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Metabolic Studies on Cardiac Tissue Obtained by Needle Biopsy in
Metabolic Studies on Cardiac Tissue Obtained by Needle Biopsy in

... many as 8 to 10) biopsy procedures, each procedure involving three to five individual cardiac punctures. A recovery period of several days is usually allowed to elapse before the biopsy procedure is repeated, but in many dogs they have been performed as often as four hours apart. No infection, prolo ...
Cardiac Markers
Cardiac Markers

... • Important for risk stratification for short-term adverse cardiac events • Little difference in cTnT vs. cTnI • Use of the 99th percentile optimizes detection of minor myocardial damage  high risk • CK-MB and myoglobin redundant today ...
Cardiac Troponin T and Cardiac Enzymes After External
Cardiac Troponin T and Cardiac Enzymes After External

... cell necrosis.3 No, or only minor, increases in cardiac troponin I levels4,5 and no increases in cardiac troponin T (cTnT) levels after ECV for atrial fibrillation and atrial flutter have been reported.6 – 8 However, it has been reported that cTnT levels are increased in patients successfully resusc ...
Left Bundle Branch Block in a 29-Year-Old Non
Left Bundle Branch Block in a 29-Year-Old Non

... that there is a connection, although likely exceedingly rare, between an LBBB and normal physiological remodeling. For example, one study showed that 27.4% of professional basketball athletes met LVH criteria by echocardiography [9]. This study, which included 529 athletes, does not mention any EKG ...
Identification of Microvascular Obstruction Christopher M. Kramer
Identification of Microvascular Obstruction Christopher M. Kramer

... inflammatory processes that lead to capillary destruction and regions of microvascular no-reflow or microvascular obstruction (MO). These regions can be visualized by CMR as regions of low signal in the first few minutes after contrast infusion [1]. See Figure 1. These regions are low signal because ...
Mean Velocity of Fiber Shortening
Mean Velocity of Fiber Shortening

... Methods Fifty patients, 7 to 62 years of age, were studied during diagnostic left heart catheterization. Their diagnoses are listed in tables 1-3. The first group consisted of 13 patients in whom mechanical performance of the left ventricle was considered to be normal. Tension-velocity data in six o ...
Mitral valve surgery in heart failure
Mitral valve surgery in heart failure

... characteristics of the patients who underwent repair and replacement were similar. The only statistical difference was that the MV replacement group included more patients who had a history of cardiac surgery (3 vs 1, P ⫽ .002). In general, surgeons chose replacement if there were anatomic abnormali ...
Cardiac Magnetic Resonance Imaging and Computed Tomography
Cardiac Magnetic Resonance Imaging and Computed Tomography

... narrowing, non-invasive imaging techniques are important tools for accurate diagnosis and further management decisions. Ideally, a comprehensive non-invasive diagnostic test is able to assess coronary anatomy and lumen defects, plaque composition, tissue perfusion, cardiac function as a result of st ...
Prolonged administration of a dithiol antioxidant protects - AJP
Prolonged administration of a dithiol antioxidant protects - AJP

... cytokine release, leukocyte activation, and generation of high levels of reactive oxygen species (3, 7, 19, 41). Leukocyte release of reactive oxygen species is very intense immediately after the onset of reperfusion (6), and there is evidence that antioxidant therapies given the first few hours of ...
Natriuretic peptide vs. clinical information for diagnosis of left
Natriuretic peptide vs. clinical information for diagnosis of left

... important, since early treatment with ACE inhibitors has been shown to delay the progression toward overt congestive heart failure (CHF) and to prolong life [1]. Since diagnosis of left ventricular systolic dysfunction solely based on clinical symptoms may be difficult [2], echocardiography is recom ...
Problem Solving Exercises in Cardiovascular
Problem Solving Exercises in Cardiovascular

... the AV node is unidirectional, a PVD is invariably not conducted to the atria; therefore it does not reset sinus rhythm (compare it with a premature atrial depolarization, see below). A PVD reflects the automaticity of an ‘ectopic’ focus. In terms of action potentials, excitation of a ventricular my ...
Double Valve Replacement (Mitral and Aortic) for Rheumatic Heart
Double Valve Replacement (Mitral and Aortic) for Rheumatic Heart

... 14%.9The data for the United Kingdom heart valve registry over the period 1987–1997 estimates early mortality at 9.3% for double valve procedures inclusive of re-operations (16). Our review identified the association of pulmonary hypertension as a strong predictor of both morbidity and mortality. Th ...
Pediatric pacemakers and ICDs: how to optimize perioperative care
Pediatric pacemakers and ICDs: how to optimize perioperative care

... Pacing and Electrophysiology group (Table 1) (8). The five-position code shown in Table 1 is often shortened to the first three positions, e.g., single chamber pacemakers can pace the atrium (AAI) or the ventricle (VVI). Dual chamber (DDD) mode is the most sophisticated and commonly used mode. Positio ...
Malignant Arrhythmia as the First Manifestation of Wolff
Malignant Arrhythmia as the First Manifestation of Wolff

... they analysed ECGs of 238 WPW cases and reported that 15% of patients had minimal delta waves and 10% of patients had PR interval longer than 120 ms on surface ECG (3). Unfortunately, the rate of arrhythmia in the minimal preexcitation group has not been reported. In case of clinical suspicion of WP ...
Cardiac sarcoma - a fatal disease: report of 2 cases
Cardiac sarcoma - a fatal disease: report of 2 cases

... or metastatic cardiac sarcoma can provide hemodynamic improvement and relief from congestive heart failure. Postsurgical adjuvant radiation and chemotherapy have not proven consistently beneficial [13, 14]. However, they can be beneficial in improving the symptoms and quality of life. The role of or ...
SYNCOPE
SYNCOPE

... Excluding those complications discussed prior (tamponade, stroke etc), syncope alone does not appear to increase the risk of death. Forty-six percent of patients with syncope had no explanation for their LOC and could have been caused by… ...
Hemolytic Anemia after Aortic Valve Replacement: a Case Report
Hemolytic Anemia after Aortic Valve Replacement: a Case Report

... layer is extirpated, red blood cells in the rapidly circulated blood flow would be injured by compact with the artificial material. Suedkamp showed that in subjects with prosthetic valves in the aortic site, if the serum level of LDH raises more than 400 U/l ,presence of events such as valvular malf ...
Pacemakers and Implantable Defibrillator - sha
Pacemakers and Implantable Defibrillator - sha

... INDICATION FOR ICD: ICD Patients at risk of developing sudden cardiac arrests due to ventricular tachycardias and fibrillations are candidates for ICDs. ICDs do not prevent the occurrence of life-threatening rhythms, h th b butt can quickly i kl tterminate i t them th when h they th occur. Recent cl ...
the current role of echocardiography in cardiac resynchronization
the current role of echocardiography in cardiac resynchronization

... cement toward anywhere in the posteriora sub-group from MADIT-CRT trial [40]. lateral free wall [42]. TARGET showed that Haugaa et al. more recently reported on there was a greater proportion of respon201 class III-IV HF patients with baseline ders at 6 months (70 % vs. 55 %, p=0.031), and follow-up ...
Diastolic closure rate of normal mitral valve - Heart
Diastolic closure rate of normal mitral valve - Heart

... phonocardiogram was obtained using a piezoelectric The mitral valve echogram was recorded using a Smith- crystal microphone placed in the second intercostal Kline Instruments Ekoline 20 ultrasound recorder pro- space at the left sternal edge. A small cannula was introviding a repetition rate of iooo ...
atrial septal defect
atrial septal defect

... interatrial septum allowing pulmonary venous return from the left atrium to pass directly to the right atrium. • Depending on the size of the defect, size of the shunt, and associated anomalies, this can result: – No significant cardiac sequelae – Right-sided volume overload – Pulmonary arterial hyp ...
NT-proBNP levels, as predictor of left ventricular systolic and
NT-proBNP levels, as predictor of left ventricular systolic and

... The syndrome of HF is a common manifestation of the later stages of various cardiovascular diseases, including coronary artery disease, hypertension, valvular disease, and primary myocardial disease. Heart failure (HF) has traditionally been divided into HF with a reduced ejection fraction (EF; syst ...
Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy
Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy

... side effects that preclude optimal medication.5 The haemodynamic indication requires a significant obstruction either at rest or under provocation. The absolute gradient level criteria were originally set higher than is currently accepted as an indication (≥30 mmHg at rest or ≥60 mmHg under provocat ...
Evaluation of Right and Left Ventricular Systolic and Diastolic
Evaluation of Right and Left Ventricular Systolic and Diastolic

... and tissue Doppler echocardiographic imaging can predict early stage and progression of diabetic cardiomyopathic changes. Objective: The aim of this study is to assess the effect of type 1 diabetes on cardiac systolic and diastolic functions in both ventricles in patients without evidence of coronar ...
A Rationale - Training Officer 101
A Rationale - Training Officer 101

... Used with Permission of Physio-Control, Inc, and according to the Material Release Form provided by Physio-Control. ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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