how the ubiquitin–proteasome system controls transcription
... destroyed by the proteasome (FIG. 2; REFS 36–38). The removal of pol II is then followed by the coordinated recruitment of the DNA-repair machinery, and repair of the damaged DNA. In this way, cells are able to use pol II to probe for DNA damage and shut down expression of the genetic information un ...
... destroyed by the proteasome (FIG. 2; REFS 36–38). The removal of pol II is then followed by the coordinated recruitment of the DNA-repair machinery, and repair of the damaged DNA. In this way, cells are able to use pol II to probe for DNA damage and shut down expression of the genetic information un ...
Document
... -function: 1. anchor integral proteins and attaches them to the cytoplasm 2. interaction with myosin = interacts with larger microfilaments made up of myosin - results in active movements within a cell (e.g. muscle cell contraction) 3. provide much of the mechanical strength of the cell – resists pu ...
... -function: 1. anchor integral proteins and attaches them to the cytoplasm 2. interaction with myosin = interacts with larger microfilaments made up of myosin - results in active movements within a cell (e.g. muscle cell contraction) 3. provide much of the mechanical strength of the cell – resists pu ...
Proteomics - University of Warwick
... An Organism is typically an individual life form composed of interdependent parts (organs). The organs have specific functions and they are composed by cells. A cell is the smallest structural and functional unit of an organ and is microscopic. Proteins do most of the work in cells and are required ...
... An Organism is typically an individual life form composed of interdependent parts (organs). The organs have specific functions and they are composed by cells. A cell is the smallest structural and functional unit of an organ and is microscopic. Proteins do most of the work in cells and are required ...
Clean Solutions Fuel Affinity Chromatography
... out non-specific proteins, the recombinant target protein can be specifically eluted by a competitor. The choice of the column matrix in this case is dependent on the selected protein tag. This should meet various requirements, such as high specificity to the matrix, simple detectability, elution wi ...
... out non-specific proteins, the recombinant target protein can be specifically eluted by a competitor. The choice of the column matrix in this case is dependent on the selected protein tag. This should meet various requirements, such as high specificity to the matrix, simple detectability, elution wi ...
Heat Shock Response and Protein Degradation
... as well as differing specificities for common target genes. These speculations have been corroborated by various recent observations. Analyses of the transcriptional properties of human HSF1 and HSF2 in yeast have identified differences in which target stress genes are induced preferentially (35). F ...
... as well as differing specificities for common target genes. These speculations have been corroborated by various recent observations. Analyses of the transcriptional properties of human HSF1 and HSF2 in yeast have identified differences in which target stress genes are induced preferentially (35). F ...
Poster - Protein Information Resource
... Name Rule Propagation Pipeline Affiliation of Sequence: Homeomorphic Family or Subfamily (whichever PIRSF is the lowest possible node) ...
... Name Rule Propagation Pipeline Affiliation of Sequence: Homeomorphic Family or Subfamily (whichever PIRSF is the lowest possible node) ...
x - Center for Eukaryotic Structural Genomics
... NMR structure determinations [1-4]. In the first stage, cloned DNA molecules coding for proteins of interest are transcribed and translated on a small scale (25 microL) to determine levels of protein expression and solubility. The amount of protein produced (typically 2-10 micrograms) is sufficient ...
... NMR structure determinations [1-4]. In the first stage, cloned DNA molecules coding for proteins of interest are transcribed and translated on a small scale (25 microL) to determine levels of protein expression and solubility. The amount of protein produced (typically 2-10 micrograms) is sufficient ...
Structural comparison of three viral fusion proteins
... regions where all three sequences overlap are 14 (orf) 18 (vaccinia) and 24 (capripox). This probably reflects the increasing difficulty in shielding the core in smaller molecules. The data base for predictive algorithms is drawn almost entirely from globular proteins, and although this may be of si ...
... regions where all three sequences overlap are 14 (orf) 18 (vaccinia) and 24 (capripox). This probably reflects the increasing difficulty in shielding the core in smaller molecules. The data base for predictive algorithms is drawn almost entirely from globular proteins, and although this may be of si ...
lecture 3
... - cis-acting (intramolecular) chaperones are relatively rare - chemical chaperones may play an important role in protecting proteins in the cell, but their extent of action is likely to be limited - organisms have evolved large families of protein molecular chaperones that have either general functi ...
... - cis-acting (intramolecular) chaperones are relatively rare - chemical chaperones may play an important role in protecting proteins in the cell, but their extent of action is likely to be limited - organisms have evolved large families of protein molecular chaperones that have either general functi ...
Explanation of Scaffold`s Display Options - Proteome Software
... question. This number is the number of assigned spectra for this protein divided by the total spectra in the sample (as seen in the Load Data View). Assigned spectra: This is the number of spectra which Protein Prophet assigns to the protein in question.The peptides represented by these spectra may ...
... question. This number is the number of assigned spectra for this protein divided by the total spectra in the sample (as seen in the Load Data View). Assigned spectra: This is the number of spectra which Protein Prophet assigns to the protein in question.The peptides represented by these spectra may ...
Document
... A major impact on any environment with Bacteria A type of virus with a highly unique structure, which injects its genome into a host, through its tail A possible alternative to Antibiotics in medicine ...
... A major impact on any environment with Bacteria A type of virus with a highly unique structure, which injects its genome into a host, through its tail A possible alternative to Antibiotics in medicine ...
Contractile Proteins - Mrs. DeNicola's Science Corner
... -They are part of what makes up our muscle fibers, along with regulatory and structural proteins -The types of contractile proteins that are in muscle fibers are actin, which is part of thin filament, and myosin, which is part of thick filament ...
... -They are part of what makes up our muscle fibers, along with regulatory and structural proteins -The types of contractile proteins that are in muscle fibers are actin, which is part of thin filament, and myosin, which is part of thick filament ...
PHD domains and E3 ubiquitin ligases: viruses make the connection
... through the multivesicular body (MVB). This structure is formed by invagination of the late-endosome membrane to generate internal vesicles into which proteins destined for the lysosome (such as MHC class I) are sorted. This sorting requires ubiquitination of the target protein and the function of V ...
... through the multivesicular body (MVB). This structure is formed by invagination of the late-endosome membrane to generate internal vesicles into which proteins destined for the lysosome (such as MHC class I) are sorted. This sorting requires ubiquitination of the target protein and the function of V ...
Membrane targeting of proteins
... 3.27 Import into mitochondria begins with signal sequence recognition at the outer membrane • Mitochondria have an inner and an outer membrane, each of which has a translocation ...
... 3.27 Import into mitochondria begins with signal sequence recognition at the outer membrane • Mitochondria have an inner and an outer membrane, each of which has a translocation ...
Document
... ORGANIC CHEMISTRY Organic compounds always contain carbon and hydrogen. Inorganic compounds typically lack carbon. ...
... ORGANIC CHEMISTRY Organic compounds always contain carbon and hydrogen. Inorganic compounds typically lack carbon. ...
Protein thermodynamics: Are native proteins
... demonstrated by showing that both the aldehyde and alcohol components could be readily exchanged. Mechanistic and mass spectrometric studies suggested that the iminium ion framed in Fig. 1b acts as the key intermediate in both aldehyde and alcohol scrambling, and found no evidence of the alternative ...
... demonstrated by showing that both the aldehyde and alcohol components could be readily exchanged. Mechanistic and mass spectrometric studies suggested that the iminium ion framed in Fig. 1b acts as the key intermediate in both aldehyde and alcohol scrambling, and found no evidence of the alternative ...
The Exocytic/Lysosomal Transport Pathway
... • Vesicle/Cargo targeting and fusion to acceptor compartment • Most regulation is mediated by cargo- and target-compartment-specific small GTPases ...
... • Vesicle/Cargo targeting and fusion to acceptor compartment • Most regulation is mediated by cargo- and target-compartment-specific small GTPases ...
Bioinformatik - Brigham Young University
... • Interacting domain pair – if at least 5 residue-residue contacts between domains (contacts – distance of less than 8 Ǻ) • Structure-structure alignments between all proteins corresponding to a given pair of interacting domains • Clustering of interface similarity, those with >50% equivalently alig ...
... • Interacting domain pair – if at least 5 residue-residue contacts between domains (contacts – distance of less than 8 Ǻ) • Structure-structure alignments between all proteins corresponding to a given pair of interacting domains • Clustering of interface similarity, those with >50% equivalently alig ...
560k ppt - UCLA.edu
... •Cycloheximide was added to prevent further protein synthesis. •After 2 h, the cells were fixed and stained with fluorescent antibodies specific for human hnRNP A or human hnRNP C. ...
... •Cycloheximide was added to prevent further protein synthesis. •After 2 h, the cells were fixed and stained with fluorescent antibodies specific for human hnRNP A or human hnRNP C. ...
Actin dynamics - Journal of Cell Science
... monomer and Arp2/3 complex (shown in red), an assembly of seven subunits including two actin-related proteins. Arp2/3 complex then initiates the growth of a new actin filament as a branch on the side of an older actin filament. The branch grows rapidly at its barbed end by addition of actin-profilin ...
... monomer and Arp2/3 complex (shown in red), an assembly of seven subunits including two actin-related proteins. Arp2/3 complex then initiates the growth of a new actin filament as a branch on the side of an older actin filament. The branch grows rapidly at its barbed end by addition of actin-profilin ...
Protein Electrophoresis
... 5 to 50 μl. It is sturdy, easy to use, highly accurate and uses standard micropipet tips. The volume is selected by twisting the top. The lightweight design and tip ejector makes operation fast & easy. A tool and instructions are included for self-calibration. ...
... 5 to 50 μl. It is sturdy, easy to use, highly accurate and uses standard micropipet tips. The volume is selected by twisting the top. The lightweight design and tip ejector makes operation fast & easy. A tool and instructions are included for self-calibration. ...
A proteomic platform that can also detect SNPs
... Purified proteins with either His 167 or Arg 167 were used to examine binding to the reagent selected against FCGR2A. The affinity for the H167R mutant is two orders of magnitude higher than that for the wildtype protein, illustrating a striking specificity among two proteins with a single amino aci ...
... Purified proteins with either His 167 or Arg 167 were used to examine binding to the reagent selected against FCGR2A. The affinity for the H167R mutant is two orders of magnitude higher than that for the wildtype protein, illustrating a striking specificity among two proteins with a single amino aci ...
Robustness of the model
... of the classes, we found that regulatory proteins were most over-represented among bottlenecks (33% vs. 21% among all nodes, p-value of one-sided Fisher’s exact test: 0.07, see Table S6). However, when we considered bottlenecks that are not hubs, coiled-coil proteins were most over-represented (25% ...
... of the classes, we found that regulatory proteins were most over-represented among bottlenecks (33% vs. 21% among all nodes, p-value of one-sided Fisher’s exact test: 0.07, see Table S6). However, when we considered bottlenecks that are not hubs, coiled-coil proteins were most over-represented (25% ...
Proteasome
Proteasomes are protein complexes inside all eukaryotes and archaea, and in some bacteria. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.