Structure-based drug design meets the ribosome
... set requiring a certain number of features to be satisfied for the pharmacophore to be robust. This requires an alignment of ligand molecules that best satisfies the model and therefore works best when there is a single, well-defined binding pocket where active ligands bind. Given that this is not t ...
... set requiring a certain number of features to be satisfied for the pharmacophore to be robust. This requires an alignment of ligand molecules that best satisfies the model and therefore works best when there is a single, well-defined binding pocket where active ligands bind. Given that this is not t ...
Unifying Bioinformatics and Chemoinformatics for
... that occurs after binding, or antagonists which nullify the effect of agonists and return a cell to normal signalling levels. GPCRs are involved in an amazing number of cellular processes, including vision, smell, mood and behavioral regulation, immune system activity, and automatic nervous system t ...
... that occurs after binding, or antagonists which nullify the effect of agonists and return a cell to normal signalling levels. GPCRs are involved in an amazing number of cellular processes, including vision, smell, mood and behavioral regulation, immune system activity, and automatic nervous system t ...
Research Article DEVELOPMENT AND CHARACTERIZATION OF COMPRESSED ODT FORMULATION OF INSOLUBLE LOW BITTER DRUG
... rapidly, usually within a matter of seconds, when placed under the tongue. ODT delayed release is a solid dosage form containing medicinal substances which disintegrates rapidly, usually within matter of seconds, when place upon the tongue, but which releases a drug (or drugs ...
... rapidly, usually within a matter of seconds, when placed under the tongue. ODT delayed release is a solid dosage form containing medicinal substances which disintegrates rapidly, usually within matter of seconds, when place upon the tongue, but which releases a drug (or drugs ...
Document
... profile, good tissular penetration and wide scope of activity have made these drugs very useful in human and veterinary medicine [2]. Lomefloxacin which is (±) 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1piperazinyl)-4-oxo-3-quinolinecarboxylic acid (Fig. 1a) is one of the synthetic antibacterial ...
... profile, good tissular penetration and wide scope of activity have made these drugs very useful in human and veterinary medicine [2]. Lomefloxacin which is (±) 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1piperazinyl)-4-oxo-3-quinolinecarboxylic acid (Fig. 1a) is one of the synthetic antibacterial ...
Herbal Supplements - St. Vincent Healthcare
... other supplements I take? Yes. It is essential that you tell your doctor about any treatments you are using, including herbal or nutritional supplements, vitamins and any other prescribed or OTC drugs. Because herbal supplements are medications, they can have side effects and interact with other med ...
... other supplements I take? Yes. It is essential that you tell your doctor about any treatments you are using, including herbal or nutritional supplements, vitamins and any other prescribed or OTC drugs. Because herbal supplements are medications, they can have side effects and interact with other med ...
Protecting Public Health from Outside the Physician`s Office: A
... As society grapples with the evolving and increasingly sophisticated nature of the pharmaceutical industry, the “big picture” in healthcare remains, of course, to take care of the patient. Any and all medical decision making, therefore, should follow the primary exhortation of the Hippocratic Oath: ...
... As society grapples with the evolving and increasingly sophisticated nature of the pharmaceutical industry, the “big picture” in healthcare remains, of course, to take care of the patient. Any and all medical decision making, therefore, should follow the primary exhortation of the Hippocratic Oath: ...
Tetracycline group in children
... some events is more with demiclocycline and minocycline, making them less suitable for oral use in children. Currently, one of the important indications for the use of tetracyclines is fevers caused by Rickettsiae and O tsutsugamushi. Doxycycline is the drug of choice for this indication. Tetracycli ...
... some events is more with demiclocycline and minocycline, making them less suitable for oral use in children. Currently, one of the important indications for the use of tetracyclines is fevers caused by Rickettsiae and O tsutsugamushi. Doxycycline is the drug of choice for this indication. Tetracycli ...
taste masking methods and agents in pharmaceutical formulations
... Ion Exchange Resins Ion exchange resins are high molecular weight polymers with cationic and anionic functional groups. They can exchange their mobile ions of equal charge with surrounding medium. Synthetic ion exchange resins have been used in pharmacy for taste masking from so many years. Drugs ar ...
... Ion Exchange Resins Ion exchange resins are high molecular weight polymers with cationic and anionic functional groups. They can exchange their mobile ions of equal charge with surrounding medium. Synthetic ion exchange resins have been used in pharmacy for taste masking from so many years. Drugs ar ...
NOVEL NANOEMULSION AS VEHICLES FOR TRANSDERMAL DELIVERY OF CLOZAPINE: IN VITRO
... GI lumen, poor membrane permeation and pre-systemic elimination [1]. By many estimates up to 40% of new chemical entities (NCEs) discovered by the pharmaceutical industry today and many existing drugs are poorly soluble or lipophilic drugs which leads to poor oral bioavailability, high intra and int ...
... GI lumen, poor membrane permeation and pre-systemic elimination [1]. By many estimates up to 40% of new chemical entities (NCEs) discovered by the pharmaceutical industry today and many existing drugs are poorly soluble or lipophilic drugs which leads to poor oral bioavailability, high intra and int ...
STUDIES ON FORMULATION AND EVALUATION OF OSMOTICALLY CONTROLLED DRUG Research Article
... Controlled drug delivery systems have been introduced to overcome the drawback of fluctuating drug levels associated with conventional dosage forms.[1] Oral controlled release system offer popularity over other delivery systems because here pharmaceutical agents are delivered in controlled pattern, ...
... Controlled drug delivery systems have been introduced to overcome the drawback of fluctuating drug levels associated with conventional dosage forms.[1] Oral controlled release system offer popularity over other delivery systems because here pharmaceutical agents are delivered in controlled pattern, ...
Structural biology and drug discovery
... kinase assisted in understanding retrospectively how structural mutations in ABL can circumvent the anticancer activity of the compound [12,13]. Another anticancer kinase inhibitor drug, Tarceva, was approved by the FDA in 2004 for the treatment of locally advanced or metastatic non-small cell lung ...
... kinase assisted in understanding retrospectively how structural mutations in ABL can circumvent the anticancer activity of the compound [12,13]. Another anticancer kinase inhibitor drug, Tarceva, was approved by the FDA in 2004 for the treatment of locally advanced or metastatic non-small cell lung ...
Factors that affect mass transport from drug eluting stents into the
... Atherosclerosis is a degenerative disease that affects coronary, carotid and other peripheral arteries in the body. Disease formation can occur as early as childhood with the development of fatty streaks within the artery wall. As the aging process progresses these fatty streaks accumulate becoming ...
... Atherosclerosis is a degenerative disease that affects coronary, carotid and other peripheral arteries in the body. Disease formation can occur as early as childhood with the development of fatty streaks within the artery wall. As the aging process progresses these fatty streaks accumulate becoming ...
Prolonged dexmedetomidine infusion to facilitate drug detoxification
... associated with agitation, restlessness, insomnia, generalized muscle and joint pain anxiety, dysphoria and various psychomimetic disturbances (1) and most of these symptoms are caused by central nervous system (CNS) hyperactivity and are very distressing which frequently leads to relapse to drug us ...
... associated with agitation, restlessness, insomnia, generalized muscle and joint pain anxiety, dysphoria and various psychomimetic disturbances (1) and most of these symptoms are caused by central nervous system (CNS) hyperactivity and are very distressing which frequently leads to relapse to drug us ...
PHARMACY TECHNICIAN (PHT) 720 clock hours/ 36 weeks (Total
... The course covers the most common tasks performed by the hospital pharmacy technician. It clarifies the difference between pharmacy stock and central supply stock. This course provides the student with an understanding of how sterile products used for parenteral administration must be prepared in an ...
... The course covers the most common tasks performed by the hospital pharmacy technician. It clarifies the difference between pharmacy stock and central supply stock. This course provides the student with an understanding of how sterile products used for parenteral administration must be prepared in an ...
The Need and Importance of Dose Flexibility - Accu
... prevalent, comprising approximately 21% of all U.S. oral solid medications today.7 The principal disadvantage of capsules, however, is the lack of flexibility, making dose adjustments impossible without multiple daily dosages or multiple dosage strengths. Tablets, on the other hand, are the most pop ...
... prevalent, comprising approximately 21% of all U.S. oral solid medications today.7 The principal disadvantage of capsules, however, is the lack of flexibility, making dose adjustments impossible without multiple daily dosages or multiple dosage strengths. Tablets, on the other hand, are the most pop ...
Grapefruit-medication interactions: Forbidden fruit or avoidable
... The interaction between medications and grapefruit is drug-specific and is not a class effect. Medications currently documented or predicted to have augmented oral bioavailability with grapefruit are shown in Table 1 and Appendix 1 (available at www.cmaj.ca/lookup/suppl/doi:10. 1503/cmaj.120951/-/DC ...
... The interaction between medications and grapefruit is drug-specific and is not a class effect. Medications currently documented or predicted to have augmented oral bioavailability with grapefruit are shown in Table 1 and Appendix 1 (available at www.cmaj.ca/lookup/suppl/doi:10. 1503/cmaj.120951/-/DC ...
Doxycycline Information Sheet for Adult Patients
... Option to Purchase Antibiotics for Anthrax Preparedness Do not take this doxycycline unless you have been told to start by a public health official. What is doxycycline? Doxycycline is a prescription drug approved by the Food and Drug Administration (FDA) to prevent anthrax. What is anthrax? Anthrax ...
... Option to Purchase Antibiotics for Anthrax Preparedness Do not take this doxycycline unless you have been told to start by a public health official. What is doxycycline? Doxycycline is a prescription drug approved by the Food and Drug Administration (FDA) to prevent anthrax. What is anthrax? Anthrax ...
Metaxalone ST - Psychotropical
... serotonergic symptoms or ST, but when it is mixed with even small doses of SRIs serious cases of ST are frequent, and fatal cases are welldocumented. Thus, we would expect no signs of ST with metaxolone by itself, but we would expect it if large doses of metaxalone are combined with therapeutic dose ...
... serotonergic symptoms or ST, but when it is mixed with even small doses of SRIs serious cases of ST are frequent, and fatal cases are welldocumented. Thus, we would expect no signs of ST with metaxolone by itself, but we would expect it if large doses of metaxalone are combined with therapeutic dose ...
Acid: LSD Today - Do It Now Foundation
... LSD-fueled psychotic episodes are like bad trips that don’t end when the drug wears off. Such reactions may be linked to the “unmasking” of pre-existing problems and may require professional intervention. Another occasional effect of LSD are flashbacks: the reemergence of effects—usually panic—days ...
... LSD-fueled psychotic episodes are like bad trips that don’t end when the drug wears off. Such reactions may be linked to the “unmasking” of pre-existing problems and may require professional intervention. Another occasional effect of LSD are flashbacks: the reemergence of effects—usually panic—days ...
peptic ulcer
... antigen test to diagnose H. pylori infection is recommended before treating the patient for H. pylori ...
... antigen test to diagnose H. pylori infection is recommended before treating the patient for H. pylori ...
Prescribing Information - Mallinckrodt Pharmaceuticals
... disorders themselves are the strongest predictors of suicide. There has been a longstanding concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. Pooled analyses of short-t ...
... disorders themselves are the strongest predictors of suicide. There has been a longstanding concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. Pooled analyses of short-t ...
Drug Therapy of Gout LSU Clinical Pharmacology Reginald D Sanders, MD
... •recently approved by FDA (not on market) •oral xanthine oxidase inhibitor •chemically distinct from allopurinol •94% of patients reached urate < 6.0 mg/dl ...
... •recently approved by FDA (not on market) •oral xanthine oxidase inhibitor •chemically distinct from allopurinol •94% of patients reached urate < 6.0 mg/dl ...
13274025
... way to achieve the present prestigious position in domestic and international markets. By now, 97% of country’s demand of medicines is produced locally mainly by national pharmaceutical companies. The pharmaceutical sector of Bangladesh is expanding rapidly and some companies have already certified ...
... way to achieve the present prestigious position in domestic and international markets. By now, 97% of country’s demand of medicines is produced locally mainly by national pharmaceutical companies. The pharmaceutical sector of Bangladesh is expanding rapidly and some companies have already certified ...
USP Overview and Some Current Activities
... Administration. USP resolves to strengthen its relationship with the Food and Drug Administration (FDA), and work with FDA and other public and private stakeholders to explore mechanisms to enable USP to provide and maintain up-to-date national standards for legally marketed drugs and excipients in ...
... Administration. USP resolves to strengthen its relationship with the Food and Drug Administration (FDA), and work with FDA and other public and private stakeholders to explore mechanisms to enable USP to provide and maintain up-to-date national standards for legally marketed drugs and excipients in ...