Pharmacological management of epilepsy
... Side-effects and interaction profiles should direct the choice of drug for the individual patient. Elderly patients are particularly sensitive to AED adverse events so low doses are recommended and prescribing drugs with a high propensity of neurotoxicity should be avoided. For provoked seizures ...
... Side-effects and interaction profiles should direct the choice of drug for the individual patient. Elderly patients are particularly sensitive to AED adverse events so low doses are recommended and prescribing drugs with a high propensity of neurotoxicity should be avoided. For provoked seizures ...
nsaids
... activity. Most act primarily by inhibiting cyclo-oxygenase leading to reduced synthesis of prostaglandins and related compounds. This mechanism probably underlies their principal therapeutic and toxic activities. However, many studies have shown a number of additional actions, including inhibition o ...
... activity. Most act primarily by inhibiting cyclo-oxygenase leading to reduced synthesis of prostaglandins and related compounds. This mechanism probably underlies their principal therapeutic and toxic activities. However, many studies have shown a number of additional actions, including inhibition o ...
Predicting Drug Metabolism - Cambridge Repository
... systems such as hepatocytes will be deployed, giving a more complete picture of hepatic metabolism, including further information about the generation of reactive intermediates. Finally, keeping in mind potential issues with allometric scaling, studies in animals provide the opportunity to investiga ...
... systems such as hepatocytes will be deployed, giving a more complete picture of hepatic metabolism, including further information about the generation of reactive intermediates. Finally, keeping in mind potential issues with allometric scaling, studies in animals provide the opportunity to investiga ...
Combination therapy: Synergism between natural plant extracts and
... Stanojevic et al. [29] investigated in vitro synergistic antibacterial activity of aqueous extract of Salvia officinalis L. and its synergistic action with the preservatives sodium nitrite, sodium benzoate and potassium sorbate against selected food spoiling bacteria. Synergism was assessed by the C ...
... Stanojevic et al. [29] investigated in vitro synergistic antibacterial activity of aqueous extract of Salvia officinalis L. and its synergistic action with the preservatives sodium nitrite, sodium benzoate and potassium sorbate against selected food spoiling bacteria. Synergism was assessed by the C ...
Initiating Methadone Treatment: Induction and stabilisation
... Nichole Riese, MD CCFP June 11, 2010 ...
... Nichole Riese, MD CCFP June 11, 2010 ...
PRODUCT MONOGRAPH
... Headaches or symptoms of hypotension, such as weakness or dizziness, particularly when arising suddenly from a recumbent position, may be due to overdosage. When they occur, the dose or frequency of application of NITROLINGUAL PUMPSPRAY (nitroglycerin) should be reduced. In cases where cyanosis shou ...
... Headaches or symptoms of hypotension, such as weakness or dizziness, particularly when arising suddenly from a recumbent position, may be due to overdosage. When they occur, the dose or frequency of application of NITROLINGUAL PUMPSPRAY (nitroglycerin) should be reduced. In cases where cyanosis shou ...
Academic paper: A Diarylquinoline Drug Active on the ATP
... worldwide basis over the past decade, but no tuberculosis-specific drugs have been discovered in 40 years. We identified a diarylquinoline, R207910, that potently inhibits both drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro (minimum inhibitory concentration 0.06 mg/ml). In mic ...
... worldwide basis over the past decade, but no tuberculosis-specific drugs have been discovered in 40 years. We identified a diarylquinoline, R207910, that potently inhibits both drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro (minimum inhibitory concentration 0.06 mg/ml). In mic ...
PHASE II DRUG METABOLISM: Glucuronidation and Sulfation
... •Glucose-1-P is derived from glycogen and the reactions are rapid, so co-substrate depletion not often observed unless in starved animals. •Cosubstrate depletion has been observed in animals with very large doses of drugs (e.g. acetaminophen), but recovery of UDPGA is rapid. Unlikely to occur in hum ...
... •Glucose-1-P is derived from glycogen and the reactions are rapid, so co-substrate depletion not often observed unless in starved animals. •Cosubstrate depletion has been observed in animals with very large doses of drugs (e.g. acetaminophen), but recovery of UDPGA is rapid. Unlikely to occur in hum ...
Fluphenazine Decanoate Injection, USP Package Insert
... tachycardia, diaphoresis, and cardiac dysrhythmias). The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc. ...
... tachycardia, diaphoresis, and cardiac dysrhythmias). The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc. ...
Somnote® CIV (Chloral Hydrate Capsules, USP 500 mg) (81 kb PDF
... insomnia—trouble falling asleep. “Approximately 80% of my patients have some sort of sleep disorder that might be contributing to the condition which I am treating, so I like to address their sleep issues early on. Somnote® is an effective sedative/hypnotic and is rather benign. It is relatively saf ...
... insomnia—trouble falling asleep. “Approximately 80% of my patients have some sort of sleep disorder that might be contributing to the condition which I am treating, so I like to address their sleep issues early on. Somnote® is an effective sedative/hypnotic and is rather benign. It is relatively saf ...
Interpretation of "Identical Medicinal Ingredient
... characteristics, density, flowability, filterability, ease of handling, mechanical properties, stability (chemical and physical), solubility, crystallinity, ease of preparation, purity, greater yields, and unique spectra and diffraction patterns. These different properties are due to the different a ...
... characteristics, density, flowability, filterability, ease of handling, mechanical properties, stability (chemical and physical), solubility, crystallinity, ease of preparation, purity, greater yields, and unique spectra and diffraction patterns. These different properties are due to the different a ...
Suboxone Contract
... part of the treatment of my addiction, and I agree to participate in a regular program of professional counseling as recommended by Dr Mian while being treated with Suboxone. I agree that professional counseling for addiction has the best results when patients also are open to support from peers who ...
... part of the treatment of my addiction, and I agree to participate in a regular program of professional counseling as recommended by Dr Mian while being treated with Suboxone. I agree that professional counseling for addiction has the best results when patients also are open to support from peers who ...
Thorough QTc Studies: Patients at Heart...
... interval is under the influence of the autonomic nervous system, which is in turn affected by the TQT study procedures. This influence could be mitigated by very careful clinical handling but not totally suppressed. In consequence, placebo adjustment of the results is a mandatory part of the design. ...
... interval is under the influence of the autonomic nervous system, which is in turn affected by the TQT study procedures. This influence could be mitigated by very careful clinical handling but not totally suppressed. In consequence, placebo adjustment of the results is a mandatory part of the design. ...
Principles of early drug discovery
... High throughput and other compound screens are developed and run to identify molecules that interact with the drug target, chemistry programmes are run to improve the potency, selectivity and physiochemical properties of the molecule, and data continue to be developed to support the hypothesis that ...
... High throughput and other compound screens are developed and run to identify molecules that interact with the drug target, chemistry programmes are run to improve the potency, selectivity and physiochemical properties of the molecule, and data continue to be developed to support the hypothesis that ...
Dabigatran
... results of this Mini‐Sentinel assessment indicate that bleeding rates associated with new use of [dabigatran] do not appear to be higher than bleeding rates associated with new use of warfarin ….” ...
... results of this Mini‐Sentinel assessment indicate that bleeding rates associated with new use of [dabigatran] do not appear to be higher than bleeding rates associated with new use of warfarin ….” ...
Drug situation in Georgia
... The Committee on Health and Social Affairs within the Parliament of Georgia closely cooperates with the Southern Caucasus Anti Drug Programme (SCAD) that has been assisting our country in the implementation of strategic measures for the purpose of drug supply and demand reduction for already six yea ...
... The Committee on Health and Social Affairs within the Parliament of Georgia closely cooperates with the Southern Caucasus Anti Drug Programme (SCAD) that has been assisting our country in the implementation of strategic measures for the purpose of drug supply and demand reduction for already six yea ...
Drugs in pregnancy
... leading to spontaneous abortions and fetal malformations, including microcephaly and cardiac anomalies . At doses of only several times the RDA , many animal models as well as human studies have shown high incidence of birth defects in mothers who ingested therapeutic doses of retinoic acid for derm ...
... leading to spontaneous abortions and fetal malformations, including microcephaly and cardiac anomalies . At doses of only several times the RDA , many animal models as well as human studies have shown high incidence of birth defects in mothers who ingested therapeutic doses of retinoic acid for derm ...
Effect of Ethanolic Pod Extract of Canavalia gladiata
... pods possesses significant antiulcer properties. In conclusion the antiulcer properties of the extract may be attributed to the presence of alkaloids and phenolic compounds present in the plant extract with various biological activities. INTRODUCTION Peptic ulcer was found to be an important problem ...
... pods possesses significant antiulcer properties. In conclusion the antiulcer properties of the extract may be attributed to the presence of alkaloids and phenolic compounds present in the plant extract with various biological activities. INTRODUCTION Peptic ulcer was found to be an important problem ...
DRUG ABSORPTION BY SUBLINGUAL AND RECTAL ROUTES
... while that of the primary metabolite (pentobarbitone)is26h. Methohexitone. Methohexitone is also a very lipophilic drug. Rectal administration of its sodium salt (10% aqueous solution) to children, undergoing elective surgical procedures, resulted in satisfactory premedication (Liu, Goudsouzian and ...
... while that of the primary metabolite (pentobarbitone)is26h. Methohexitone. Methohexitone is also a very lipophilic drug. Rectal administration of its sodium salt (10% aqueous solution) to children, undergoing elective surgical procedures, resulted in satisfactory premedication (Liu, Goudsouzian and ...
Prescribing for Pregnant or Lactating Women
... Prescribing Considerations for Women Who Are Pregnant To best address all of these potential concerns, recommendations for drug use during pregnancy are often criteria-based using data and results from available studies. These criteria often include: - what (if any) information is known from studies ...
... Prescribing Considerations for Women Who Are Pregnant To best address all of these potential concerns, recommendations for drug use during pregnancy are often criteria-based using data and results from available studies. These criteria often include: - what (if any) information is known from studies ...
Ciprofloxacin sensitizes hormone-refractory prostate cancer cell
... for 24 h exposure of ciprofloxacin (the only drug that would be tested for 24 h on LNCaP). LNCaP cells were approximately 10 times more sensitive to doxorubicin than PC-3 cells for 48 and 72 h treatments. Therefore, the cytotoxic activity of doxorubicin was cell line-dependent (Tables 1, 2). Median ...
... for 24 h exposure of ciprofloxacin (the only drug that would be tested for 24 h on LNCaP). LNCaP cells were approximately 10 times more sensitive to doxorubicin than PC-3 cells for 48 and 72 h treatments. Therefore, the cytotoxic activity of doxorubicin was cell line-dependent (Tables 1, 2). Median ...
Akamin
... dizziness or vertigo have been reported with minocycline therapy. Patients who experience these symptoms should be cautioned about driving vehicles or using hazardous machinery while on minocycline therapy. These symptoms may disappear during therapy and usually disappear rapidly when the drug is di ...
... dizziness or vertigo have been reported with minocycline therapy. Patients who experience these symptoms should be cautioned about driving vehicles or using hazardous machinery while on minocycline therapy. These symptoms may disappear during therapy and usually disappear rapidly when the drug is di ...
OVERVIEW OF CHIRALITY AND CHIRAL DRUGS
... biological matrices or drug targets such as proteins, nucleic acids, and biomembranes (e.g., phospholipids and glycolipids). These biological matrices display complex three-dimensional structures that are capable of recognizing specifically a drug molecule in only one of the many possible arrangemen ...
... biological matrices or drug targets such as proteins, nucleic acids, and biomembranes (e.g., phospholipids and glycolipids). These biological matrices display complex three-dimensional structures that are capable of recognizing specifically a drug molecule in only one of the many possible arrangemen ...
Formulary additions . . . . . .1
... For zolpidem products, data show the risk for next-morning impairment is highest for patients taking the extended-release forms of these drugs (Ambien CR and generics). Women appear to be more susceptible to this risk because they eliminate zolpidem from their bodies more slowly than men. Because us ...
... For zolpidem products, data show the risk for next-morning impairment is highest for patients taking the extended-release forms of these drugs (Ambien CR and generics). Women appear to be more susceptible to this risk because they eliminate zolpidem from their bodies more slowly than men. Because us ...
Topical Corticosteroids: Making Sense of the Options
... prescribing decisions are based on differences in potency, formulation, side-effect profile, patient factors, and the intended use. Here we will review what distinguishes currently available agents and how prescribing patterns are evolving based on new options and new understandings of the importanc ...
... prescribing decisions are based on differences in potency, formulation, side-effect profile, patient factors, and the intended use. Here we will review what distinguishes currently available agents and how prescribing patterns are evolving based on new options and new understandings of the importanc ...