Remodelling of gap junctions and connexin expression in diseased
... Smaller areas of gap junction disarray than those found at the infarct border zone have been reported in end-stage human heart failure due to idiopathic dilated cardiomyopathy and myocarditis,51 and in the ventricles of patients with compensated hypertrophy due to valvular aortic stenosis.52 In deco ...
... Smaller areas of gap junction disarray than those found at the infarct border zone have been reported in end-stage human heart failure due to idiopathic dilated cardiomyopathy and myocarditis,51 and in the ventricles of patients with compensated hypertrophy due to valvular aortic stenosis.52 In deco ...
The Brugada ECG Pattern - Circulation: Arrhythmia and
... characterized by right precordial ST-segment elevation followed by a negative T-wave and a high incidence of ventricular fibrillation (VF) in the absence of structural heart disease.1 The typical ECG anomaly is currently known as the Brugada ECG pattern and the conglomerate of features as the Brugad ...
... characterized by right precordial ST-segment elevation followed by a negative T-wave and a high incidence of ventricular fibrillation (VF) in the absence of structural heart disease.1 The typical ECG anomaly is currently known as the Brugada ECG pattern and the conglomerate of features as the Brugad ...
1 Cold acclimation increases cardiac myofilament function and
... used as an estimate of the rate of cross-bridge cycling at each activation pCa (Gillis et al., 2007). ...
... used as an estimate of the rate of cross-bridge cycling at each activation pCa (Gillis et al., 2007). ...
Aldosterone Receptor Antagonist and Heart Failure Following Acute
... the RAAS with ACEIs and ARBs have been shown to incompletely suppress aldosterone levels over the longterm, termed as aldosterone escape.24,25 Aldosterone escape happens even with the use of higher doses of ACEIs or ARBs or their use in combination.26 Although the mechanisms of aldosterone escape ar ...
... the RAAS with ACEIs and ARBs have been shown to incompletely suppress aldosterone levels over the longterm, termed as aldosterone escape.24,25 Aldosterone escape happens even with the use of higher doses of ACEIs or ARBs or their use in combination.26 Although the mechanisms of aldosterone escape ar ...
Theoretical considerations for mapping activation in human cardiac fibrillation Wouter-Jan Rappel
... model (parameter set #1 from Ref. 24). Activation is plotted in all figures using a gray scale with white corresponding to depolarized tissue and black corresponding to repolarized tissue. The wavelength kspiral of the rotor indicates the spatial scale between successive arms of the spiral. The red ...
... model (parameter set #1 from Ref. 24). Activation is plotted in all figures using a gray scale with white corresponding to depolarized tissue and black corresponding to repolarized tissue. The wavelength kspiral of the rotor indicates the spatial scale between successive arms of the spiral. The red ...
The Association of Postoperative Right Ventricular Restrictive
... Background --- The increase in survival rate of Tetralogy of Fallot (TOF) patients lead to an increase in the number of post-op patients requiring critical follow-up. Abnormal Right Ventricular (RV) physiology is a significant long-term problem for these patients. Some studies show that RV restricti ...
... Background --- The increase in survival rate of Tetralogy of Fallot (TOF) patients lead to an increase in the number of post-op patients requiring critical follow-up. Abnormal Right Ventricular (RV) physiology is a significant long-term problem for these patients. Some studies show that RV restricti ...
Repolarization Changes Underlying Long
... changes that persist after the restoration of a normal activation pattern. Animal studies, however, have yielded disparate conclusions, both regarding the spatial pattern of repolarization changes in cardiac memory and the underlying mechanisms. The present study was undertaken to produce 3-dimensio ...
... changes that persist after the restoration of a normal activation pattern. Animal studies, however, have yielded disparate conclusions, both regarding the spatial pattern of repolarization changes in cardiac memory and the underlying mechanisms. The present study was undertaken to produce 3-dimensio ...
Brugada Syndrome (2015)
... nocturnal bradycardia. ECG changes of BrS can also be brought out following a meal and on standing. Rarely ST changes of BrS may be seen in inferior or lateral leads. Misdiagnosis of Brugada Syndrome Spurious BrS type ECG changes can be seen in patients following cardioversion and last for a fe ...
... nocturnal bradycardia. ECG changes of BrS can also be brought out following a meal and on standing. Rarely ST changes of BrS may be seen in inferior or lateral leads. Misdiagnosis of Brugada Syndrome Spurious BrS type ECG changes can be seen in patients following cardioversion and last for a fe ...
Program of Cell Survival Underlying Human and Experimental
... Correspondence to Stephen F. Vatner, MD, Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 S Orange Ave, MSB G-609, Newark, NJ 07103. E-mail [email protected] ...
... Correspondence to Stephen F. Vatner, MD, Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 S Orange Ave, MSB G-609, Newark, NJ 07103. E-mail [email protected] ...
ELECTROCARDIOGRAPHY
... It is generally known that heart works very effectively during rest condition; however it can increase its output according to tissue oxygen and substrate demand in couple of seconds. This quick and effective process is an evidence of perfect nervous and humoral regulation. Regulation of the heart a ...
... It is generally known that heart works very effectively during rest condition; however it can increase its output according to tissue oxygen and substrate demand in couple of seconds. This quick and effective process is an evidence of perfect nervous and humoral regulation. Regulation of the heart a ...
Changes in cardiac troponin I concentration and in stallions
... The actual half life (T1/2) of circulating cTnI is relatively short (2 hours).6 Small amounts are initially released from the cytoplasm, resulting in early diagnostic sensitivity, while cTn reaches and persists in circulation following myocardial cell necrosis due to the continual slow release and d ...
... The actual half life (T1/2) of circulating cTnI is relatively short (2 hours).6 Small amounts are initially released from the cytoplasm, resulting in early diagnostic sensitivity, while cTn reaches and persists in circulation following myocardial cell necrosis due to the continual slow release and d ...
Obstructive Sleep Apnea and its Relationship to Cardiac Arrhythmias
... between OSA and cardiac arrhythmias, with special attention to both the possible pathophysiologic mechanisms explaining the high incidence of cardiac arrhythmias in OSA patients and the appropriate management for this patient population. We have already summarized the primary acute and chronic effec ...
... between OSA and cardiac arrhythmias, with special attention to both the possible pathophysiologic mechanisms explaining the high incidence of cardiac arrhythmias in OSA patients and the appropriate management for this patient population. We have already summarized the primary acute and chronic effec ...
ECG TUTORIAL for Clinicians
... QT Interval (QTc 0.44s) Poor Man's Guide to the upper limit of QT: @ 70 bpm, QT 0.40s; for every 10 bpm increase above 70 bpm subtract 0.02s, and for every 10 bpm decrease below 70 bpm add 0.02s. For example: QT 0.38 @ 80 bpm QT 0.42 @ 60 bpm Frontal Plane QRS Axis: +90° to -30° (in the adult) ...
... QT Interval (QTc 0.44s) Poor Man's Guide to the upper limit of QT: @ 70 bpm, QT 0.40s; for every 10 bpm increase above 70 bpm subtract 0.02s, and for every 10 bpm decrease below 70 bpm add 0.02s. For example: QT 0.38 @ 80 bpm QT 0.42 @ 60 bpm Frontal Plane QRS Axis: +90° to -30° (in the adult) ...
Accepted Manuscript
... the quality and availability of expertise in the area where care is provided. When these guidelines are used as the basis for regulatory or payer decisions, the goal should be improvement in quality of care. The Task Force recognizes that situations arise in which additional data are needed to infor ...
... the quality and availability of expertise in the area where care is provided. When these guidelines are used as the basis for regulatory or payer decisions, the goal should be improvement in quality of care. The Task Force recognizes that situations arise in which additional data are needed to infor ...
Ca2+ Homeostasis in Normal and Diseased Heart Editorial
... cytosolic Ca2+ dysregulation. Patients have normal heart structure and function in resting state, but burst severe ventricular tachycardia morphologies when under acute emotional stress or after exercise [3]. More than 70 mutations of RyR, which are distributed in three hotspots in amino acid sequen ...
... cytosolic Ca2+ dysregulation. Patients have normal heart structure and function in resting state, but burst severe ventricular tachycardia morphologies when under acute emotional stress or after exercise [3]. More than 70 mutations of RyR, which are distributed in three hotspots in amino acid sequen ...
Contemporary Pacemakers - CCM, University of Pittsburgh
... “nontracking” mode (ie, dual-chamber pacing without atrial synchronous pacing [DDI] or ventricular inhibitory [VVI] pacing) will be activated to avoid inappropriate rapid ventricular pacing. Most dual-chamber pacemakers are able to detect atrial arrhythmias and allow automatic switching between diff ...
... “nontracking” mode (ie, dual-chamber pacing without atrial synchronous pacing [DDI] or ventricular inhibitory [VVI] pacing) will be activated to avoid inappropriate rapid ventricular pacing. Most dual-chamber pacemakers are able to detect atrial arrhythmias and allow automatic switching between diff ...
Here - The Egyptian Cardiac Rhythm Association
... electrophysiologic study. Recurrent ventricular tachycardia was defined as well tolerated to allow adequate mapping when systolic pressure was ⬎70 mm Hg with no signs of low cerebral flow or cardiac output. These patients were selected to undergo radiofrequency energy (RF) ablation. The VT was inces ...
... electrophysiologic study. Recurrent ventricular tachycardia was defined as well tolerated to allow adequate mapping when systolic pressure was ⬎70 mm Hg with no signs of low cerebral flow or cardiac output. These patients were selected to undergo radiofrequency energy (RF) ablation. The VT was inces ...
Catheter Ablation as Treatment for Atrial Fibrillation
... present time. The procedure also can be done using cryoablation technology. Use of currently available radiofrequency catheters for AF has a steep learning curve because they require extensive guiding to multiple ablation points. One of the potential advantages to cryoablation techniques is that cry ...
... present time. The procedure also can be done using cryoablation technology. Use of currently available radiofrequency catheters for AF has a steep learning curve because they require extensive guiding to multiple ablation points. One of the potential advantages to cryoablation techniques is that cry ...
SMART Biphasic Application Note
... function.10,32,33 Too many shocks can cause transient cardiac injury, such as decreased contractility and reduced cardiac output during the critical period immediately after severe cardiac compromise.10,33,34 While this type of injury is not permanent, clinical data suggest that during a code this s ...
... function.10,32,33 Too many shocks can cause transient cardiac injury, such as decreased contractility and reduced cardiac output during the critical period immediately after severe cardiac compromise.10,33,34 While this type of injury is not permanent, clinical data suggest that during a code this s ...
Myocardial strain imaging: how useful is it in clinical
... Currently, the most widely used strain modality is STE which can track speckles essentially independent of angle. Importantly, the measurements are still angle dependent because radial strain has opposite polarity of longitudinal and circumferential strains. Therefore, with increasing deviation from ...
... Currently, the most widely used strain modality is STE which can track speckles essentially independent of angle. Importantly, the measurements are still angle dependent because radial strain has opposite polarity of longitudinal and circumferential strains. Therefore, with increasing deviation from ...
Association between collagen cross
... proved critically important for the discovery of pathophysiological mechanisms and for the ...
... proved critically important for the discovery of pathophysiological mechanisms and for the ...
PREVALENCE OF LEFT VENTRICULAR HYPERTROPHY AND ITS
... who helped me during various phases of this work. Last but not least, I wish to express my utmost gratitude to my wife Amana, my daughters Salha and Samira and my son Imran for their constant tireless encouragement and inspiration during the dark hours of this work. ...
... who helped me during various phases of this work. Last but not least, I wish to express my utmost gratitude to my wife Amana, my daughters Salha and Samira and my son Imran for their constant tireless encouragement and inspiration during the dark hours of this work. ...
Techniques for Ventricular Repolarization Instability Assessment
... 1) Membrane Currents and AP: Establishing a relationship between ECG and AP properties can prove fundamental for a better understanding of the mechanisms underlying cardiac arrhythmias. The AP associated with each cardiac cell is the result of ion charges moving in and out of the cell through voltag ...
... 1) Membrane Currents and AP: Establishing a relationship between ECG and AP properties can prove fundamental for a better understanding of the mechanisms underlying cardiac arrhythmias. The AP associated with each cardiac cell is the result of ion charges moving in and out of the cell through voltag ...
Cellular Physiology and Biochemistr and Biochemistry
... however, the extra material surrounding the heart increases diffusion distance and hence may hamper oxygen and substrate supply to central cell layers. Nevertheless myocardial slices from fetal and neonatal hearts have been employed as scaffolds for integration of embryonic stem cell-derived cardiom ...
... however, the extra material surrounding the heart increases diffusion distance and hence may hamper oxygen and substrate supply to central cell layers. Nevertheless myocardial slices from fetal and neonatal hearts have been employed as scaffolds for integration of embryonic stem cell-derived cardiom ...
PART IV LABORATORY EXAMINATION
... When a heart muscle cell is stimulated, it depolarizes. As a result, the outside of the cell, in the area where the stimulation has occurred, becomes negative, while the inside of the cell becomes positive. This produces a difference in electrical voltage on the outside of the cell between the stimu ...
... When a heart muscle cell is stimulated, it depolarizes. As a result, the outside of the cell, in the area where the stimulation has occurred, becomes negative, while the inside of the cell becomes positive. This produces a difference in electrical voltage on the outside of the cell between the stimu ...
Ventricular fibrillation
Ventricular fibrillation (V-fib or VF) is a condition in which there is uncoordinated contraction of the cardiac muscle of the ventricles in the heart, making them quiver rather than contract properly. Ventricular fibrillation is the most commonly identified arrhythmia in cardiac arrest patients. While there is some activity, the lay person is usually unable to detect it by palpating (feeling) the major pulse points of the carotid and femoral arteries. Such an arrhythmia is only confirmed by electrocardiography. Ventricular fibrillation is a medical emergency that requires prompt Advanced Life Support interventions. If this arrhythmia continues for more than a few seconds, it will likely degenerate further into asystole (""flatline""). This condition results in cardiogenic shock and cessation of effective blood circulation. As a consequence, sudden cardiac death (SCD) will result in a matter of minutes. If the patient is not revived after a sufficient period (within roughly 5 minutes at room temperature), the patient could sustain irreversible brain damage and possibly become brain-dead, due to the effects of cerebral hypoxia. On the other hand, death often occurs if sinus rhythm is not restored within 90 seconds of the onset of VF, especially if it has degenerated further into asystole.