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chapt12_lecturenew
chapt12_lecturenew

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to specify axonal trajectories and target specificity of Jessell, 2000; Shira-
to specify axonal trajectories and target specificity of Jessell, 2000; Shira-

... provide new insight into how these pathways may operate as “choice points” between incompatible behaviors. The pathway-specific projections of Lhx6expressing neurons in the MEApd show preferential activation by reproductive olfactory cues such as female urine. In contrast, these cells appear unrespo ...
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Nonsynaptic plasticity



Nonsynaptic plasticity is a form of neuroplasticity that involves modification of ion channel function in the axon, dendrites, and cell body that results in specific changes in the integration of excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs). Nonsynaptic plasticity is a modification of the intrinsic excitability of the neuron. It interacts with synaptic plasticity, but it is considered a separate entity from synaptic plasticity. Intrinsic modification of the electrical properties of neurons plays a role in many aspects of plasticity from homeostatic plasticity to learning and memory itself. Nonsynaptic plasticity affects synaptic integration, subthreshold propagation, spike generation, and other fundamental mechanisms of neurons at the cellular level. These individual neuronal alterations can result in changes in higher brain function, especially learning and memory. However, as an emerging field in neuroscience, much of the knowledge about nonsynaptic plasticity is uncertain and still requires further investigation to better define its role in brain function and behavior.
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