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supporting cells - Daniela Sartori
supporting cells - Daniela Sartori

... Synaptic Plasticity • Repeated use of a synapse can increase or decrease its ease of transmission – = synaptic facilitation or synaptic depression – High frequency stimulation often causes enhanced excitability • Called long-term potentiation – Believed to underlie learning ...
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Neurons, Synapses, the Nervous System

... impulse) is an all-or-none response to depolarization of the nerve cell. A stimulus opens voltage-gated sodium channels and Na+ ions enter the cell, bringing the membrane potential to a positive value. In order to generate an action potential, a certain level of depolarization must be achieved, know ...
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Nervous System

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Nonsynaptic plasticity



Nonsynaptic plasticity is a form of neuroplasticity that involves modification of ion channel function in the axon, dendrites, and cell body that results in specific changes in the integration of excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs). Nonsynaptic plasticity is a modification of the intrinsic excitability of the neuron. It interacts with synaptic plasticity, but it is considered a separate entity from synaptic plasticity. Intrinsic modification of the electrical properties of neurons plays a role in many aspects of plasticity from homeostatic plasticity to learning and memory itself. Nonsynaptic plasticity affects synaptic integration, subthreshold propagation, spike generation, and other fundamental mechanisms of neurons at the cellular level. These individual neuronal alterations can result in changes in higher brain function, especially learning and memory. However, as an emerging field in neuroscience, much of the knowledge about nonsynaptic plasticity is uncertain and still requires further investigation to better define its role in brain function and behavior.
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