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Aortic-Valve Stenosis - American College of Cardiology
Aortic-Valve Stenosis - American College of Cardiology

... alvular aortic stenosis is a progressive disease in which the end stage is characterized by obstruction of left ventricular outflow, resulting in inadequate cardiac output, decreased exercise capacity, heart failure, and death from cardiovascular causes. The prevalence of aortic stenosis is only abo ...
Development of the Heart
Development of the Heart

... At the end of 4th week, 2 endocardial cushions on dorsal & ventral walls of atrioventricular canal , develop from mesenchymal cells of cardiac jelly. (B) During 5th week, the AV- endocardial cushions meet and unite in the middle line to form a septum and divide the common A-V canal into right & le ...
Diagnosis of Acute Myocardial Infarction
Diagnosis of Acute Myocardial Infarction

... Diagnosis of acute myocardial infarction (AMI) has to be made early in the emergency triage since maximal mortality occurs within first hour and the benefits of all interventions are greater once these are instituted early. Diagnosis is easy and based on simple principals of good history, physical e ...
Aortic valve calcification using multislice CT
Aortic valve calcification using multislice CT

... therapy was not accompanied by any effect on the progression of stenosis hemodynamics and degree of calcification. The study by Rossebo et al. demonstrated similar results [30] , that is, simvastatin and ezetimibe did not reduce the composite outcome of combined aortic valve events and ischemic even ...
Relative Dipolar Behavior of the Equivalent T Wave Generator
Relative Dipolar Behavior of the Equivalent T Wave Generator

... highly significant (P < .005). We also found that in contrast to the considerable mobility exhibited by the equivalent QRS dipole, the ST-T dipole locus remained nearly stationary during most of ventricular recovery. Presumably because repolarization is temporally and spatially a relatively diffuse ...
In vivo model of drug-induced valvular heart disease in
In vivo model of drug-induced valvular heart disease in

... to the left ventricular outflow tract diameter. For the mitral and tricuspid valve, the regurgitant area ratio (jet/atrium) was calculated in the view with the largest colour Doppler signal (long axis or four chamber view). The pulmonary regurgitant flows were coded as present or absent in the short-a ...
12/07 Atrial Septal Defects
12/07 Atrial Septal Defects

... increases in right-sided pressure. TEE is much more sensitive than TTE for detection of left-to-right shunt as negative right atrial contrast (93% vs. 58% in one study). TEE can detect flow through multiple ASDs. ...
THE TOTAL CAVOPULMONARY CONNECTION RESISTANCE: A
THE TOTAL CAVOPULMONARY CONNECTION RESISTANCE: A

... 2.) SVR typically goes down with exercise demonstrating the impact of the peripheral muscular dynamics and the vasodilation that occurs to aid the increase in cardiac output43. Studies have shown a drop of almost 50% in SVR. This is accomplished in the model by decreasing the SVRI progressively fro ...
the carotid pulse i: diagnosis of aortic stenosis by external
the carotid pulse i: diagnosis of aortic stenosis by external

... The brachial pulse is unreliable in the diagnosis of aortic stenosis as it may fail to show distinctive changes (Hancock and Abelmann, 1957; Hancock and Fleming, 1963). The carotid pulse should be more satisfactory for this purpose, since it reflects central events more clearly and external recordin ...
New-born Babies with Abnormal Heart Rhythm CA6034 v1.1
New-born Babies with Abnormal Heart Rhythm CA6034 v1.1

... judgement, knowledge and expertise of relevant clinicians. It is advised that the rationale for any departure from relevant guidance should be documented in the patient's case notes. The Trust's guidelines are made publicly available as part of the collective endeavour to continuously improve the qu ...
Arrhythmia Surgery in Patients With and Without Congenital Heart
Arrhythmia Surgery in Patients With and Without Congenital Heart

... was used to treat atrioventricular nodal reentry tachycardia (Fig 2). Accessory connections (Fig 3A and B) were divided by both epicardial and endocardial resection techniques. Focal (automatic) atrial tachycardia (Fig 4) was treated by isolation, resection, or cryoablation of the affected atrial ti ...
The STS Mitral Repair/Replacement Composite Score: A Report of
The STS Mitral Repair/Replacement Composite Score: A Report of

... analyses of 3-year outcomes. Overall mortality was 2.9% (1,773/61,201) and the frequency of any major morbidity was 17.0% (10,381/61,201). Figure 2 provides the estimated distributions of risk-standardized mortality and any-ornone morbidity across STS ACSD participant sites, both of which show subst ...
Left Ventricular Diastolic Dysfunction and Obesity: A Systematic
Left Ventricular Diastolic Dysfunction and Obesity: A Systematic

... [29]. The last but not the least possibility might be hyperinsulinemia caused by insulin resistance [30], it is major condition linking metabolic abnormalities and impairment of left ventricular diastolic function in obesity, effects of insulin on myocytes and interstitial fibrosis may contribute to ...
The Three-Dimensional Arrangement of the Myocytes Aggregated
The Three-Dimensional Arrangement of the Myocytes Aggregated

... 4 cm water, and an FiO2 of 50%. Muscular relaxation was achieved with 4 mg pancuronium given intravenously. Continuous anaesthesia consisted of 2–3% of isoflurane in the inhaled gases, while analgesia was provided by fentanyl intravenously (10 mg/kg/hr). The animals were placed in the supine positio ...
ardiovascular-system - bloodhounds Incorporated
ardiovascular-system - bloodhounds Incorporated

...  Thicker walls than atria  Actual pumps of heart  Right ventricle  Pumps blood into pulmonary trunk ...
Morphological and Functional Modeling of the Heart Valves and
Morphological and Functional Modeling of the Heart Valves and

... techniques, bioprosthetic valves, robotic surgery and percutaneous interventions, which have led to a twofold increase in the number of valve procedures performed in the United States since 1985 (Jablokow (2009)). There has been a major trend in cardiac therapy towards minimally invasive transcathet ...
Structural Heart Disease - Circulation: Cardiovascular Interventions
Structural Heart Disease - Circulation: Cardiovascular Interventions

... Background—Aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) has been associated with poor outcomes, but little is known about how it evolves over time. We evaluated left ventricular (LV) function, remodeling, and the occurrence and evolution of AR after TAVI by using ca ...
PDF file - Via Medica Journals
PDF file - Via Medica Journals

... vessels. However, to date this system has been developed sufficiently only for the echocardiography. On foetal post-mortem examination of the great arteries there are no such standards available. Therefore, it is very difficult for both pathologists and cardiologists to assess whether the vessel dia ...
Rapid Ventricular Transvenous Pacing via Pulmonary Artery
Rapid Ventricular Transvenous Pacing via Pulmonary Artery

... endograft are ideally such that there is little to no forward flow to cause misplacement of the graft as it is deployed. An ideal system to allow such hemodynamics is easily controllable, has a rapid onset and offset, and allows return of normal hemodynamics when the therapy is stopped with no side ...
Adrenomedullin-epinephrine cotreatment enhances cardiac output and left
Adrenomedullin-epinephrine cotreatment enhances cardiac output and left

... baseline) and 18 ⫾ 31% (P ⫽ not significant) with EPI. LV systolic capacitance decreased by ⫺37 ⫾ 22% and peak positive derivative of LV pressure (dP/dtmax) increased by 32 ⫾ 7% with AM-EPI (P ⬍ 0.05, AM-EPI interaction), whereas no significant effects were observed with EPI. Mean arterial pressure ...
Inhibition in the human heart
Inhibition in the human heart

... a variety of arrhythmias (table 1) were studied in the electrophysiology laboratory. All patients gave informed written and verbal consent before entering the study. There were 14 men and two women in the study with a mean age of 52 + 14 years. Three to four electrode catheters were inserted percuta ...
Transmitral Flow Changes during DipyridamoleInduced lschemia*
Transmitral Flow Changes during DipyridamoleInduced lschemia*

... 21 women; typical for in ...
Physiological systolic and diastolic changes of the left and right
Physiological systolic and diastolic changes of the left and right

... heart has come into the focus of interest e.g. in case of secondary pulmonary hypertension. The process of contraction of the right ventricle differs importantly to the left ventricle and the evaluation of right ventricular volume and ejection fraction by standard two-dimensional echocardiography is ...
Sudden cardiac death in chronic kidney disease: epidemiology and prevention
Sudden cardiac death in chronic kidney disease: epidemiology and prevention

... with the subsequent development of heart failure. 19 Progressive hypertrophy is partly explained by hypertension, but not by a wide array of potential risk factors, including moderate anemia.20 lvH could predispose individuals to sudden death through prolongation of corrected Qt (Qtc) interval or by ...
Valvular Regurgitation - Gvsu - Grand Valley State University
Valvular Regurgitation - Gvsu - Grand Valley State University

...  Total volume of blood pumped by the ventricle in a single beat ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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