Hatch-Waxman Turns 30 - Yale Law School Legal Scholarship
... same time, the Hatch-Waxman Act reduced drug prices for unpatented drugs by facilitating regulatory approval of low-cost, high-quality generic prescription drugs. 2 Generic drugs are therapeutically equivalent to brand-name products made by first-entry or pioneer manufacturers. The factors defining ...
... same time, the Hatch-Waxman Act reduced drug prices for unpatented drugs by facilitating regulatory approval of low-cost, high-quality generic prescription drugs. 2 Generic drugs are therapeutically equivalent to brand-name products made by first-entry or pioneer manufacturers. The factors defining ...
Prescription Nation 2016 - National Safety Council
... families and communities are left to suffer in its path. These highly addictive medicines have been incorrectly marketed as the most effective method for treating pain and, subsequently, liberally prescribed. Prescription opioids also serve as gateway drugs to heroin, which has a nearly identical ch ...
... families and communities are left to suffer in its path. These highly addictive medicines have been incorrectly marketed as the most effective method for treating pain and, subsequently, liberally prescribed. Prescription opioids also serve as gateway drugs to heroin, which has a nearly identical ch ...
QUANTIFICATION OF HEALTH COMMODITIES: ARV COMPANION GUIDE Forecasting ARV Drugs Using the Morbidity
... patients on nonstandard ARV drug regimens who may have entered the program already on ART, as well as patients who are on individualized salvage therapy. ARV drugs have several characteristics that affect the management of the commodities and that pose unique challenges in quantification. Those char ...
... patients on nonstandard ARV drug regimens who may have entered the program already on ART, as well as patients who are on individualized salvage therapy. ARV drugs have several characteristics that affect the management of the commodities and that pose unique challenges in quantification. Those char ...
Surrogate Endpoints: A Regulatory View
... There is a possible concern about the measurement error since LL relies on two angiographies at two time points and the associated diameter measurements. There have now been a number of randomized trials involving drug-eluting stents. ...
... There is a possible concern about the measurement error since LL relies on two angiographies at two time points and the associated diameter measurements. There have now been a number of randomized trials involving drug-eluting stents. ...
Hypersensitivity Reactions to Biological Drugs
... According to the Spanish Agency for Medicines and Health Care Products (AEMPS), this definition includes around 2080 formulations corresponding to various products, including natural biological substances, hormones, nucleic acids, and monoclonal antibodies (mAbs). A specific group of biological drug ...
... According to the Spanish Agency for Medicines and Health Care Products (AEMPS), this definition includes around 2080 formulations corresponding to various products, including natural biological substances, hormones, nucleic acids, and monoclonal antibodies (mAbs). A specific group of biological drug ...
Cefalexin
... 15% of a dose is bound to plasma proteins. The plasma half-life is about 1 hour; it increases with reduced renal function. Cefalexin is widely distributed in the body but does not enter the CSF in significant quantities. It crosses the placenta and small quantities are found in breast milk. Cefalexi ...
... 15% of a dose is bound to plasma proteins. The plasma half-life is about 1 hour; it increases with reduced renal function. Cefalexin is widely distributed in the body but does not enter the CSF in significant quantities. It crosses the placenta and small quantities are found in breast milk. Cefalexi ...
Levaquin Drug Patient Education levofloxacin
... Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare pra ...
... Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare pra ...
Exposure and Response after a Single Dose
... From Eq. 3-16, it should be evident that half-life is controlled by V and CL, and not vice versa. To appreciate the application of Eq. 3-16, consider creatinine, a product of muscle catabolism and used as a measure of renal function. For a typical 70-kg, 60-year-old patient, creatinine has a clearan ...
... From Eq. 3-16, it should be evident that half-life is controlled by V and CL, and not vice versa. To appreciate the application of Eq. 3-16, consider creatinine, a product of muscle catabolism and used as a measure of renal function. For a typical 70-kg, 60-year-old patient, creatinine has a clearan ...
FORMULATION AND EVALUATION OF OXICONAZOLE NITRATE
... increase the residence time of OXZ in the vagina. This purpose can be achieved by gelling of the OXZ using bioadhesive gelling agent. A gel can be described as the cross-linked material that retains a large amount of solvent inside its medium and if the solvent retained in organic one, such material ...
... increase the residence time of OXZ in the vagina. This purpose can be achieved by gelling of the OXZ using bioadhesive gelling agent. A gel can be described as the cross-linked material that retains a large amount of solvent inside its medium and if the solvent retained in organic one, such material ...
Psychopharmacologic Therapy
... the human genome has revolutionized medicine and the way drugs are used to fight diseases. Before the human genome discovery, diseases were treated by intervening at the level of symptoms— the final phase in a complex cascade of biochemical processes. Treating symptoms usually involved guessing whic ...
... the human genome has revolutionized medicine and the way drugs are used to fight diseases. Before the human genome discovery, diseases were treated by intervening at the level of symptoms— the final phase in a complex cascade of biochemical processes. Treating symptoms usually involved guessing whic ...
Yohimbine: Old Drug with New Interactions
... yohimbine is used with these drugs, the blood pressure should be carefully monitored. Yohimbine may interact with drugs that inhibit synaptic norepinephrine uptake to produce an excessive increase in blood pressure. (This interaction may be favorable in patients with tricyclic antidepressant–induced ...
... yohimbine is used with these drugs, the blood pressure should be carefully monitored. Yohimbine may interact with drugs that inhibit synaptic norepinephrine uptake to produce an excessive increase in blood pressure. (This interaction may be favorable in patients with tricyclic antidepressant–induced ...
Express Results™ Integrated Multi-Drug Screen
... tension and sweating. MDMA is not clearly a stimulant, although it has, in common with amphetamine drugs, a capacity to increase blood pressure and heart rate. MDMA does produce some perceptual changes in the form of increased sensitivity to light, difficulty in focusing, and blurred vision in some ...
... tension and sweating. MDMA is not clearly a stimulant, although it has, in common with amphetamine drugs, a capacity to increase blood pressure and heart rate. MDMA does produce some perceptual changes in the form of increased sensitivity to light, difficulty in focusing, and blurred vision in some ...
The effect of Lisinopril on blood glucose level given
... Background: In diabetic patients, ACE (Angiotensin converting enzyme) inhibitors prevent the development and progression of incipient or established nephropathy and delay the progression of diabetic retinopathy hence these drugs are routinely prescribed with oral anti-diabetic drugs in these conditi ...
... Background: In diabetic patients, ACE (Angiotensin converting enzyme) inhibitors prevent the development and progression of incipient or established nephropathy and delay the progression of diabetic retinopathy hence these drugs are routinely prescribed with oral anti-diabetic drugs in these conditi ...
Product Monograph - Paladin Labs Inc.
... arrhythmia have occurred following the use of 5-HT1 agonists. BELLERGAL Spacetabs should not be given to patients who have documented ischemic or vasospastic coronary artery disease (see CONTRAINDICATIONS). Oral administration of nitroglycerin markedly decreases the first-pass metabolism of dihydro ...
... arrhythmia have occurred following the use of 5-HT1 agonists. BELLERGAL Spacetabs should not be given to patients who have documented ischemic or vasospastic coronary artery disease (see CONTRAINDICATIONS). Oral administration of nitroglycerin markedly decreases the first-pass metabolism of dihydro ...
NIZORAL 200 MG TABLETS
... obvious risk factors for liver disease. Cases have been reported that occurred within the first month of treatment, including some within the first week. The cumulative dose of the treatment is a risk factor for serious hepatotoxicity. Monitor liver function in all patients receiving treatment with ...
... obvious risk factors for liver disease. Cases have been reported that occurred within the first month of treatment, including some within the first week. The cumulative dose of the treatment is a risk factor for serious hepatotoxicity. Monitor liver function in all patients receiving treatment with ...
Canaccord Genuity Annual Growth Conference
... the successful and timely completion of clinical studies, the establishment and maintenance of corporate alliances, the market potential of our product candidates, the impact of competitive products and pricing, new product development, uncertainties related to the regulatory approval process and ot ...
... the successful and timely completion of clinical studies, the establishment and maintenance of corporate alliances, the market potential of our product candidates, the impact of competitive products and pricing, new product development, uncertainties related to the regulatory approval process and ot ...
Calcium Channel Blocking Agents
... This information in this Handbook is intended for use by and with experienced physicians and pharmacists. The information is not intended to replace sound professional judgment in individual situations, and should be used in conjunction with other reliable sources of information. Decisions about par ...
... This information in this Handbook is intended for use by and with experienced physicians and pharmacists. The information is not intended to replace sound professional judgment in individual situations, and should be used in conjunction with other reliable sources of information. Decisions about par ...
pharmaceuticals: restrictions in use and availability
... from governments; products which clearly do not meet the criteria have been omitted after consultation with governments. Information received from non-governmental organizations has, in each case, been verified with governments. The information provided also includes references to relevant legal or ...
... from governments; products which clearly do not meet the criteria have been omitted after consultation with governments. Information received from non-governmental organizations has, in each case, been verified with governments. The information provided also includes references to relevant legal or ...
and clinical implications Chantal Guillemette1,3
... expression of 19 enzymatically active UGT proteins with distinct but sometimes overlapping substrate specificity. The substantial contribution of UGT1A and UGT2B enzymes in drug metabolism predominates whereas for UGT2A it is still uncertain. The human liver certainly expresses by far the widest var ...
... expression of 19 enzymatically active UGT proteins with distinct but sometimes overlapping substrate specificity. The substantial contribution of UGT1A and UGT2B enzymes in drug metabolism predominates whereas for UGT2A it is still uncertain. The human liver certainly expresses by far the widest var ...
Choose the Only FDA-approved Hyaluronidase
... • Hyaluronidase should not be applied directly to the cornea. It is not for topical use. The most frequently reported adverse reactions have been local injection site reactions, such as erythema and pain. Hyaluronidase has been reported to enhance the adverse reactions associated with co-administere ...
... • Hyaluronidase should not be applied directly to the cornea. It is not for topical use. The most frequently reported adverse reactions have been local injection site reactions, such as erythema and pain. Hyaluronidase has been reported to enhance the adverse reactions associated with co-administere ...
APhA BOOKS AND ELECTRONIC PRODUCTS 2014
... Understanding Drug Action: An Introduction to Pharmacology Peripheral Brain for the Pharmacist Pharmacy Ethics: A Foundation for Professional Practice Understanding Pharmacy Calculations ...
... Understanding Drug Action: An Introduction to Pharmacology Peripheral Brain for the Pharmacist Pharmacy Ethics: A Foundation for Professional Practice Understanding Pharmacy Calculations ...
Perioperative anesthesia clinical considerations of
... to supplement the diet.’’ Dietary supplements typically include vitamins, minerals, herbs or other botanicals, amino acids, and substances such as enzymes, organ tissues, and metabolites. Dietary supplements are marketed as extracts, concentrates, tablets, capsules, gelcaps, liquids, and powders. Un ...
... to supplement the diet.’’ Dietary supplements typically include vitamins, minerals, herbs or other botanicals, amino acids, and substances such as enzymes, organ tissues, and metabolites. Dietary supplements are marketed as extracts, concentrates, tablets, capsules, gelcaps, liquids, and powders. Un ...
Trimethoprim-Sulfamethoxazole Induced Rash & Fetal Hematologic
... diffuse maculopapular rash with erythematous base. His medical history revealed pyelolithotomy operation 4 weeks earlier and TMP /SMZ 480 mg po twise daily was prescribed on the postoperative 9th day because of fever. On the 5th day of therapy, erythematous rash face spreaded all over his body. Tho ...
... diffuse maculopapular rash with erythematous base. His medical history revealed pyelolithotomy operation 4 weeks earlier and TMP /SMZ 480 mg po twise daily was prescribed on the postoperative 9th day because of fever. On the 5th day of therapy, erythematous rash face spreaded all over his body. Tho ...
The background and rationale for a new fixed-dose
... A fourth drug is recommended for the 2-month intensive phase combination in addition to INH, RMP and PZA in case of TB characterised by a large bacillary load, such as pulmonary TB that is sputum smear-positive or extensive parenchymal involvement, in order to reduce the risk of the development of d ...
... A fourth drug is recommended for the 2-month intensive phase combination in addition to INH, RMP and PZA in case of TB characterised by a large bacillary load, such as pulmonary TB that is sputum smear-positive or extensive parenchymal involvement, in order to reduce the risk of the development of d ...