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Mutant ryanodine receptors in catecholaminergic polymorphic
Mutant ryanodine receptors in catecholaminergic polymorphic

... study, we reviewed all three Finnish families with a known RyR2 mutation. There were 22 affected live family members in these families who showed evidence of the disease and were 10 years or older. One patient had another serious disease and six patients refused the electrophysiology study. MAP reco ...
The clinical utility of new cardiac imaging modalities in Australasian
The clinical utility of new cardiac imaging modalities in Australasian

... a genetic condition resulting in arrhythmias and sudden death.20 Right ventricular function is important in patients in pulmonary hypertension and with adult congenital heart disease,21 for which CMR is critical to decision making (eg, timing of surgery, replacement of cardiac valves). In patients w ...
Familial hypertrophic cardiomyopathy: Basic concepts and future
Familial hypertrophic cardiomyopathy: Basic concepts and future

... possibility of complications, including sudden death. In children, several mutations have been identified that do not cause physical symptoms, despite impressive clinical presentation (significant left ventricular hypertrophy) [31]. Other mutations are associated with survival comparable to control ...
Cardiovascular Emergencies - Paramedic Association of Manitoba
Cardiovascular Emergencies - Paramedic Association of Manitoba

... contraction (atrial systole) and allow the blood to flow into the relaxed right ventricle (ventricular diastole). It is important to remember that the majority of ventricular filling is passive. Approximately 25 ml of blood is contributed during atrial sytole. This is often referred to as “atrial ki ...
Arrhythmogenic Right Ventricular Dysplasia (ARVD) Diagnosis In
Arrhythmogenic Right Ventricular Dysplasia (ARVD) Diagnosis In

... The Bangkok Medical Journal Vol. 4; September 2012 ...
Full Text  - Asian Journal of Sports Medicine
Full Text - Asian Journal of Sports Medicine

... study showed that long term use of AAS leads to mild hypertrophy without significant change in systolic or diastolic function [12]. Data primarily from Framingham’s heart study have shown left ventricular hypertrophy (LVH) either physiologic or pathologic is an independent risk factor for arrhythmia ...
Control of Cardiac Output 2 - Dr. Ford
Control of Cardiac Output 2 - Dr. Ford

... increases the flow of blood into the ventricles. This is most important for the right ventricle. Thus inspiration increases venous return to the right heart and increases right heart output. During expiration the pressure within the thorax increases and reduces venous return. However venous return d ...
Proceedings of the 33rd World Small Animal Veterinary
Proceedings of the 33rd World Small Animal Veterinary

... Disturbances of sinus impulse formation Sinus arrest Sinus arrest is a period where there is no evidence of atrial activity for a period in excess of the two preceding R - R intervals, and implies that there is a depression in automaticity within the sinus node. It is usually recognised in dogs with ...
Twist Mechanics of the Left Ventricle
Twist Mechanics of the Left Ventricle

... For example, LV systolic twisting and untwisting can almost double with short-term exercise because of augmented rotation of both apical and basal levels (40), storing additional potential energy that is released for improving diastolic suction (41,42). Long-term exercise training may, however, redu ...
Familial atrial septal defect in a single - Heart
Familial atrial septal defect in a single - Heart

... m2 and a QP/QS of Ig9/1. The child had an operation under cardiopulmonary bypass at age 8 years, and is now doing well. Case 3 Kim (i i years) has had a negative physical examination. Electrocardiogram and chest x-ray were within normal limits. A recent dye dilution curve suggested a left-to-right s ...
Editorial Heart Failure A PKGarious Balancing Act - VU-dare
Editorial Heart Failure A PKGarious Balancing Act - VU-dare

... particular show how things go awry in HFpEF. The data set is unique—left ventricular endocardial biopsies from nearly 150 patients with nonischemic HFrEF, HFpEF, or aortic stenosis (the latter obtained at surgery from the left ventricular outflow tract). The measurements include passive tension in i ...
Increases Left-to-Right Ventricular Systolic Interaction
Increases Left-to-Right Ventricular Systolic Interaction

... Background. The right ventricle (RV) receives part of its systolic pumping force from the left ventricle through systolic ventricular interaction. The purpose of this study was to determine the effects of dilated cardiomyopathy on left ventricular to right ventricular (LV-to-RV) systolic interaction ...
Understanding Preload
Understanding Preload

... defined as the maximum degree of myocardial fiber stretch or tension before ventricular contraction, determined by the mean sarcomere length at the end of diastole. Since sarcomere length cannot be determined in the intact heart, other indices of preload such as ventricular end diastolic volume (EDV ...
Right ventricular function
Right ventricular function

... occur with little or no apparent change in basal compliance characteristics. That is, despite a doubling or tripling of right ventricular end diastolic volume, there may be little or no change in right ventricular end diastolic pressure. It must be remembered however that, unlike the left ventricle, ...
Cardio81-ECGPt2
Cardio81-ECGPt2

...  due to pulmonary artery stenosis – pulmonary valve inadequate  right ventricle must generate greater pressure for normal output  detected on ECG with: large negative wave in limb lead I axial deviation to the right eg/ left ventricle hypertrophy o due to hypertension (greater pressure in aorta) ...
Prevention of Recurrences of Ventricular Arrhythmias in Patients
Prevention of Recurrences of Ventricular Arrhythmias in Patients

... effect of catecholamines and a possible increase of the threshold for ventricular fibrillation, can explain this association (29 -31). It should be mentioned however that placebo controlled randomized studies on the effectiveness of beta -blocker therapy in patients with ventricular tachycardia or f ...
Tissue doppler echocardiography for evaluating left ventricular
Tissue doppler echocardiography for evaluating left ventricular

... left ventricle dysfunctions more sensitively than conventional echocardiography in many diseases which standard LV parameters were normal.1 In addition, when compared to conventional Doppler parameters, TDE data are relatively independent from preload and afterload so it is useful in assessment of d ...
Atrial Septal Defect Presenting in a 70-Year
Atrial Septal Defect Presenting in a 70-Year

... vena cava (SVC) into the RA (SVC type) and rarely at the entry of the inferior vena cava (IVC) into the RA (IVC type).2 ASDs often go unrecognized for the first 2 decades and initial diagnosis in adulthood is common. Although patients survive into adulthood, life expectancy is not Access this articl ...
Pediatric Pulseless Ventricular Tachycardia
Pediatric Pulseless Ventricular Tachycardia

... content associated with this publication. Introduction Pulseless ventricular tachycardia is an uncommon presentation to the pediatric emergency department (ED) or the pediatric ICU (PICU); however, if unrecognized or inappropriately treated, it can lead to significant morbidity and mortality. Arrhyt ...
12. Anesthesia For Patients With Congenital Heart
12. Anesthesia For Patients With Congenital Heart

... dyspnea on exertion and cannot keep up with siblings or peers during play or exercise. Significant left ventricular or aortic obstruction may be accompanied by fainting spells; this is also seen with cardiac arrhythmias, such as supraventricular or ventricular tachycardia. Angina is observed in some ...
Direct Percutaneous Left Ventricular Access and Port Closure
Direct Percutaneous Left Ventricular Access and Port Closure

... Bethesda and Gaithersburg, Maryland; and Washington, DC Objectives This study sought to evaluate feasibility of nonsurgical transthoracic catheter-based left ventricular (LV) access and closure. Background Implanting large devices, such as mitral or aortic valve prostheses, into the heart requires s ...
Abstract
Abstract

... Background and Purpose: An arteriovenous (AV) fistula is the current gold standard for chronic hemodialysis access. However, a substantial number of shunt will fail because of stenosis or obstruction at anastomotic site or venous outflow. Tissue-engineered blood vessels have been proposed for dialys ...
Properties of Cardiac Muscle
Properties of Cardiac Muscle

... Myocardial fibers have ‘Functional syncytium’ & NOT ‘anatomical syncytium’, because they present in contact but NOT in continuity. ...
Case report: Persistent truncus arteriosus with intact ventricular
Case report: Persistent truncus arteriosus with intact ventricular

... desaturated blood from the right ventricle is ejected into systemic circulation, resulting from hypoxemia and cyanotic membranes [7]. In the present report, pulmonary circulatory in adequancy and pulmonary hypertension were marked by cyanosis and thickening of arterial wall and severe purulent pneum ...
Relationship between urolithiasis and diastolic functions of the heart
Relationship between urolithiasis and diastolic functions of the heart

... that reduction in functional capacity is similar in patients with diastolic dysfunction and systolic dysfunction (8), * Correspondence: [email protected] ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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