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Time-dependent remodeling of transmural architecture underlying
Time-dependent remodeling of transmural architecture underlying

... heart failure is not well understood. We hypothesized that these geometric alterations in heart failure may be accounted for by regionally selective remodeling of myocardial sheets (15, 26). Specifically, the early changes of LV geometry may be associated with selective remodeling of the sheet struc ...
Geometrical considerations in cardiac electrophysiology and
Geometrical considerations in cardiac electrophysiology and

... This says that the ionic current is equal to the product of membrane capacitance and the rate of change of transmembrane potential (with an opposite sign). Thus, we can estimate net ionic current from the first derivative of the membrane potential waveform. This is the methodology used by Bányász et ...
Manifest and Concealed Reentry
Manifest and Concealed Reentry

... findings in both man and experimental animals are in agreement with those of Moe and Mendez who stated that reciprocal responses can be so readily induced in normal animal hearts that their occurrence must be considered a normal physiologic response.10 This reentry can be either manifest or conceale ...
Dilated Right Pulmonary Veins in Mitral Insufficiency
Dilated Right Pulmonary Veins in Mitral Insufficiency

... in mitral stenosis and left heart failure. These have Regurgitation of contrast substance during angi emphasized the dilatation of the superior pulmonary ography into the pulmonary veins has been reveins and the decrease in caliber of the inferior ported. Ross and Criley’3 and Arvidsson’4 both pulmo ...
Dilated Right Pulmonary Veins in Mitral Insufficiency
Dilated Right Pulmonary Veins in Mitral Insufficiency

... in mitral stenosis and left heart failure. These have Regurgitation of contrast substance during angi emphasized the dilatation of the superior pulmonary ography into the pulmonary veins has been reveins and the decrease in caliber of the inferior ported. Ross and Criley’3 and Arvidsson’4 both pulmo ...
CV - Division of Cardiology
CV - Division of Cardiology

... Physical Diagnostic Course Participant: Regular contributor to this annual effort since 1999. (6 sessions x medical students, annually) Physician Shadowing: Hosted countless premed and accelerated track WSU (MEDSTART) medical students as part of shadowing experience to expose trainees to the daily r ...
Syncope
Syncope

... Despite the widespread use of drug therapy, none of these pharmacologic agents have been demonstrated to be effective in large prospective randomized clinical trials. A small study has reported the efficacy of midodrine. Metoprolol, propranolol and nadolol are no more effective than placebo. ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... 3.3.1 Individuals without known heart disease . . . . . . . 3.3.2 Patients with ischaemic heart disease . . . . . . . . . 3.3.3 Patients with inheritable arrhythmogenic diseases . 3.4 Prevention of sudden cardiac death in special settings . 3.4.1 Screening the general population for the risk of sudd ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... 3.3.1 Individuals without known heart disease . . . . . . . 3.3.2 Patients with ischaemic heart disease . . . . . . . . . 3.3.3 Patients with inheritable arrhythmogenic diseases . 3.4 Prevention of sudden cardiac death in special settings . 3.4.1 Screening the general population for the risk of sudd ...
Arrhythmia ToolBox Resources
Arrhythmia ToolBox Resources

... Content Course I: AACN - Basic ECG Interpretation by American Association of Critical-Care Nurses (ACCN) is designed to provide knowledge and enhance skills in adult ECG interpretation basics including rhythm categories of sinus, atrial, junctional, ventricular, and heart blocks, cardiac anatomy and ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... 3.3.1 Individuals without known heart disease . . . . . . . 3.3.2 Patients with ischaemic heart disease . . . . . . . . . 3.3.3 Patients with inheritable arrhythmogenic diseases . 3.4 Prevention of sudden cardiac death in special settings . 3.4.1 Screening the general population for the risk of sudd ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... 3.3.1 Individuals without known heart disease . . . . . . . 3.3.2 Patients with ischaemic heart disease . . . . . . . . . 3.3.3 Patients with inheritable arrhythmogenic diseases . 3.4 Prevention of sudden cardiac death in special settings . 3.4.1 Screening the general population for the risk of sudd ...
PDF
PDF

... a mutation in Scn5a (1798insD), ventricular activation ended after the end of the QRS complex (12.9 + 0.1 vs. ...
2015 ESC Guidelines for the management of
2015 ESC Guidelines for the management of

... 3.3.1 Individuals without known heart disease . . . . . . . 3.3.2 Patients with ischaemic heart disease . . . . . . . . . 3.3.3 Patients with inheritable arrhythmogenic diseases . 3.4 Prevention of sudden cardiac death in special settings . 3.4.1 Screening the general population for the risk of sudd ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... 3.3.1 Individuals without known heart disease . . . . . . . 3.3.2 Patients with ischaemic heart disease . . . . . . . . . 3.3.3 Patients with inheritable arrhythmogenic diseases . 3.4 Prevention of sudden cardiac death in special settings . 3.4.1 Screening the general population for the risk of sudd ...
Pericardial Disease: Etiology, Pathophysiology
Pericardial Disease: Etiology, Pathophysiology

... of immunosuppressive agents. Thus, Pneumococcus and Streptococcus, which in the past were frequent causes of acute pericarditis often ending fatally, are now less common, having been replaced to some extent by such organisms as coagulase-positive Staphylococcus,5 which increasingly are resistant to ...
Prosthetic Heart Valves in the Aortic Position: A Review Hadi
Prosthetic Heart Valves in the Aortic Position: A Review Hadi

... construction. If more or less blood is required to be circulated through the body (depending on the physical or mental conditions), the heart rate needs to increase or decrease [10]. The regulation of heart rate is directly controlled by the neural network, which is achieved specifically by the symp ...
Mortality Study of the Significance of Extrasystoles in an
Mortality Study of the Significance of Extrasystoles in an

... a high incidence of death from myocardial infarction, often of a sudden nature, particularly in persons under the age of 56 years. There were too few cases of the individual types of complex ventricular extrasystoles to determine whether this was a characteristic of the group as a whole or of one or ...
Changes in Intracellular Na+ following Enhancement of Late Na+
Changes in Intracellular Na+ following Enhancement of Late Na+

... 55207). This maneuver was previously tested and validated by ElShrif et al. [39]. In this study, using the TNNP formulation of INa in ORd model, conduction velocity (CV) yielded values that closely matched experimental data [40] and could also replicate the main characteristics of INa, restitution p ...
cardiovascular magnetic resonance in the prediction of outcome
cardiovascular magnetic resonance in the prediction of outcome

... This work was supervised by Dr Francisco Leyva and Professor John Sanderson, Professor of Clinical Cardiology, University of Birmingham. Dr Shajil Chalil was my immediate predecessor as research fellow, and he devised the CMR-TSI technique with Dr Leyva and Dr Stegemann. My work followed on from Dr ...
Module 3 - Cardiac Arrhythmias-Mechanisms of Arrhythmias
Module 3 - Cardiac Arrhythmias-Mechanisms of Arrhythmias

... caffeine or nicotine can lead to arrhythmia in some people. A heart attack or an underlying condition that damages the heart's electrical system also can cause an arrhythmia. These conditions include high blood pressure (hypertension), coronary artery disease, heart failure, overactive or underactiv ...
Noninvasive electrocardiographic imaging for cardiac
Noninvasive electrocardiographic imaging for cardiac

... We show a noninvasive isochrone map depicting the sequence of epicardial activation for subject N (Fig. 2c, right). Four sites of early epicardial activation (labeled 1–4) corresponded to the epicardial breakthroughs in Figure 2a (right). These four breakthrough sites have also been mapped directly ...
Review for EKG`s 2016 ACLS v5.1
Review for EKG`s 2016 ACLS v5.1

... The patient’s heart rate reveals a great deal of information. If the rate is slow (under 60 beats per minute), we call it bradycardia. If the heart rate is fast (over 100 beats per minute), then it is called tachycardia. ECG monitors display the heart rate. When an ECG strip is printed, most printer ...
EAE/ASE Recommendations for Image Acquisition and Display
EAE/ASE Recommendations for Image Acquisition and Display

... avoids geometric assumptions; (2) the assessment of regional left ventricular (LV) wall motion and quantification of systolic dyssynchrony; (3) presentation of realistic views of heart valves; (4) volumetric evaluation of regurgitant lesions and shunts with 3DE color Doppler imaging; and (5) 3DE str ...
EAE/ASE recommendations for image acquisition and display using
EAE/ASE recommendations for image acquisition and display using

... avoids geometric assumptions; (2) the assessment of regional left ventricular (LV) wall motion and quantification of systolic dyssynchrony; (3) presentation of realistic views of heart valves; (4) volumetric evaluation of regurgitant lesions and shunts with 3DE color Doppler imaging; and (5) 3DE str ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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