Towards the Discovery of New Antimicrobials: the Bifunctional
... [3] Zapun, A., Contreras-Martel, C., and Vernet, T. (2008). Penicillin-binding proteins and beta-lactam resistance. FEMS Microbiology Reviews, 32(2), pp.361-385. [4] Zavascki, P., Carvalhaes, G., Picão, C., and Gales, C. (2010). Mul@drug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii ...
... [3] Zapun, A., Contreras-Martel, C., and Vernet, T. (2008). Penicillin-binding proteins and beta-lactam resistance. FEMS Microbiology Reviews, 32(2), pp.361-385. [4] Zavascki, P., Carvalhaes, G., Picão, C., and Gales, C. (2010). Mul@drug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii ...
Lecture 5: Applications in Biomolecular Simulation and Drug
... The complex between the two molecules highly stimulates the response of the T-cells of the immune system. The grp94 protein alone does not have this property. The activity that stimulates the immune response is due to the ability of grp94 to bind different peptides. Characterization of peptide bindi ...
... The complex between the two molecules highly stimulates the response of the T-cells of the immune system. The grp94 protein alone does not have this property. The activity that stimulates the immune response is due to the ability of grp94 to bind different peptides. Characterization of peptide bindi ...
Name of Student: Dominik Sommerfeld
... the human genome are subjected to phosphorylation on multiple sites, and there may be in excess of 500,000 phosphorylation sites (P-sites) in the human proteome. To ensure signalling fidelity amidst the vast complement of potential substrate P-sites, protein kinases must exert specificity for their ...
... the human genome are subjected to phosphorylation on multiple sites, and there may be in excess of 500,000 phosphorylation sites (P-sites) in the human proteome. To ensure signalling fidelity amidst the vast complement of potential substrate P-sites, protein kinases must exert specificity for their ...
Expression patterns of genes encoding endomembrane proteins
... wheat cDNAs encoding three distinct proteins of the endomembrane system were cloned and characterized. The proteins encoded were homologues (i) of the ER translocon component Sec61a, (ii) the vacuolar sorting receptor BP-80 which is located in the Golgi and clathrin-coated prevacuole vesicles (CCV ) ...
... wheat cDNAs encoding three distinct proteins of the endomembrane system were cloned and characterized. The proteins encoded were homologues (i) of the ER translocon component Sec61a, (ii) the vacuolar sorting receptor BP-80 which is located in the Golgi and clathrin-coated prevacuole vesicles (CCV ) ...
Proteins Animal By-Products Seed By
... The bodies of our livestock, pets, and ourselves have many uses for proteins. Enzymes, antibodies, many hormones, and substances that help the blood to clot, are all proteins. Proteins form part of muscles and many cell structures, including the cell membrane. During the process of digestion, protei ...
... The bodies of our livestock, pets, and ourselves have many uses for proteins. Enzymes, antibodies, many hormones, and substances that help the blood to clot, are all proteins. Proteins form part of muscles and many cell structures, including the cell membrane. During the process of digestion, protei ...
Food Microbiology-Single Cell Protein-UNIT-2-2012
... those fed SMD or SC. Diet-induced accumulation of low levels of docosahexaenoic acid [22:6(n-3)] was detected only in Artemia fed the rVtg-based diets. Tilapia (Oreochromis mossambicus) larvae were fed solely yeast diets singly or in combination (d 3–22), or a staggered regimen of yeast (d 3–12) fol ...
... those fed SMD or SC. Diet-induced accumulation of low levels of docosahexaenoic acid [22:6(n-3)] was detected only in Artemia fed the rVtg-based diets. Tilapia (Oreochromis mossambicus) larvae were fed solely yeast diets singly or in combination (d 3–22), or a staggered regimen of yeast (d 3–12) fol ...
Gene7-08
... into the nucleus and RNA out of the nucleus. 6. Proteins that are actively transported into the nucleus require specific NLS sequences, which are short, but do not seem to share common features except for their basicity. 7. Proteins that are exported from the nucleus have specific NES sequences, whi ...
... into the nucleus and RNA out of the nucleus. 6. Proteins that are actively transported into the nucleus require specific NLS sequences, which are short, but do not seem to share common features except for their basicity. 7. Proteins that are exported from the nucleus have specific NES sequences, whi ...
Research Express@NCKU
... Betanodavirdae family, is the causative agent of viral nervous necrosis (fish encephalitis) that results in high mortality rates in hatchery-reared larvae and juveniles of marine fishes in Taiwan, Japan, Australia, and Europe. Betanodaviruses are neuropathogenic and inflicts conspicuous damage chara ...
... Betanodavirdae family, is the causative agent of viral nervous necrosis (fish encephalitis) that results in high mortality rates in hatchery-reared larvae and juveniles of marine fishes in Taiwan, Japan, Australia, and Europe. Betanodaviruses are neuropathogenic and inflicts conspicuous damage chara ...
Chapter 1. Introduction 1. Introduction 1.1 Peptidyl
... Galat, 1993; Rahfeld, et al., 1994a). Even though cyclophilins and FKBPs are known for several decades, the cellular function of these enzymes is not yet completely understood. They are, however, implicated in the folding of newly synthesized proteins, transport and assembly of essential cellular pr ...
... Galat, 1993; Rahfeld, et al., 1994a). Even though cyclophilins and FKBPs are known for several decades, the cellular function of these enzymes is not yet completely understood. They are, however, implicated in the folding of newly synthesized proteins, transport and assembly of essential cellular pr ...
Amino Acid Uptake for the Synthesis of Secretory Protein by the
... that mlJk proteins are of matIlID!lJ'y gland origin. Of the lactoproteins 8)1J1thesi.zed, casein IC't'OIInts for 80 per ceat or the total proteins. Mammary secretory cells synthesize e.>selltially six In8jof- II1IIJIldW'}"SJI(lclftc proteiJU Demely. tIS .. .u" ,... K-caseUIs and two odIer wbey )IJ'O ...
... that mlJk proteins are of matIlID!lJ'y gland origin. Of the lactoproteins 8)1J1thesi.zed, casein IC't'OIInts for 80 per ceat or the total proteins. Mammary secretory cells synthesize e.>selltially six In8jof- II1IIJIldW'}"SJI(lclftc proteiJU Demely. tIS .. .u" ,... K-caseUIs and two odIer wbey )IJ'O ...
Protein
... • To gain one pound muscle in 2 weeks an athlete would need an extra 7-8 g protein/day intake. – 1 oz meat, 1 cup milk, 3 slices bread. ...
... • To gain one pound muscle in 2 weeks an athlete would need an extra 7-8 g protein/day intake. – 1 oz meat, 1 cup milk, 3 slices bread. ...
realburn
... The process of protein denaturation and aggregation can be modeled as a statistical process Rate of protein unfolding similar to the Arrhenius equation As the temperature increases, a protein is unable to remain in its normal, folded conformation and begins to transition into its unfolded state. At ...
... The process of protein denaturation and aggregation can be modeled as a statistical process Rate of protein unfolding similar to the Arrhenius equation As the temperature increases, a protein is unable to remain in its normal, folded conformation and begins to transition into its unfolded state. At ...
Introduction to Proteomics
... Only “Proteomics” is the large-scale screening of the proteins of a cell, organism or biological fluid, a process which requires stringently controlled steps of sample preparation, 2-D electrophoresis, image detection and analysis, spot identification, and database searches. The core technology of p ...
... Only “Proteomics” is the large-scale screening of the proteins of a cell, organism or biological fluid, a process which requires stringently controlled steps of sample preparation, 2-D electrophoresis, image detection and analysis, spot identification, and database searches. The core technology of p ...
Protein
... Protein Digestion • The protein strand is broken and the amino acids are released. • Occurs by the protease enzymes secreted by the pancreas and GI mucosal cells. • Amino acids are absorbed, transported to cells and then used to build proteins. ...
... Protein Digestion • The protein strand is broken and the amino acids are released. • Occurs by the protease enzymes secreted by the pancreas and GI mucosal cells. • Amino acids are absorbed, transported to cells and then used to build proteins. ...
Enhanced Detection of Host-Cell Proteins in
... Host-cell proteins (HCPs) are proteins produced by the host cells during recombinant protein drug production. These HCPs contaminate the biotherapeutic drug protein at low levels (1-100 ppm) even after several steps of extensive purification [1]. Since even low level HCPs can stimulate a immunogenic ...
... Host-cell proteins (HCPs) are proteins produced by the host cells during recombinant protein drug production. These HCPs contaminate the biotherapeutic drug protein at low levels (1-100 ppm) even after several steps of extensive purification [1]. Since even low level HCPs can stimulate a immunogenic ...
Display of Artificial Scaffolding Proteins on Yeast Surface
... scaffolding proteins derived from C. thermocellum CipA on its cell surface. However, FACS analysis of yeast strains displaying the scaffolding proteins with different numbers of cohesins indicated that the expression level of the proteins decreased, as the copy number of cohesins increased. Especial ...
... scaffolding proteins derived from C. thermocellum CipA on its cell surface. However, FACS analysis of yeast strains displaying the scaffolding proteins with different numbers of cohesins indicated that the expression level of the proteins decreased, as the copy number of cohesins increased. Especial ...
news and views Mechanics of the ribosome
... 6. Garrett, R. A. et al. (eds) Ribosomes: Structure, Function, Antibiotics and Cellular Interactions (ASM, Washington DC, in the press). 7. Capel, M. S. et al. Science 238, 1403–1406 (1987). ...
... 6. Garrett, R. A. et al. (eds) Ribosomes: Structure, Function, Antibiotics and Cellular Interactions (ASM, Washington DC, in the press). 7. Capel, M. S. et al. Science 238, 1403–1406 (1987). ...
bio4751Ch15-Part2W
... G. Overview of phospholipase C-b pathway H. We can activate these pathways with drugs I. Ca++ is a ubiquitous intracellular messenger J. G-protein linked receptors required for vision and smell K. How is a response desensitized? L. Summary ...
... G. Overview of phospholipase C-b pathway H. We can activate these pathways with drugs I. Ca++ is a ubiquitous intracellular messenger J. G-protein linked receptors required for vision and smell K. How is a response desensitized? L. Summary ...
Aggresomes: A Cellular Response to Misfolded Proteins
... Endogenous PS1 is endoproteolytically processed into z27-kD NH2-terminal and 17-kD COOH-terminal fragments (Thinakaran et al., 1996). Transfection of PS1 (Thinakaran et al., 1996) or the highly homologous PS2 (Kim, 1997) into mammalian cells leads to increased steady-state accumulation of processed ...
... Endogenous PS1 is endoproteolytically processed into z27-kD NH2-terminal and 17-kD COOH-terminal fragments (Thinakaran et al., 1996). Transfection of PS1 (Thinakaran et al., 1996) or the highly homologous PS2 (Kim, 1997) into mammalian cells leads to increased steady-state accumulation of processed ...
Facilitated diffusion is a process by which molecules are
... Another type of protein embedded in the plasma membrane is a carrier protein. This protein binds a substance and, in doing so, triggers a change of its own shape, moving the bound molecule from the outside of the cell to its interior; depending on the gradient, the material may move in the opposite ...
... Another type of protein embedded in the plasma membrane is a carrier protein. This protein binds a substance and, in doing so, triggers a change of its own shape, moving the bound molecule from the outside of the cell to its interior; depending on the gradient, the material may move in the opposite ...
Facilitated diffusion is a process by which molecules are
... Another type of protein embedded in the plasma membrane is a carrier protein. This protein binds a substance and, in doing so, triggers a change of its own shape, moving the bound molecule from the outside of the cell to its interior; depending on the gradient, the material may move in the opposite ...
... Another type of protein embedded in the plasma membrane is a carrier protein. This protein binds a substance and, in doing so, triggers a change of its own shape, moving the bound molecule from the outside of the cell to its interior; depending on the gradient, the material may move in the opposite ...
Degradation of DNA damage-independently stalled RNA
... damage the cellular pathway for removal of DNA damageindependently stalled RNAPII complexes is less well understood. However, removal of persistently stalled RNAPII complexes is important as it frees the gene for subsequent polymerases and thus ensures continued transcription. In vivo transcription ...
... damage the cellular pathway for removal of DNA damageindependently stalled RNAPII complexes is less well understood. However, removal of persistently stalled RNAPII complexes is important as it frees the gene for subsequent polymerases and thus ensures continued transcription. In vivo transcription ...
Lecture 13
... • While exciting, these are often very difficult experiments, requiring a lot of time and good control experiments • The data one gets is often ambiguous, but no more so than solid state structures obtained in X-Ray crystallography • It’s crucial to differentiate between solution state and gas phase ...
... • While exciting, these are often very difficult experiments, requiring a lot of time and good control experiments • The data one gets is often ambiguous, but no more so than solid state structures obtained in X-Ray crystallography • It’s crucial to differentiate between solution state and gas phase ...
Proteasome
Proteasomes are protein complexes inside all eukaryotes and archaea, and in some bacteria. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.