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Lecture nerve
Lecture nerve

... 9. neuron is hyperpolarized – no new AP can be generated with a normal stimulus 10. all voltage-gated channels closed, Na/K pump “resets” ion distribution to resting situation ...
chapter_12 - The Anatomy Academy
chapter_12 - The Anatomy Academy

... membrane due to opening of gated Na+ channels • Na+ rushes in down concentration and electrical gradients • Na+ diffuses for short distance inside membrane producing a change in voltage called a local potential ...
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Nervous System Neuron: nerve cell, functional unit of nervous

... Purpose of the refractory period is to make the stimulus reach the end because of the potassium. Parts of axon not covered by myelin the action potential jumps Nodes of Ranvier which have voltage gated channels. This is known as the refractory period. Cell begins to Reset Once refectory, +40 mV is r ...
Slide 1 - AccessPharmacy
Slide 1 - AccessPharmacy

... Glutamatergic neurotransmission. Glutamic oxaloacetic transaminase (GOT) converts α-ketoglutarate to glutamate in mitochondria. Glutamate also forms from glutamine via mitochondrial glutaminase. Glutamate is transported into vesicles [6] by VGlut1 (or possibly other subtypes) for exocytotic release ...
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... Describe the structural and functional organization of the nervous system into Central Nervous System and Peripheral Nervous System (Afferent and Efferent Divisions). b. Describe the functional organization of the Efferent Division of the Peripheral Nervous System into Autonomic Nervous System and S ...
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...  CNS: neurons, composed of:  Cell body, contains nucleus  Axon, transmits message to next cell  Dendrites, receives messages from cells  Three classes of neurons in CNS  Afferent (sensory)  Efferent (motor)  Interneurons in CNS ...
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... • In addition to the resting (K+ leakage) channels, neurons can have a large variety of gated ion channels which will open transiently in the presence of certain stimuli or chemical signals. These gated channels may be permeable to Na+, Cl- or Ca++. • When these gated channels open, the voltage acro ...
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... little less negative than the equilibrium potential for K+ . Depolarization of a small region of an axon can be experimentally induced by a pair of stimulating electrodes that act as if they were injecting positive charges into the axon. If the depolarization is below a certain level, it will simply ...
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... of the vesicles to move to the end of the axon and discharge their contents into the synaptic cleft. Released neurotransmitters diffuse across the cleft, and bind to receptors on the other cell's membrane, causing ion channels on that cell to open. Some neurotransmitters cause an action potential, o ...
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Psych 9A. Lec. 05 PP Slides: Brain and Nervous System

... • These cells have many functions, both during development and in supporting the function of the mature nervous system. • They may also constitute a separate, slow signal system. • Oligodendrocytes: produce myelin sheaths for neuron axons (white ...
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End-plate potential



End plate potentials (EPPs) are the depolarizations of skeletal muscle fibers caused by neurotransmitters binding to the postsynaptic membrane in the neuromuscular junction. They are called ""end plates"" because the postsynaptic terminals of muscle fibers have a large, saucer-like appearance. When an action potential reaches the axon terminal of a motor neuron, vesicles carrying neurotransmitters (mostly acetylcholine) are exocytosed and the contents are released into the neuromuscular junction. These neurotransmitters bind to receptors on the postsynaptic membrane and lead to its depolarization. In the absence of an action potential, acetylcholine vesicles spontaneously leak into the neuromuscular junction and cause very small depolarizations in the postsynaptic membrane. This small response (~0.5mV) is called a miniature end plate potential (MEPP) and is generated by one acetylcholine-containing vesicle. It represents the smallest possible depolarization which can be induced in a muscle.
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