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Echocardiographic Evaluation Before Bidirectional Glenn Operation
Echocardiographic Evaluation Before Bidirectional Glenn Operation

... body through the pulmonary vascular bed. Impedance to blood flow through the pulmonary circulation leads to poor postoperative outcomes after BDG.1–3 In addition, the presence of aortic arch obstruction is a risk factor for late mortality after stage I Norwood operation.4 –5 Therefore, adequate eval ...
Atrium-Selective Sodium Channel Block as a Strategy
Atrium-Selective Sodium Channel Block as a Strategy

... Methods and Results—Whole-cell patch clamp techniques were used to evaluate inactivation of peak sodium channel current (INa) in myocytes isolated from canine atria and ventricles. The electrophysiological effects of therapeutic concentrations of ranolazine (1 to 10 ␮mol/L) and lidocaine (2.1 to 21 ...
Arterial Stiffness in the Young: Assessment
Arterial Stiffness in the Young: Assessment

... suggested to cause permanent alterations in cardiovascular structure and physiology through the process of programming. Indeed, there is evidence that individuals who are born small may be at risk for arterial dysfunction in child- and adulthood. In very low birth weight, premature infants, reduced ...
SERIES ‘‘PULMONARY HYPERTENSION: BASIC CONCEPTS FOR PRACTICAL MANAGEMENT’’
SERIES ‘‘PULMONARY HYPERTENSION: BASIC CONCEPTS FOR PRACTICAL MANAGEMENT’’

... progressive increase in pulmonary vascular resistance, ultimately leading to right ventricular failure and death. The functional capacity of the right ventricle is a major prognostic determinant. Our understanding of right ventricle performance in pulmonary hypertension has been hindered by the lack ...
Haemodynamics in Essential Hypertension
Haemodynamics in Essential Hypertension

... Pascual, Sannerstedt & Mitchell, 197 lb). The left ventricular ejection rate is increased (Frohlich et al., 1969, 1970). Only one study (in older patients with more severe, but labile, hypertension) demonstrated normal heart rate and increased stroke volume (Finkielman, Worcel & Agrest, 1965). The c ...
Outcome after mitral valve surgery for mitral valve regurgitation
Outcome after mitral valve surgery for mitral valve regurgitation

... The repair of degenerative mitral valve regurgitation has been shown to be an effective procedure with durable results. The techniques for mitral valve repair are not completely risk-free for late failure, and the identification of factors associated with this increased risk is of clinical relevance ...
ACC/AHA/ESC 2006 guidelines for management of patients with
ACC/AHA/ESC 2006 guidelines for management of patients with

... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
High diagnostic accuracy of NT-proBNP for cardiac origin of pleural effusions
High diagnostic accuracy of NT-proBNP for cardiac origin of pleural effusions

... Ninety-three patients were evaluated, 27% with cardiac effusion and 73% with exudative effusions of various cause. Levels of NT-proBNP in pleural fluid and serum correlated closely. Serum and pleural fluid NT-proBNP levels were significantly elevated in patients with cardiac effusion. With a cut-off ...
ACC/AHA/ESC 2006 Guidelines for Management of Patients With
ACC/AHA/ESC 2006 Guidelines for Management of Patients With

... This document was approved by the American College of Cardiology Foundation Board of Trustees in August 2006, by the American Heart Association Science Advisory and Coordinating Committee in July 2006, and by the European Society of Cardiology Committee for Practice Guidelines in July 2006. When cit ...
ACC/AHA/ESC 2006 Guidelines for Management of
ACC/AHA/ESC 2006 Guidelines for Management of

... This document was approved by the American College of Cardiology Foundation Board of Trustees in August 2006, by the American Heart Association Science Advisory and Coordinating Committee in July 2006, and by the European Society of Cardiology Committee for Practice Guidelines in July 2006. When cit ...
Print - Circulation
Print - Circulation

... cycle length (<300 milliseconds) are associated with a significantly increased risk of initiation of VF. To decrease the risk of ventricular proarrhythmia, short CLs should be avoided. (Circulation. 1994;89:413-422.) Key Words * atrial fibrillation * ventricles * fibrillation * defibrillation * hear ...
Genetics - Circulation
Genetics - Circulation

... and GATA4,7–10 most cases of congenital heart disease have no identified cause or association. Such sporadic cases may be due to an unknown teratogen, spontaneous mutation, or inconsistent expression of an inherited origin. The last possibility is supported by the increased incidence of congenital h ...
ACC/AHA/ESC Practice Guidelines
ACC/AHA/ESC Practice Guidelines

... This document was approved by the American College of Cardiology Foundation Board of Trustees in August 2006, by the American Heart Association Science Advisory and Coordinating Committee in July 2006, and by the European Society of Cardiology Committee for Practice Guidelines in July 2006. When thi ...
dbl dobutamine hydrochloride injection
dbl dobutamine hydrochloride injection

... The mechanism of the sustained improvement in ventricular function following prolonged or intermittent infusions of dobutamine hydrochloride is not understood. However, in studies involving prolonged infusions of dobutamine hydrochloride in humans, mitochondrial ultrastructural and biochemical chang ...
Transvenous Temporary Cardiac Pacing
Transvenous Temporary Cardiac Pacing

... the balloon-tipped catheter or via electrocardiographic monitoring. Of course, placement of a temporary pacing wire with use of fluoroscopy is easier and safer due to direct visualization of the lead, and it would be preferable if a procedure room is readily available next to the cardiac care unit o ...
No. 86 of 2015 - Repatriation Medical Authority
No. 86 of 2015 - Repatriation Medical Authority

... Authority is of the view that it is more probable than not that cardiomyopathy and death from cardiomyopathy can be related to relevant service rendered by veterans or members of the Forces under the VEA, or members under the MRCA. Note: relevant service is defined in the Schedule 1 – Dictionary. ...
Echocardiography in the Management of Patients with Left
Echocardiography in the Management of Patients with Left

... time) and expert opinion from high-volume MCS-device implantation centers to provide consensus recommendations and sample protocols for the timing and performance of echocardiography during LVAD patient selection, device implantation, and postoperative management. The authors’ goal is to provide a g ...
Arterial pulsatility and aortic valve function under continuous flow left
Arterial pulsatility and aortic valve function under continuous flow left

... the control variable and a reference model was used for regulating the CF-LVAD speed. Continuous and varying speed CF-LVAD assistance provided the same mean arterial pressure and flow rate, while the index of pulsatility doubled in both arterial pressure and pump flow rate signals under pulsatile pu ...
Advances in Arrhythmia and Electrophysiology
Advances in Arrhythmia and Electrophysiology

... degree of sedation with anesthesia, as well as electrophysiological recovery of ablated tissue, might have contributed to the additional yield of NIPS above and beyond PES immediately after the procedure. At 1-year follow-up, patients without any inducible VT at NIPS had significantly better arrhyth ...
Advances in Arrhythmia and Electrophysiology
Advances in Arrhythmia and Electrophysiology

... Appreciating that the muscular rim is an infolding of the atrial wall is relevant to defining the site of the true septum that should be the target area for the transseptal puncture.29 It is the thin floor of the fossa, measuring approximately 1–3 mm in thickness in normal hearts that allows direct ...
pdf 12 MB - Cardio Symposium 2011
pdf 12 MB - Cardio Symposium 2011

... independent business that we have built together. But if we are to address the major health issues facing a largely urbanised population of 9 billion in 2050 – it is only together with our scientific and business partners in all aspects of the health profession that we will able to do this. Ceva wil ...
Understanding diastolic heart failure
Understanding diastolic heart failure

... not fully compensated for in late diastole due to left atrial dysfunction. Furthermore in a group of subjects with treated hypertension, the most common risk factor for this form of heart failure, despite a normal resting echocardiogram, there were already substantial abnormalities of both systolic ...
Targeted Neonatal Echocardiography in the Neonatal Intensive
Targeted Neonatal Echocardiography in the Neonatal Intensive

... and tissue perfusion.’’1 The primary goals of TNE are to provide noninvasive information on the underlying cardiovascular pathophysiology causing hemodynamic instability and the response to treatment in an individual patient over time. We are aware that the current indications for TNE have been prim ...
Arrhythmogenesis by single ectopic beats originating in the Purkinje
Arrhythmogenesis by single ectopic beats originating in the Purkinje

... 2010; doi:10.1152/ajpheart.01237.2009.—Cells in the Purkinje system (PS) are known to be more vulnerable than ventricular myocytes to secondary excitations during the action potential (AP) plateau or repolarization phases, known as early afterdepolarizations (EADs). Since myocytes have a lower intri ...
Combined angiotensin receptor blocker and ACE inhibitor on
Combined angiotensin receptor blocker and ACE inhibitor on

... increased and accompanied by a significant decrease in LV elastance (Ees; Table 1). In the pacing-only group, Ea and total systemic resistance were significantly increased and SV was decreased. In the groups treated with ARB or ACEI, total systemic resistance, Ea, and end-diastolic volume were signi ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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