl ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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