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Chapter_20_Heart
Chapter_20_Heart

... – Preload: the degree of stretch in the heart before it contracts. Greater the preload on fibers just before they contract greater is the force of contraction (Frank-Starling law of the heart). This law equalizes the volume of blood flowing to both systemic and ...
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... good neurological function. An effective drug or intervention limited to this population by randomizing only these patients could lead to impressive improvement in survival. If survival were increased from 30% to 37.5%, then ≈3700 lives would be saved every year through the improved treatment of thi ...
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... bstructive hypertrophic cardiomyopathy (HCM) is characterized by asymmetrical septal hypertrophy and dynamic left ventricular (LV) outflow tract obstruction.1 In patients with symptomatic obstructive HCM, surgical resection (myectomy) of the basal septum relieves LV outflow obstruction with improvem ...
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... prognostic indicators of cardiovascular morbidity and mortality.1 If timely detected it helps in guiding future therapeutic options to change the course of events to a significant measure.2 LVH has many underlying causes one of which is hypertension. Hypertension is prevalent in 25% of the populatio ...
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... In contrast, cardiac muscle has a long Ap refractory period that lasts about 250msec . This is almost as long as the period of contraction—300 msec (between the Ap and contractile response , there is a slightly delay),so the cardiac muscle cannot be restimulated until contraction is almost over, sum ...
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... 9. Mallidi J, Nadkarni GN, Berger RD, Calkins H, Nazarian S. Metaanalysis of catheter ablation as an adjunct to medical therapy for treatment of ventricular tachycardia in patients with structural ...
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... the highest risk who will benefit from the most intense therapy while reassuring and sparing invasive procedures in those at lower risk” • A low risk patient may only require clinical evaluation and stress test or echo while a high risk patient may need to go directly to cardiac ...
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... thicker than most of the left ventricular free wall (Fig. 3); the ratio of septal thickness to that of the posterior free wall was usually 1.3 or greater (mean 1.5) (14). In addition, the thickened left ventricular wall (particularly the ventricular septum) characteristically showed two other morpho ...
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XStrain™ 4D

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Mitral valve prolapse by Ronald Hoffman, M.D., CNS May 1996
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... actually experiencing a panic attack. Once people experience this, they generally have a persistent fear of having another attack, which puts them on a "hair trigger," ready to respond to the slightest symptoms by releasing the very stress hormones that induce the panic attacks, thus escalating a ne ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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