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Fetal interventions in congenital heart disease - sha
Fetal interventions in congenital heart disease - sha

... Development of HLHS • Only a small subset of HLHS patients, those with patency (ie, not atresia) of the mitral and aortic valves and with only mild hypoplasia of the left ventricle, may be amenable to a 2-ventricle repair • In some cases, HLHS may be the consequence of ...
Ventricular Arrhythmias in the Absence of Structural Heart Disease
Ventricular Arrhythmias in the Absence of Structural Heart Disease

... origin in the heart, and the most common areas are the ventricular outflow tracts and left ventricular fascicles. The morphology of the QRS complexes on electrocardiogram is an excellent tool to identify the site of origin of the rhythm. Although these arrhythmias are common and generally carry an e ...
Valvular Stenosis - Grand Valley State University
Valvular Stenosis - Grand Valley State University

... Concurrent decrease in volume flow rate may obscure disease progression resulting in no change in jet velocity ...
Autoregulation of cardiac output is overcome by adrenergic
Autoregulation of cardiac output is overcome by adrenergic

... intact. Following instrumentation, the preparation was transferred to an organ bath containing 0.9% NaCl and perfusion with Ringer’s solution was resumed. The double-bored cannulae (see Franklin and Axelsson, 1994) allowed continuous measurements of pressure at the tip of insertion. Pressure cannula ...
Cardiac Screening before Participation in Sports
Cardiac Screening before Participation in Sports

... high. The so-called modern standards for interpretation of ECG that have been developed by consensus groups may or may not apply to young athletes. Proper use of the history and physical examination is essential. AHA recommendations propose a comprehensive history and physical examination with 8 his ...
Course Book Cardiovascular Disease 2013-2014
Course Book Cardiovascular Disease 2013-2014

... CV Diseases is comprised of 12 lectures on six major topics in cardiac and vascular pathophysiology. This is not meant to be an exhaustive overview of cardiology, but rather discussion of the most important areas based on their prevalence in patients seen in the hospital or a cardiology practice. Th ...
Quantitative study of infarcted myocardium in - Heart
Quantitative study of infarcted myocardium in - Heart

... We have also examined the hearts of 5 patients dying in intractable left ventricular failure between two and three weeks after the initial infarction, and found that the myocardial damage both in extent and distribution was similar to that described among the shocked patients, i.e. the total ventric ...
1999 - Pediatrics
1999 - Pediatrics

... At later stages in severe cases of left heart hypoplasia (LHH), the right ventricle has to act as a systemic pump. This model, based on mechanical intervention with normal hemodynamics, is one possible experimental approach to study human hypoplastic left heart syndrome. Production of chick LHH was ...
Straddling Right Atrioventricular Valves in
Straddling Right Atrioventricular Valves in

... (fig. 2). Case 2 had pulmonary atresia, with the aorta arising entirely from the morphologically right ventricle (fig. 3). Cases 3 and 4 both exhibited double outlet from the morphologically right ventricle. In both, the aorta was anterior, but was to the left in case 4; it was slightly to the right ...
Balloon Aortic Valvuloplasty in the TAVI Era
Balloon Aortic Valvuloplasty in the TAVI Era

... Answer: Possibly. Two hundred ten consecutive patients who underwent BAV from 2003 to 2008 at our institution were evaluated retrospectively for clinical and procedural predictors of mortality.23 Findings are listed in Table 1. Interestingly, in this one retrospective series, clinical parameters inc ...
Crescendo in Depolarization and Repolarization
Crescendo in Depolarization and Repolarization

... marker of arrhythmia risk supported by extensive clinical evidence of its utility in stratifying risk for sudden cardiac death.9 –12 Furthermore, this phenomenon may be a trigger for arrhythmias by establishing steep repolarization gradients leading to reentry and wavebreak.5,6,13–15 ...
Giant right ventricular outflow tract thrombus in hereditary
Giant right ventricular outflow tract thrombus in hereditary

... a, Additional file 1). Supplemental contrast-enhanced imaging revealed no contrast uptake in the structure, consistent with a large right ventricular thrombus (Fig. 3, panel b, Additional file 2). Cardiac magnetic resonance imaging (MRI) confirmed an approximately 7 cm long thrombus attached to the ...
Cardiac involvement in adult and juvenile idiopathic
Cardiac involvement in adult and juvenile idiopathic

... increased prevalence of traditional cardiovascular risk factors in JDM and DM/PM, which need attention. The risk of developing atherosclerotic coronary artery disease is increased twofold to fourfold in DM/PM. New and improved diagnostic methods have in recent studies in PM/DM and JDM demonstrated a ...
Atrial Septal Defect Guideline
Atrial Septal Defect Guideline

...  Anticoagulation required post device closure  Prevent formation of clots  Recommended for 6-12 months Relatively low risk ...
The Age-Associated Alterations in Late Diastolic Function in Mice
The Age-Associated Alterations in Late Diastolic Function in Mice

... al., 1996). Because only diastolic function was modified by caloric restriction, the systolic and diastolic changes likely represent independent processes that occur with aging. Systolic function. — Systolic function is considered to be relatively well preserved with age. This is primarily because l ...
Slide 1
Slide 1

... rule out the possibility of an etiology other than heart failure. ...
Signs of PAH
Signs of PAH

... Prevalence of PAH in SSc • Patients ≥18 yr old, meeting ACR criteria for SSc, or 3 of 5 features of CREST, or Alarcon-Segovia criteria for MCTD • 815 patient charts retrospectively analyzed for PAH; 122 (15%) ...
Heart HORMONES - Sinoe Medical Association
Heart HORMONES - Sinoe Medical Association

... They can be divided in seven phases. The description below is about the left heart, although it can be the same for the right heart. The difference is in the lower pressures reached by the right ventricle and pulmonary artery pressures. Phase 1 - It is the onset of ventricular systole and coincides ...
Percutaneous Management of Atrial Septal Defects
Percutaneous Management of Atrial Septal Defects

... done percutaneously with more than one device as long as the devices remain stable, do not interfere with surrounding structures, and obliterate shunt flow. If multiple ASDs are close together, a thin-stalked device with a large left atrial disk may be placed to cover these fenestrations.10 Surgical ...
Impact of Papillary Muscles Approximation on the Adequacy of Mitral
Impact of Papillary Muscles Approximation on the Adequacy of Mitral

... use of MVCD in the choice of surgical strategy on the ...
Features of Carcinoid Heart Disease Identified by 2
Features of Carcinoid Heart Disease Identified by 2

... causing severe pulmonary stenosis. Pulmonary valve (PV) cusps do not coapt leading to a large area of noncoaptation (dashed arrow). B, Poststenotic dilation of the pulmonary artery (dashed arrow) in a patient with carcinoid involvement of the pulmonary valve (PV) and severe pulmonary stenosis. Pulmo ...
Matrix Metalloproteinases and Their Tissue Inhibitors in Cardiac
Matrix Metalloproteinases and Their Tissue Inhibitors in Cardiac

... Amyloid cardiomyopathy due to immunoglobulin light chain protein (AL-CMP) deposition has an accelerated clinical course and a worse prognosis compared with non–light chain cardiac amyloidoses (ie, forms associated with wild-type or mutated transthyretin [TTR]). We therefore tested the hypothesis tha ...
MYOCARDITIS
MYOCARDITIS

... • A variety of cardiac symptoms can be induced by myocarditis – Chest pain may occur, usually due to concomitant pericarditis – Excessive fatigue or decreased exercise ability may be the initial sign of myocardial dysfunction – Since both ventricles are generally involved, patients develop biventri ...
Right ventricular function in patients with pulmonary hypertension
Right ventricular function in patients with pulmonary hypertension

... (MPI) has been proposed6 – 8 for the evaluation of combined systolic and diastolic ventricular function. This index that can be measured by both pulsed-wave Doppler and tissue Doppler imaging (TDI), has been proved to correlate well with invasive procedures such as catheterization,9 to reflect disea ...
Left Heart Failure With a Normal Ejection Fraction: Identification of
Left Heart Failure With a Normal Ejection Fraction: Identification of

... syndrome, a single pathophysiologic mechanism, diastolic dysfunction, is often ascribed to explain this condition. In view of the clinical heterogeneity of these patients, we hypothesized that subgroups of HFNEF patients may have different underlying pathophysiologic mechanisms. Methods and Results: ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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