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Print - Circulation
Print - Circulation

... levels. However, in the presence of pulmonary vascular obstruction, right heart pressures are in excess of this relationship,"'9 20 and left ventricular assistance may have an opposite and detrimental effect on right ventricular outflow pressure due to augmented flow through the elevated pulmonary v ...
Cardiac Resynchronization Therapy in 2015
Cardiac Resynchronization Therapy in 2015

... evolved dramatically over the past 40 years. Medications such as angiotensin-converting enzyme inhibitors [1, 2], angiotensin receptor blockers [3, 4], beta blockers [5, 6], and aldosterone receptor antagonists [7, 8] have led to significant improvements in both symptom control and survival in patie ...
Percutaneous Balloon Valvuloplasty
Percutaneous Balloon Valvuloplasty

... Careful measurement of postprocedural gradients allows differentiation of infundibular stenosis from residual valvular stenosis. Postprocedural RV and pulmonary artery angiography help assess the severity of pulmonic insufficiency that has developed as a result of the procedure and also can address ...
The Teleost Heart: A Morphological Approach*
The Teleost Heart: A Morphological Approach*

... applied to all fish heart ventricles (Santer 1985). The external shape, the architectural organization, the histology, the coronary distribution, the relative mass, the work dynamics, etc., vary widely between species. In an attempt to classify this variability, several authors have grouped the vent ...
Echocardiographic Assessment of Right Ventricular Diastolic
Echocardiographic Assessment of Right Ventricular Diastolic

... 1.5) and with good RV and LV systolic function were included. Exclusion Criteria are as follows: presence of pulmonary valve atresia with ventricular septal defect (VSD), double-outlet right ventricle (DORV), associated complex congenital heart disease such as TOF with atrio-ventricular septal defec ...
Acute Electrophysiologic Effects of Inhaled Salbutamol in Humans*
Acute Electrophysiologic Effects of Inhaled Salbutamol in Humans*

... of these agents. This study is the first to evaluate the cardiac electrophysiologic effects of a single, regular dose of an inhaled ␤2-agonist in humans. Salbutamol was selected, as it is one of the most widely used inhaled ␤2-agonists and would ensure improved correlation with standard clinical pra ...
Recommendations for Cardiovascular Magnetic Resonance in
Recommendations for Cardiovascular Magnetic Resonance in

... magnetic resonance (CMR) in relation to adults with congenital heart disease (CHD). Cardiovascular magnetic resonance can provide assessments of anatomical connections, biventricular function, myocardial viability, measurements of flow, angiography, and more, without ionizing radiation. It should be ...
Doping and effects of anabolic androgenic steroids on the heart: histological,
Doping and effects of anabolic androgenic steroids on the heart: histological,

... has occurred without evident coronary thrombosis or atherosclerosis, leading to the hypothesis that AAS may induce coronary vasospasm and cardiac arrhythmias in susceptible individuals. Similarly, there are several case reports of increased thromboembolic risk.4 Therefore, in the management of arrhy ...
Transesophageal echocardiography in the OR and ICU
Transesophageal echocardiography in the OR and ICU

... (RWMA). TEE can be used to evaluate the extension of the ischemic area via examination of the myocardial segmental kinesis using a segmental model of the LV in which 16 or 17 segments are recognized.18 This imaging technique can also be used to assess cardiac function and any associated complication ...
Recommendations for cardiovascular magnetic resonance in adults
Recommendations for cardiovascular magnetic resonance in adults

... magnetic resonance (CMR) in relation to adults with congenital heart disease (CHD). Cardiovascular magnetic resonance can provide assessments of anatomical connections, biventricular function, myocardial viability, measurements of flow, angiography, and more, without ionizing radiation. It should be ...
Ultrafast Computed Tomography Analysis of Regional Radius
Ultrafast Computed Tomography Analysis of Regional Radius

... The technical details of the ultrafast CT scanner have been previously described.18 Studies were performed in 13 healthy male volunteers ages 21-36 years (mean age, 23±4 years) who were free of cardiac disease as assessed by history, physical examination, and ECG. Additionally, 18 patients with mode ...
ABC of clinical electrocardiography Broad complex tachycardia—Part I
ABC of clinical electrocardiography Broad complex tachycardia—Part I

... P wave accurately. ...
21 January 2015
21 January 2015

... It is imperative to differentiate between normal sinus arrhythmia (which can include pauses in the healthy neonate of up to 1.5 seconds), (2) benign arrhythmias (including premature atrial contractions, premature ventricular contractions, nodal or junctional rhythm and wandering atrial rhythm), (3) ...
Examination of the Heart
Examination of the Heart

... Palpation Usually inspection and palpation are discussed together because there is an intimate relationship between these two processes in the heart examination. Palpation not only confirms the results in inspection, but also discovers diagnostic signs. ...
The Effect of PEEP on Cardiac Output
The Effect of PEEP on Cardiac Output

... during a baseThey found ...
The Effect of PEEP on Cardiac Output
The Effect of PEEP on Cardiac Output

... during a baseThey found ...
The Effect of PEEP on Cardiac Output
The Effect of PEEP on Cardiac Output

... during a baseThey found ...
Heart size-independent analysis of myocardial
Heart size-independent analysis of myocardial

... connected to a rodent ventilator after endotracheal intubation (7). Anesthesia was maintained by the administration of 0.5–1.0% isoflurane. After bilateral vagotomy, cardiac catheterization was performed with a 1.4-Fr high-fidelity micromanometer catheter inserted retrograde through the right caroti ...
Management of Paradoxical Low-Flow, Low
Management of Paradoxical Low-Flow, Low

... is often associated with a LG, even with severe stenosis. However, flow and gradient are not synonymous and provide complementary information; flow is of prognostic importance as a marker for reduced cardiac pump function and worse outcomes, whereas gradient is of diagnostic importance because a LG wi ...
Cardiac Surgery: Heart Valve Disease
Cardiac Surgery: Heart Valve Disease

... If you have BAV, please read the following. It is important to understand the nature of this disease and how it may affect you and your family. The aortic valve controls the flow of blood from the heart out to the body. Normally, the aortic valve has three leaflets that keep blood moving in one dire ...
presentation, diagnosis, and management
presentation, diagnosis, and management

... There is some evidence that the use of leucocyte interferonalpha controls the secretion of tumour products. It stimulates T lymphocytes and can produce a notable reduction in tumour size with evidence of survival benefit. Interferonalpha can be used in conjunction with somatostatin antagonists. Unfo ...
Echocardiography use in the diagnosis and management of cardiac
Echocardiography use in the diagnosis and management of cardiac

... stroke (particularly in stroke units) as a major cornerstone in the diagnostic work-up with a 1:3 ratio of TTE alone vs. TOE. This careful cardiodiagnostic approach appears to be justified even in patients with already known cerebral small vessel disease or artery-to-artery brain embolism from extra ...
Late Ventricular Potentials in Cardiac and Extracardiac
Late Ventricular Potentials in Cardiac and Extracardiac

... arise in the viable cells inside the necrotic and fibrotic mass, or in the injured myocardial fibers, with slow conduction (Cain et al, 1996; La Vecchia et al, 1998; Turrini et al, 1999). An anatomical substrate, able to cause delayed conduction and produce LVPs, was reported in several other clinic ...
as PDF
as PDF

... recommended cardiac pacing for specific conditions (vasovagal syncope, hypertrophic cardiomyopathy, heart failure with prolonged QRS duration, etc). Since over 10 years, left ventricular resynchronisation therapy has proved to be beneficial to patients presenting heart failure with complete left bun ...
Recommendations for echocardiography use in the diagnosis and
Recommendations for echocardiography use in the diagnosis and

... TOE has revolutionized the search for cardiac sources of embolism because of its (near) non-invasive nature and its relatively good sensitivity and high specificity.8 In current clinical practice, echocardiography is used in over 80% of patients with acute stroke (particularly in stroke units) as a ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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