Experiment Designs for the Assessment of Drug Combination
... To establish sensitization, the one-sided situation, is simple: we carry a dose-ranging experiment with a combination of both agents to estimate its ED50; all we need to prove is showing that this ED50 of B used in combination with agent A is smaller than the ED50 of agent B when used alone. To esta ...
... To establish sensitization, the one-sided situation, is simple: we carry a dose-ranging experiment with a combination of both agents to estimate its ED50; all we need to prove is showing that this ED50 of B used in combination with agent A is smaller than the ED50 of agent B when used alone. To esta ...
ASSESSMENT OF INTERFERON, PEGINTERFERON, TENOFOVIR, ENTECAVIR, LAMIVUDINE
... Seven drugs currently available as therapeutic options for HBeAgpositive adults with hepatitis B and without cirrhosis were compared: 1) interferon alpha; 2) peginterferon alfa-2a; 3) peginterferon alfa-2b; 4) tenofovir; 5) entecavir; 6) lamivudine; and 7) adefovir. METHODS A Markov model of health ...
... Seven drugs currently available as therapeutic options for HBeAgpositive adults with hepatitis B and without cirrhosis were compared: 1) interferon alpha; 2) peginterferon alfa-2a; 3) peginterferon alfa-2b; 4) tenofovir; 5) entecavir; 6) lamivudine; and 7) adefovir. METHODS A Markov model of health ...
History of Doping in Sport
... proprietary interest in their own special 'doping recipes'. Swimmers, distance runners, sprinters and cyclists used a wide assortment of drugs to gain an edge over their opponents (Boje, 1939; Hoberman, 1992b; Prokop, 1970). As early as 1865, a doping episode involving canal swimmers of Amsterdam wa ...
... proprietary interest in their own special 'doping recipes'. Swimmers, distance runners, sprinters and cyclists used a wide assortment of drugs to gain an edge over their opponents (Boje, 1939; Hoberman, 1992b; Prokop, 1970). As early as 1865, a doping episode involving canal swimmers of Amsterdam wa ...
oral proton pump inhibitors
... factors: a prospective cohort study. BMJ 2012; 344: e372 Medicines and Healthcare Products Regulatory Agency. Drug Safety Update April 2012. Proton pump inhibitors in long-term use: increased risk of fracture. Available at:https://www.gov.uk/drug-safety-update/proton-pump-inhibitors-in-long-term-use ...
... factors: a prospective cohort study. BMJ 2012; 344: e372 Medicines and Healthcare Products Regulatory Agency. Drug Safety Update April 2012. Proton pump inhibitors in long-term use: increased risk of fracture. Available at:https://www.gov.uk/drug-safety-update/proton-pump-inhibitors-in-long-term-use ...
Current trends in the development of antiviral drugs
... Especially for serious diseases, like AIDS and hepatitis C, the need for safer and more effective drugs is increased. In the first part of the thesis older, but still important drugs are described and also their structures are given. Some of them have a wide spectrum of activity, such as ribavirin, ...
... Especially for serious diseases, like AIDS and hepatitis C, the need for safer and more effective drugs is increased. In the first part of the thesis older, but still important drugs are described and also their structures are given. Some of them have a wide spectrum of activity, such as ribavirin, ...
... Appropriate use of antibiotics is critical since: Antimicrobial resistance is increasing, leading not only to increased costs of patient care but also to increased morbidity and mortality In the hospital setting: Over 50% of patients in hospital receive antibiotics during their stay – at least 50% u ...
Resistance is futile: the bacteriocin model for addressing the
... the selection for mutations that confer resistance is not taking place in multiple species simultaneously, as is the case with broad-spectrum antibiotics. Secondly, bacteriocins occur in constantly changing and evolving combinations, thus allowing the producer strains to keep pace with emergent resi ...
... the selection for mutations that confer resistance is not taking place in multiple species simultaneously, as is the case with broad-spectrum antibiotics. Secondly, bacteriocins occur in constantly changing and evolving combinations, thus allowing the producer strains to keep pace with emergent resi ...
anti-seizure medication review - Idaho Society of Health
... • Drug rash with eosinophilia and systemic symptoms(DRESS) ...
... • Drug rash with eosinophilia and systemic symptoms(DRESS) ...
Studies of Retroviral Reverse Transcriptase and
... A ‘lead’ is a chemical compound that has pharmacological or biological activity, and has the potential to be optimised to a drug candidate. Large libraries (106-107) of diverse substances may be tested on drug target using real (usually in vitro) or virtual (in silico) high-throughput screening [1]. ...
... A ‘lead’ is a chemical compound that has pharmacological or biological activity, and has the potential to be optimised to a drug candidate. Large libraries (106-107) of diverse substances may be tested on drug target using real (usually in vitro) or virtual (in silico) high-throughput screening [1]. ...
FORMULATION AND IN VITRO EVALUATION OF DICLOFENAC SODIUM SUSTAINED RELEASE
... Objective: The main objectives of the present study is to develop sustained release matrix tablet of diclofenac sodium (DS) using carnauba wax (CW) as a matrix former, in addition, polyethylene glycol (PEG6000) and polyvinyl pyrrolidone (PVP k30) were used as channeling agents to modify and control ...
... Objective: The main objectives of the present study is to develop sustained release matrix tablet of diclofenac sodium (DS) using carnauba wax (CW) as a matrix former, in addition, polyethylene glycol (PEG6000) and polyvinyl pyrrolidone (PVP k30) were used as channeling agents to modify and control ...
Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis
... many drugs have the potential to kill rapidly dividing, metabolically active mycobacteria, few drugs are active when the population of M. tuberculosis has switched its genetic programme to a quiescent, dormant phenotype. These persisters provide the major challenge for the immune system as well as f ...
... many drugs have the potential to kill rapidly dividing, metabolically active mycobacteria, few drugs are active when the population of M. tuberculosis has switched its genetic programme to a quiescent, dormant phenotype. These persisters provide the major challenge for the immune system as well as f ...
Pharmacy Therapeutics Policies and Procedures
... The safety risk / benefit of a product will be compared with other treatments. We will minimize the potential for errors caused by product characteristics such as name, dosage form, and packaging that pose threats to patient safety or increase the potential for errors in the health care system. ...
... The safety risk / benefit of a product will be compared with other treatments. We will minimize the potential for errors caused by product characteristics such as name, dosage form, and packaging that pose threats to patient safety or increase the potential for errors in the health care system. ...
pdf
... network, indicating an important number of shared targets. Moreover, 90% of nervous system compounds were found within the giant component, including antidepressants, antipsychotics, and opioids. Cardiovascular system drugs were the second (20%) most highly represented group within the giant compone ...
... network, indicating an important number of shared targets. Moreover, 90% of nervous system compounds were found within the giant component, including antidepressants, antipsychotics, and opioids. Cardiovascular system drugs were the second (20%) most highly represented group within the giant compone ...
Document
... stenocardia attacks became more frequent. What medication was administered? A *Isadrin B Salbutamol C Aminophylline D Cromolyn sodium E Phenotherol 1. The patient of 40 years suffered from bronchial asthma for 10 years. Acompanying this disease is cardiac arrhythmia (tachycardia). Specify the drug w ...
... stenocardia attacks became more frequent. What medication was administered? A *Isadrin B Salbutamol C Aminophylline D Cromolyn sodium E Phenotherol 1. The patient of 40 years suffered from bronchial asthma for 10 years. Acompanying this disease is cardiac arrhythmia (tachycardia). Specify the drug w ...
ENHANCEMENT OF DISSOLUTION OF NIFEDIPINE BY SURFACE SOLID DISPERSION TECHNIQUE Research Article
... by their solubility and dissolution rate. Several studies were carried out to increase the dissolution rate of drugs [1]. One such study was solid dispersion which has shown promising results in improving solubility, wettability, dissolution rate of drug and subsequently its bioavail ...
... by their solubility and dissolution rate. Several studies were carried out to increase the dissolution rate of drugs [1]. One such study was solid dispersion which has shown promising results in improving solubility, wettability, dissolution rate of drug and subsequently its bioavail ...
The Rational Use of Drugs - Part 4
... Agonist A is a full agonist and agonist B is a partial agonist. However, agonist A and agonist B have equal ...
... Agonist A is a full agonist and agonist B is a partial agonist. However, agonist A and agonist B have equal ...
Product Monograph - Paladin Labs Inc.
... Use in Pregnancy: Propylthiouracil, used judiciously, is an effective drug for the treatment of hyperthyroidism in pregnant women. However, the drug readily crosses the placental barrier and can induce goiter and even cretinism in the developing fetus. Since thyroid hormone does not cross the placen ...
... Use in Pregnancy: Propylthiouracil, used judiciously, is an effective drug for the treatment of hyperthyroidism in pregnant women. However, the drug readily crosses the placental barrier and can induce goiter and even cretinism in the developing fetus. Since thyroid hormone does not cross the placen ...
View - SciTechnol
... novel and successful medical therapy in reducing flashbacks in subjects suffering from PTSD. This result suggests that the origin of flashbacks in PTSD is closely related to abnormal excitement of memory-related circuits comprised of the acetylcholine-based basal forebrain, amygdala, and hippocampus ...
... novel and successful medical therapy in reducing flashbacks in subjects suffering from PTSD. This result suggests that the origin of flashbacks in PTSD is closely related to abnormal excitement of memory-related circuits comprised of the acetylcholine-based basal forebrain, amygdala, and hippocampus ...
PHYSICOCHEMICAL CHARACTERIZATION OF SPRAY DRIED FORMULATION CONTAINING AMORPHOUS DRUG Research Article
... spray drying on the solid state and phase transformation of the drug is not completely explored. The drug model selected for this investigation is a synthetic selective peptide leukotriene receptor antagonist (LTRA) named Zafirlukast, which is a prescription drug for asthmatic patients. Amorphous ne ...
... spray drying on the solid state and phase transformation of the drug is not completely explored. The drug model selected for this investigation is a synthetic selective peptide leukotriene receptor antagonist (LTRA) named Zafirlukast, which is a prescription drug for asthmatic patients. Amorphous ne ...
Teaching Philosophy - Center for Excellence in Teaching and
... Experiential Teaching: Similarly, I believe that an optimal experiential rotation is underpinned by 4 main qualities. I try to incorporate these qualities into my experiential rotations every month. 1. Assuring: Students need to achieve a standard level of clinical knowledge before initiating patie ...
... Experiential Teaching: Similarly, I believe that an optimal experiential rotation is underpinned by 4 main qualities. I try to incorporate these qualities into my experiential rotations every month. 1. Assuring: Students need to achieve a standard level of clinical knowledge before initiating patie ...
Weight Loss Drugs
... the RxFiles Advisory Committee. Prepared by: L. Kolodziejak MSc Canditdate, L. Regier BSP, BA, B. Jensen BSP DISCLAIMER: The content of this newsletter represents the research, experience and opinions of the authors and not those of the Board or Administration of Saskatoon Health Region (SHR). Neith ...
... the RxFiles Advisory Committee. Prepared by: L. Kolodziejak MSc Canditdate, L. Regier BSP, BA, B. Jensen BSP DISCLAIMER: The content of this newsletter represents the research, experience and opinions of the authors and not those of the Board or Administration of Saskatoon Health Region (SHR). Neith ...
Medication Payment Assistance in Ontario
... insurance and Trillium Drug Program. Get the receipt for your percentage of the drug costs. Submit claims to TDP immediately. Do it when you acquire your receipt or insurance statement. In any given TDP fiscal quarter, once you reach your deductible you can use TDP fully. Sometimes, this will happen ...
... insurance and Trillium Drug Program. Get the receipt for your percentage of the drug costs. Submit claims to TDP immediately. Do it when you acquire your receipt or insurance statement. In any given TDP fiscal quarter, once you reach your deductible you can use TDP fully. Sometimes, this will happen ...
Prescribing Information
... fever, other skin reactions were associated with organ dysfunctions, including elevations in hepatic serum biochemistries. During the Phase 3 clinical trials, treatment-related rashes with at least Grade 2 severity were reported in 3% of subjects receiving EDURANT. No grade 4 rash was reported. Over ...
... fever, other skin reactions were associated with organ dysfunctions, including elevations in hepatic serum biochemistries. During the Phase 3 clinical trials, treatment-related rashes with at least Grade 2 severity were reported in 3% of subjects receiving EDURANT. No grade 4 rash was reported. Over ...
Quantum of Effectiveness Evidence in FDA`s Approval of
... Background: This study serves as a follow-up to a March 2012 analysis conducted by Frank Sasinowski that reviewed the quantum of effectiveness evidence that is required to secure FDA approval of therapies for rare diseases, or orphan drugs, from the 1983 enactment of the Orphan Drug Act through June ...
... Background: This study serves as a follow-up to a March 2012 analysis conducted by Frank Sasinowski that reviewed the quantum of effectiveness evidence that is required to secure FDA approval of therapies for rare diseases, or orphan drugs, from the 1983 enactment of the Orphan Drug Act through June ...
Structure-based design of enzyme inhibitors and receptor ligands
... simpler molecule, was not only very active but also highly selective, compared to its action on the homologous serine protease, trypsin. Removal of the β-diketone partial structure led to a significant reduction in biological activity which was, nevertheless, acceptable because it could be compensat ...
... simpler molecule, was not only very active but also highly selective, compared to its action on the homologous serine protease, trypsin. Removal of the β-diketone partial structure led to a significant reduction in biological activity which was, nevertheless, acceptable because it could be compensat ...