Priority Issues From the AAMI/FDA Infusion Device Summit
... The Association for the Advancement of Medical Instrumentation (AAMI), a nonprofit organization founded in 1967, is a diverse alliance of more than 6,000 members from around the world united by one critical mission—supporting the healthcare community in the development, management and use of safe an ...
... The Association for the Advancement of Medical Instrumentation (AAMI), a nonprofit organization founded in 1967, is a diverse alliance of more than 6,000 members from around the world united by one critical mission—supporting the healthcare community in the development, management and use of safe an ...
Prodrugs for Amines
... appear to be less promiscuous than esterases. Indeed amides also undergo hydrolysis by esterases in vitro [9], but the rates are usually too slow and insufficiently competitive to be used for amine release in vivo. Nevertheless, several successful N-acyl prodrugs are in clinical use or in developmen ...
... appear to be less promiscuous than esterases. Indeed amides also undergo hydrolysis by esterases in vitro [9], but the rates are usually too slow and insufficiently competitive to be used for amine release in vivo. Nevertheless, several successful N-acyl prodrugs are in clinical use or in developmen ...
Needle Free Injection Systems - The Pharma Innovation Journal
... piercing the skin with a conventional needle. Needle-free technology offers the very obvious benefit of reducing patient concern about the use of needle. Needle free injection gives very effective injections for a wide range of drugs and bioequivalent to syringe and needle, results in less pain, and ...
... piercing the skin with a conventional needle. Needle-free technology offers the very obvious benefit of reducing patient concern about the use of needle. Needle free injection gives very effective injections for a wide range of drugs and bioequivalent to syringe and needle, results in less pain, and ...
University of Groningen Analytical solution for facilitated transport
... other models for the case of steady state and “equilibrium core” with good agreement. Folkner and Noble (1983) reported the transient =ux for one-dimensional transport in rectangular, cylindrical and spherical co-ordinates using numerical techniques. Nearly all models mentioned in the previous secti ...
... other models for the case of steady state and “equilibrium core” with good agreement. Folkner and Noble (1983) reported the transient =ux for one-dimensional transport in rectangular, cylindrical and spherical co-ordinates using numerical techniques. Nearly all models mentioned in the previous secti ...
study of formulation, characterisation and wound healing potential of
... The aim of this study was to investigate the feasibility of Curcumin patches formulation (CPF) as a transdermal therapeutic system for wound healing potential. A combination of Poly Vinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) most strongly enhanced the permeation of Curcumin patch which permeat ...
... The aim of this study was to investigate the feasibility of Curcumin patches formulation (CPF) as a transdermal therapeutic system for wound healing potential. A combination of Poly Vinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) most strongly enhanced the permeation of Curcumin patch which permeat ...
Mucoadhesive Drug Delivery Systems
... get disrupted by the swelling & hydration of the bioadhesive polymer. • Eating and drinking may become restricted • There is possibility that Patient may swallow the tablet • The drug contained in swallowed saliva follows the per oral route & advantages of buccal route is lost. • Only drug with smal ...
... get disrupted by the swelling & hydration of the bioadhesive polymer. • Eating and drinking may become restricted • There is possibility that Patient may swallow the tablet • The drug contained in swallowed saliva follows the per oral route & advantages of buccal route is lost. • Only drug with smal ...
Full circle: Years in Industry informs Al Weimer`s work in fuels
... various institutions aiming, ultimately, to garner fuel from non-food plants, wood waste, algae or other photosynthesizing sources. Also a CU professor of chemical and biological engineering, Weimer leads “Team Weimer,” a group of 10 Ph.D. students and three postdoctoral researchers, in efforts havi ...
... various institutions aiming, ultimately, to garner fuel from non-food plants, wood waste, algae or other photosynthesizing sources. Also a CU professor of chemical and biological engineering, Weimer leads “Team Weimer,” a group of 10 Ph.D. students and three postdoctoral researchers, in efforts havi ...
The Ophthalmology Market
... The problem with this is that there can be insufficient contact time between the eye and the threaputic product. To address this universities and companies have been looking at ways of increasing viscosity of the product. Related approaches to this include using liposomes, “nano carriers”, and other ...
... The problem with this is that there can be insufficient contact time between the eye and the threaputic product. To address this universities and companies have been looking at ways of increasing viscosity of the product. Related approaches to this include using liposomes, “nano carriers”, and other ...
Using METHOCEL Cellulose Ethers for Controlled
... METHOCEL is a trademark of The Dow Chemical Company for a line of cellulose ether products. An initial letter identifies the type of cellulose ether, its “chemistry.” “A” identifies methylcellulose (MC) products. “E,” “F,” and “K” identify different hydroxypropyl methylcellulose (HPMC) products (Fig ...
... METHOCEL is a trademark of The Dow Chemical Company for a line of cellulose ether products. An initial letter identifies the type of cellulose ether, its “chemistry.” “A” identifies methylcellulose (MC) products. “E,” “F,” and “K” identify different hydroxypropyl methylcellulose (HPMC) products (Fig ...
The impact of polypharmacology on chemical biology Albert Antolín Hernández
... drug promiscuity and with ongoing academic efforts to rationally design multitarget drugs. Drug discovery is, slowly, becoming a more holistic endeavor. Unfortunately, this holistic perspective is not permeating to other disciplines. Since the 1990s, the field of chemical biology has emerged to use ...
... drug promiscuity and with ongoing academic efforts to rationally design multitarget drugs. Drug discovery is, slowly, becoming a more holistic endeavor. Unfortunately, this holistic perspective is not permeating to other disciplines. Since the 1990s, the field of chemical biology has emerged to use ...
Text
... higher deposition in the epidermis and dermis being recorded [27]. The improved anesthetic effect after vesicular delivery could be thus attributed to improved skin accumulation. In another report, liposomal tetracaine increased both drug permeation through, and deposition into, human skin compared ...
... higher deposition in the epidermis and dermis being recorded [27]. The improved anesthetic effect after vesicular delivery could be thus attributed to improved skin accumulation. In another report, liposomal tetracaine increased both drug permeation through, and deposition into, human skin compared ...
uniformity (a required drug dose). This led to the develop-
... forms are simple oral, topical, inhaled, or injections, more sophisticated delivery systems need to take into account pharmacokinetic principles, specific drug characteristics, and variability of response from one person to another and within the same person under different conditions. The efficacy ...
... forms are simple oral, topical, inhaled, or injections, more sophisticated delivery systems need to take into account pharmacokinetic principles, specific drug characteristics, and variability of response from one person to another and within the same person under different conditions. The efficacy ...
API Particle Engineering Innovations
... substantially improved. Increased regulatory requirements and the transition to hydrofluoroalkane (HFA) propellants have been primary drivers of this innovation (Figure 1). Valves have been improved to function in HFA propellants and meet more stringent regulatory requirements on dosing uniformity a ...
... substantially improved. Increased regulatory requirements and the transition to hydrofluoroalkane (HFA) propellants have been primary drivers of this innovation (Figure 1). Valves have been improved to function in HFA propellants and meet more stringent regulatory requirements on dosing uniformity a ...
reaction kinetics and mechanistic studies of nitric oxide
... Engineering and Technology (BUET) in 2008. Arif is currently a Chemical Engineering graduate student at North Carolina A&T State University. He completed his coursework in 2012, and is working on his thesis entitled: “Chemical Reactive Separations in Energy and Environmental Processes”, under the su ...
... Engineering and Technology (BUET) in 2008. Arif is currently a Chemical Engineering graduate student at North Carolina A&T State University. He completed his coursework in 2012, and is working on his thesis entitled: “Chemical Reactive Separations in Energy and Environmental Processes”, under the su ...
Lipid Nanoparticulate Drug Delivery Systems: A
... and hexagonal mesophases (HII) are the most important and have been extensively investigated for their ability to sustain the release of a wide range of bioactives from low molecular weight drugs to proteins, peptides and nucleic acids. ...
... and hexagonal mesophases (HII) are the most important and have been extensively investigated for their ability to sustain the release of a wide range of bioactives from low molecular weight drugs to proteins, peptides and nucleic acids. ...
PATENTED TECHNOLOGY IN SOFT GELATIN CAPSULE
... 1. Softgels ability to enhance bioavailability not only makes them the preferred dosage form for new chemical entities with poor oral bioavailability, they can also be used for reformulation of existing drugs, with the purpose of life-cycle extension. Two of such applications are briefly described h ...
... 1. Softgels ability to enhance bioavailability not only makes them the preferred dosage form for new chemical entities with poor oral bioavailability, they can also be used for reformulation of existing drugs, with the purpose of life-cycle extension. Two of such applications are briefly described h ...
PDF - Journal of Applied Pharmaceutical Science
... certain bacteria at acidic pH. Under alkaline conditions, lysozyme is inactivated and the tissue is susceptible to microbial infection. In addition to avoiding irritation, it results in obtaining efficient drug permeation and prevents the growth of bacteria (Arora et al., 2002). Concentration gradie ...
... certain bacteria at acidic pH. Under alkaline conditions, lysozyme is inactivated and the tissue is susceptible to microbial infection. In addition to avoiding irritation, it results in obtaining efficient drug permeation and prevents the growth of bacteria (Arora et al., 2002). Concentration gradie ...
FORMULATION, CHARACTERIZATION AND COMPARATIVE IN VITRO IN VIVO EVALUATION
... considered as the primary release mechanism followed by matrix erosion. In addition, it was also observed that increasing the concentration of EC from F-1 to F-3 tablets has decreased r2 value of Hixson-Crowell model indicating that the release is more likely to occur by diffusion rather than tablet ...
... considered as the primary release mechanism followed by matrix erosion. In addition, it was also observed that increasing the concentration of EC from F-1 to F-3 tablets has decreased r2 value of Hixson-Crowell model indicating that the release is more likely to occur by diffusion rather than tablet ...
Needle-Free Injection Systems Introduction Objective Needle vs
... compromise pork safety and it should never be injected in the loin or ham muscles. Types of Needle-free Injection Systems Needle-free injection systems are not a new development. The earliest systems were developed in the 1930s and have been used in a wide variety of medical areas over the years.4 T ...
... compromise pork safety and it should never be injected in the loin or ham muscles. Types of Needle-free Injection Systems Needle-free injection systems are not a new development. The earliest systems were developed in the 1930s and have been used in a wide variety of medical areas over the years.4 T ...
optimale Arbeitsbedingungen - Schweizerische Akademie der
... poster session, the latest research results of Master and Ph. D. students, as well as post-docs of all three Swiss Academic Institutions for Pharmaceutical Sciences (ETH Zürich, School of Pharmaceutical Sciences of the Universities Lausanne and Geneva EPLG in Genève and the University of Basel). Mas ...
... poster session, the latest research results of Master and Ph. D. students, as well as post-docs of all three Swiss Academic Institutions for Pharmaceutical Sciences (ETH Zürich, School of Pharmaceutical Sciences of the Universities Lausanne and Geneva EPLG in Genève and the University of Basel). Mas ...
Effects of chemical weapons on cancer development in human
... Some toxic chemical agents are necessary for human use in agriculture and industries such as riot control agents, herbicides, smoke and flame. Therefore, these chemicals have been excluded from the definition of chemical weapon. However, use of these chemicals in large quantities may cause a mass de ...
... Some toxic chemical agents are necessary for human use in agriculture and industries such as riot control agents, herbicides, smoke and flame. Therefore, these chemicals have been excluded from the definition of chemical weapon. However, use of these chemicals in large quantities may cause a mass de ...
Core-Shell Type Lipid-Polymer Hybrid Nanoparticles as
... synthesized with a lipid shell and a core that was made from inorganic materials such as silica, 40 magnetic iron oxide, 41 or organic materials such as polysaccharides, 42 polystyrene, 43 polyelectrolyte capsule, 44 or polymer microgels. 45 Comprehensive reviews by Troutier and Ladaviere 46 and Ric ...
... synthesized with a lipid shell and a core that was made from inorganic materials such as silica, 40 magnetic iron oxide, 41 or organic materials such as polysaccharides, 42 polystyrene, 43 polyelectrolyte capsule, 44 or polymer microgels. 45 Comprehensive reviews by Troutier and Ladaviere 46 and Ric ...
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
... The most efficient means to deliver drugs into the posterior segment is through direct injection into the vitreous cavity (Figure 1, arrow 7) [5]. Using a high-gauge needle, therapeutics may be introduced into the vitreous through simple injection, producing high concentrations of drug locally surro ...
... The most efficient means to deliver drugs into the posterior segment is through direct injection into the vitreous cavity (Figure 1, arrow 7) [5]. Using a high-gauge needle, therapeutics may be introduced into the vitreous through simple injection, producing high concentrations of drug locally surro ...
Using Dow Excipients for Controlled Release of
... Effects of Tablet Dimensions .................................................................................................................................24 Reworkability ............................................................................................................................. ...
... Effects of Tablet Dimensions .................................................................................................................................24 Reworkability ............................................................................................................................. ...
Biodegradable polyesters for medical and ecological applications
... A variety of polymers have been used for medical care including preventive medicine, clinical inspections, and surgical treatments of diseases19–23). Among the polymers employed for such medical purposes, a specified group of polymers are called polymeric biomaterials when they are used in direct co ...
... A variety of polymers have been used for medical care including preventive medicine, clinical inspections, and surgical treatments of diseases19–23). Among the polymers employed for such medical purposes, a specified group of polymers are called polymeric biomaterials when they are used in direct co ...
Nicholas A. Peppas
Nicholas (Nikolaos) A. Peppas (Greek: Νικόλαος Α. Πέππας; born in Athens, Greece on August 25, 1948) is a chemical and biomedical engineer whose leadership in biomaterials science and engineering, drug delivery, bionanotechnology, pharmaceutical sciences, chemical and polymer engineering has led to numerous biomedical products or devices.