Neural Substrate Expansion for the Restoration of Brain
... damage is one of the principal objectives of modern translational neuroscience. Electrical stimulation approaches, such as deep-brain stimulation, have achieved the most clinical success, but they ultimately may be limited by the computational capacity of the residual cerebral circuitry. An alternat ...
... damage is one of the principal objectives of modern translational neuroscience. Electrical stimulation approaches, such as deep-brain stimulation, have achieved the most clinical success, but they ultimately may be limited by the computational capacity of the residual cerebral circuitry. An alternat ...
STINGLESS BEES: THE NEUROBIOLOGY OF FORAGING Abstract
... to indicate the existence of a rich food source and stimulate the bees to leave the nest and search for it; however, there was no correlation between foraging movements (including the number of jostles) in the nest and distance or direction of the food source (Barth et al., 2008). The spatial infor ...
... to indicate the existence of a rich food source and stimulate the bees to leave the nest and search for it; however, there was no correlation between foraging movements (including the number of jostles) in the nest and distance or direction of the food source (Barth et al., 2008). The spatial infor ...
Anterograde or retrograde transsynaptic labeling
... order to fully understand the information transformations carried out by the nervous system. Ideally, a method for this task would be rapid and straightforward in its application, could be delivered in vivo to most or all locations, and could be used ex vivo in slice or explant cultures. It would al ...
... order to fully understand the information transformations carried out by the nervous system. Ideally, a method for this task would be rapid and straightforward in its application, could be delivered in vivo to most or all locations, and could be used ex vivo in slice or explant cultures. It would al ...
Crossmodal and action-specific: neuroimaging the human mirror
... A human ‘mirror neuron system’? Macaque and human brains differ significantly, therefore the findings from macaques do not necessarily extend to humans in a straight forward manner. Indeed, the lastknown common ancestor of macaques and humans is estimated to have lived 30 million years ago, resultin ...
... A human ‘mirror neuron system’? Macaque and human brains differ significantly, therefore the findings from macaques do not necessarily extend to humans in a straight forward manner. Indeed, the lastknown common ancestor of macaques and humans is estimated to have lived 30 million years ago, resultin ...
rEvIEW - McLoon Lab
... are more motile than their dendritic counterpart, and their movement is regulated by actin dynamics. Interestingly, dendritic protrusions that had contacts with astrocytes survived longer and were morphologically more mature than those without such contacts28. These observations suggest that astrocy ...
... are more motile than their dendritic counterpart, and their movement is regulated by actin dynamics. Interestingly, dendritic protrusions that had contacts with astrocytes survived longer and were morphologically more mature than those without such contacts28. These observations suggest that astrocy ...
Document
... The drug incorporated into the GIRES™ pouch is released from the formulation by diffusion through the film. In order to gain a better understanding of the impact of drug physicochemical properties on its release from the GIRESTM system a number of compounds with diverse physicochemical properties we ...
... The drug incorporated into the GIRES™ pouch is released from the formulation by diffusion through the film. In order to gain a better understanding of the impact of drug physicochemical properties on its release from the GIRESTM system a number of compounds with diverse physicochemical properties we ...
Multiple System Atrophy
... that limb. CRPS is believed to be caused by damage to, or malfunction of, the peripheral and central nervous systems. The central nervous system is composed of the brain and spinal cord, and the peripheral nervous system involves nerve signaling from the brain and spinal cord to the rest of the body ...
... that limb. CRPS is believed to be caused by damage to, or malfunction of, the peripheral and central nervous systems. The central nervous system is composed of the brain and spinal cord, and the peripheral nervous system involves nerve signaling from the brain and spinal cord to the rest of the body ...
The concept of a reflex
... before additional injury can occur. To help an organism avoid injury reflex arcs provide a means for immediate withdrawal from dangerous stimuli. While all sensory information does eventually get sent to the brain for analysis, the advantage of a reflex arc is that it can process the rapid, protecti ...
... before additional injury can occur. To help an organism avoid injury reflex arcs provide a means for immediate withdrawal from dangerous stimuli. While all sensory information does eventually get sent to the brain for analysis, the advantage of a reflex arc is that it can process the rapid, protecti ...
Mouse Nerve Growth Factor Prevents Degeneration of Axotomized
... total dose of 5 mg). qehicle consisted of roughly 300.~1 acetic-acidacidified artificial CSF. DH 7.0 Iin mM: NaCl. 122.6: NaHCO,. 26.2: KCl, 5.4; MgSO,, 2.0; NaH,PO,: 1.2; CaCl,, 2:O; glucose, 10.0 (Cole et al., 1989)]. Following delivery of NGF, the ventricular access device was further washed with ...
... total dose of 5 mg). qehicle consisted of roughly 300.~1 acetic-acidacidified artificial CSF. DH 7.0 Iin mM: NaCl. 122.6: NaHCO,. 26.2: KCl, 5.4; MgSO,, 2.0; NaH,PO,: 1.2; CaCl,, 2:O; glucose, 10.0 (Cole et al., 1989)]. Following delivery of NGF, the ventricular access device was further washed with ...
Impact of early-life stress on the medial prefrontal cortex functions
... glutamate receptors 1 and 2, Ca2+/calmodulin-dependent protein kinase II, postsynaptic density protein 95) in the mPFC and by the atrophy of dendritic trees and reduced spine density in layer II/III pyramidal neurons of the mPFC [15]. Interestingly, in adult animals subjected to ELS, Baudin et al. ( ...
... glutamate receptors 1 and 2, Ca2+/calmodulin-dependent protein kinase II, postsynaptic density protein 95) in the mPFC and by the atrophy of dendritic trees and reduced spine density in layer II/III pyramidal neurons of the mPFC [15]. Interestingly, in adult animals subjected to ELS, Baudin et al. ( ...
Document
... disease of the brain that results in dementia Parkinson’s disease – degeneration of the dopamine-releasing neurons of the substantia nigra Huntington’s disease – a fatal hereditary disorder caused by accumulation of the protein huntingtin that leads to degeneration of the basal nuclei ...
... disease of the brain that results in dementia Parkinson’s disease – degeneration of the dopamine-releasing neurons of the substantia nigra Huntington’s disease – a fatal hereditary disorder caused by accumulation of the protein huntingtin that leads to degeneration of the basal nuclei ...
Nervous system power point # 3
... vesicles to release neurotransmitter by exocytosis 4 Neurotransmitter diffuses across the synaptic cleft and binds to specific receptors on the postsynaptic membrane. ...
... vesicles to release neurotransmitter by exocytosis 4 Neurotransmitter diffuses across the synaptic cleft and binds to specific receptors on the postsynaptic membrane. ...
Use of Amino Acids as Inducers for High
... system, amino acid analogues or D2O, which is toxic in conventional protein production systems, reducing protein yields, is not toxic, hardly affecting the final protein yields. However, one drawback of the current cSPP system is the use of IPTG (isopropyl--D-thiogalactopyranoside) as an inducer fo ...
... system, amino acid analogues or D2O, which is toxic in conventional protein production systems, reducing protein yields, is not toxic, hardly affecting the final protein yields. However, one drawback of the current cSPP system is the use of IPTG (isopropyl--D-thiogalactopyranoside) as an inducer fo ...
Functional Imaging of Central Nervous System Involvement in
... given the fact that the activation level of S2 depends on either direct or indirect inputs from S1.33 Besides, this study demonstrated the functional relevance of cortical S1 and S2 reorganization with respect to the central processing of tactile stimuli. As a possible explanation, it was suggested ...
... given the fact that the activation level of S2 depends on either direct or indirect inputs from S1.33 Besides, this study demonstrated the functional relevance of cortical S1 and S2 reorganization with respect to the central processing of tactile stimuli. As a possible explanation, it was suggested ...
At the root of embodied cognition: Cognitive science meets
... the type of action that it affords an interacting subject. This means that the type of interaction that is established with an object is a constitutive part of the representation of the object itself. In other words, different objects can be represented in function of the same type of interaction they ...
... the type of action that it affords an interacting subject. This means that the type of interaction that is established with an object is a constitutive part of the representation of the object itself. In other words, different objects can be represented in function of the same type of interaction they ...
[ 181 Dynamic Imaging of Neuronal Cytoskeleton
... remain viable for 5 - 7 days and develop a polarity similar to that observed in cultured hippocampal neurons, 14 which develop a single long axon and several minor processes. 15 These cultures contain very few glial cells (<5%). For studies of events such as synapse formation that require cortical n ...
... remain viable for 5 - 7 days and develop a polarity similar to that observed in cultured hippocampal neurons, 14 which develop a single long axon and several minor processes. 15 These cultures contain very few glial cells (<5%). For studies of events such as synapse formation that require cortical n ...
List of Possible Research Questions
... Blood-Brain Barrier: The blood-brain barrier only allows certain things to pass. What is the exact mechanism of the blood-brain barrier? How does it selectively keep out certain things? Glycogen Again: How is the size of glycogen molecules controlled? Glycogen Metabolism: How many glycogen phosphory ...
... Blood-Brain Barrier: The blood-brain barrier only allows certain things to pass. What is the exact mechanism of the blood-brain barrier? How does it selectively keep out certain things? Glycogen Again: How is the size of glycogen molecules controlled? Glycogen Metabolism: How many glycogen phosphory ...
Kandel ch. 43 + Two review papers
... highly organized connections with virtually the entire cerebral cortex, as well as the hippocampus and amygdala. Finally, a wide range of motor and nonmotor behaviors have been correlated with activity in individual basal ganglia neurons in experimental animals and with metabolic activity in the bas ...
... highly organized connections with virtually the entire cerebral cortex, as well as the hippocampus and amygdala. Finally, a wide range of motor and nonmotor behaviors have been correlated with activity in individual basal ganglia neurons in experimental animals and with metabolic activity in the bas ...
Cystic Fibrosis and CFTR Gene - Atlas of Genetics and Cytogenetics
... mutation DF508. DF508 homozygotes present a classical form of the disease with an increase in electrolytes in sweat, pancreatic insufficiency and obstructive pathology of lungs. The DF508 accounts for 66 % of the mutations, 40 % of these patients are compound heterozygotes with DF508 on one allele a ...
... mutation DF508. DF508 homozygotes present a classical form of the disease with an increase in electrolytes in sweat, pancreatic insufficiency and obstructive pathology of lungs. The DF508 accounts for 66 % of the mutations, 40 % of these patients are compound heterozygotes with DF508 on one allele a ...
File
... • Both elicit different responses on various effectors Terminating Autonomic Neurotransmitter Actions • The enzyme acetylcholinesterase rapidly decomposes the acetylcholine that cholinergic fibers release. • Norepinephrine from adrenergic fibers is removed by active transport. ...
... • Both elicit different responses on various effectors Terminating Autonomic Neurotransmitter Actions • The enzyme acetylcholinesterase rapidly decomposes the acetylcholine that cholinergic fibers release. • Norepinephrine from adrenergic fibers is removed by active transport. ...
Pharmacodynamic Effects of a D-Amino Acid Oxidase Inhibitor
... changes in synaptic strength that maintain ongoing neuropathic pain states with NMDA-related mechanisms of action may help to discover new analgesics. Given these notions of plasticity and pain states, we reasoned that DAAO inhibitors may alter the neurotransmission of pain signals under certain con ...
... changes in synaptic strength that maintain ongoing neuropathic pain states with NMDA-related mechanisms of action may help to discover new analgesics. Given these notions of plasticity and pain states, we reasoned that DAAO inhibitors may alter the neurotransmission of pain signals under certain con ...
15-2 Sensory Receptors
... • The Spinothalamic Pathway • Provides conscious sensations of poorly localized (“crude”) touch, pressure, pain, and temperature • First-order neurons • Axons of first-order sensory neurons enter spinal cord • And synapse on second-order neurons within ...
... • The Spinothalamic Pathway • Provides conscious sensations of poorly localized (“crude”) touch, pressure, pain, and temperature • First-order neurons • Axons of first-order sensory neurons enter spinal cord • And synapse on second-order neurons within ...
Antipyretic-analgesic and antiinflammatory drugs
... anesthetics has been identified and characterized. a. The smallest unmyelinated fibers, which conduct impulses for pain, temperature, and autonomic activity, conduct slowly and are the first to be blocked by local anesthetics. b. Critical length is the exposure time required by an anesthetic in orde ...
... anesthetics has been identified and characterized. a. The smallest unmyelinated fibers, which conduct impulses for pain, temperature, and autonomic activity, conduct slowly and are the first to be blocked by local anesthetics. b. Critical length is the exposure time required by an anesthetic in orde ...
Basic Science Award Recipients 2003
... “Targeting the ER-Mitochondrial Interface to Combat Age-Related Disease” The combination of an aging global population and the prevalence of age-onset diseases is generating a public health burden that is becoming insurmountable. Interventions causing real or perceived energy-depletion, e.g. dietary ...
... “Targeting the ER-Mitochondrial Interface to Combat Age-Related Disease” The combination of an aging global population and the prevalence of age-onset diseases is generating a public health burden that is becoming insurmountable. Interventions causing real or perceived energy-depletion, e.g. dietary ...
Cell Density in the Border Zone Around Old Small Human Brain
... patient died after a brain stem infarct. The patients were selected among the total number of neuroautopsy cases performed at the Institute of Neuropathology of Rigshospitalet from 1979 to 1984. After immersion fixation in formalin for at least two weeks, the cerebral hemispheres were separated from ...
... patient died after a brain stem infarct. The patients were selected among the total number of neuroautopsy cases performed at the Institute of Neuropathology of Rigshospitalet from 1979 to 1984. After immersion fixation in formalin for at least two weeks, the cerebral hemispheres were separated from ...
Clinical neurochemistry
Clinical neurochemistry is the field of neurological biochemistry which relates biochemical phenomena to clinical symptomatic manifestations in humans. While neurochemistry is mostly associated with the effects of neurotransmitters and similarly-functioning chemicals on neurons themselves, clinical neurochemistry relates these phenomena to system-wide symptoms. Clinical neurochemistry is related to neurogenesis, neuromodulation, neuroplasticity, neuroendocrinology, and neuroimmunology in the context of associating neurological findings at both lower and higher level organismal functions.