Cardiac function in hereditary transthyretin amyloidosis
... Background: Hereditary transthyretin amyloidosis (ATTR) is a lethal disease in which misfolded transthyretin (TTR) proteins accumulate as insoluble aggregates in tissues throughout the body. A common mutation is the exchange of valine to methionine at place 30 (TTR V30M), a form endemically found in ...
... Background: Hereditary transthyretin amyloidosis (ATTR) is a lethal disease in which misfolded transthyretin (TTR) proteins accumulate as insoluble aggregates in tissues throughout the body. A common mutation is the exchange of valine to methionine at place 30 (TTR V30M), a form endemically found in ...
real heart valve operation in cardiovascular model with
... Modeling valves' function may provide a tool for studying the heart's performance, as well as, it helps to represent some of the most common heart’s abnormalities such as mitral valve regurgitation and aortic stenosis. Cardiovascular system models using electrical systems do not model chambers and t ...
... Modeling valves' function may provide a tool for studying the heart's performance, as well as, it helps to represent some of the most common heart’s abnormalities such as mitral valve regurgitation and aortic stenosis. Cardiovascular system models using electrical systems do not model chambers and t ...
Influence of physical exercise and relationship with biochemical
... pivotal for the management of patients in the acute care setting, admitted with suspected cardiac pathologies. It was earlier determined that the adoption of sex-, race- and agerelated reference limits is essential for clinical interpretation of results of natriuretic peptides measurement, and relat ...
... pivotal for the management of patients in the acute care setting, admitted with suspected cardiac pathologies. It was earlier determined that the adoption of sex-, race- and agerelated reference limits is essential for clinical interpretation of results of natriuretic peptides measurement, and relat ...
Assessment of Longitudinal Myocardial Stiffness Is Not - J
... It is still unclear which percentage of transverse and longitudinal stiffness contributes to total myocardial stiffness, although there is no doubt that both are important in regulating the diastolic function of the myocyte, and this is even more relevant in the context of pathologies such as hypert ...
... It is still unclear which percentage of transverse and longitudinal stiffness contributes to total myocardial stiffness, although there is no doubt that both are important in regulating the diastolic function of the myocyte, and this is even more relevant in the context of pathologies such as hypert ...
Pulmonary artery banding and ventricular septal defect enlargement
... Background: In patients with univentricular atrioventricular connection and the aorta originating from an incomplete ventricle, subaortic stenosis is generally due to a restrictive ventricular septal defect (RVSD), that may be present at birth or develop after palliative procedures. In particular, a ...
... Background: In patients with univentricular atrioventricular connection and the aorta originating from an incomplete ventricle, subaortic stenosis is generally due to a restrictive ventricular septal defect (RVSD), that may be present at birth or develop after palliative procedures. In particular, a ...
Why QRS Duration Should Be Replaced by Better Measures of
... the mid-septal region, which suggests activation by slow conduction through the left bundle-branch, in others, LV endocardial activation occurred as a result of right-to-left transseptal spread of activation [40]. A characteristic finding in true LBBB patients also seems to be a long (>40 ms) transs ...
... the mid-septal region, which suggests activation by slow conduction through the left bundle-branch, in others, LV endocardial activation occurred as a result of right-to-left transseptal spread of activation [40]. A characteristic finding in true LBBB patients also seems to be a long (>40 ms) transs ...
Aortic Stenosis: Pathophysiology, Diagnosis, and Medical Management of
... compromise of atrial kick as a result of atrial fibrillation, ventricular pacing, and/or intravascular fluid volume overload may precipitate pulmonary congestion, hypotension, and angina.7,21,22 Atrial arrhythmias may result from an extension of calcific infiltrates from the aortic valve into the co ...
... compromise of atrial kick as a result of atrial fibrillation, ventricular pacing, and/or intravascular fluid volume overload may precipitate pulmonary congestion, hypotension, and angina.7,21,22 Atrial arrhythmias may result from an extension of calcific infiltrates from the aortic valve into the co ...
Determinants of the relation between systolic pressure and
... Patiznts with normal mt atrial pressure (Table IA). In the 22 palients with normal mean right atrial pressure (58 mm H& peak rigbl vcmricular systolic pressure ranged from 20 to 97 mm Hg. The pulmonary valve closure-tricuspi? valve opening interval increased as an approximately I&S function of peak ...
... Patiznts with normal mt atrial pressure (Table IA). In the 22 palients with normal mean right atrial pressure (58 mm H& peak rigbl vcmricular systolic pressure ranged from 20 to 97 mm Hg. The pulmonary valve closure-tricuspi? valve opening interval increased as an approximately I&S function of peak ...
Chronic Care Programme
... ACE inhibitors and β-blockers and aldosterone antagonists which have been shown to provide mortality benefit.[18] Treatment of CHF aims to relieve symptoms, maintain a euvolemic state (normal fluid level in the circulatory system), and to improve prognosis by delaying progression of heart failure an ...
... ACE inhibitors and β-blockers and aldosterone antagonists which have been shown to provide mortality benefit.[18] Treatment of CHF aims to relieve symptoms, maintain a euvolemic state (normal fluid level in the circulatory system), and to improve prognosis by delaying progression of heart failure an ...
Circulation Research SEPTEMBER
... (8). Isoproterenol produced less of an increment in maximum systolic pressure when the heart was paced at 430 beats/min than when a spontaneous heart rate obtained (Fig. 3). Upon cessation of pacing, each of the four animals studied showed an increase in their response to isoproterenol (P < 0.05). T ...
... (8). Isoproterenol produced less of an increment in maximum systolic pressure when the heart was paced at 430 beats/min than when a spontaneous heart rate obtained (Fig. 3). Upon cessation of pacing, each of the four animals studied showed an increase in their response to isoproterenol (P < 0.05). T ...
Management of patients treated with left ventricular assist devices
... dysfunction is a consequence of ischemia, stunning, infarction or a combination of these abnormalities. In order to prevent the deleterious consequences of low flow, treatment usually involves the use of vasoactive agents, especially if ischemia appears less likely. Traditionally, the treatment of l ...
... dysfunction is a consequence of ischemia, stunning, infarction or a combination of these abnormalities. In order to prevent the deleterious consequences of low flow, treatment usually involves the use of vasoactive agents, especially if ischemia appears less likely. Traditionally, the treatment of l ...
Myocardial Function and Coronary Blood Flow Response to Acute
... The hemodynamic measurements were made in duplicate in the control state and during the course of ischemia in both groups. Baseline hemodynamic values prior to ischemia were not significantly different in the control and diabetic groups (Tables 1 and 2). Between 30 and 60 minutes of ischemia in the ...
... The hemodynamic measurements were made in duplicate in the control state and during the course of ischemia in both groups. Baseline hemodynamic values prior to ischemia were not significantly different in the control and diabetic groups (Tables 1 and 2). Between 30 and 60 minutes of ischemia in the ...
Heterogeneous responses of systolic and diastolic left ventricular
... target recruitment of relevant subgroups into clinical studies investigating therapies aimed at specific underlying mechanisms of the disease.18,19 In clinical practice, these patients are diagnosed by criteria established by the European Society of Cardiology (ESC).20 However, it can be difficult to ...
... target recruitment of relevant subgroups into clinical studies investigating therapies aimed at specific underlying mechanisms of the disease.18,19 In clinical practice, these patients are diagnosed by criteria established by the European Society of Cardiology (ESC).20 However, it can be difficult to ...
Use of implantable cardioverter defibrillators in patients with left
... non-sustained VT, especially in the early post-operative period. Sustained VT/VF may be well tolerated, at least in the short term, and refractory to ICD therapy. Frequent ICD shocks will contribute to premature generator depletion. One group suggested that LVAD patients who develop VT/VF should be ...
... non-sustained VT, especially in the early post-operative period. Sustained VT/VF may be well tolerated, at least in the short term, and refractory to ICD therapy. Frequent ICD shocks will contribute to premature generator depletion. One group suggested that LVAD patients who develop VT/VF should be ...
HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis
... categories: the arrhythmic events and the electrocardiographic (ECG) aspects. The arrhythmic events are due to runs of torsades de pointes VT, which, according to its duration, produces syncope, cardiac arrest, and—when it deteriorates into VF —sudden death. Among untreated patients, the natural his ...
... categories: the arrhythmic events and the electrocardiographic (ECG) aspects. The arrhythmic events are due to runs of torsades de pointes VT, which, according to its duration, produces syncope, cardiac arrest, and—when it deteriorates into VF —sudden death. Among untreated patients, the natural his ...
Northwest Community EMS System VENTRICULAR
... Most common rhythm in sudden cardiac death Significant heart disease: CAD, ACS, AMI Same causes as VT May be preceded by significant PVCs or VT but can occur spontaneously Cardiomyopathy, mitral valve prolapse, cardiac trauma, hypoxia Cocaine toxicity, electrolyte imbalances, acidosis, proarrhythmic ...
... Most common rhythm in sudden cardiac death Significant heart disease: CAD, ACS, AMI Same causes as VT May be preceded by significant PVCs or VT but can occur spontaneously Cardiomyopathy, mitral valve prolapse, cardiac trauma, hypoxia Cocaine toxicity, electrolyte imbalances, acidosis, proarrhythmic ...
distribution of edema
... pronounced in the morning owing to the recumbent posture assumed during the night. Less common causes of facial edema include trichinosis, allergic reactions, and myxedema. Edema limited to one leg or to one or both arms is usually the result of venous and/or ...
... pronounced in the morning owing to the recumbent posture assumed during the night. Less common causes of facial edema include trichinosis, allergic reactions, and myxedema. Edema limited to one leg or to one or both arms is usually the result of venous and/or ...
12 Lead EKG 101
... Bundle branch is a significant complication of infarction. Since the left anterior descending artery is the primary supplier of the bundle branches, BBB is considered a complication of anterior septal infarcts. When BBB is the result of MI, the incidence of pump failure is 65-70% and the in-hospital ...
... Bundle branch is a significant complication of infarction. Since the left anterior descending artery is the primary supplier of the bundle branches, BBB is considered a complication of anterior septal infarcts. When BBB is the result of MI, the incidence of pump failure is 65-70% and the in-hospital ...
Pericarditis
... • Implantable cardioverter–defibrillators (ICDs) to prevent sudden death associated with lethal dysrhythmias • Heart transplantation and some medical therapies have been shown to prolong life. ...
... • Implantable cardioverter–defibrillators (ICDs) to prevent sudden death associated with lethal dysrhythmias • Heart transplantation and some medical therapies have been shown to prolong life. ...
Clinical Meaning of Ascites in Patients with Endomyocardial Fibrosis
... hemodynamic changes that lead to the genesis of ascites. When we analyzed ascites in relation to the chamber involved, we observed that biventricular involvement was present in 52.5% of patients, right ventricular involvement was present in 60.7% and prevalent involvement of the left ventricle was p ...
... hemodynamic changes that lead to the genesis of ascites. When we analyzed ascites in relation to the chamber involved, we observed that biventricular involvement was present in 52.5% of patients, right ventricular involvement was present in 60.7% and prevalent involvement of the left ventricle was p ...
Diagnosis and Management of Diastolic Dysfunction and Heart Failure
... needs, whether at rest or during exercise, but at a higher filling pressure. Transmission of higher end-diastolic pressure to the pulmonary circulation may cause pulmonary congestion, which leads to dyspnea and subsequent right-sided heart failure. With mild dysfunction, ...
... needs, whether at rest or during exercise, but at a higher filling pressure. Transmission of higher end-diastolic pressure to the pulmonary circulation may cause pulmonary congestion, which leads to dyspnea and subsequent right-sided heart failure. With mild dysfunction, ...
Arrhythmogenic right ventricular cardiomyopathy (ARVC
... cardiomyopathy and a frequent cause of sudden death in the young. Affected individuals typically present between the second and fourth decade of life with arrhythmias coming from the right ventricle. Pathogenic mutations in genes encoding the cardiac desmosome can be found in approximately 60% of in ...
... cardiomyopathy and a frequent cause of sudden death in the young. Affected individuals typically present between the second and fourth decade of life with arrhythmias coming from the right ventricle. Pathogenic mutations in genes encoding the cardiac desmosome can be found in approximately 60% of in ...
Diastolic Heart Failure — Abnormalities in Active
... of the echocardiographic measurements. The increment in left ventricular diastolic volume that occurred between the opening of the mitral valve and the point of minimal diastolic pressure was calculated first by determining, with the use of Doppler echocardiographic techniques, the fraction of the t ...
... of the echocardiographic measurements. The increment in left ventricular diastolic volume that occurred between the opening of the mitral valve and the point of minimal diastolic pressure was calculated first by determining, with the use of Doppler echocardiographic techniques, the fraction of the t ...
Pathophysiology of right ventricular failure
... becomes more circular in contour, a steeper relationship between volume and stretch develops, and the Frank-Starling relation becomes more important (29). Global function of the RV depends on independent but coordinated contributions from both the RV free wall and the interventricular septum. In an ...
... becomes more circular in contour, a steeper relationship between volume and stretch develops, and the Frank-Starling relation becomes more important (29). Global function of the RV depends on independent but coordinated contributions from both the RV free wall and the interventricular septum. In an ...
Multidimensional Rhythm Disturbances as a Precursor of Sustained
... increased gradually several hours before the onset. MKLT provided greater sensitivity and specificity (70% and 93%) compared with the best traditional method (68% and 67%, respectively). We present a theoretical analysis of MKLT and describe the effects of ectopy and slow changes in cardiac cycles o ...
... increased gradually several hours before the onset. MKLT provided greater sensitivity and specificity (70% and 93%) compared with the best traditional method (68% and 67%, respectively). We present a theoretical analysis of MKLT and describe the effects of ectopy and slow changes in cardiac cycles o ...
Hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.