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Types of neurons - Brigham Young University
Types of neurons - Brigham Young University

...  An AP reaches the axon terminal of the presynaptic cell and causes V-gated Ca2+ channels to open.  Ca2+ rushes in, binds to regulatory proteins & initiates NT exocytosis.  NTs diffuse across the synaptic cleft and then bind to receptors on the postsynaptic membrane and initiate some sort of resp ...
signal transduction the ligand-gated ion channels
signal transduction the ligand-gated ion channels

... are conducted down the axon at rates of 1 – 100m / sec • Many axons are insulated by a myelin sheath to increase the speed of transmission (many are not insulated) ...
CNS neurotransmitters
CNS neurotransmitters

... qualities of morphine and other opioid analgesics. It had been known for quite awhile that most “drug receptors” were in fact receptors for endogenous transmitters. It was surprising, therefore, when tissue from mouse brain was shown to avidly bind opioids, such as morphine and heroin, in a stereo-s ...
Part 1: True/False
Part 1: True/False

... C. Waking up in the middle of the night and writing unintelligible notes to himself D. Showing that 'stuff' dripping from the vagus nerve slows down the heart <––– E. Showing that heartbeat is controlled by vagus nerve 15. Neuropeptide Y is a peptide neurotransmitter. What can you say about this pep ...
Role of Neurotransmitters on Memory and Learning
Role of Neurotransmitters on Memory and Learning

... throughout the body and brain to communicate across systems such as the endocrine, neurological, gastrointestinal and even the immune system. As they travel, they inform, regulate and synchronize. Peptides are the largest category of informational substances and one kind or another is produced in ev ...
Part 1: True/False
Part 1: True/False

... 5. __ The two main families of neurotransmitter receptors are ligand-gated and neural-gated. 6. __ Postsynaptic responses mediated by G-protein coupled receptors are faster than those mediated through ligand-gated channels. 7. __ NMDA receptors allow passage of large amounts of chloride and calcium ...
Midterm 2 review - UCSD Cognitive Science
Midterm 2 review - UCSD Cognitive Science

... o makes NPs have a slower response when there is increased demand  co-localize w/ and modulate effects of other NTs o i.e. (NP + Glutamate)  act both as NTs and Neuromodulators  released by repetitive stimulation Or burst firing o may be how they are released w/ other classical NTs  broken down ...
Are You suprised ?
Are You suprised ?

... superfamily and is implicated in the generation and modulation of various cognitive, behavioral and developmental functions. We previously demonstrated that membrane cholesterol is necessary for ligand binding, and G-protein coupling of serotonin1A receptors. Interestingly, recently reported crystal ...
John F. MacDonald 2014 - Canadian Association for Neuroscience
John F. MacDonald 2014 - Canadian Association for Neuroscience

... field of ion channels where he focused on their regulation by cell signaling pathways. He discovered the regulation of glutamate receptors by phosphorylation and postsynaptic scaffolding proteins. John also made major contributions that included the identification of nonselective cation channels in ...
Chapter 6
Chapter 6

... _________ shows abnormal accumulations of a small fibrillar peptide, termed beta ______, in the spaces around synapses. These accumulations of tissue are referred to as neuritic _______. Another abnormal clump of proteins, called neurofibrillary tangles, have been identified as a modified form of th ...
THE WORKING OF THE HUMAN BRAIN
THE WORKING OF THE HUMAN BRAIN

... synapse ...
* Certain neurons in the brain have receptors (opioid receptors) for
* Certain neurons in the brain have receptors (opioid receptors) for

... Acupuncture causes the body to release what substance? What other functions do enkephalins have? * Certain neurons in the brain have receptors (opioid receptors) for opiate drugs such as morphine and heroin. * Naturally occurring NT’s called enkephalins bind to these opioid receptors and have an ana ...
Drug Sensitivity
Drug Sensitivity

... Neurotransmitter binds receptor and opens channel ...
Interference to Neurotransmitter function
Interference to Neurotransmitter function

... Neurons start to degenerate in the substantia nigra in the midbrain. The substantia nigra has a role in the smooth and coordinated production of voluntary movements. Neurons in the substantia nigra produce the neurotransmitter dopamine. When this area is damaged, the levels of dopamine are reduced. ...
1.nerve notes
1.nerve notes

... (like insulation on an electrical cord ) Multiple Sclerosis - the myelin sheath is attacked by the immune system (autoimmune disease) After the myelin is destroyed it leaves behind scar tissue (sclerosis means scar). The scar blocks the message from being sent. ...
What are affective disorders?
What are affective disorders?

... ◦ over 10% with ~ 5% (11,000,000) suffering from a depressive episode in any given year ◦ untreated - 25 - 30% will attempt or commit suicide ◦ 2X greater prevalence in women than men ◦ estimated only ~ 50% receive specific treatment ...
Chapter 4 lec 2
Chapter 4 lec 2

... effects but, in general, the behavioral effects of NE release are excitatory ...
Neurodegenerative Disease Research
Neurodegenerative Disease Research

... David Hyde studies the mechanisms underlying retinal development and regeneration in zebrafish. Unlike that of most vertebrates, the zebrafish retina and central nervous system (including the brain) possess a robust regeneration response. By studying the mechanism of zebrafish retinal regeneration, ...
Identification of chemical probes for ionotropic glutamate receptors
Identification of chemical probes for ionotropic glutamate receptors

... Project outline Ligand-gated ion channels are cell surface proteins that play an important role in fast synaptic transmission and in the modulation of cellular activity. Glutamate receptor ion channels, in particular, mediate excitatory responses at the majority of CNS synapses and transduce the bin ...
Chapter 3 PowerPoint Outline
Chapter 3 PowerPoint Outline

...  Loss of interest and pleasure in life Dopamine  Found in the brain, inhibitory in nature  Motivation, reward, pleasure  Regulation of muscle movement  Regulation of perception of reality  Abnormally low levels linked with Parkinson’s disease [also ADHD]  Abnormally high levels linked with sc ...
Key Learning Guide - City Vision University
Key Learning Guide - City Vision University

... 2. The left side of the brain is the locus of ________________ thought. 3. The right side of the brain is the locus of ________________ thought. 4. Chemical messengers are called______________________. 5. Neurons have a central body with wispy tendrils called ___________________. ...
PSY103_Lecture_CH2_WordScript
PSY103_Lecture_CH2_WordScript

... called neurotransmitters that travel across a synaptic gap and fit into slots (receptors) like a key in a lock. - After firing, the sending neuron reabsorbs excess neurotransmitters (process called reuptake) ...
CH4
CH4

...  A chemical that is likely to be abused  An “exogenous” chemical that significantly alters the function of certain bodily cells when taken in relatively low doses (chemical is not required for normal cellular functioning) ...
Test 5 Study Guide
Test 5 Study Guide

... o The brain waves produced by normal adults while resting with their eyes closed are alpha waves. o In deep sleep the EEG pattern is characterized as "slow wave."\Hallucinogenic drugs, such as LSD, function by stimulating serotonin receptors. Neurotransmitters influence brain chemistry and behavior ...
Brain Anatomy
Brain Anatomy

... Gage began to have startling changes in personality in mood. He became extravagant and anti-social, a fullmouth and a liar with bad manners, and could no longer hold a job or plan his future. "Gage was no longer Gage", said his friends of him. He died in 1861, thirtheen years after the accident, pen ...
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Clinical neurochemistry



Clinical neurochemistry is the field of neurological biochemistry which relates biochemical phenomena to clinical symptomatic manifestations in humans. While neurochemistry is mostly associated with the effects of neurotransmitters and similarly-functioning chemicals on neurons themselves, clinical neurochemistry relates these phenomena to system-wide symptoms. Clinical neurochemistry is related to neurogenesis, neuromodulation, neuroplasticity, neuroendocrinology, and neuroimmunology in the context of associating neurological findings at both lower and higher level organismal functions.
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